Factors Affecting Non-sentinel Lymph Node Metastasis in Early-Stage Breast Cancer.

Objective Breast cancer most commonly metastasizes to axillary lymph nodes via lymphatic drainage. Today, axillary lymph node surgery is at least as important as primary breast surgery. In today's breast surgery, supported by chemotherapy and radiotherapy, current approaches are taken to avoid axillary dissection in appropriate patient groups.

Predictive value of the Naples prognostic score for no-reflow phenomenon after saphenous vein graft stenting.

Background: No-reflow is a critical adverse event associated with percutaneous coronary intervention (PCI), particularly during saphenous vein graft (SVG) procedures. The Naples Prognostic Score (NPS) reflects inflammatory status, but its relationship with no-reflow remains unclear. Therefore, we aimed to evaluate the relationship between NPS and no-reflow occurrence following SVG PCI.

Long-term Impact of Continuous Glucose Monitoring Assistance on Glycemic Control in Children and Adolescents with Type 1 Diabetes Following the 2023 Kahramanmaraş Earthquake.

Objective: This study aimed to evaluate the impact of continuous glucose monitoring (CGM) assistance on glycemic control in children with type 1 diabetes (T1D) in earthquake-affected regions, comparing those who benefited from CGM with those who did not. Additionally, the study assessed changes in CGM metrics over nine months of CGM use.

Methods: A multicenter, cross-sectional study was conducted across 11 centers in Türkiye.

Could MOTS-C Levels in Children with Type 1 Diabetes Mellitus Be an İndicator for Early Diabetic Kidney Disease?

Objective: The aim of our study was to compare serum MOTS-c levels in children with Type 1 diabetes mellitus (T1DM) to those of healthy children. We also aimed to examine whether serum MOTS-c levels could be used as an early indicator of DKD by correlating with changes in GFR and microalbuminuria.

Methods: We recruited 82 patients who were being treated for insulin-dependent diabetes at the outpatient pediatric endocrinology clinic.

Apnea-hypopnea duration may be a better choice rather than apnea-hypopnea index for forecasting complications in OSAS.

Objective: Mean apnea-hypopnea duration (AHD) is the mean duration of apnea-hypopneas experienced during sleep and was found as an indicator of blood oxygenation. The aim of this study was to compare and define the differences in clinical, demographic and polysomnographic characteristics of obstructive sleep apnea (OSA) patients in long and short AHD groups and investigate the relationship between apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and sleepiness.

Methods: The cross-sectional analysis included 511 OSA patients who were >18 years and followed up between June 2019 and December 2019 in the Sleep Center of university hospital.

Evaluating single-dose methotrexate alone versus methotrexate with letrozole for treating ectopic pregnancy: a comparative study.

Purpose: Ectopic pregnancy (EP) constitutes 1-2% of all pregnancies. Methotrexate (MTX) is commonly used in treating EP, but it has some limitations and potential side effects. Clinical studies have shown that letrozole, an aromatase inhibitor, may potentially be used in conjunction with MTX therapy.

Are Cases of Nonvisualized Appendix on Ultrasound Not Actually Appendicitis? Single-Center Results.

Background: Ultrasonography (USG), which is used as the first step in the diagnosis of acute appendicitis (AA), sometimes cannot visualize the appendix. The aim of this study was to retrospectively analyze the clinical, imaging, and pathology results of these cases and to provide information to clinicians about the next step to be taken.

Methods: The study was performed retrospectively between January 1, 2021 and December 31, 2021.

Efficacy of Ruxolitinib in the management of chronic GVHD.

Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for hematological diseases, with success rates improving due to advancements in conditioning regimens and new anti-graft versus host disease (GVHD) drugs. Ruxolitinib, an oral selective Janus kinase (JAK) 1 and 2 inhibitor has been used to mitigate the effects of various inflammatory and myeloproliferative syndromes, given the JAK kinase pathway's central role in cytokine signaling during inflammatory and immune processes. In this study we aimed to assess ruxolitinib's efficacy in patients with chronic GVHD (cGVHD).

Evaluation of the lacrimal punctum parameters in Turkish population with anterior segment optic coherence tomography.

Purpose: To determine the anatomical parameters of puncta in Turkish population without any complaint of epiphora, using anterior segment optic coherence tomography (AS-OCT).

Materials And Methods: The healthy participants between 26 and 83 years old who applied to our outpatient clinic from May 2022 to June 2022 for spectacle prescription or the accompanying person of the patients were included in the study. All participants underwent AS-OCT (Revo 60, OPTOPOL Technology, Zawiercie, Poland).

The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation.

Purpose: To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility.

Methods: A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE.

Low-Dose Ionizing Radiation Exposure and Its Impact on Skin Aging Among Healthcare Workers.

Background: Ionizing radiation (IR) is a occupational risk for healthcare professionals, which can result in a range of health issues.

Objectives: This study aims to assess the relationship between low-dose IR exposure and the development of early aging-related skin wrinkles in healthcare workers.

Methods: In the current cross-sectional study, 70 health workers exposed to low-dose ionizing radiation for at least five years were compared with 70 non-exposed health workers.

The effectiveness of optic nerve sheath diameter in predicting large vessel occlusion in ischemic stroke patients.

Aim: This study assessed the effectiveness of ultrasonography-measured optic nerve sheath diameter (ONSD) in predicting large vessel occlusion (LVO) in ischemic stroke patients.

Materials And Methods: This single-center, prospective observational study involved patients presenting to the emergency department within 24 hours of symptom onset with moderate to severe stroke, and healthy volunteers.

Results: The study included 133 ischemic stroke patients and 63 healthy volunteers.

The assessment of the relationship between the development of cardiovascular diseases and SCUBE-1 level in individuals exposed to loud noise.

Development of industry in the modern world, the number of individuals working in noisy environments is increasing with each passing day. Noise causes an increase in the incidence of cardioembolic events, yet the relevant underlying pathophysiology remains unclear. In this study, we aimed to investigate the relationship between signal peptide and complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 (SCUBE-1) in the pathophysiology of cardioembolic events in individuals exposed to noisy environments.

Predictors of long-term all-cause mortality after carotid artery stenting: evaluation of the Naples prognostic score.

Background: Mortality in patients after carotid artery stenting (CAS), a treatment approach for atherosclerotic carotid artery stenosis, is influenced by numerous factors. This study aimed to investigate the prognostic value of the Naples prognostic score (NPS), which reflects nutritional and inflammatory status, in CAS patients.

Methods: We retrospectively included 697 patients who underwent CAS from January 2016 to December 2020 at our institute.

Measurement of thiol/disulfide homeostasis and ischemic modified albumin levels in patients with uterine leiomyomas.

Objective: The aim is to contrast the serum levels of thiol-disulfide homeostasis and ischemic modified albumin between patients with leiomyoma and healthy individuals and to assess the impact of oxidative stress on the etiopathogenesis of leiomyoma.

Methods: In this prospective case-control study, a total of 154 participants were included, consisting of 77 cases diagnosed with leiomyoma and 77 healthy individuals without leiomyoma. The demographic characteristics and ultrasonographic findings of the participants were recorded, and parameters such as albumin, ischemia-modified albumin, and thiol-disulfide homeostasis were evaluated.

An Echocardiographic Study of a Rare Cause of Mitral Regurgitation: Hypoplastic Posterior Mitral Valve Leaflet.

Background: The precise etiology of hypoplasia of the posterior mitral valve leaflet (PMVL) remains incompletely elucidated; however, it has been hypothesized to stem from genetic mutations occurring during fetal development. Herein, we present the anatomical characteristics of the mitral valve and associated cardiac pathologies in patients with hypoplastic PMVL.

Methods: This single-center retrospective study involved patients who presented between 2015 and 2021 at a tertiary healthcare facility.

Ipsilateral Distal Both Bone Forearm and Lateral Humeral Condyle Fractures With Posterolateral Elbow Dislocation: A Rare Injury in a Child.

Lateral humeral condyle fractures are common in children, but concomitant elbow dislocation is rare. This case report involves a 10-year-old girl with an ipsilateral distal both-bone forearm fracture and a lateral humeral condyle fracture accompanied by a posterolateral elbow dislocation. Closed reduction of the elbow was performed in the emergency department without delay, and the patient was operated on as soon as possible.

Effects of virtual reality exercise on pain, joint motion, and quality of life in patients with frozen shoulder: a randomized controlled study.

Background: Restriction of shoulder movements in frozen shoulder may negatively affect individual's daily living activities. The effect of the virtual reality (VR)-based exercise program, which is an innovative application and has been used in the field of physiotherapy in recent years, is unknown on patients diagnosed with frozen shoulder.

Objective: This study was conducted to determine the effects of a VR-based exercise program provided to patients with frozen shoulder on their pain, joint motion, and quality of life.

Digital media use and its effects on digital eye strain and sleep quality in adolescents: A new emerging epidemic?

This study examines the association between excessive digital media use and adverse health outcomes, specifically Digital Eye Strain (DES) and Poor Sleep Quality (PSQ), in adolescents. A cross-sectional survey of 512 participants (aged 11-18 years) assessed DES and PSQ using the Computer Vision Syndrome Questionnaire and the Pittsburgh Sleep Quality Index. We found a high prevalence of DES (63.

The role of serum biomarkers in determining systemic inflammation and cardiovascular risk in pseudoexfoliation syndrome.

Purpose: To investigate the role of hematological and atherogenic biomarkers in evaluating systemic inflammation and cardiovascular risk in patients with pseudoexfoliation syndrome.

Methods: This retrospective study included 200 patients, 90 with pseudoexfoliation (PEX) syndrome (Group 1) and 110 healthy controls (Group 2). Twelve-hour fasting blood samples were collected to measure complete blood count, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) (neutrophil x platelet/lymphocyte), systemic inflammatory response index (SIRI) (neutrophil x monocyte/lymphocyte), pan-immune inflammation value (PIV) (neutrophil x platelet x monocyte/lymphocyte), C-reactive protein (CRP), uric acid, glucose, triglycerides (TG), total cholesterol, HDL, LDL, non-HDL, and triglyceride-glucose (TyG) index (Ln (TG [mg/dL] × glucose [mg/dL]/2)).

Clinical and genetic characteristics of patients with monocarboxylate transporter-8 deficiency: a multicentre retrospective study.

Unlabelled: Allan-Herndon-Dudley syndrome is a neurodevelopmental disorder characterized by motor and intellectual disabilities. Despite its rarity, there has been a rise in interest due to ongoing research and emerging therapy suggestions. In this multicenter, retrospective, cross-sectional study, the genetic characteristics and clinical data of twenty-one cases of genetically confirmed MCT8 deficiency were evaluated.

The role of hyaluronan modification in the etiopathogenesis of gastric cancer.

Objective: Gastric cancer is the second most common cancer in the world, accounting for 650,000 deaths per year, and is observed in approximately 10% of the patients diagnosed. Extracellular matrix abnormalities have been documented in gastric cancer patients. The aim of our study was to understand the role of high levels of hyaluronan, an extracellular matrix glycosaminoglycan, and its mechanistic role in gastric cancer pathobiology.

Comparison of tip-bendable aspiration-assisted and standard access sheaths in the treatment of lower calyceal stones.

Objective: The aim of this study was to compare the success and complication rates of retrograde intrarenal surgery for lower calyceal renal stones performed with novel tip-bendable suction ureteral access sheaths and standard ureteral access sheaths.

Methods: Between March 2023 and March 2024, a total of 88 patients underwent retrograde intrarenal surgery for lower renal calyceal stones smaller than 20 mm. Based on the access sheath used, patients were divided into two groups: Group 1 (n=43) included patients treated with novel tip-bendable suction ureteral access sheaths and Group 2 (n=45) included patients treated with standard ureteral access sheaths.