Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease.

Importance: Patients with juvenile idiopathic arthritis (JIA) may develop adult rheumatic diseases later in life, and prolonged or recurrent disease activity is often associated with substantial disability; therefore, it is important to identify patients with JIA at high risk of developing adult rheumatic diseases and provide specialized attention and preventive care to them.

Objective: To elucidate the full extent of the genetic association of JIA with adult rheumatic diseases, to improve treatment strategies and patient outcomes for patients at high risk of developing long-term rheumatic diseases.

Design, Setting, And Participants: In this genetic association study of 4 disease genome-wide association study (GWAS) cohorts from 2013 to 2024 (JIA, rheumatoid arthritis [RA], systemic lupus erythematosus [SLE], and systemic sclerosis [SSc]), patients in the JIA cohort were recruited from the US, Australia, and Norway (with a UK cohort included in the meta-analyzed cohort), while patients in the other 3 cohorts were recruited from US and Western European countries.

Geographic and socioeconomic disparities in mortality burden attributable to long-term exposure to NO across 231 cities in China from 2015 to 2019.

Research on geographic and socioeconomic disparities of NO attributed mortality burden is limited. This study aims to quantify the geographic and socioeconomic differences in the association between long-term exposure to NO and mortality burden in China. We estimated the all-cause mortality burden of adults over 16 years old attributable to NO exposure above 10 µg/m for 231 Chinese cities from 2015 to 2019, and geographic and socioeconomic differences .

Application of Proteomic Methods in Oomycete Biology.

The biochemical makeup of any organism provides insight into key factors regarding its biological functions. These factors can be explored using proteomics, which allows us to obtain a snapshot of the protein content and abundance in an organism, cell type or sub-cellular compartment. Here, we describe proteomic methodologies that can be used to dissect the biochemical mechanism of phytopathogenicity in oomycetes.

Anti-VEGF therapy for proliferative diabetic retinopathy in Kearns-Sayre syndrome.

Purpose: Multiple mitochondrial syndromes, such as Kearns-Sayre, involve the concurrence of diabetes mellitus and inherited pigmentary retinopathy. It is rare, however, for proliferative disease to develop in these patients as existing inner retinal dysfunction is thought to be protective.

Methods: To our knowledge this is the first description of proliferative diabetic retinopathy (PDR) in Kearns-Sayre syndrome.

Inflammation of adenohypophysis is commonly associated with headache in surgically managed Rathke's cleft cysts.

Purpose: Rathke's cleft cysts (RCC) are present in up to 20% of autopsy studies but only a minority necessitate surgical treatment. Inflammation of RCC is thought to be significant in three processes: the development of classical symptoms, a predisposition to rupture or apoplexy, and increasing the rate of RCC recurrence. We aim to characterize clinical presentation, histological and radiological findings in patients with surgically managed RCC.

Eating disorders and disordered eating symptoms in individuals at clinical high risk for psychosis: a systematic review and meta-analysis.

Background: Eating disorders (EDs) are among the least studied mental disorders in individuals at clinical high risk for psychosis (CHR-P). The primary aim (a) of this systematic review and meta-analysis was to identify factors predicting ED diagnoses in CHR-P individuals. The secondary aim (b) was providing a comprehensive clinical description of individuals with both CHR-P and EDs/ED-related symptoms.

A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.

Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal.

Extreme Heat Stress and Unplanned Hospital Admissions.

Objectives: The burden and health impact of heat stress on child hospitalization is limited. This study aims to investigate associations between extreme heat stress exposure based on a Universal Thermal Climate Index (UTCI), emergency department (ED) visits, and ED visits that translate into unplanned hospital admissions.

Methods: This population-based case-crossover study included all ED visits and unplanned hospital admissions among children and adolescents aged 0 to 18 years from New South Wales, Australia, from July 2001 to June 2020.

The Potential of Targeting APE1/Ref-1 as a Therapeutic Intervention for Duchenne Muscular Dystrophy.

Inflammation and oxidative stress play crucial roles in the development and progression of skeletal muscle diseases. This review aims to examine the existing evidence regarding the involvement and inhibition of APE1/Ref-1 (apurinic/apyrimidinic endonuclease 1/redox factor 1) in diseases, then extrapolate this evidence to the context of skeletal muscle and discuss the potential beneficial effects of APE1/Ref-1 inhibition in ameliorating myopathy with a particular focus on dystrophic pathology. Currently, therapeutic interventions targeting pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor erythroid 2-related factor 2 (NRF2), have shown limited efficacy in both clinical and preclinical settings.

Insight into the Structure of the Neutral Amino Acid Transporter BAT2 Enabled the Discovery of Tiagabine as an Inhibitor.

The sodium-dependent membrane transporter SLC6A15 (BAT2) belongs to the SLC6 family, which comprises carriers of amino acids and monoamines. BAT2 is expressed in the central nervous system (CNS), including the glutaminergic and GABAergic system. SLC6A15 supplies neurons with neutral amino acids.

Web-Based Passive Surveillance: Multifactorial Assessment of Sonali Chicken Diseases and Antimicrobial Prescription Pattern in Bangladesh.

Despite the significant growth in Sonali chicken production across Bangladesh, inadequate disease surveillance and control measures along with indiscriminate antimicrobial use remain major challenges to the sector. In this study, we evaluated the disease burden and antimicrobial prescription patterns of Sonali chickens in Bangladesh using a web-based data recording system from 2020 to 2021 and analyzed 1690 cases. The diagnoses recorded in the system were presumptive, as they were based on clinico-epidemiological history, clinical signs, and gross necropsy findings noted by registered veterinarians.

Demographics of Feline Lymphoma in Australian Cat Populations: 1705 Cases.

Lymphoma is the most common haematopoietic cancer in cats with few large studies evaluating breed and sex as risk factors for the disease. Australia's geographic isolation and quarantine rules have led to a potentially restricted genetic pool and, currently, there have not been any large local epidemiological studies reported. A total of 1705 lymphoma cases were identified from several sources and compared to a reference population of 85,741 cats, and represent cats that are presented to veterinary clinics.

Applications of Next-Generation Sequencing Technologies and Statistical Tools in Identifying Pathways and Biomarkers for Heat Tolerance in Livestock.

The climate change-associated abnormal weather patterns negatively influences the productivity and performance of farm animals. Heat stress is the major detrimental factor hampering production, causing substantial economic loss to the livestock industry. Therefore, it is important to identify heat-tolerant breeds that can survive and produce optimally in any given environment.

Prognostic Factors in 26 Cats Undergoing Surgery for Extra-Hepatic Biliary Obstruction.

Surgical management of feline extra-hepatic biliary obstruction (EHBO) has poor survival rates with few prognostic factors reported in the literature. The etiology and clinical findings of feline EHBO and their influence on short-(2 weeks-6 months) and long-term (>6 months) survival and prognosis were examined in an observational clinical retrospective study of 26 client-owned cats undergoing surgery for biliary obstruction at one institution between 2012 and 2020. The etiology of EHBO was determined in 21/26 cats, which included inflammatory causes (14/21), neoplastic causes (6/21), and a duodenal foreign body (1/21).

Epidemiology and Molecular Characterisation of Multidrug-Resistant Isolated from Cow Milk.

Antimicrobial resistance (AMR) is a growing global concern and poses a significant threat to public health. The emergence of multidrug-resistant organisms, including , also presents a risk of transmission to humans through the food chain, including milk. This study aimed to investigate the prevalence of in raw milk in the Chattogram metropolitan area (CMA) of Bangladesh and their phenotypic and genotypic antimicrobial resistance patterns.

A Comparison of Physical Activity and Exercise Recommendations for Public Health: Inconsistent Activity Messages Are Being Conveyed to the General Public.

We examined the similarities and differences between government-supported public health activity recommendations from the World Health Organization (WHO), the Centers for Disease Control and Prevention (CDC), the National Health Service (NHS), the Department of Health and Aged Care (DHAC), and one of the most renowned public health activity recommendations, the 10,000 Steps Program. The findings derived from our evaluation suggest a lack of consistency in public health activity recommendations, including the nomenclature used to describe aerobic activity, the amount of time required per week to meet the minimum recommendation for moderate and vigorous activity, and variations in the intensities required to meet aerobic activity recommendations. We also found that moderate-intensity activity (3.

To Change or Not to Change: Perceptions and Experiential Knowledge of Tennis Coaches When Modifying Grip Technique.

The purpose of this study was to explore the experiential knowledge of tennis coaches as it related to the development of grip positions in tennis athletes. Accredited tennis coaches (n = 11) completed semi-structured interviews consisting of open-ended questions about their coaching background, the importance of grip positions compared with other areas of foundational development, and their opinions on using physically-constraining tools (PCTs). Two major themes, "Grip positions are an adaptive skill" and "Why and how do I modify an athlete's grip?", were identified.

Quantification of Ground Reaction Forces During the Follow Through in Trained Male Cricket Fast Bowlers: A Laboratory-Based Study.

Ground reaction forces (GRFs) are known to be high during front foot contact of fast bowling deliveries in cricket. There is a lack of published data on the GRFs during follow through foot contacts. The aim of this study was to quantify and compare peak GRFs and impulse of the delivery stride and the follow through of fast bowling deliveries.

The Role of Pharmacists in Minimizing the Risk Inherent in Unbundled Telehealth Services: A 12-Month Retrospective Case Study.

Pharmacists have often been viewed as the last line of defence against prescription errors in traditional care models. Although a large number of chronic care patients are using telehealth services to increase their access to continuous care, researchers have yet to investigate prescription safety in such settings in Australia. The absence of this literature is particularly concerning in the context of the Australian Government's admission in a 2024 report that the national health system has not adequately addressed the World Health Organization's 'Medication without harm' objective.

Epidemiology of Lymphatic Filariasis Antigen and Microfilaria in Samoa, 2019: 7-9 Months Post Triple-Drug Mass Administration.

The elimination of lymphatic filariasis (LF) as a public health problem remains an ongoing challenge in the Pacific region. This study reports on antigen (Ag) and microfilaria (Mf) prevalence in Samoa in 2019, 7-9 months after the completion of the first round of triple-drug mass drug administration (MDA). It evaluates the effectiveness of the intervention for reducing Ag prevalence to below a 2% threshold, and how this differs between 5-9-year-olds and ≥10-year-olds.

Risk Identification and Mitigation of Skin and Soft Tissue Infections in Military Training Environments.

Objective: Staphylococcus aureus (SA), including methicillin-resistant strains (MRSAs), is a major cause of skin and soft tissue infections (SSTIs) in military populations. This study investigated SSTI incidence and SA carriage in a military training site over 16 weeks using a prospective observational cohort design.

Methods: Two training cohorts provided pre- and post-training self-collected swabs for bacterial carriage, and environmental swabs from accommodations, personal items, and training facilities.

From Paper to Digital: Performance and Challenges of the Electronic Hepatitis B Surveillance System in Ninh Binh, Northern Vietnam (2017-2022).

Hepatitis B remains a major public health issue in Vietnam. Mandatory reporting to the national electronic communicable disease surveillance system (eCDS) has been required since July 2016. We conducted an evaluation of the hepatitis B surveillance system in Ninh Binh, the province with the highest reported burden of hepatitis B in Northern Vietnam, between 2017 and 2022.

Impact of COVID-19 Vaccination in Thailand: Averted Deaths and Severe Infections Across Age Groups.

The COVID-19 pandemic has underscored the pivotal role of vaccines in mitigating the devastating impact of the virus. In Thailand, the vaccination campaign against SARS-CoV-2 began on 28 February 2021, initially prioritizing healthcare professionals before expanding into a nationwide effort on 7 June 2021. This study employs a mathematical model of COVID-19 transmission with vaccination to analyze the impact of Thailand's COVID-19 vaccination program from 1 March 2021 to 31 December 2022.