Insights from traditional fermented legumes towards the innovation of modern plant-based meat analogues.

There has been a major growth in the development of plant-based meat alternatives (PBMA) in recent years. However, current PBMA often contain ultra processed ingredients and numerous additives to be able to mimic animal-based meat (ABM) including the meaty (umami) flavour, characteristic firm/chewy structure and juicy mouthfeel. In this review, the potential of ancient fermentation techniques as a minimally processed alternative to ABM and current PBMA are explored.

Incidence and risk factors of cervical laceration following vaginal deliveries in Punakha, Bhutan.

Background: Cervical laceration is a critical health issue with significant maternal morbidity and mortality worldwide. This study aimed to evaluate the incidence and risk factors of cervical laceration among mothers following spontaneous vaginal delivery in Punakha, Bhutan.

Methods: This retrospective study using a population-based sampling technique included 180 mothers who had spontaneous vaginal delivery.

Harnessing Lithiophilic Hetero-Interfacial Chemistry for Stable Lithium Metal Batteries with Low Negative/Positive Capacity Ratios.

Lithium (Li) metal batteries hold great promise for next-generation energy storage due to their high energy density. However, their application is hindered by uncontrollable Li plating/stripping, leading to limited cycle life, especially under practical conditions with a low negative/positive (N/P) capacity ratio. Here, it is demonstrated that stable cycling of low N/P ratio Li metal batteries can be realized by harnessing hetero-interfacial redox chemistry to regulate Li nucleation and deposition behavior.

Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.

Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.

Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.

Expanding the Ingredient Basket in Aquaculture: Growth Performance and Feed Utilization of Australian Hybrid Abalone () Fed Methanotrophic Single Cell Protein.

There is growing interest in the use of single cell proteins (SCPs) derived from methanotrophic bacteria for inclusion in aquafeed to reduce reliance on other, potentially less sustainable proteins. This two-part experiment aimed to investigate first (i) the dose effect of replacing soy protein concentrate with SCP in Australian hybrid abalone diets () and second, (ii) the potential for improved palatability of the SCP by using commercially produced liquid protein hydrolysate (PH). This was assessed in a 2 × 2 factorial experimental design.

Cortical Activation and Functional Connectivity Response to Different Interactive Modes of Virtual Reality (VR)-Induced Analgesia: A Prospective Functional Near-Infrared Spectroscopy (fNIRS) Study.

Aim: Virtual reality (VR) can be analgesic through intercortical modulation. This study investigated neural activities and correlates during different interactive modes.

Methods: Fifteen healthy participants (4M, 11F, age 21.

Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling.

Background: Diabetic wounds pose significant clinical challenges due to impaired healing processes, often resulting in chronic, nonhealing ulcers. Asiaticoside (AC), a natural triterpene derivative from , has demonstrated notable anti-inflammatory and wound-healing properties. However, the synergistic effects of nitric oxide (NO)-a recognized promoter of wound healing-combined with AC in treating diabetic wounds remain inadequately explored.

Dog agility tunnel risks for incidents.

Background: Flexible tunnels are the second most common obstacle on all dog agility courses, surpassed only by jumps. There has been a lot of debate and concern regarding risk factors associated with slips, falls and delayed exits (unseen slips, missteps, trips, falls). However, only one study was found which focused on the tunnel-related injuries, and it relied on handler reporting and did not consider base rates of the risk factors.

A N-of-1 social network approach to study the social dynamics of alcohol consumption.

Introduction: The aim of this study was to investigate how the dynamics of the social environment impacted the alcohol consumption of individuals who self-identified as heavy drinkers.

Methods: A mixed methods approach including N-of-1 study with daily Ecological Momentary Assessment (EMA) followed by a social network egonet interview. Qualitative data was analysed using deductive and inductive approaches.

Cardiovascular Risk and Plasma N-terminal Pro-B-type Natriuretic Peptide in Adults With Resistance to Thyroid Hormone β.

Purpose: People with resistance to thyroid hormone due to defective thyroid receptor β (RTHβ) exhibit adverse cardiovascular outcomes and premature mortality. Whether this reflects increased global cardiovascular disease (CVD) risk or hyperthyroxinemia-associated effects on cardiac rhythm and contractility is unknown. We determined CVD risk and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations as a marker of reduced cardiac function in 99 individuals (mean age 41 years, 37% males) with RTHβ.

Secondary Meniere's Syndrome Following Excessive Noise Exposure.

Background: The effects of noise on the vestibular and balance function are under-studied. Studies have demonstrated that like the cochlea, the otolith organs are also sensitive to sound but the exact mechanism is unclear. Both impulse and continuous noise exposure may damage the cochlear and/or vestibular organ and lead to the formation of endolymphatic hydrops.

Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial.

Background: In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD.

Health system characteristics and evidence-based asthma care.

Asthma is a common and complex syndrome, and a major cause of morbidity and healthcare costs. Clinicians have an array of evidence-based investigations and effective interventions at their disposal, but outcomes have not improved as much as trial evidence would suggest they could. This article discusses drivers behind this discrepancy using illustrative examples to highlight information gaps and barriers that impair the delivery of community and emergency asthma care and appropriate referral to specialist asthma services.

Miliary Mesothelioma.

Miliary spread of mesothelioma is a rare but important manifestation of late-stage disease, likely due to hematogenous dissemination. This case highlights characteristic CT imaging findings, emphasizing the need for awareness among clinicians and radiologists. Recognizing this pattern can aid in diagnosis, prognostication, and appropriate referral for palliative management.

Evidence and Gap Map of Whole-School Interventions Promoting Mental Health and Preventing Risk Behaviours in Adolescence: Programme Component Mapping Within the Health-Promoting Schools Framework: An evidence and gap map.

Adolescence is a vulnerable period for the onset of mental disorders and risk behaviours. Whole-school interventions hold vast potential in improving mental health and preventing risk behaviours in this developmentally-sensitive cohort. Modelled on the World Health Organisation's Health-Promoting Schools Framework, whole-school interventions aspire for change across eight domains: (i) school curriculum, (ii) school social-emotional environment, (iii) school physical environment, (iv) school governance and leadership, (v) school policies and resources, (vi) school and community partnerships, (vii) school health services and (viii) government policies and resources.

Performance of ambiguity-resolved detector for GNSS mixed-integer model.

Teunissen (J Geod 98(83):1-16, 2024) proposed the ambiguity-resolved (AR) detection theory for GNSS mixed-integer model validation. In this contribution, we study the performance of the AR detector through analysis and simulation experiments and compare it with the ambiguity-float (AF) and ambiguity-known (AK) detectors. We describe how the detectors can be implemented and how to evaluate their performance by computing the power as functions of the model misspecifications' size.

Applying first & second harmonic spectral phasor analysis on a single-wavelength calcium fluorophore.

Ratiometric and single-wavelength fluorophores are limited in their ability to provide basal level activity prior to treatment. This study presents a novel approach to characterise cell-wide basal activity of calcium using first and second harmonic spectral phasor analysis. Cells stained with the single-wavelength calcium fluorophore Oregon Green™ BAPTA 1-AM exhibited significant differences in wavelength or width in the nucleus, cytoplasm and membrane under basal conditions.

Volunteer Experiences of a School-Based Volunteer Program.

Issue Addressed: Individuals engage in volunteer activities due to a range of intrinsic, extrinsic, and altruistic factors; and this can have a positive impact on their subjective wellbeing. Within a school context, mentoring programs can connect adult volunteers with students, to provide social and/or academic support; however, evaluation data related to these programs is limited and often focused on student perspectives. This paper explores EdConnect volunteers' perspective on volunteering in primary and secondary schools in Western Australia and Victoria.

Outcomes of Fontan operation in patients with conotruncal anomalies from Australia and New Zealand Fontan Registry: a review of 1835 patients.

Objectives: The impact of conotruncal anomalies (CTAs), including tetralogy of Fallot, truncus arteriosus, ventriculo-arterial discordance, double outlet right ventricle (DORV), and interrupted aortic arch type B, on long-term outcomes remains poorly described in the Fontan cohort. We sought to review the outcomes of Fontan patients with conotruncal anomalies in Australia and New Zealand.

Methods: We reviewed the data from 1835 patients who underwent a Fontan operation between 1975 and 2023 from the Australia and New Zealand Fontan Registry.

Cerebral Edema Progression and Outcomes in Large Infarct Patients Undergoing Endovascular Thrombectomy.

Objective: The goal was to analyze the progression of cerebral edema post-endovascular thrombectomy (EVT) in large infarcts and its association with functional outcomes.

Methods: A secondary analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core trial was conducted in patients with large ischemic cores randomized to receive either EVT or medical management (MM) alone. Patients who had follow-up imaging within 7 days post-randomization were involved.

A systematic review of prevention strategies for type 2 diabetes in First Nations children and young people.

Introduction: There is a high prevalence of type 2 diabetes (T2D) in First Nations populations worldwide, increasingly at younger ages. This review aims to identify interventions for the prevention of T2D in First Nations children and young people aged 4-25 years.

Methods: A systematic search of both published and unpublished literature until March 2024 was performed using 15 electronic databases, including MEDLINE, CINAHL, EMBASE, Scopus, Cochrane Library, ATSIHealth, OpenGrey and specific First Nations databases.

Similar Return-to-Sports After Anterior Cruciate Ligament Reconstruction With or Without Meniscal Repair in Skeletally Immature Patients: A Prospective, Comparative Cohort Study.

Background: Pediatric anterior cruciate ligament reconstruction (ACLR) in skeletally immature patients is still controversially debated, with several gaps in its literature. More information is needed about the role of concomitant meniscal injuries in postoperative outcomes and return to pre-injury sports level (RTS).

Methods: Fifty skeletally immature patients who underwent ACLR were enrolled prospectively: 21 had meniscal injury additionally, and 29 did not.

Enhanced imaging of porcine thoracic aorta vasa vasorum with contrast micro-computed tomography.

The vasa vasorum (VV) have gathered considerable interest over the last decade due to its role in vascular wall biology and pathology; however, while the coronary VV are relatively well studied, the anatomy of peripheral VV, such as those of the aorta, remains poorly described, hampering knowledge of their role in peripheral vascular diseases. Through careful retrieval of the porcine thoracic aorta and successful microthrombi removal, the thoracic aorta was perfused with BriteVu™ followed by micro-computed tomography (micro-CT) scanning to image the VV and obtain a 3D reconstruction. We used commercially available software and its thresholding algorithms.