Surgical margin and other prognostic factors of invasive vulvar squamous cell carcinoma: A clinicopathological mono-center study.

Objective: To evaluate prognostic factors in women with invasive VSCC at Sun Yat-sen University Cancer Center (SYSUCC).

Methods: 137 patients with VSCC at SYSUCC were retrospectively analyzed. The Kaplan-Meier method assessed the overall survival (OS) and progression-free survival (PFS) time.

Cerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant ventriculitis treated with intrathecal and intravenous polymyxin B.

is a major pathogen of nosocomial meningitis and ventriculitis. Due to very limited antibiotic treatment options, polymyxins are often used as a last-line therapy. To optimise polymyxin use in the intraventricular environment, cerebrospinal fluid (CSF) proteomics was employed to investigate host-pathogen-polymyxin interactions in a 69-year-old patient with multidrug-resistant ventriculitis treated with a combination of intrathecal (ITH; 50,000 IU q24h/q48h), intraventricular (IVT; 50,000 IU q48h), and intravenous (500,000 IU, q12h) polymyxin B.

Advanced deep transfer learning techniques for efficient detection of cotton plant diseases.

Introduction: Cotton, being a crucial cash crop globally, faces significant challenges due to multiple diseases that adversely affect its quality and yield. To identify such diseases is very important for the implementation of effective management strategies for sustainable agriculture. Image recognition plays an important role for the timely and accurate identification of diseases in cotton plants as it allows farmers to implement effective interventions and optimize resource allocation.

HRP-integrated CRISPR-Cas12a biosensor for rapid point-of-care detection of Langya henipavirus.

Global pandemic has emphasized the needs for advanced pathogen diagnosis in dealing with newly emerged infectious threats, including the Langya henipavirus (LayV). LayV, as an emerging zoonotic pathogen, has potential to cause pandemic, but lacks of rapid diagnostic tools, particularly at point-of-care level. Here, we leveraged the merits of CRISPR-Cas12a biosensing and established a highly sensitive LayV detection method.

Meta-analyses reveal climate change impacts on an ecologically and economically significant oyster in Australia.

Global oceans are warming and acidifying because of increasing greenhouse gas emissions that are anticipated to have cascading impacts on marine ecosystems and organisms, especially those essential for biodiversity and food security. Despite this concern, there remains some skepticism about the reproducibility and reliability of research done to predict future climate change impacts on marine organisms. Here, we present meta-analyses of over two decades of research on the climate change impacts on an ecologically and economically valuable Sydney rock oyster, .

Outcomes and Toxicities After Treatment for Men Diagnosed With Localized Prostate Cancer in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.

Purpose: Current management for clinically localized prostate cancer in low- and middle-income countries (LMICs) includes surgery, external beam radiation therapy (EBRT), and brachytherapy either alone or in combination, with plus or minus hormone therapy. The toxicity profiles and oncological outcomes of these treatment modalities vary. This systematic review and meta-analysis aimed to determine the prevalence of treatment-related outcomes and toxicities for men diagnosed with localized prostate cancer in LMICs.

Hydrophobic dual-polymer-reinforced graphene composite aerogel for efficient water-oil separation.

Addressing the environmental challenges posed by oil spills and industrial wastewater is critical for sustainable development. Graphene aerogels demonstrate significant potential as highly efficient adsorbents due to their high specific surface area, excellent structural tunability and outstanding chemical stability. Among available fabrication methods, the hydrothermal self-assembly technique stands out for its low cost, high tunability and good scalability.

Patient, Caregiver, and Provider Perspectives on Improving Provider-Patient Interactions in Hemodialysis: A Qualitative Study.

Background: Improving interactions between people receiving hemodialysis and health care providers of facility-based hemodialysis care is a top priority for patients, caregivers, and health care providers.

Objective: To identify challenges for high-quality clinical interactions in facility-based hemodialysis care as well as potential solutions.

Design: Multicentre qualitative study using focus groups and semi-structured interviews to elicit the perspectives of patients, caregivers, and health care providers.

Correction of meta-analysis after retraction of article on the effects of anti-androgens in polycystic ovary syndrome.

[This corrects the article DOI: 10.1016/j.eclinm.

A historico-medical perspective on ancient epidemics and their impact on past human societies.

The present article reviews the major historical plague epidemics that characterised human history by combining data derived from historical sources and biomedical evidence emerged in recent years thanks to advancements of palaeogenetics and palaeopathology. Notes are offered on the Plague of Athens, the Antonine Plague, the Plague of Cyprian, the Justinian Plague, the Black Death down to more recent centuries and presenting key aspects that continued to be preserved over time and would also partly characterise the recent COVID-19 pandemic.

Osteomyelitis and Septic Arthritis in the Darwin Prospective Melioidosis Study.

Background: Melioidosis is a multisystem infectious disease caused by the environmental bacterium . Osteomyelitis (OM) and septic arthritis (SA) are uncommon primary presentations for melioidosis but important secondary foci, often requiring prolonged therapy and multiple surgeries. We characterized the epidemiology, presentation, treatment, and outcomes of patients from 24 years of the Darwin Prospective Melioidosis Study (DPMS).

Whole Genome Sequencing Reveals Genetic Differences Between Symbiodiniaceae Populations Among Reproductively and Geographically Isolated Colonies in Western Australia.

Significant genetic differentiation between Symbiodiniaceae populations in coral hosts can be induced by a range of factors including geography, latitude, depth, temperature and light utilisation. The conventional method of measuring Symbiodiniaceae diversity involving the ITS2 region of rDNA has several limitations, stemming from insufficient genetic resolution and the multi-copy nature of the marker. This could be improved by using higher throughput whole genome sequencing to identify fine-scale population genetic differences and provide new insight into factors influencing coral-Symbiodiniaceae associations.

Characteristics, Contamination Levels, and Ecosystem Risk Assessment of Microplastics in Surface Water of a Highly Urbanized River from a Developing Country.

Microplastic (MP) contamination poses significant risks to ecosystems and human health. However, the absence of standardized protocols, detailed polymer identification, and sources identification hinders the development of targeted mitigation strategies, particularly in developing nations. There is a scarcity of comprehensive data on MP distribution, sources, and transport mechanisms in freshwater environments.

Retrospective analysis of custom 3D-printed drill guides and titanium plate use in spinal stabilization of eleven dogs.

Introduction: Congenital vertebral malformations are common developmental abnormalities in screw-tailed brachycephalic dog breeds. Subsequent vertebral instability and/or vertebral canal stenosis caused by these malformations can lead to spinal cord compression manifesting in pain, paraparesis, ataxia and/or paralysis. Various methods for spinal stabilization are in common use.

Effect of randomised blood pressure lowering treatment and intensive glucose control on dementia and cognitive decline according to baseline cognitive function and other subpopulations of individuals with type 2 diabetes: Results from the ADVANCE trial.

Background And Aims: Accumulating evidence indicates that reducing high blood pressure (BP) prevents dementia and mild cognitive impairment (MCI). Furthermore, although diabetes is a risk factor for dementia and MCI, there is uncertainty of the effect of intensive glucose control on these endpoints. This study aimed to determine the effects of BP-lowering (vs placebo) and intensive glucose-lowering (vs standard control) treatments according to baseline cognition and other characteristics on dementia and cognitive decline (CD) in people with type 2 diabetes mellitus (T2DM).

A Review of the Enablers and Barriers of Medical Student Participation in Research.

Unlabelled: Although research is an integral component in medicine, student participation in research remains limited. This is a systematic review conducted using rapid review methods conforming to the WHO and Cochrane guidelines to synthesise evidence on the enablers and barriers of medical student participation in research. PubMed, EMBASE, and PsycINFO were searched, yielding 27 final studies.

Peer Mentoring by Medical Students for Medical Students: A Scoping Review.

Medical school transitions pose challenges for students. Mentoring programs may aid students, but evidence supporting peer/near-peer mentoring in medical school is unclear. Our review explores peer mentoring's benefits, elements for success and challenges.

Exploring Quality of Life in Adults Living With Late-onset Pompe Disease: A Combined Quantitative and Qualitative Analysis of Patient Perceptions from Australia, France, Italy, and the Netherlands.

Late-onset Pompe disease (LOPD) is a rare, autosomal recessive metabolic disorder that is heterogeneous in disease presentation and progression. People with LOPD report a significantly lower physical, psychological, and social quality of life (QoL) than the general population. This study investigated how individuals' self-reported LOPD status (improving, stable, declining) relates to their QoL.

Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer.

Objective: Metastatic breast cancer (MBC) is associated with burdensome side effects, including cognitive changes that require ongoing monitoring. Cognitive ecological momentary assessments (EMAs) allow for assessment of individual cognitive functioning in natural environments and can be administered via smartphones. Accordingly, we sought to establish the feasibility, reliability, and validity of a commercially available cognitive EMA platform.

Towards a Techno-Hauntological Aesthetic: Immiscible Time and the Spiritual Imagination in (Shishenji, 2019) by Huang Hsin-Chien.

This article discusses and explores acclaimed new media artist Huang Hsin-Chien's virtual reality (VR) experience (Shishenji, 2019). In this film, through the process of the body illusion or the body replacement program, a component specific to VR, viewers embody the soul of a political prisoner deceased during Taiwan's martial law era. juxtaposes Taiwan's traditional spiritual traditions with references to the Ghost Festival () and includes a dystopic vision of the future that appears towards the end of the film.

"Equity" in genomic health policies: a review of policies in the international arena.

Introduction: The field of genomics is rapidly evolving and has made significant impact on the diagnosis and understanding of rare and genetic diseases, in guiding precision medicine in cancer treatment, and in providing personalized risk assessment for disease development and treatment responses. However, according to the literature, there is widespread socio economic and racial inequities in the diagnosis, treatment, and in the use of genomic medicine services. This policy review sets out to explore the concept of equity in access to genomic care, the level of inclusion of equity and how it is addressed and what mechanisms are in place to achieve equity in genomic care in the international health policy.

Leveraging new methodologies for public health crisis management.

Evidence-based medicine is critical in public health emergencies, offering a framework for decision-making and adaptive healthcare responses. By relying on up-to-date and reliable evidence, EBM enables healthcare systems to respond quickly to evolving crises and ensures efficient resource allocation. This perspective presents the importance of evidence-based medicine in public health emergencies, emphasizing the need for rapid decision-making and preparedness.