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Two cases of complete response after imatinib mesylate treatment of advanced GIST.

Anticancer Res

January 2007

Second Department of Internal Medicine-Propaedeutic, University General Hospital, Attikon University of Athens, 1 Rimini street, Haidari 12462, Athens, Greece.

Background: Imatinib mesylate has undoubted efficacy in the treatment of advanced gastrointestinal stromal tumors (GISTs), but complete responses have only been reported rarely.

Case Report: A 47-year-old man with liver metastasis from GIST achieved a complete response after 7 months of treatment with imatinib and a 47-year old woman with local relapse of GIST on the stomach after gastrectomy, showed complete remission, 9 months after treatment with imatinib.

Conclusion: Although the response rate is high in patients with advanced GIST treated with imatinib mesylate, complete responses remain rare.

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