Closing the gap in kidney disease: validating the reporting of Aboriginal and/or Torres Strait Islander identification in a clinical quality registry using linked data.

Objective: To examine the accuracy of the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), the population-based clinical quality registry for people with kidney failure, in identifying Aboriginal and/or Torres Strait Islander people.

Design: Population-based cohort study of reporting accuracy.

Setting: New South Wales, 2006-2020.

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8 T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction.

Apoptosis is crucial for maintaining internal homeostasis. Apoptotic vesicles (ApoVs) derived from mesenchymal stem/ stromal cells (MSCs-ApoVs) as natural lipid nanoparticles are attractive candidates for the next generation of immunotherapies. However, the therapeutic potential of MSCs-ApoVs in managing hypersensitivity reactions mediated by CD8 T cells remains elusive.

Patients' perspectives of receiving an early vocational rehabilitation following major traumatic injury.

Purpose: Return to work (RTW) after a major traumatic injury (MTI; traumatic brain injury, spinal cord injury, multi-trauma orthopaedic injury) is an important rehabilitation outcome. This study aimed to explore the experience of early vocational rehabilitation (EVR) after MTI, and RTW barriers/facilitators.

Methods: Adopting a qualitative design, 24 people with MTI were interviewed about participating in the Early Intervention Vocational Rehabilitation Service (EIVRS).

Applied sports science and medicine for female cricket players: Systematic scoping review.

This review mapped currently available sports science and sports medicine (SSSM) research specific to female cricket players. Original research was included if data on female cricket players was presented, all ages and levels worldwide, from the earliest records to 19 January 2025. Databases searched included MEDLINE, SPORTDiscus, EBSCOhost, ProQuest Health, ScienceDirect, Medical Complete, and Scopus, along with trial registers and grey literature.

Children with high actual and perceived motor skill competence are more physically active: A pooled latent profile analysis of cross-sectional data.

The aim was to determine profiles according to actual and perceived motor competence and provide a comparison of profiles according to moderate-to-vigorous-intensity physical activity (MVPA) in children. Cross-sectional data were pooled from four Australian studies (481 children, 54.5% boys; 3.

Reciprocal associations between trajectories of physical activity and physical function among older women: findings from the Australian Longitudinal Study on Women's Health.

Background: While physical activity (PA) is known to improve physical function (PF), and functional decline impacts the capacity to engage in PA, the reciprocal relationship between PA and PF remains unclear.

Methods: Data were from participants in the 1921-26 cohort of the Australian Longitudinal Study on Women's Health (N=8,238). PA and PF were assessed at three-year intervals from 1999 (73-78y) to 2011 (85-90y).

Validity and reliability of a novel impulse-based method to analyse human striking performance.

We investigated the criterion validity and within- and between-day reliability of a novel method for human striking performance assessment. The Impulse Block Method allows the measurement and calculation of a range of striking variables using a load cell incorporating an impact absorption block and laser gate timer. To assess the criterion validity, we performed repeated drop tests and compared the relationship and agreement between predicted and measured velocity and initial momentum (calculated from impulse) with predicted values using linear regression and Bland-Altman plots (Experiment 1).

Evaluating Pelvic Floor Dysfunction in Female Horse Show Jumpers Using the Australian Pelvic Floor Questionnaire.

BACKGROUND Pelvic floor dysfunction (PFD) significantly reduces quality of life. During horseback riding, the movement of the horse's back affects the tension of the pelvic floor muscles. This study aimed to compare reported symptoms of pelvic floor dysfunction in women with past, current, and no history of horse show jumping.

Strategies used by organisms to survive very cold climates - student's guide.

We briefly examine how cold-hardiness in general, including freeze-tolerance, freeze-avoidance and dehydration strategies allow survival in cold climates, through the eyes of some specific insects and fish. Strategies do vary with geography and latitude, even between two types of insects living in the same area. We look at ice nucleation proteins to enhance freezing and antifreeze proteins to help avoid ice formation or, in some cases, to hinder what is known as recrystallization, as a frozen organism thaws.

Economic returns on investing in early childhood development in Vietnam: a cost-benefit analysis.

Background: Economic evidence on the long-term benefits of investing in early childhood development is limited. This study aimed to estimate the potential long-term economic benefits of an early childhood development intervention 'Learning Clubs' in Vietnam.

Methods: We conducted a cost-benefit analysis to estimate the costs and benefits of the intervention compared to the standard of care from a limited societal perspective.

The feasibility and acceptability of an online mindfulness-based stress reduction program for chronic musculoskeletal pain: protocol for a pilot randomised controlled trial.

Background: Chronic musculoskeletal pain conditions affect millions of people worldwide and place a significant burden on individuals and the healthcare systems. Managing chronic musculoskeletal pain requires a multidisciplinary approach that considers biological, psychological, and social factors. However, access to multidisciplinary pain care is challenging, and long wait times can lead to increased stress and health deterioration.

The National Paediatric Applied Research Translation Initiative (N-PARTI): using implementation science to improve primary care for Australian children with asthma, type 1 diabetes, and infections.

General practice-based care for Australian children is facing low levels of clinical guideline adherence particularly in three key areas: asthma, type 1 diabetes and antibiotic use. We offer an implementation science-informed position paper, providing a broad overview of how we aim to address this issue. This is the co-designed National Paediatric Applied Research Translation Initiative (N-PARTI), a bespoke, three-phased research solution by deploying mixed methods, simulation and scale-up of evidence into practice.

Capturing sexual orientation and gender identity information in electronic medical records to inform the person-centred care of sexual and gender minority people.

Background: The healthcare disparities of sexual and gender minority (SGM) people are globally recognised. Research from the United States has advocated for sexual orientation and gender identity (SOGI) information capture via the electronic medical record (EMR) to support the generation of knowledge regarding SGM people's healthcare needs and the appropriate care for this population. In November 2022, The Royal Melbourne Hospital (RMH) enabled the SOGI capture EMR functionality.

A scoping review of digital health technologies in multimorbidity management: mechanisms, outcomes, challenges, and strategies.

Introduction: Multimorbidity amplifies healthcare burdens due to the intricate requirements of patients and the pathophysiological complexities of multiple diseases. To address this, digital health technologies play a crucial role in effective healthcare delivery, requiring comprehensive evidence on their applications in managing multimorbidity. Therefore, this scoping review aims to identify various types of digital health technologies, explore their mechanisms, and identify barriers and facilitators within the context of multimorbidity.

Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

In the last two decades, novel and promising cell-based therapies have populated the treatment landscape for haematological tumors. However, commonly exploited T and NK cell-based therapies show limited applicability to solid tumors. This is mainly given by the impaired tumor trafficking capability and limited effector activity of these cells within a highly immunosuppressive tumor microenvironment.

Movimente program: effectiveness and moderators of a cluster-randomized controlled trial on self-reported physical activity among Brazilian adolescents.

Background: School-based intervention are needed due to the low levels of physical activity among adolescents.

Objective: To evaluate a school-based intervention's effectiveness and potential sociodemographic moderators on physical activity (PA) among Brazilian adolescents.

Design: The Movimente Program was a cluster randomized controlled trial conducted at six elementary schools in southern Brazil in 2017.

Global, regional, and national burden of kidney cancer and attributable risk factors in adults aged 65 years and older from 1990 to 2021 and projections to 2040.

Background: Identifying the past and future burden of kidney cancer (KC) and its temporal trends among older adults (≥ 65 years) at global, regional, and national levels is critical for effective prevention strategies.

Methods: The age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were calculated using data from the Global Burden of Disease (GBD) study from 1990 to 2021. These indicators were stratified by sex, age, and socio-demographic index (SDI).

Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.

Background: Previous studies have shown that the referral situation after cognitive screening is not optimistic. However, little is known about the situation in China. The current study assessed the cognitive function of older adults with an Eight-item Ascertain Dementia (AD8) score of ≥ 2 in a community health center and investigated their willingness to accept referrals.

The effect of 5% and 10% povidone-iodine antiseptic concentrations on postoperative sensorineural hearing loss in tympanoplasty: a triple-blind randomized clinical trial.

Purpose: To evaluate the ototoxicity of povidone iodine (PVP-I) at concentrations of 5% and 10% during tympanoplasty by assessing frequency-specific audiometric outcomes and graft success rates in a large cohort of patients.

Methods: This prospective, triple-blinded, randomized clinical trial enrolled 542 patients undergoing primary tympanoplasty. After excluding patients for inadequate follow-up, 204 ears received 10% PVP-I and 199 ears received 5% PVP-I.

Forb diversity globally is harmed by nutrient enrichment but can be rescued by large mammalian herbivory.

Forbs ("wildflowers") are important contributors to grassland biodiversity but are vulnerable to environmental changes. In a factorial experiment at 94 sites on 6 continents, we test the global generality of several broad predictions: (1) Forb cover and richness decline under nutrient enrichment, particularly nitrogen enrichment. (2) Forb cover and richness increase under herbivory by large mammals.

ICU requirements.

This section outlines the essential requirements for managing trauma patients in ICUs across Europe. It emphasizes the need for ICU accreditation at the highest national level and highlights criteria, including staffing, equipment, training programmes, protocols, and documentation for quality control. Key requirements encompass 24/7 admission capability, trained staff, multidisciplinary rounds, specialised observation beds, organ donation programmes, and participation in trauma resuscitations and hospital disaster planning.

Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes.

Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels. Clusters fall into two types: "non-diabetogenic hyperinsulinemia," where clusters are not associated with increased T2D risk, and "diabetogenic hyperinsulinemia," where T2D associations are driven by body fat distribution, liver function, circulating lipids, or inflammation.