Synthesis of some novel pyrazolo[3,4-] pyrimidin-4(5)-one derivatives as potential antimicrobial agent.

Objectives: The aim of the present work was to synthesize a novel series of pyrazolo[3,4-]pyrimidin-4(5)-one derivatives and evaluate their antimicrobial activity.

Methods: Cyclization of an ortho-amino ester of 1-(2,4-dinitrophenyl)pyrazole with various aliphatic/aromatic nitriles under different reaction conditions such as conventional and microwave assisted synthesis, provided pyrazolo[3,4-] pyrimidin-4(5)-one derivatives. All the synthesized compounds were evaluated for their antimicrobial activity against selected bacteria and fungi by agar well diffusion method.

Phytochemical and pharmacological profile of Ipomoea aquatica.

Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found throughout India, Ceylon, Tropical Asia, Africa, and Australia. Traditionally, I.

Quality by design approach for oral bioavailability enhancement of irbesartan by self-nanoemulsifying tablets.

The present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the investigation, IRB-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed using Capryol 90 - Cremophor RH40 - Transcutol P as three component (oil - surfactant - cosurfactant) SNEDDS system. On the basis of ternary phase diagram IRB-loaded SNEDDS were optimized by using Design of Experiments (DoE) and Principal component analysis (PCA) with amount of oil and surfactant: cosurfactant ratio (Km) as factors.

Formulation and evaluation of periodontal in situ gel.

Background: The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease.

Materials And Methods: Temperature-sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochloride was formulated by cold method using different polymers.

Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: an integrated approach of principal component analysis and Box-Behnken experimental design.

Poor mechanical properties of crystalline drug particles require wet granulation technique for tablet production which is uneconomical, laborious, and tedious. The present investigation was aimed to improve flow and mechanical properties of racecadotril (RCD), a poorly water soluble antidiarrheal agent, by a crystallo-co-agglomeration (CCA) technique. The influence of various excipients and processing conditions on formation of directly compressible agglomerates of RCD was evaluated.

Influence of excipients and processing conditions on the development of agglomerates of racecadotril by crystallo-co-agglomeration.

Purpose: The purpose of the present investigation was to improve the flow and mechanical properties of racecadotril by a crystallo-co-agglomeration (CCA) technique. Direct tableting is a requirement of pharmaceutical industries. Poor mechanical properties of crystalline drug particles require wet granulation which is uneconomical, laborious, and tedious.

Development and Evaluation of Carbon Nanotubes Doped Sustained Release Microspheres of Metoprolol Tartrate.

A highly water soluble antihypertensive drug, metoprolol tartrate (MT) was selected as a model drug for preparation ofmulti-walled carbon nanotubes (MWCNTs) impregnated ethyl cellulose (EC) microspheres with aim to increase encapsulation efficiency and sustained release rate. Carbon nanotubesdrug adsorbate (MWCNTs:MT) loaded EC microspheres were optimized by Central Composite Design of experiment. The effects of independent variables (MWCNTs:MT and EC:adsorbate) were evaluated on responses like entrapment efficiency (EE) and time required for 50% drug release (t50).

Prefilled syringes: An innovation in parenteral packaging.

Parenteral administration of pharmaceutical products is one of the most popular methods used to produce quick onset of action and also 100% bioavailability. Main problem occurs with the parenteral drug delivery is lack of convenience, affordability, accuracy, sterility, safety etc. Such drawbacks with this delivery system makes it less preferable.

Sphaeranthus indicus flower derived constituents exhibits synergistic effect against acetylcholinesterase and possess potential antiamnestic activity.

Objective: The present investigation was aimed at discovery of novel acetylcholinesterase (AChE) inhibitors.

Methods: In vitro AchE inhibitory activity of various extracts of Sphaeranthus indicus flower heads was carried out. The petroleum ether fraction of S.

Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material.

The aim of this investigation was to develop fast dissolving tablet of cinnarizine. A combination of super disintegrants, i.e.

Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan.

Irbesartan (IRB) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water-soluble IRB. The solubility of IRB in various oils was determined to identify the oil phase of SNEDDS.

Solubility of aceclofenac in polyamidoamine dendrimer solutions.

In the present study we investigated the effect of polyamidoamine (PAMAM) dendrimers on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimers in distilled water. The effect of variables, such as pH condition, concentration, temperature and generation (molecule size) of dendrimer, has been investigated.

Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery.

Background And Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water soluble TEL.

Materials And Methods: The solubility of TEL in various oils was determined to identify the oil phase of a SNEDDS.

Development of the UV spectrophotometric method of Olmesartan medoxomil in bulk drug and pharmaceutical formulation and stress degradation studies.

A simple, sensitive, specific, spectrophotometric method was developed for the detection of Olmesartan medoxomil (OLM) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of the drug were established. OLM was subjected to stress degradation under different conditions recommended by the International Conference on Harmonization (ICH).