74 results match your criteria: "Aston University Birmingham[Affiliation]"
PLoS Med
December 2024
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.
Background: Clozapine is widely regarded as a highly efficacious psychotropic drug that is largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is not well-established due to the absence of analytic cohort studies.
View Article and Find Full Text PDFRisk Anal
July 2024
Operations and Information Management Department, Aston Business School, Aston University Birmingham, Birminghamm, UK.
Due to the importance of the commercial aviation system and, also, the existence of countless accidents and unfortunate occurrences in this industry, there has been a need for a structured approach to deal with them in recent years. Therefore, this study presents a comprehensive and sequential model for analyzing commercial aviation accidents based on historical data and reports. The model first uses the failure mode and effects analysis (FMEA) technique to determine and score existing risks; then, the risks are prioritized using two multi-attribute decision making (MADM) methods and two novel and innovative techniques, including ranking based on intuitionistic fuzzy risk priority number and ranking based on the vague sets.
View Article and Find Full Text PDFThis research letter discusses the perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in this area. A mixed methods online survey was created, and a total of 174 community pharmacy staff completed the survey. The results highlight the range of conditions currently encountered in community pharmacy and the breadth of challenges facing community pharmacy staff, in particular challenges surrounding providing a differential diagnosis.
View Article and Find Full Text PDFChem Sci
March 2024
Aston Advanced Materials Research Centre, Aston University Birmingham B4 7ET UK
We report for the first time a reversible addition-fragmentation chain transfer polymerisation-induced self-assembly (RAFT-PISA) formulation in ionic liquid (IL) that yields worm gels. A series of poly(2-hydroxyethyl methacrylate)--poly(benzyl methacrylate) (PHEMA--PBzMA) block copolymer nanoparticles were synthesised RAFT dispersion polymerisation of benzyl methacrylate in the hydrophilic IL 1-ethyl-3-methyl imidazolium dicyanamide, [EMIM][DCA]. This RAFT-PISA formulation can be controlled to afford spherical, worm-like and vesicular nano-objects, with free-standing gels being obtained over a broad range of PBzMA core-forming degrees of polymerisation (DPs).
View Article and Find Full Text PDFAt times of severe social disruption, be that war, conflict, pandemic, or economic downturn, both the availability and consumption of healthy dietary patterns can be adversely affected with any effects often outlasting the initial social disruption. For instance, when the COVID-19 pandemic hit and lockdown restrictions followed, households were reported to consume unhealthy diets. In some cases, this seemed to be a response to the situation and a coping mechanism.
View Article and Find Full Text PDFObjective: To synthesise qualitative research exploring the care-giving experiences of parents of young people with profound and multiple learning disabilities (PMLD) and complex healthcare needs, in the transition to adulthood years.
Method: Four databases were systematically searched: Scopus, WoS Core Collection, Medline and SciELO. Included papers were assessed for quality and thematically synthesised.
Int J Orthop Trauma Nurs
November 2023
RCSI Medical University Bahrain, Bahrain; Aston University, UK.
J Am Heart Assoc
May 2023
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China.
Background COVID-19 vaccines have demonstrated effectiveness against SARS-CoV-2 infection, hospitalization, and mortality. The association between vaccination and risk of cardiovascular complications shortly after SARS-CoV-2 infection among patients with cardiovascular disease remains unknown. Methods and Results A case-control study was conducted with cases defined as patients who had myocardial infarction or stroke within 28 days after SARS-CoV-2 infection between January 1, 2022 and August 15, 2022.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2023
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2).
View Article and Find Full Text PDFBioeng Transl Med
September 2022
Regenerative Medicine Institute, Biomedical Sciences Building National University of Ireland Galway Galway Ireland.
Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high-quality, clinically-compliant GMP cells to replace costly, high-risk and limited scale manual expansion processes. We present the design of a fully automated, robot-assisted platform incorporating the use of multiliter stirred tank bioreactors for scalable production of adherent human stem cells. The design addresses a needle-to-needle closed process incorporating automated bone marrow collection, cell isolation, expansion, and collection into cryovials for patient delivery.
View Article and Find Full Text PDFChem Sci
April 2022
Department of Chemistry, University of Warwick Coventry CV4 7AL UK
Three fluorinated, hydrophobic initiators have been utilised for the synthesis of low molecular mass fluoro-poly(acrylic acid) heterotelechelic homopolymers to mimic high chi ()-low diblock copolymers with ultrafine domains of sub-2 nm length scale. Polymers were obtained by a simple photoinduced copper(ii)-mediated reversible-deactivation radical polymerisation (Cu-RDRP) affording low molecular mass (<3 kDa) and low dispersity ( = 1.04-1.
View Article and Find Full Text PDFAm J Respir Cell Mol Biol
March 2022
College of Health and Life Sciences Aston University Birmingham, United Kingdom.
This paper offers a detailed review of the UK's trade performance during the COVID-19 crisis and reflects on how this may be revived. During 2020, UK goods exports contracted more sharply than those of its international peers. Statistics suggest that UK had a deeper decline and slower recovery than Germany, Italy, Spain and the US.
View Article and Find Full Text PDFMov Disord Clin Pract
July 2021
Department of Neurology, Movement Disorders and Neuromodulation Unit Charité University Medicine Berlin Berlin Germany.
Background: Tics describe a wide range of sudden and repetitive behaviors. Their multifaceted clinical features may resemble other explosive behaviors, including repetitive episodes of aggression toward others (allo-aggression) reported by subjects without tics. Here, we document 3 exemplary cases that help disentangle allo-aggressive behaviors from tics.
View Article and Find Full Text PDFThis paper makes an innovative contribution to the extant literature by analysing the determinants of economic stimulus packages implemented by governments in response to the COVID-19 pandemic. In particular, we explore whether stock market declines observed in many countries can predict the size of COVID-19 stimulus packages. Moreover, we explore whether a country's level of income can augment the underlying relationship between stock market declines and stimulus packages.
View Article and Find Full Text PDFJ Chem Technol Biotechnol
April 2021
Centre for Biological Engineering, School of AACME, Chemical Engineering Department Loughborough University Loughborough UK.
Background: Traditional large-scale culture systems for human mesenchymal stem/stromal cells (hMSCs) use solid microcarriers as attachment substrates. Although the use of such substrates is advantageous because of the high surface-to-volume ratio, cell harvest from the same substrates is a challenge as it requires enzymatic treatment, often combined with agitation. Here, we investigated a two-phase system for expansion and non-enzymatic recovery of hMSCs.
View Article and Find Full Text PDFChin J Physiol
November 2020
Department of Anatomy, Edo University Iyamho, Edo State, Nigeria.
Although selenium is known to be essential for reproductive function, studies have indicated the adverse effect with its prolonged use. The present study investigated the duration-related effect of selenium administrations on reproductive hormones and estrous cycle indices in adult female Wistar rats exposed to a model of light pollution using altered photoperiod (AP). Ninety-six cyclic female Wistar rats displaying 4-5 days' estrous cycle length (ECL) and weighing 148-152 g were randomly divided into short and long experimental cohorts consisting of six groups each and spanning for 1 and 8 weeks, respectively.
View Article and Find Full Text PDFBackground: Whole-cell phenotypic screening is the driving force behind modern anti-tubercular drug discovery efforts. Focus has shifted from screening for bactericidal scaffolds to screens incorporating target deconvolution. Target-based screening aims to direct drug discovery toward known effective targets and avoid investing resources into unproductive lines of enquiry.
View Article and Find Full Text PDFRSC Adv
September 2020
Aston Institute of Materials Research, Aston University Birmingham B4 7ET UK +44 (0)121 204 4870.
Magnetosomes are nano-sized magnetic nanoparticles with exquisite properties that can be used in a wide range of healthcare and biotechnological applications. They are biosynthesised by magnetotactic bacteria (MTB), such as MSR-1 (). However, magnetosome bioprocessing yields low quantities compared to chemical synthesis of magnetic nanoparticles.
View Article and Find Full Text PDFBackground: The loss of efficiency and performance of bioprocesses on scale-up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at the larger scale in a bench-scale two-compartment reactor [plug flow reactor (PFR) + stirred tank reactor (STR)] using the cadaverine-producing recombinant DM1945 Δact3 Ptuf-ldcC_OPT. The new scale-down strategy developed here studied the effect of increasing the magnitude of fermentation gradients by considering not only the average cell residence time in the PFR ( ), but also the mean frequency at which the bacterial cells entered the PFR ( ) section of the two-compartment reactor.
View Article and Find Full Text PDFBackground Women are underrepresented in cardiac resynchronization therapy (CRT) trials. Some studies suggest that women fare better than men after CRT. We sought to explore clinical outcomes in women and men undergoing CRT-defibrillation or CRT-pacing in real-world clinical practice.
View Article and Find Full Text PDFEur Cardiol
July 2019
Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust Birmingham, UK.
The development of a subnormal level of testosterone (T) is not universal in ageing men, with 75% of men retaining normal levels. However, a substantial number of men do develop T deficiency (TD), with many of them carrying a portfolio of cardiovascular (CV) risk factors, including type 2 diabetes (T2D) and the metabolic syndrome. TD increases the risk of CV disease (CVD) and the risk of developing T2D and the metabolic syndrome.
View Article and Find Full Text PDFPLoS One
February 2020
School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia.
Mel4 is a novel cationic peptide with potent activity against Gram-positive bacteria. The current study examined the anti-staphylococcal mechanism of action of Mel4 and its precursor peptide melimine. The interaction of peptides with lipoteichoic acid (LTA) and with the cytoplasmic membrane using DiSC(3)-5, Sytox green, Syto-9 and PI dyes were studied.
View Article and Find Full Text PDFJ Arrhythm
December 2018
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University Tianjin China.
Background: Brugada syndrome is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation (VT/VF), potentially leading to sudden cardiac death (SCD). T-T intervals, (T-T)/QT ratio and T-T dispersion have been proposed for risk stratification, but their predictive values in Brugada syndrome have been challenged recently.
Methods: A systematic review and meta-analysis was conducted to examine their values in predicting arrhythmic and mortality outcomes in Brugada Syndrome.