4,487 results match your criteria: "Attikon University Hospital.[Affiliation]"
An artificial neural network approach to diagnose and predict liver dysfunction and failure in the critical care setting.
Hippokratia
January 2024
Department of Anesthesiology, College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio, USA.
Article Synopsis
- Detecting liver dysfunction in ICU patients is complicated due to their often asymptomatic nature, prompting the need for a predictive model to enhance early diagnosis and improve outcomes.
- A novel Liver Failure Risk Index was developed using machine learning techniques, analyzing data from open-access patient databases, including vital signs and liver function tests.
- The best model achieved 83.3% sensitivity and 77.5% specificity, identifying severe liver dysfunction a median of 17.5 hours prior to clinical diagnosis, allowing for timely intervention.
Horner's syndrome as an unusual complication of retropharyngeal schwannoma excision.
Hippokratia
January 2024
ENT Department, Nicosia General Hospital, Nicosia, Cyprus.
The Assisi think tank focus review on postoperative radiation for lobular breast cancer.
Radiother Oncol
December 2024
Radiation Oncology Section, University of Perugia and Perugia General Hospital, Italy.
Article Synopsis
- * The meeting involves discussion of pre-selected topics by working groups, which are informed by systematic reviews and surveys reflecting current clinical practices.
- * The Assisi Working Group specifically examines lobular carcinoma, offering recommendations for locoregional therapy, especially radiation therapy for non-metastatic cases.
Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome.
Am J Respir Crit Care Med
December 2024
First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital.
Article Synopsis
- Aging affects how driving pressure impacts mortality in patients with ARDS, particularly highlighting that this relationship may be stronger in older individuals, especially those aged 80 and above.!* -
- A study analyzed data from over 4,500 ARDS patients and found that the difference in driving pressure between those who survived and those who did not varied significantly with age, indicating a critical age-related factor in mortality risk.!* -
- The results suggest that a personalized approach to mechanical ventilation based on a patient's age could be beneficial for managing ARDS, as certain thresholds for driving pressure may have different implications for older populations.!*
Hypokalaemia in patients with type 2 diabetes and chronic kidney disease: the effect of finerenone - a FIDELITY analysis.
Eur Heart J Cardiovasc Pharmacother
October 2024
National and Kapodistrian University of Athens, School of Medicine, Department of Cardiology, Attikon University Hospital, Athens, Greece.
Article Synopsis
- Hypokalaemia, or low potassium levels, increases the risk of heart-related issues and death in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D).
- An analysis from the FIDELITY study showed that a significant percentage of patients experienced treatment-emergent hypokalaemia while on finerenone or placebo, with lower potassium levels correlating to higher cardiovascular risks.
- Finerenone was effective in lowering the incidence of hypokalaemia and also reduced the overall risk of cardiovascular events and arrhythmias, regardless of the initial potassium levels in patients.
Evaluating Combinations of Biological and Clinicopathologic Factors Linked to Poor Outcomes in Resected Colorectal Liver Metastasis: An External Validation Study.
Ann Surg Oncol
January 2025
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Article Synopsis
- Some studies found that specific gene markers (KRAS or BRAF) combined with other health factors can lead to bad results for people with liver cancer, making surgery not very helpful.
- The research looked at data from over 1,600 patients to see how long they lived after surgery and found many didn’t survive long, especially those with risky KRAS mutations.
- The findings suggest that in some cases, surgery might not be the best option for these patients, similar to those who only got treatment without surgery.
Safety and efficacy of up to 60 h of iv istaroxime in pre-cardiogenic shock patients: Design of the SEISMiC trial.
ESC Heart Fail
October 2024
Cardiovascular Markers in Stress Conditions (MASCOT), Université Paris Cité, Inserm UMR-S 942, Paris, France.
Article Synopsis
- Cardiogenic shock (CS) poses significant health risks, necessitating effective interventions to maintain blood pressure and tissue perfusion, while current treatments, like inotropes, can lead to serious side effects.
- The SEISMiC study aims to evaluate the safety and effectiveness of istaroxime, a new drug that may improve blood flow without overstimulating adrenergic receptors, in patients at risk for CS.
- This multinational, double-blind study involves patients with severe heart failure and aims to measure the drug's impact on blood pressure and other cardiac metrics over a 60-hour period, aiming to clarify istaroxime's potential benefits in managing pre-CS conditions.
The emergence of streptococcal epiglottitis in adults amid Increasing iGAS cases.
Infect Dis Now
December 2024
National & Kapodistrian University of Athens, School of Medicine, 2(nd) Otolaryngology Department, "Attikon" University Hospital, Athens, Greece.
Surgical anatomy of the cystic artery: A systematic review with meta-analysis.
Ann Anat
January 2025
Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Greece.
Background: The current evidence-based systematic review with meta-analysis presents a detailed overview of the cystic artery (CA) surgical anatomy, including its origin, number, topography, and morphometry. Moreover, the surgical implications of these variants are further discussed.
Methods: According to the Evidence-Based Anatomy Workgroup and PRISMA 2020 guidelines, the systematic review was performed using four online databases.
The Effects of Burst Steroid Therapy on Short-term Decongestion in Acute Heart Failure Patients With Pro-inflammatory Activation: A Post Hoc Analysis of the CORTAHF Randomized, Open-label, Pilot Trial.
J Card Fail
September 2024
Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland. Electronic address:
Article Synopsis
- A study looked at how steroids, like prednisone, help reduce congestion in patients with acute heart failure (AHF).
- Patients taking prednisone showed more improvement in their congestion levels compared to those receiving regular care.
- The results suggest that steroids can help with symptoms related to congestion, but more research is needed to confirm these findings.
Enfortumab Vedotin Following Platinum Chemotherapy and Avelumab Maintenance in Patients with Metastatic Urothelial Carcinoma: A Retrospective Data from the ARON-2 Study.
Target Oncol
November 2024
Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
Article Synopsis
- - Enfortumab vedotin (EV) is effective for patients with advanced urothelial carcinoma who have previously received platinum chemotherapy and immune therapy, despite lacking research on those treated with avelumab maintenance.
- - A study of 182 patients showed a median overall survival of 12.7 months and a progression-free survival of 7.9 months, with 39% achieving a positive response to EV after avelumab treatment.
- - The study confirms EV's effectiveness, suggesting it can be a viable option for patients previously treated with avelumab, with manageable side effects like grade ≥ 3 neuropathy and skin rash occurring in a minority of cases.
Risk of major adverse cardiovascular events and all-cause mortality under treatment with GLP-1 RAs or the dual GIP/GLP-1 receptor agonist tirzepatide in overweight or obese adults without diabetes: a systematic review and meta-analysis.
Ther Adv Neurol Disord
September 2024
Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, Chaidari, Athens 12462, Greece.
Article Synopsis
- GLP-1 receptor agonists (liraglutide, semaglutide, tirzepatide) may lower cardiovascular risk in overweight/obese individuals without diabetes.
- A systematic review of 16 trials involving over 28,000 participants showed these medications reduced major adverse cardiovascular events and all-cause mortality compared to placebo.
- While they significantly lowered the risk of myocardial infarction, the relationship with stroke is less clear due to limited data.
Breakage and detachment of the rigid cystoscope's distal tip: an unusual case of urological instrument malfunction.
Cent European J Urol
March 2024
1 Department of Urology, Aristotle University of Thessaloniki, School of Medicine, "G. Gennimatas" General Hospital, Thessaloniki, Greece.
Herein, we describe an unusual case of cystoscope damage during a planned laser cystolithotripsy in a 65-year-old male with a previous history of radical prostatectomy for prostate cancer and subsequent serial urethral dilations for bladder neck contracture. Upon crossing the penile urethra without exerting significant pressure, we noticed the cystoscope's distal metallic tip detachment. Therefore, we re-introduced another 22Fr cystoscope and removed the broken part with alligator forceps.
View Article and Find Full Text PDFRenal Actinomycosis in Humans-A Narrative Review.
Microorganisms
September 2024
Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Article Synopsis
- Actinomycosis of the kidney is a very rare infection, making diagnosis difficult due to its common symptoms and unclear imaging results.
- Fever occurs in about 56% of cases, and risk factors include previous urogenital surgery, kidney stones, or cancer.
- Treatment typically involves antibiotics, surgery, or a combination of both, and accurate diagnosis is essential, often confirmed through biopsies or culture tests.
From a Cup of Tea to Cardiovascular Care: Vascular Mechanisms of Action.
Life (Basel)
September 2024
Hippokration General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Tea consumption is increasingly recognized for its potential benefits to cardiovascular health. This study reviews the available research, concentrating on the major components of tea and their mechanisms of action in the cardiovascular system. Tea is abundant in bioactive compounds, such as flavonoids and polysaccharides, which possess significant antioxidant and anti-inflammatory properties.
View Article and Find Full Text PDFAttendance in a Neonatal Follow-Up Program before and in the Time of COVID-19 Pandemic: A Mixed Prospective-Retrospective Observational Study.
Children (Basel)
September 2024
Laboratory of Primary Health Care, School of Medicine, General Medicine and Health Services Research Aristotle University, 54124 Thessaloniki, Greece.
Background: Attendance to neonatal follow-up programs presents a significant factor associated with positive long-term outcomes of high-risk infants. Strategies to maximize participation benefit not only future interventions' effectiveness but also healthcare systems and society. While a number of studies have focused on attrition or loss to follow-up, no studies have focused on the contributive risk factors to abstaining from neonatal follow-up programs specifically during the COVID-19 pandemic.
View Article and Find Full Text PDFEffects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review.
Clin Microbiol Infect
January 2025
Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV), Basel, Switzerland. Electronic address:
Background: Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.
View Article and Find Full Text PDFEmpirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines.
Diseases
September 2024
Department of Urology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Background/objectives: Male infertility is a prevalent issue impacting numerous couples worldwide. This review aims to evaluate the effectiveness of empirical therapies for male infertility, focusing on both lifestyle modifications and medical treatments. This study provides a comprehensive overview of interventions aimed at improving male fertility outcomes.
View Article and Find Full Text PDFSex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS.
J Clin Anesth
December 2024
Amsterdam University Medical Center, Department of Anaesthesiology, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands; Amsterdam University Medical Center, Department of Intensive Care, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.
Article Synopsis
- The study aimed to investigate whether there are differences in postoperative pulmonary complications (PPCs) between males and females following surgery under general anesthesia, using data from the LAS VEGAS study involving 146 hospitals across 29 countries.
- A total of 9,697 patients were analyzed in two cohorts: an unmatched cohort (55.1% female, 44.9% male) and a matched cohort (50% female and male), finding no significant differences in PPC rates between the genders in both cohorts.
- The study concluded that, in this international patient population, the incidence of PPCs did not differ significantly between males and females, as well as noting comparable hospital stays and mortality rates.*
Concurrent validity, cut-offs and ability to change of patient-reported outcome measures for rhinitis and asthma in MASK-air.
Clin Transl Allergy
September 2024
Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Article Synopsis
- - Patient-reported outcome measures (PROMs) are tools that help assess a patient's health at a specific time and are important for personalized healthcare.
- - The paper reviews the use of visual analog scales (VAS) for measuring asthma and allergic rhinitis control, particularly focusing on the MASK-air app, which includes electronic VAS forms.
- - A randomized controlled trial was conducted to validate the electronic VAS, and further evaluations confirmed the effectiveness of VAS questions and additional medication scores for allergic asthma symptoms.
Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial.
Circulation
December 2024
Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (W.T.A.).
Article Synopsis
- An interatrial shunt is being studied as a potential treatment for heart failure, aimed at lowering left atrial pressure and improving symptoms and outcomes for patients.
- In a clinical trial involving 508 patients, participants were randomly assigned to receive either the shunt or a placebo, with their progress tracked over a maximum of two years.
- Results showed that while the shunt had no major safety issues, it did not significantly improve overall effectiveness compared to the placebo, although it appeared to reduce adverse cardiovascular events in patients with reduced left ventricular ejection fraction.
Coronary Implications of COVID-19.
Med Princ Pract
September 2024
Second Department of Cardiology, Attikon University Hospital, Athens, Greece.
Patients with SARS-CoV-2 infection carry an increased risk of cardiovascular disease encompassing various implications, including acute myocardial injury or infarction, myocarditis, heart failure, and arrhythmias. A growing volume of evidence correlates SARS-CoV-2 infection with myocardial injury, exposing patients to higher mortality risk. SARS-CoV-2 attacks the coronary arterial bed with various mechanisms including thrombosis/rupture of preexisting atherosclerotic plaque, de novo coronary thrombosis, endotheliitis, microvascular dysfunction, vasculitis, vasospasm, and ectasia/aneurysm formation.
View Article and Find Full Text PDFAttainment of EULAR/ERA-EDTA targets of therapy with current immunosuppressive regimens and adjustments in treatment: a multicentre, real-life observational study.
RMD Open
September 2024
Rheumatology Unit, National and Kapodistrian University of Athens, Athens, Greece
Article Synopsis
- The study aimed to evaluate the effectiveness of conventional immunosuppressive treatments in patients with lupus nephritis (LN) by assessing response rates over one year and identifying predictors of non-response.
- Involving 140 patients, the research found that around 69.2% achieved a positive response by 12 months, although 20% needed changes in their treatment due to insufficient progress.
- Increased chronicity at the start was linked to a higher chance of not responding to treatment, indicating that both chronicity and histological activity are important factors influencing patient outcomes.
Deep negative T-waves in a patient with three different QRS morphologies in a single electrocardiographic strip: What is going on?
J Electrocardiol
September 2024
Department of Cardiology, Attikon University Hospital, Athens, Greece.
Evaluation of the attributable fraction and burden of HPV-related oropharyngeal cancers in Greece-the ORPHEAS study.
ESMO Open
October 2024
2nd Department of Pathology, Medical School, National and Kapodistrian University of Athens ('Attikon' University Hospital), Athens.
Background: Herein, we evaluated the attributable fraction (AF) of human papillomavirus (HPV)-mediated (HPV+) oropharyngeal carcinomas (OPCs) in Greece over a recent calendar period.
Patients And Methods: ORPHEAS, a retrospective, observational, multicenter, cross-sectional study with prospective recruitment, included adult patients with OPC in 2017-2022, each of them with a high-quality, treatment-naïve tumor specimen. The primary endpoint was the HPV-AF, defined as combined positivity for p16 (p16) overexpression and HPV DNA presence by central laboratory testing, among included patients.