Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach.

Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy, and cardiovascular disease. Aldose reductase (AR), a key enzyme in the polyol pathway, is an important therapeutic target for managing these complications.

Novel technique and outcomes of umbilical reconstruction during cytoreductive surgery; a multi-centre study.

Background: The goal of cytoreductive surgery for peritoneal malignancy is to remove all macroscopic disease, which occasionally requires the excision of the umbilicus. While the absence of the umbilicus can be aesthetically undesirable for patients, umbilical reconstruction is rarely performed due to the perceived complexity and increased risk of wound infections (Sakata et al. in Colorectal Dis 23:1153-1157, 2021).

Shallow groundwater near a deep-well CO storage site-15 years of stable water quality for agricultural use.

Injecting CO into deep geological formations can be an effective carbon removal and storage technology to mitigate global climate change. Interaction of injected CO with rock formations changes pH and hydrochemistry within the deep injection zone (> 800 m depth). However, cap rocks and multiple tight aquitards typically act as barriers to protect the shallow aquifer from changes in the injection zone.

Composite Primary Outcomes Reported in Studies of Critical Care: A Scoping Review.

Objective: Composite primary outcomes (CPO) (incorporating both mortality and non-mortality outcomes) offer several advantages over mortality as an outcome for critical care research. Our objective was to explore and map the literature to report on CPO evaluated in critical care research.

Data Sources: PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Scopus, and Cochrane Library from January 2000 to January 2024.

Lived experiences of empowerment in parents of trans children and adolescents.

The construct of empowerment is associated with beneficial outcomes in numerous populations with well-being across multiple domains. Within families, empowerment has been found to be related to both parent and child well-being. As such, empowerment appears to be a promising concept to support parents of young (< 18 years) trans and gender diverse children and adolescents; however, what empowerment means for parents of trans children and adolescents is not known.

Digestion of food proteins: the role of pepsin.

The nutritive value of a protein is determined not only by its amino acid composition, but also by its digestibility in the gastrointestinal tract. The interaction between proteins and pepsin in the gastric stage is the first step and plays an important role in protein hydrolysis. Moreover, it affects the amino acid release rates and the allergenicity of the proteins.

Ag(I)-promoted fragment coupling of peptide thioamides.

Despite advances in solid phase peptide synthesis and peptide ligation, challenges remain in the assembly of polypeptides through coupling of peptide fragments. Herein we describe a new method for peptide fragment coupling employing the Ag(I)-promoted transformation of peptide thioamides. This process proceeds an isoimide-tethered intermediate, which undergoes an O-N acyl transfer to generate the polypeptide.

Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression-Quantitative Trait Loci.

Asthma is a genetically complex inflammatory airway disease associated with over 200 Single nucleotide polymorphisms (SNPs). However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct expression quantitative trait loci (eQTL) analysis using a meta-analysis of nasal and lung samples.

A Systematic Review of International Bereavement Models of Care and Implementation Barriers and Facilitators.

Bereavement care can facilitate adjustment to death and reduce immediate distress and long-term morbidity, mortality and health service utilisation. This systematic review aimed to identify international models of bereavement care, and barriers and facilitators to implementing such models. A systematic search of MEDLINE, Embase, CINAHL and PsycINFO identified 64 studies for inclusion.

Australian Community Pharmacists' Preparedness to Offer and Discuss Hepatitis C Testing and Treatment With Pharmacy Clients: A Representative Cross-Sectional Survey.

The World Health Organisation (WHO) has set goals to eliminate hepatitis C (HCV) as a global health threat by 2030. To meet this goal, Australia must increase testing and diagnosis, including expanding access to care through community pharmacists. This study aims to explore community pharmacists' preparedness to discuss and offer HCV testing and treatment.

Strategic Inhibition of CHRM Autoantibodies: Molecular Insights and Therapeutic Potentials in Long COVID.

In addition to the conventional symptoms reported for COVID-19, it is becoming increasingly clear that patients with long COVID are exhibiting new symptoms due to the emergence of autoantibodies against G-protein-coupled receptors, among which human muscarinic cholinergic receptors (CHRMs) have been prominently reported. With a chronic condition such as long COVID, additional symptoms caused by anti-CHRM autoantibodies (AAbs) have proven to be an added burden on these patients. The origins of these AAbs, their interactions with, and effects on the function of neural and non-neural cells within the nervous system have remained unknown.

Does Self-Compassion Expressive Writing Benefit People With an Ostomy? A Randomized Controlled Trial.

Purpose: The purpose of this study was to investigate whether a self-compassion expressive writing activity could improve psychological well-being in people with an ostomy, as assessed by changes in body image distress, ostomy-specific quality of life (QOL), self-compassion, and dispositional disgust.

Design: Randomized controlled trial design was used.

Subjects And Setting: The sample comprised 175 English-speaking patients over 18 years of age with a fecal or urinary ostomy; all participants resided in Australia and New Zealand.

Visual Stimulus Materials Used in Spoken Narrative Discourse Elicitation After Traumatic Brain Injury: A Scoping Review.

Purpose: Management of discourse is acknowledged as a critical component of speech-language pathology practice with cognitive communication after traumatic brain injury (TBI). This scoping review aimed to collate the visual materials that are being used in empirical research for spoken narrative elicitation post-TBI, in both assessment and treatment contexts. We aimed to examine the format, structure, and sources for visuals used.

Low-vibration cryogenic test facility for next generation of ground-based gravitational-wave observatories.

We present the design and commissioning of a cryogenic low-vibration test facility that measures displacement noise from a gram-scale silicon cantilever at the level of 10-16m/Hz at 1 kHz. This sensitivity is necessary for future tests of thermal noise models on cross sections of silicon suspension samples proposed for future gravitational-wave detectors. A volume of ∼36 l is enclosed by radiation shields cooling an optical test cavity that is suspended from a multi-stage pendulum chain providing isolation from acoustic and environmental noise.

The Effect of Being Born Moderate-to-Late Preterm on Lung Function and Respiratory Morbidity at 9 to 10 Years of Age.

The effect of moderate-late preterm (MLP; 32 to 36 completed weeks' gestation) birth on childhood respiratory health is unclear. To assess the effect of being born MLP, compared with being born at term (≥37 completed weeks' gestation), on lung function and respiratory morbidity at 9-10 years of age. Prospective cohort of children born MLP or at term at the Royal Women's Hospital, Victoria, Australia.

Post-exercise neural plasticity is augmented by adding blood flow restriction during low work rate arm cycling.

Blood flow restriction (BFR) combined with low work rate exercise can enhance muscular and cardiovascular fitness. However, whether neural mechanisms mediate these enhancements remains unknown. This study examined changes in corticospinal excitability and motor cortical inhibition following arm cycle ergometry with and without BFR.

Are we maintaining minimal residual disease in myeloma?

Minimal residual disease (MRD) has emerged as an important prognostic maker in patients with multiple myeloma at different stages of their treatment. Moreover, it is being increasingly incorporated as an endpoint in various clinical trials. Since maintenance therapy is an integral part of myeloma treatment, especially in the upfront setting post autologous transplantation, it is imperative to understand the role of MRD testing in the maintenance stetting.

Developing an Online Education Resource to Enhance Physical Therapists' Use of Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, and Other Related Identities Affirming Care: A Mixed Methods Study.

Introduction: The objective of this study is to develop and evaluate an evidence-based, clinically relevant, and user-friendly eLearning resource to facilitate the provision of safe and affirming physical therapy services for individuals with lesbian, gay, bisexual, transgender, queer, intersex, and other related identities or experiences (LGBTQIA+).

Review Of Literature: When accessing physical therapy, individuals who are LGBTQIA+ can experience assumptions, discrimination, discomfort, and encounter health professionals who lack knowledge about LGBTQIA+ health.

Subjects: Nine consumers and end-users participated in codesign and 20 physical therapists (evaluated the resource).

On the Mechanism of Light-Driven O Evolution by the Mn(III) Complex [Mn(salpd)(OH)] and Quinone.

In this study, we apply TD-DFT and DFT calculations to explore the mechanistic details of O evolution in an artificial system that closely resembles Photosystem II (PSII). The reaction involves mononuclear Mn(III) complex [Mn(salpd)(OH)] and -benzoquinone under light-driven conditions. Our calculations reveal that the Schiff-base ligand salpd plays a crucial role in several key steps of the reaction, including the light-mediated oxidation of [Mn(salpd)(OH)] to [Mn(salpd)(OH)] by -benzoquinone, the subsequent oxidation of [Mn(salpd)(OH)] to the key Mn(V) intermediate [Mn(salpd)(O)], and the critical O-O bond formation step.

Undescribed Hitherto Universal Properties of Isotherms of Excess Adsorption of Liquids and Gases. Connection of Peculiar Points of an Isotherm with Extremums of Its Curvature.

In the proposed paper, a new result is presented, which is as follows: the point on the equilibrium excess adsorption isotherm at which the rate of increase of concentration of a component in the adsorption phase reaches its mean value is the point at which the curvature of the isotherm takes its extreme value. This regularity also holds in the case of the adsorption of gases. This result is confirmed and valid for isotherms of various types.

Medication Management of Patients With Cancer Undergoing Surgery From Preadmission to Discharge: A Mixed-Methods Systematic Review.

Aim(s): To identify and synthesise available evidence about regular medication management processes, from preadmission to discharge from hospital, in patients with cancer undergoing surgery.

Design: Mixed-methods systematic review.

Methods: Studies published from inception of each database until February 2023 were screened, utilising four main search concepts.

Characterization of academic output (h-index) by Australian urologists according to gender and rurality.

Background: As the number of practicing female urologists in Australia continues to increase alongside the academic development of the specialty, it is essential to examine how gender and rurality impact academic performance and expectations. This study aims to assess differences in h-index related to both gender and rurality among Australian urologists.

Methods: We identified all active, practicing Australian urologists through the Urological Society of Australia and New Zealand (USANZ) membership database.