[Whether to implant a defibrillator or not? The Possibility of Using the MADIT-ICD Benefit Score Calculator in Real Practice].

Aim: To study the predictive capabilities of the MADIT-ICD Benefit Score calculator in assessing the benefit of implantable cardioverter defibrillator (ICD) placement for the primary prevention of sudden cardiac death (SCD).

Material And Methods: This study included 388 patients with NYHA II-IV functional class chronic heart failure (CHF) with a left ventricular ejection fraction (LVEF) ≤35 % who underwent ICD placement for the primary prevention of SCD. Patients were followed up for two years to record the endpoints of first-time paroxysmal sustained ventricular tachyarrhythmia (VT) or non-arrhythmic death.

[The evolution of personnel potential of Oblast leading health care institution].

The state health care policy in Russia is directed at improving medical care quality and population satisfaction with it. The functioning of medical organizations beloning to national health care system has determinative impact on population health. The increasing of level of organization of their functioning is imposible without target manpower policy, upgrading qualification and professionalism of health care workers.

Novel hemizygous variant leads to combined immunodeficiency with defective platelet calcium signaling and cell mobility.

Background: To date, fewer than 20 patients have been identified as having germline biallelic mutations in the coronin-1A gene () and its protein with clinical features of combined immunodeficiency characterized by T-cell lymphopenia ranging from the severe phenotype to the mild phenotype, recurrent infections, and lymphoproliferative disorders. However, the effects of CORO1A protein disruption on actin-dependent functions in primary cells have not been fully delineated.

Objective: We sought to characterize the underlying defects of actin-dependent cellular functions in a female patient with combined immunodeficiency caused by a novel missense variant in the gene in combination with a heterozygous microdeletion of chromosome 16p11.

A scoping review of literature on clozapine from former USSR states published in Russian language.

Objective: Access to literature on clozapine in Russian language remains strikingly limited. We aimed to identify and translate clinical evidence on clozapine-based treatment outcomes.

Methods: We performed a systematic review in PubMed, Embase and scientific indexes from former USSR states searching for articles published in Russian from the database inception till January 2023 and summarized the data in a scoping review (PROSPERO Reg.

[Nutrition of pregnant. Comparative analysis based on data from a survey of residents of Russian Federation and the Republic of Azerbaijan (on the example of Astrakhan and Baku)].

Poor nutrition of the expectant mother leads to an unfavorable course of pregnancy and a number of serious deviations in the development of the child. Therefore, a multifaceted study of the actual nutrition of a pregnant woman is relevant, including the identification of trends associated with geographical, ethnic, and family characteristics. The study was aimed at conducting a comparative analysis of the nutrition of pregnant women from two cities, Astrakhan (Russian Federation) and Baku (Republic of Azerbaijan), by means of a questionnaire.

[Effects of antimicrobial peptide from lactoferrin in blood serum and urine in patients with renal colica with urolithiasis and pyelonephritis].

Aim: To evaluate the role of lactoferrin and lactoferricin in blood serum and urine in patients with an attack of renal colic against the background of urolithiasis and pyelonephritis.

Materials And Methods: We examined 149 patients admitted to the urological department of the City Clinical Hospital No. 3 of Astrakhan, according to emergency indications, with an attack of renal colic.

[Social portrait of persons older the active working age visiting of health centers.].

Persons older an active working age, having behind shoulders a cargo of the collected chronic pathology are ready to performance of any instructions from medical workers. Doctors of the centers of health have more possibilities of carrying out of educational work on the population and delivery of recommendations on conducting a healthy way of life, conservation and strengthening of health. On the basis of it sociological interrogation of 135 respondents, with objective of concept of a social portrait of potential visitors of the center of health among persons older an active working age has been lead.

Research of Russian physicians' opinions on tuberculosis pharmacogenetics.

Background: There is currently no widespread implementation of pharmacogenetic testing (PGx) methods in the practice of phthisiology service.

Objective: The aim of this study is to determine how informed and prepared phthisiologists, residents, and postgraduate students of the Russian Medical Academy of Continuing Professional Education (RMACPE, Moscow) use PGx techniques in their work to improve treatment safety, predict the occurrence of adverse reactions (ADRs), and personalize therapy.

Methods: A survey was conducted among phthisiologists (n = 314) living in different regions of the Russian Federation and studying at RMACPE, such as residents and post-graduate students (n = 185).

Combination of Bacteriophages and Antibiotics for Prevention of Vascular Graft Infections-An In Vitro Study.

(1) Background: Implant-associated bacterial infections are usually hard to treat conservatively due to the resistance and tolerance of the pathogens to conventional antimicrobial therapy. Bacterial colonization of vascular grafts may lead to life-threatening conditions such as sepsis. The objective of this study is to evaluate whether conventional antibiotics and bacteriophages can reliably prevent the bacterial colonization of vascular grafts.

[The regional provision of population with specialized medical care according to profile of cardiovascular surgery].

The diseases of circulatory system take leading position in structure of mortality. The efficiency of development of scientifically-proved and modern models of medical care support is to be based on data of monitoring of level, dynamics and structure of corresponding pathology. The accessibility and timeliness of high-tech medical care support directly depends on degree of influence of relevant regional characteristics.

[Rare complication of echinococcosis in clinical practice].

The authors report retroperitoneal echinococcosis with destruction of the bodies and left transverse processes of L4-5 vertebrae, recurrence and pathological fracture of L4-5 vertebrae with secondary spinal stenosis and left-sided monoparesis. Retroperitoneal echinococcectomy, pericystectomy, decompressive laminectomy L5 and foraminotomy L5-S1 on the left were performed. Therapy with albendazole was prescribed in postoperative period.

Composition of Bacteriophages for Therapeutic and Prophylactic Use in Monkeys.

Keeping rhesus monkeys as laboratory animals requires timely prevention and treatment of infections, including diseases of bacterial etiology. Based on our own studies of the microflora of healthy and sick monkeys, as well as analysis of published reports, we identified clinically significant representatives of pathogenic and opportunistic bacteria: E. coli, Staphylococcus aureus, Klebsiella spp.

[An integrated approach to reducing hyperesthesia of teeth in patients with underlying somatic pathology].

The Aim Of The Study: Was to analyze the effectiveness of therapeutic and preventive measures aimed at reducing hyperesthesia of hard dental tissues in patients with background somatic diseases.

Materials And Methods: The study involved 113 patients with increased tooth sensitivity and treated in the gastroenterological and endocrinological departments of the S.M.

Echocardiographic Predictors of Ventricular Tachyarrhythmias in Patients With Cardioverter-Defibrillator Implanted for Primary Prevention of Sudden Cardiac Death. Results From a two-Year Prospective Follow-up Study.

Aim      To compare variables of transthoracic EchoCG for determining echocardiographic predictors and their prognostic role in the development of persistent paroxysmal ventricular tachyarrhythmias (VT) in patients with ischemic CHF who had been implanted with a cardioverter defibrillator (CD) for primary prevention of sudden cardiac death.Material and methods  This single-site prospective study included 176 patients with CHF of ischemic origin aged 58.7±7.

Colchicine in Cardiac Surgery: The COCS Randomized Clinical Trial.

In patients who underwent cardiac surgery, first-time postoperative atrial fibrillation (POAF) is associated with increased incidence of hospital-acquired complications and mortality. Systemic inflammation is one of confirmed triggers of its development. The anti-inflammatory properties of colchicine can be effective for the POAF prevention.

Survival and freedom from reoperation after the Ross procedure in a Russian adult population: A single-center experience.

Objectives: To evaluate our 12-year experience with the Ross procedure in adults.

Methods: A retrospective analysis of 215 cases of the Ross procedure was performed. The mean age of the patients was 36 ± 11.

Electrophysiological Evidence for Anti-epileptic Property of Taurine.

Taurine, 2-aminoethanesulfonic acid, is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Several lines of evidence suggest that taurine may function as a potent inhibitory neuromodulator that regulate neuronal activity in many cerebral areas. Parenteral injection of kainic acid (KA), a glutamate receptor agonist, causes severe and stereotyped behavioral convulsions in mice and is used as a rodent model for human temporal lobe epilepsy.

An international guideline with six personalised titration schedules for preventing myocarditis and pneumonia associated with clozapine.

White blood cell (WBC) monitoring has reduced clozapine-treated patient deaths associated with agranulocytosis to a rarity. However, clozapine protocols and package inserts worldwide provide no instructions for preventing myocarditis or pneumonia during clozapine titrations. Prescribers worldwide are largely unaware of that.

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines.

Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells. Chemical compounds able to restore the level of PA catabolism in tumors could become potential antineoplastic agents.

Surgical treatment of Kommerell's diverticulum.

Kommerell's diverticulum (KD) is a rare congenital vascular abnormality due to the formation of an abnormal aortic arch, most commonly associated with dilatation at the proximal part of the aberrant subclavian artery. This article describes an option of surgical treatment in a patient with KD. The proposed new technique of aortic arch surgical reconstruction with a stent-graft placement in the descending aorta reduces CPB time, aortic clamp and circulatory arrest time.

[Maintenance of persons older the active working age high-tech medical care on the example of the astrakhan region with 2015 for 2019.].

In article dynamics of variation of a population older an active working age of the Astrakhan area and a level of their security is presented by high-tech medical care. Total parameters for the five years' period on all medical organizations which have rendered the given type of the help of the considered category of persons are in detail presented and analysed. The increase of quantity of the rendered high-tech types of the help in 1,6 times, and security in 1,5 times in spite of the fact that the quantity of persons of a pension age grows from year to year is revealed.

Assessing the biological effects of microwave irradiation on human semen and determining the role of seminal plasma polyamines in this process.

The aim of the present study was to investigate the influence of millimeter-wave electromagnetic (MW) irradiation on normal and pathological human sperm , and to evaluate a possible role of polyamines (PA) in this process. The stability of sperm membranes, the number of apoptotic gametes, and the content of seminal plasma PA in the ejaculates of fertile and subfertile men were compared before and after short-term MW electromagnetic exposure . The ejaculate samples were collected from healthy donors [n=25, age 22-38 years old (y.