The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome.

Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane-impermeant biotin to label and capture the surface-accessible proteome in the neo-native (intact) heart. Using quantitative proteomics, we identified 701 heart cell surfaceome accessible by the coronary artery, including receptors, cell surface enzymes, adhesion and junctional molecules.

Carbon Dioxide Upgrading to Biodegradable Plastics through Photo/Electro-Synthetic Biohybrid Systems.

The escalating emissions of anthropogenic carbon dioxide (CO) and the pervasive issue of nondegradable plastic pollution underscore dual urgent challenges in pursuit of a sustainable society. Achieving such sustainability in the plastic industry, while effectively addressing these environmental concerns, necessitates the development and implementation of innovative strategies for the synthesis of biodegradable polymers utilizing CO as feedstocks. The technologies not only facilitate the mitigation of elevated atmospheric CO concentrations but also introduce a renewable carbon resource for polymer manufacturing.

Phenobarbital toxicosis in a pied butcherbird, Cracticus nigrogularis.

A wild, adult male pied butcherbird (Cracticus nigrogularis) accidentally ingested 263 mg/kg of oral phenobarbital. Pronounced sedation was observed by 30 mins, followed by altered consciousness, marked ataxia and increased respiratory effort. The serum phenobarbital level on admission to a wildlife hospital was 84.

Reference Values of Handgrip and Lower Extremity Strength for Vietnamese Men and Women: The Vietnam Osteoporosis Study.

Background: Falls and sarcopenia are significant public health issues in Vietnam. Despite muscle strength being a critical predictor for these conditions, reference data on muscle strength within the Vietnamese population are lacking.

Purpose: To establish the reference ranges for muscle strength among Vietnamese individuals.

Influence of Ni on carbon nanotube production with Fe-based catalysts.

This study investigates the role of Ni in CNT production using Fe-based catalysts. Among the various catalysts used, such as 40Fe-0Ni, 40Fe-1Ni, 40Fe-3Ni, 40Fe-5Ni, 40Fe-7Ni, and 40Fe-10Ni, the 40Fe-5Ni catalyst achieved a notable yield of 5.80 gC per g metal, which is higher than the 1.

Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network.

Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and supramolecular interactions. In this communication, we expand the capabilities of covalent poly(ethylene glycol) (PEG) networks through co-assembly of supramolecular peptide nanofibers.

Multilingualism and developmental language disorder in Southeast Asian speech-language pathology practice: An international survey.

Purpose: This study aims to explore the current practices and challenges faced by speech-language pathologists in three Southeast Asian countries (Malaysia, Indonesia, and Vietnam) in assessing and treating multilingual children with developmental language disorder.

Method: A survey was designed and administered to 110 speech-language pathologists across Malaysia, Indonesia, and Vietnam. The survey contained 60 questions on current practices and knowledge of existing resources for assessing and treating multilingual children with developmental language disorder.

Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents.

Background And Aim: Cannabis use disorder (CUD) is strongly influenced by genetic factors; however the mechanisms underpinning this association are not well understood. This study investigated whether a polygenic risk score (PRS) based on a genome-wide association study for CUD in adults predicts cannabis use in adolescents and whether the association can be explained by inter-individual variation in structural properties of brain white matter or risk-taking behaviors.

Design And Setting: Longitudinal and cross-sectional analyses using data from the IMAGEN cohort, a European longitudinal study integrating genetic, neuroimaging and behavioral measures.

Barriers and Enablers of Primary Healthcare Professionals in Health Research Engagement: A Systematic Review of Qualitative Studies.

Health professional engagement ensures relevant, clinically focused research that informs evidence-based care. Research shows health professionals may not engage optimally in research. Understanding barriers and enablers influencing participation is necessary to enhance engagement.

Provided and received positive and negative social control, relationship satisfaction, and sedentary behavior in parent-child dyads.

Background: The close relationship processes and health model and the dyadic health influence model posit that relationship beliefs (eg, relationship satisfaction) and influence strategies (eg, provision and receipt of positive and negative social control) mediate health behavior change. However, evidence for such mediation in parent-child dyads is limited.

Purpose: Two complementary mediation hypotheses were tested: (1) social control forms indirect relationships with sedentary behavior (SB), via relationship satisfaction acting as a mediator; and (2) relationship satisfaction forms indirect relationships with SB, with social control operating as a mediator.

Genotyping as Part of Routine Clinical Care-The Outcomes for a Large Paediatric Vascular Anomaly Cohort.

We describe the phenotypic and genotypic spectrum of patients with vascular anomaly (VA) in a paediatric multi-disciplinary VA clinic. We measured the clinical utility of genotyping by comparing pre and posttest diagnosis and management. A 46-month retrospective analysis occurred for 250 patients offered genetic testing in the VA clinic.

Substance use and psychiatric outcomes following substance use disorder treatment: An 18-month prospective cohort study in Chile.

Background And Aims: Evidence from high-income countries has linked duration and compliance with treatment for substance use disorders (SUDs) with reductions in substance use and improvements in mental health. Generalizing these findings to other regions like South America, where opioid and injection drug use is uncommon, is not straightforward. We examined if length of time in treatment and compliance with treatment reduced subsequent substance use and presence of psychiatric comorbidities.

Comparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin.

Western flower thrips, Frankliniella occidentalis (Thysanoptera: Thripidae) is an invasive agricultural pest with developed resistance to abamectin in some strains due to frequent treatment with the pesticide. In this study, we examined differentially expressed proteins (DEPs) between abamectin-resistant (Aba; under abamectin selective pressure) and susceptible strains (Aba; without abamectin selective pressure) of F. occidentalis.

Patient Experiences of Receiving Stroke Discharge Information in Accordance With Preferences.

Aims: To examine survivors' experiences of discharge information including risk communication after hospitalisation for a stroke and the characteristics associated with receiving information in accordance with their preferences.

Background: With advances in acute stroke care and an ageing population, the number of survivors of stroke is increasing. It is important that healthcare providers ensure patients have adequate information after a stroke-related hospitalisation.

Circular mRNA Vaccine against SARS-COV-2 Variants Enabled by Degradable Lipid Nanoparticles.

The emergence of mRNA vaccines offers great promise and a potent platform in combating various diseases, notably COVID-19. Nevertheless, challenges such as inherent instability and potential side effects of current delivery systems underscore the critical need for the advancement of stable, safe, and efficacious mRNA vaccines. In this study, a robust mRNA vaccine (cmRNA-1130) eliciting potent immune activation has been developed from a biodegradable lipid with eight ester bonds in the branched tail (AX4) and synthetic circular mRNA (cmRNA) encoding the trimeric Delta receptor binding domain of the SARS-CoV-2 spike protein.

Two decades of advances in sequence-based prediction of MoRFs, disorder-to-order transitioning binding regions.

Introduction: Molecular recognition features (MoRFs) are regions in protein sequences that undergo induced folding upon binding partner molecules. MoRFs are common in nature and can be predicted from sequences based on their distinctive sequence signatures.

Areas Covered: We overview twenty years of progress in the sequence-based prediction of MoRFs which resulted in the development of 25 predictors of MoRFs that interact with proteins, peptides and lipids.

Blood Group B May Reduce Risk of Rebleeding in Patients With Upper Gastrointestinal Haemorrhage due to Peptic Ulcer Disease.

Risk stratification tools for the prediction of complications in patients with upper gastrointestinal haemorrhage are crucial for appropriate management. Blood group status has been associated with the risk of bleeding, thrombosis and risk of peptic ulcer disease (PUD). We assessed the influence of blood group status on rebleeding and other complications in 699 patients with PUD bleeding.

Digital Dentists: A Curriculum for the 21st Century.

Future health professionals, including dentists, must critically engage with digital health technologies to enhance patient care. While digital health is increasingly being integrated into the curricula of health professions, its interpretation varies widely depending on the discipline, health care setting, and local factors. This viewpoint proposes a structured set of domains to guide the designing of a digital health curriculum tailored to the unique needs of dentistry in Australia.

Debate: Where to next for universal school-based mental health interventions?

In this article, we evaluate the current state of universal school-based mental health prevention. We argue that the field is at another pivotal turning point, with many unanswered questions. As youth mental health issues rise in prominence and prevalence, schools increasingly adopt mental health and well-being programmes.

Improving Real-Time Feedback During Cochlear Implantation: The Auditory Nerve Neurophonic/Cochlear Microphonic Ratio.

Objectives: Real-time monitoring of cochlear function to predict the loss of residual hearing after cochlear implantation is now possible. Current approaches monitor the cochlear microphonic (CM) during implantation from the electrode at the tip of the implant. A drop in CM response of >30% is associated with poorer hearing outcomes.

'Truly, Madly, Deeply': Using Law to Compel Health and Lifestyle Influencers to Tell the Truth.

Influencers are content creators who post online about their lives and can amass a significant following. Influencers can be dangerous by negatively affecting their followers' body image and marketing products in a deceptive way. The limited academic writings which consider influencer regulation note an incongruency between influencer conduct and the corresponding regulatory system.

Cough Syncope and Fatal Motor Vehicle Accidents: Two Australian Cases.

Cough syncope is an uncommon but well-recognised medical condition diagnosed primarily on the history provided by the sufferer. In situations where the sufferer is in control of a motor vehicle, syncope can lead to accidents involving death and injury. In the medico-legal setting, cough syncope can be a contested cause of such accidents.

Voluntary Assisted Dying and Conscientious Objection: An Analysis from Victoria, Australia.

This article analyses qualitative empirical research conducted by this author to gain a deeper understanding of the rationale behind conscientious objection (CO) to voluntary assisted dying (VAD) and its impact on the operation of VAD in Victoria, Australia. It begins by providing an overview of the Australian legal approach to CO in the context of VAD. It then discusses the spectrum of attitudes that exist towards VAD, illuminating some of the nuance and complexity of the individual and institutional approaches.

Termination Laws in Australia and Aotearoa New Zealand - Do They Align with Midwives' Scope of Practice?

This article examines whether the current termination laws of Australia and Aotearoa New Zealand align with the midwifery scope of practice. It begins with an introduction to termination of pregnancy from a health care perspective. An overview of previous and current legal frameworks in Australia and Aotearoa New Zealand that impact upon the provision of termination of pregnancy health services is provided.