Top Ten Tips Palliative Care Clinicians Should Know About Rheumatology.

Systemic autoimmune rheumatic diseases (SARDs) consist of a broad range of immune-mediated multisystem diseases. They are chronic, incurable illnesses that often present in early to mid-life and can be associated with a high symptom burden, disability, and early mortality. Treatment guidelines for similar chronic, life-limiting conditions with uncertain disease courses now recommend palliative care (PC) assessment at the time of diagnosis.

Physical activity alleviated associations of oxidation capacity of the atmosphere with platelet-based inflammatory indicators: findings from the Henan Rural Cohort Study.

: several adverse effects of ozone (O) and nitrogen dioxide (NO) are assessed using combined oxidant capacity (O) and redox-weighted oxidant capacity (Owtx) as surrogates. However, the associations of oxidant capacity (O and Owtx) with platelet-based inflammatory indicators and the potential modifying role of physical activity (PA) remain unclear. : 31 318 participants were selected from the baseline survey of the Henan Rural Cohort Study.

Increasing access to pain care services to improve rural pain management: a realist review investigating factors affecting uptake, implementation, and sustainability.

Guideline-based care for chronic pain is challenging to deliver in rural settings. Evaluations of programs that increase access to pain care services in rural areas report variable outcomes. We conducted a realist review to gain a deep understanding of how and why such programs may, or may not, work.

Improving Therapeutic Adherence and Reducing Therapeutic Inertia in the Management of People with Cardiometabolic Diseases: A Call-to-Action from the Middle East.

Hypertension, dyslipidemia, and type 2 diabetes are highly prevalent and poorly controlled cardiometabolic diseases in the Middle East. Therapeutic non-adherence and therapeutic inertia are major contributors to this suboptimal disease control. Regardless of the cardiometabolic disease, evidence-based solutions may be used to improve therapeutic non-adherence and overcome inertia, and thereby help to alleviate the heavy burden of cardiovascular disease in the Middle East.

Factors Relating to Sprint Swimming Performance: A Systematic Review.

Background: Swimming performance depends on a wide variety of factors; however, the interaction between these factors and their importance varies between events. In sprint events, the characterized pacing underlines its specific development, as swimmers must achieve the highest possible speed while sustaining it to the greatest extent possible.

Objectives: The aim of this review was to identify the key factors underlying sprint swimming performance and to provide in-depth and practical evidence-based information to optimize performance.

Prevalence of metabolic syndrome among pregnant women: a systematic review and meta-analysis.

Purpose: Metabolic syndrome (MetS) is a cluster of risk factors that increase the risk of cardiometabolic diseases. The prevalence of MetS and individual components across pregnancy has not been reviewed in the literature. This research was conducted to identify the prevalence of MetS and its components among pregnant women.

The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.

Background: The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.

Ravulizumab demonstrates long-term efficacy, safety and favorable patient survival in patients with paroxysmal nocturnal hemoglobinuria.

Ravulizumab is a second-generation complement component 5 (C5) inhibitor (C5i) approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) following positive results from two pivotal trials in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH. In both trials, after the 26week primary evaluation period, all patients received ravulizumab for up to 6 years. To report ravulizumab treatment outcomes in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH treated for up to 6 years.

Lactobacillus and Saccharomyces fermentation products impact performance and the fecal microbiome in weanling pigs inoculated with enterotoxigenic Escherichia coli.

Background: Enterotoxigenic F4 E. coli (F4-ETEC) pose an economic threat to the swine industry through reduced growth, increased mortality and morbidity, and increased costs associated with treatment. Prevention and treatment of F4-ETEC often relies on antimicrobials; however, due to the threat of antimicrobial resistance, antimicrobial use is being minimized, and hence alternative control methods are needed.

A systematic review to determine the effect of strategies to sustain chronic disease prevention interventions in clinical and community settings.

This review assessed the effect of strategies designed to sustain the delivery of evidenced based interventions (EBIs) which target behavioural risk factors linked to leading causes of chronic disease in clinical and community settings. Seven electronic databases were searched for randomised controlled studies published from earliest record to November 2022. Studies were included if they tested a strategy to sustain the delivery of an EBI within clinical or community settings.

BCL6 coordinates muscle mass homeostasis with nutritional states.

Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action.

Multi-study fMRI outlooks on subcortical BOLD responses in the stop-signal paradigm.

This study investigates the functional network underlying response inhibition in the human brain, particularly the role of the basal ganglia in successful action cancellation. Functional magnetic resonance imaging (fMRI) approaches have frequently used the stop-signal task to examine this network. We merge five such datasets, using a novel aggregatory method allowing the unification of raw fMRI data across sites.

Tracking Physical Activity and Nutrition Policies and Practices in Early Childhood Education and Care: Five Years Post-Implementation of a Provincial-Level Active Play Standard.

Early childhood education and care (ECEC) settings are key for improving health behaviors, including physical activity (PA) and nutrition. In 2017, the province of British Columbia (BC) implemented a provincial-level Active Play policy supported by a capacity-building intervention. Significant improvements in all PA policies and practices and the majority of nutrition policies were observed post-implementation.

Atrial septal defect closure via a partial lower ministernotomy.

Patients with secundum atrial septal defects preferentially undergo device closure;  however, this procedure is not always feasible. Instead, patients can safely undergo surgical closure. At a time when minimally invasive surgery can now be utilized with improved cosmetic results and the same excellent outcomes as a conventional sternotomy for an atrial septal defect closure, we propose the partial lower ministernotomy as the new standard for surgical atrial septal defect closure.

Sonographer Experiences of Interprofessional Ultrasound Education: A Qualitative Study.

Introduction: Point-of-care ultrasound (POCUS) technology has evolved rapidly and is being embraced by many health professionals as a valuable clinical tool. Sonographers are now teaching ultrasound skills to other health professionals in the clinical setting, including doctors, nurses, midwives, paramedics, and physiotherapists. The purpose of this study was to understand the breadth of the opportunities, transitions, and challenges experienced by sonographer educators navigating new interprofessional teaching roles.

Antigen 43 associated with membrane vesicles contributes to bacterial cell association and biofilm formation.

Bacterial membrane vesicles (MVs) are produced by all bacteria and contribute to numerous bacterial functions due to their ability to package and transfer bacterial cargo. In doing so, MVs have been shown to facilitate horizontal gene transfer, mediate antimicrobial activity, and promote biofilm formation. Uropathogenic is a pathogenic Gram-negative organism that persists in the urinary tract of its host due to its ability to form persistent, antibiotic-resistant biofilms.

Canadian Men's Intimate Partner Relationship Break-Ups During COVID-19: Implications for Mental Health Promotion.

COVID-19 impacted many men's intimate partner relationships, with distressed and disrupted partnerships consistently featured in commentaries with linkages to mental health challenges. The current study draws from interviews with 23 Canadian-based men, 19-50 years old, who experienced a break-up during COVID-19. Addressing the research question, "What are the connections between masculinities, men's mental health, and intimate partner relationship break-ups during COVID-19?", three thematic findings were derived: (1) Virtually Together and Growing Apart, (2) Mentally Trapped, and Failing Fast and Slow, and (3) Introspections and Moving On.

Distribution and role of peripheral arterial chemoreceptors in cardio-respiratory control of the south american rattlesnake (Crotalus durissus).

Peripheral arterial chemoreceptors monitor the levels of arterial blood gases and adjust ventilation and perfusion to meet metabolic demands. These chemoreceptors are present in all vertebrates studied to date but have not been described fully in reptiles other than turtles. The goals of this study were to 1) identify functional chemosensory areas in the South American rattlesnake (Crotalus durissus) 2) determine the neurochemical content of putative chemosensory cells in these areas and 3) determine the role each area plays in ventilatory and cardiovascular control.

Exploration of hospital room design on emotions, activity, and social connections after stroke: a qualitative study of patient experiences using virtual reality.

Unlabelled: Stroke patients are rarely asked about their responses to specific design attributes. Virtual reality (VR) offers a promising tool to explore how hospital environments are experienced after stroke.

Purpose: To gather perspectives and emotional responses regarding physical design attributes of hospital patient rooms after stroke.

"We Want to Well Outlive Us": Behind the Dissemination and Sustainability of in Australia.

is a free, weekly organized mass participation physical activity event providing a remarkable example of at-scale dissemination, with over 1 million participants and 150,000 volunteers in Australia. This qualitative study draws on stakeholders' experiences to explore how succeeded with its dissemination and sustainability in Australia. Maximum variation and snowball sampling methods were used to select interviewees representing three stakeholder groups: Australia employees; volunteer organizers (event directors and ambassadors); and local external stakeholders (e.

Conjugation of PDLA onto MgO microspheres: comparison between solution grafting and melt grafting methods.

Magnesium oxide (MgO) is known for its bioactivity and osteoconductivity when incorporated into biodegradable poly(lactic acid) (PLA), whereas the weak interfacial bonding between MgO microspheres (mMPs) and PLA often leads to suboptimal composite properties with uncontrollable functionality. Conjugation of mMPs with PLA may offer a good way to enhance their compatibility. In this study, we systematically investigated two grafting techniques, solution grafting (Sol) and melt grafting (Mel), to decorate poly (D-lactic acid) (PDLA) on mMPs pre-treated by prioritized hydration to obtain Sol MPs and Mel MPs, in order to optimize the grafting efficiency and improve their controllability in the properties including the crystal structure and surface morphology.

How can we make therapy better for autistic adults? Autistic adults' ratings of helpfulness of adaptations to therapy.

Autistic people experience more mental health conditions like depression or anxiety than non-autistic people. They are also more likely to experience difficulties in accessing mental health supports Clinicians have published suggestions on how to improve therapy for autistic people. However, whether these ways to adapt (i.