5 results match your criteria: "Associated Laboratory for the National Reference Centre for Gonococci[Affiliation]"

Molecular epidemiology of penicillinase-producing Neisseria gonorrhoeae isolates in France.

Clin Microbiol Infect

December 2017

APHP, Saint Louis-Lariboisière-Fernand Widal Hospital Group, Laboratory of Bacteriology, Paris, France; Associated Laboratory for the National Reference Centre for gonococci, Paris, France; IAME, UMR 1137, INSERM, Université Paris Diderot, Paris, France. Electronic address:

Objectives: Characterizing the molecular epidemiology of antibiotic resistance is crucial for a better understanding of the evolution and spread of resistance in Neisseria gonorrhoeae. Here, we examine the molecular epidemiology of penicillinase-producing N. gonorrhoeae (PPNG) isolates in France.

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Two extended-spectrum cephalosporin-resistant Neisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistant N.

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Molecular epidemiology and mechanisms of resistance of azithromycin-resistant Neisseria gonorrhoeae isolated in France during 2013-14.

J Antimicrob Chemother

September 2016

APHP, Lariboisière-Fernand Widal Hospital, Laboratory of Bacteriology and Associated Laboratory for the National Reference Centre for Gonococci, F-75010 Paris, France INSERM, IAME, UMR 1137, F-75018 Paris, France University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, F-75018 Paris, France

Objectives: The objective of this study was to determine the prevalence and mechanisms of azithromycin resistance of Neisseria gonorrhoeae French isolates from 2013 to 2014.

Methods: N. gonorrhoeae samples isolated in a network of laboratories were tested for susceptibility to azithromycin between April 2013 and March 2014.

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Assessment of coinfection of sexually transmitted pathogen microbes by use of the anyplex II STI-7 molecular kit.

J Clin Microbiol

March 2015

APHP, Groupe Hospitalier Saint Louis-Lariboisière-Fernand Widal, Laboratory of Bacteriology-Virology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France INSERM, IAME, UMR 1137, Paris, France University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.

Anyplex STI-7 is a new molecular kit that detects seven sexually transmitted pathogens. Among 202 subjects screened for genital infection, 143 (70.4%) were diagnosed with at least one pathogen, in concordance with reference methods.

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We report the first case in France of a high-level azithromycin-resistant Neisseria gonorrhoeae (minimum inhibitory concentration (MIC) = 96 mg/L) assigned to MLST7363 (NG-MAST ST6360), also resistant to ciprofloxacin and tetracycline but susceptible to ceftriaxone. The patient was a 51 year-old heterosexual man who returned following 1g azithromycin monotherapy. Mechanisms of azithromycin resistance were a C2599T mutation in the four copies of the rrl gene and a novel mutation in the promoter of the mtrR gene.

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