2,681 results match your criteria: "Athens General Hospital "Laiko"[Affiliation]"

Article Synopsis
  • Wheezing in early childhood, primarily from viral infections like rhinoviruses, is a key indicator of potential asthma development and can lead to persistent respiratory issues.
  • Various respiratory viruses and certain bacteria are linked to wheezing and asthma attacks, with specific pathogens identified as having significant associations.
  • Asthma-related airway changes can start as early as age 1-3, influenced by genetics, environmental factors, and recurrent infections, although most infants who experience wheezing do not continue developing asthma.
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Background/aim: The tumor protein 53 (TP53) tumor suppressor protein (17p13.1) acts as a significant regulator for the cell cycle normal function. The gene is frequently mutated in colorectal adenocarcinoma (CRC) patients and is associated to poor prognosis and low response rates to chemo-targeted therapy.

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Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023.

Atheroscler Plus

March 2024

1st Department of Propedeutic Medicine, School of Medicine, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be adequately managed at different clinical settings. 2023 guidelines of the Hellenic Atherosclerosis Society focus on the assessment of ASCVD risk, laboratory evaluation of dyslipidemias, new and emerging lipid-lowering drugs, as well as diagnosis and treatment of lipid disorders in women, the elderly and in patients with familial hypercholesterolemia, acute coronary syndromes, heart failure, stroke, chronic kidney disease, diabetes, autoimmune diseases, and non-alcoholic fatty liver disease.

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Context: One of the major prognostic indices in neuroendocrine tumors (NETs) is Ki67 proliferation index.

Objective: To identify optimal grading Ki67 cutoffs to delineate differences in prognosis of patients with small intestinal NETs (SI-NETs).

Methods: Multicenter retrospective cohort analysis of 551 SI-NET patients diagnosed from 1993 through 2021 at 5 European referral centers with a mean (±SD) follow-up time of 51.

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What is New on Diabetic Neuropathy? Insights from the 2023 ADA and EASD Conferences.

Int J Low Extrem Wounds

February 2024

Department of Medicine, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK.

Diabetic neuropathy is a common complication of diabetes; yet its pathophysiology is still incompletely understood and until today, there is no specific treatment against it. In the two 2023 large congresses on diabetes (American Diabetes Association, ADA, European Association for the Study of Diabetes, EASD), several high-level studies have been presented. They have attempted to delineate the pathophysiology of DN, the characteristics of affected patients, and future potential treatments.

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Letter: Severe underweight and sarcopenia in decompensated cirrhosis are associated with high FGF21 levels.

Aliment Pharmacol Ther

March 2024

2nd Department of Internal Medicine and Research Laboratory, Medical School, National & Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.

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Article Synopsis
  • The study investigates the immunological and metabolic health of people living with HIV (PLWH) on combined antiretroviral therapy (cART) at Laiko General Hospital in Athens, focusing on potential health issues compared to the general population.
  • It examines specific plasma markers and compares those receiving integrase strand transfer inhibitors (INSTIs) and protease inhibitors (PIs), finding higher IL-6 levels in the PIs group and normal-range LBP mostly in the INSTIs group.
  • Overall, glucose, total cholesterol, and LDL cholesterol levels increased after viral suppression, particularly in the PIs group, although many other parameters showed no significant differences between the treatment groups.
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Article Synopsis
  • High mortality rates among people who inject drugs (PWID) in Greece, primarily due to overdose and HIV, have been documented in a study covering 2018-2022.
  • The study found a crude mortality rate of 3.52 deaths per 100 person-years, with notable increases in Athens, and highlighted that younger, daily injectors not in treatment had higher risks of death.
  • Results indicate an urgent need for preventive measures, especially in Thessaloniki, and suggest that the COVID-19 pandemic may have exacerbated these trends in Athens.
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Background And Aim: Serum alkaline phosphatase (ALP) activity has been associated with atherosclerotic cardiovascular disease (ASCVD). We aimed to investigate the association of ALP with ASCVD in patients with dyslipidemia.

Methods: We conducted a retrospective cohort study including consecutive adults with dyslipidemia followed-up for ≥3 years (from 1999 to 2022) in the outpatient Lipid Clinic of Ioannina University General Hospital, Greece.

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Background: Checkpoint inhibitor (CPI)-associated diabetes mellitus (CPI-DM) is a rare immune-related adverse event (irAE) that presents with variable clinical manifestations. Data about its pathogenesis have not yet been adequately studied.

Methods: Applying the recently updated diagnostic criteria from the American Diabetes Association, we retrospectively reviewed the medical records of all CPI-treated patients referred to our endocrinological unit for managing their endocrine irAEs and analyzed the incidence of CPI-DM, its clinical characteristics, and its management.

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Background: Previous meta-analyses resurrected the debated statement "the lower, the better" following blood pressure (BP)-lowering treatment. We investigated the benefits of BP-lowering treatment at different BP targets by prevention category.

Methods: The meta-analysis protocol was registered at the International Prospective Register of Systematic Reviews (CRD42022379249).

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Non-invasive tools for liver steatosis and steatohepatitis predict incidence of diabetes, cardiovascular disease and mortality 20 years later: The ATTICA cohort study (2002-2022).

Clin Nutr

March 2024

Department of Medicine, Devision of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA; Department of Medicine, Boston VA Healthcare System, Boston, MA, 02215, USA. Electronic address:

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) or, as recently renamed, metabolic dysfunction-associated steatotic liver disease (MASLD), has common metabolic pathways with diabetes and cardiovascular disease (CVD). Non-invasive tools (NITs) for liver steatosis and steatohepatitis (MASH) were studied as potential predictors of diabetes, cardiovascular disease (CVD) and mortality over a 20-year period.

Methods: In 2001-02, 3042 individuals from the Attica region of Greece were recruited randomly, and were stratified by subgroups of sex, age and region to reflect the general urban population in Athens, Greece.

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The ideal approach to the secondary dyslipidemia goal of lowering triglycerides (TG) is not well established. The available ω-3 fatty acid products differ from each other in composition and content. The purpose of the present study was to investigate the effect of a highly purified eicosapentaenoic acid (EPA) formulation on cardiometabolic biomarkers in high cardiovascular (CV) risk patients.

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JCO We report 3-year efficacy and safety results from the phase III CheckMate 649 trial. Patients with previously untreated advanced or metastatic gastroesophageal adenocarcinoma were randomly assigned to nivolumab plus chemotherapy or chemotherapy. Primary end points were overall survival (OS) and progression-free survival (PFS) by blinded independent central review (BICR) in patients whose tumors expressed PD-L1 combined positive score (CPS) ≥5.

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Gonadal dysfunction in women with diabetes mellitus.

Endocrine

August 2024

Department of Clinical Therapeutics, Endocrine Unit and Diabetes Centre, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

It is well known that both type 1 and type 2 diabetes mellitus (DM) are related to increased risk for cardiovascular (CV) and chronic kidney disease (CKD). However, besides these prominently presented complications, DM has also been associated with reproductive dysfunctions. It seems that these disorders are met in up to 40% of women with DM and consist of delayed menarche, all types of menstrual disorders, such as amenorrhea, oligomenorrhea, menstrual irregularity, as well as menorrhagia, infertility, characteristics of polycystic ovary syndrome (PCOS) and early (or rarely late) menopause.

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Article Synopsis
  • Long non-coding RNAs (lncRNAs) HOTAIR, LINC00951, POLR2E, and HULC have been linked to esophageal cancer development, particularly in Eastern populations, but their relationship with known prognostic factors in Western patients is not fully understood.
  • A study analyzed tissue samples from 95 esophageal cancer patients and 121 healthy controls, revealing that some lncRNAs' presence correlated with various cancer characteristics and prognostic markers, while HULC did not show significant differences.
  • The findings suggest that these genetic markers could serve as valuable tools for predicting esophageal cancer risk and outcomes, but further research with larger groups is needed to confirm their clinical relevance.
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Article Synopsis
  • - The SUN4P project investigates stroke healthcare quality in Greece by analyzing patient data from nine hospitals for first-ever strokes between 2019-2021.
  • - Out of 892 patients studied, the majority had ischemic strokes, with only a small percentage receiving treatment in specialized acute stroke units; yet, a high percentage received follow-up medications upon discharge.
  • - This study marks the first comprehensive data collection on stroke care quality in Greece, aiming to enhance treatment standards and outcomes for stroke patients nationwide.
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Obesity and atherosclerotic cardiovascular disease in adults with heterozygous familial hypercholesterolemia: An analysis from HELLAS-FH registry.

J Clin Lipidol

June 2024

1st Propedeutic Department of Medicine, School of Medicine, National and Kapodistrian University of Athens, Laiko General Hospital of Athens, Athens, Greece (Dr Liberopoulos). Electronic address:

Article Synopsis
  • Familial hypercholesterolemia (FH) and obesity are linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), but their combined impact is not well understood.
  • The study analyzed adults with heterozygous FH from the HELLAS-FH registry and found that obesity significantly raises the odds of coronary artery disease (CAD), while other complications like stroke or peripheral artery disease were not similarly affected.
  • The findings highlight that over half of the adults with HeFH are either overweight or obese, and obesity independently contributes to a higher prevalence of CAD among them.
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Background: Myosteatosis in cirrhotic patients has been evaluated in limited studies with conflicting results and no systematic review or meta-analysis have been performed in this setting.

Methods: We searched for all articles published until June 2023 to evaluate the prevalence of myosteatosis in cirrhosis and chronic liver disease.

Results: Seventeen studies focused on cirrhosis and five studies in patients with chronic liver disease were included: the overall pooled prevalence of myosteatosis was 46% [95% Confidence Interval (CI) 36-57%] and 33% (95% CI 15-59%), respectively (p = 0.

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Update on antiphospholipid syndrome.

Rheumatology (Oxford)

February 2024

Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

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Article Synopsis
  • The study investigated the influence of specific long non-coding RNA polymorphisms on esophageal cancer susceptibility in Western populations, focusing on HOTAIR, LINC00951, POLR2E, and HULC.
  • Analysis involved tissue samples from 95 esophageal cancer patients and 121 healthy control subjects, revealing that HOTAIR rs920778 was significantly more present in certain cancer types, while POLR2E rs3787016 was more common in controls and linked to less severe disease in cancer patients.
  • The findings suggest HOTAIR rs920778 could be targeted for therapy, and POLR2E rs3787016 may help assess cancer risk and treatment outcomes.
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Glucocorticoid discontinuation rate and risk factors for relapses in a contemporary cohort of patients with giant cell arteritis.

Rheumatol Int

April 2024

School of Medicine, General Hospital of Athens "Hippokration", 2nd Department of Medicine and Laboratory, Clinical Immunology-Rheumatology Unit, National and Kapodistrian University of Athens, 114 Vass. Sophias Ave., 115 27, Athens, Greece.

The rates of relapses and therapy discontinuation in patients with giant cell arteritis (GCA) in the modern therapeutic era have not been defined. We aimed to evaluate the glucocorticoid (GC) discontinuation rate and the factors associated with relapses in a contemporary GCA cohort. Patient and treatment data were collected cross-sectionally at first evaluation and 2 years later (second evaluation), in a multicenter, prospective GCA cohort.

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Coronavirus disease 2019 (COVID‑19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS‑CoV‑2), has triggered a worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically every organ. Melatonin, an ancient antioxidant found in all living organisms, has been suggested as a safe and effective therapeutic option for the treatment of SARS‑CoV‑2 infection due to its good safety characteristics and broad‑spectrum antiviral medication properties. Melatonin is essential in various metabolic pathways and governs physiological processes, such as the sleep‑wake cycle and circadian rhythms.

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