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Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.
Am J Physiol Cell Physiol
April 2005
Division of Pulmonary and Critical Care Medicine, Pulmonary Section, Atlanta Veterans Affairs and Emory University Medical Centers (151-P) 1670 Clairmont Road, Decatur, GA 30033, USA.
Recently, we demonstrated that the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands, either 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) or ciglitazone, increased endothelial nitric oxide (.NO) release without altering endothelial nitric oxide synthase (eNOS) expression (4). However, the precise molecular mechanisms of PPAR-gamma-stimulated endothelial.
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