2,703 results match your criteria: "Assistance Publique-Hôpitaux de Paris-Université Pierre et Marie Curie[Affiliation]"

Article Synopsis
  • - This study explores how machine learning can predict whether individuals with traumatic brain injury (TBI) will return to work one year after their injury, using data collected from 586 hospitalized patients across Europe.
  • - By analyzing hospital stay and follow-up data, the researchers found that including follow-up information significantly improved prediction accuracy, going from around 81% to 88%.
  • - The final model, which included five key predictors, achieved 90% accuracy and can help clinicians set realistic goals and tailor interventions for TBI patients, enhancing their chances of returning to work.
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Impact of Fetal Umbilical Cord Blood CD34+ Cells on Breast Cancer Cell Lines: A Mechanism of Fetal Microchimerism.

Cells Tissues Organs

October 2024

Service de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, Paris, France.

Introduction: Fetal microchimerism could be involved in the regulation of breast cancer oncogenesis. CD34+ cells could be of a particular interest as up to 12% of the CD34+ population in maternal blood are of fetal origin. The aim of this research was to analyze the impact of umbilical cord blood (UCB) CD34+ on MCF-7 and MDA-MB-231 breast cancer cell lines, in order to uncover novel biological mechanisms and suggest novel treatment options for breast cancer.

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Background: Myosin heavy chain 7 ()-related myopathies (-RMs) are a group of muscle disorders linked to pathogenic variants in the gene, encoding the slow/beta-cardiac myosin heavy chain, which is highly expressed in skeletal muscle and heart. The phenotype is heterogeneous including distal, predominantly axial or scapuloperoneal myopathies with variable cardiac involvement.

Methods: We retrospectively analysed the clinical, muscle MRI, genetic and myopathological features of 57 patients.

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Spontaneous intracranial hypotension is generally secondary to cerebrospinal fluid leaks. Spinal magnetic resonance imaging is an important part of the diagnostic workup, especially to display spinal longitudinal epidural collections. Other causes of leaks include nerve root sleeve tear and cerebrospinal fluid-venous fistula.

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Epidemiology and outcomes of patients with tuberculosis requiring extracorporeal membrane oxygenation: An ELSO registry analysis.

Intensive Crit Care Nurs

February 2025

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Article Synopsis
  • This study looked at patients with tuberculosis who needed a special life support system called ECMO, which helps patients with serious breathing problems.
  • Researchers checked data from 2003 to 2022 to see how well these patients did after using ECMO.
  • The results showed that while ECMO can help, it’s really important to start it on time and manage it carefully to reduce problems and help patients recover better.
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Health status of individuals with polyhandicap across a 5-year follow-up period.

Sci Rep

October 2024

EA 3279, CEReSS - Research Centre on Health Services and Quality of Life, Aix Marseille University, 27, Boulevard Jean-Moulin, Marseille, France.

The present longitudinal study examined a large sample of individuals with PIMD/Polyhandicap to: (i) describe the evolution over time of the health status in terms of severity, (ii) identify the potential predictors of health status change. This study used the data of the French national EVAL-PLH cohort. Inclusion criteria were: individuals with PIMD/Polyhandicap; age > 3 years at the time of inclusion; age at onset of cerebral lesion younger than 3 years old.

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Purpose: To better characterise the effects of corticosteroids on the course of pure idiopathic orbital inflammation syndrome (pIOIS).

Methods: This was a national, multicentre, prospective, non-interventional cohort study (). Among the 35 patients with histologically proven orbital inflammation who had previously been studied for their IgG4 immunostaining status, we selected those with a negative IgG4 status (ie, pIOIS) who received corticosteroids as single first-line treatment.

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Article Synopsis
  • - Mastocytosis is a disorder characterized by an abnormal increase of mast cells in one or more organs, with varying symptoms and outcomes; it's classified into cutaneous, systemic, and MC sarcoma types by the WHO.
  • - The disease often involves a specific mutation (D816V) in most systemic mastocytosis cases, affecting life expectancy significantly based on the type, with those having nonadvanced forms generally living near-normal lifespans, while advanced forms have limited life expectancies.
  • - Recently, a group of experts proposed updated diagnostic criteria and classifications for mastocytosis, aiming to unify different classifications from previous organizations to improve research and clinical comparisons.
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Prognostic impact of high-intensity lipid-lowering therapy under-prescription after acute myocardial infarction in women.

Eur J Prev Cardiol

November 2024

Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), 20 rue Leblanc, 75015 Paris, France.

Aims: Women are less likely to receive lipid-lowering therapy (LLT) after acute myocardial infarction (AMI). We analysed whether this under-prescription currently persists and has an impact on long-term outcomes.

Methods And Results: The FAST-MI programme consists of nationwide registries including all patients admitted for AMI ≤ 48 h from onset over a 1 month period in 2005, 2010, and 2015, with long-term follow-up.

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The International Patient Organisation for Primary Immunodeficiencies (IPOPI) held its second Global Multi-Stakeholders' Summit, an annual stimulating and forward-thinking meeting uniting experts to anticipate pivotal upcoming challenges and opportunities in the field of primary immunodeficiency (PID). The 2023 summit focused on three key identified discussion points: (i) How can immunoglobulin (Ig) therapy meet future personalized patient needs? (ii) Pandemic preparedness: what's next for public health and potential challenges for the PID community? (iii) Diagnosing PIDs in 2030: what needs to happen to diagnose better and to diagnose more? Clinician-Scientists, patient representatives and other stakeholders explored avenues to improve Ig therapy through mechanistic insights and tailored Ig preparations/products according to patient-specific needs and local exposure to infectious agents, amongst others. Urgency for pandemic preparedness was discussed, as was the threat of shortage of antibiotics and increasing antimicrobial resistance, emphasizing the need for representation of PID patients and other vulnerable populations throughout crisis and care management.

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Allogeneic hematopoietic stem cell transplantation (HSCT) is the only established curative option for Fanconi anemia (FA)-associated bone marrow failure (BMF)/aplastic anemia (AA) and acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS). We performed a retrospective multicenter study on 813 children with FA undergoing first HSCT between 2010 and 2018. Median duration of follow-up was 3.

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Objective: The long-term impact of type 2 diabetes mellitus (T2DM) after an acute myocardial infarction (AMI) has not been thoroughly investigated yet. This study aimed to assess the long-term impact of T2DM after AMI.

Research Design And Methods: We analyzed the data of three nationwide observational studies from the French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) program, conducted over a 1-month period in 2005, 2010, and 2015.

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Article Synopsis
  • This study explores how adaptive optics-transscleral flood illumination (AO-TFI) imaging can provide detailed insights into retinal pigment epithelium (RPE) changes in cases of central serous chorioretinopathy (CSCR) compared to standard clinical imaging.
  • Researchers analyzed 125 AO-TFI images from both affected and healthy eyes, finding significant changes in RPE contrast and patterns during different stages of CSCR.
  • The findings indicate that AO-TFI not only gives a clearer picture of outer retinal abnormalities but also reveals previously undetectable RPE issues, underscoring the need for further research to assess the clinical implications of these findings in understanding CSCR progression.
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Gonadotropic status in adult women with pituitary stalk interruption syndrome.

Eur J Endocrinol

June 2024

Department of Endocrinology, Diabetology and Nutrition, Ambroise Paré University Hospital, Assistance Publique-Hôpitaux de Paris, F-92100 Boulogne Billancourt, France.

Objective: Pituitary stalk interruption syndrome (PSIS) is a rare cause of congenital hypopituitarism. Limited data exist on the gonadotropic status and fertility of adult women with PSIS. Our study aims to describe pubertal development and the evolution of gonadotropic function and fertility in adult women with PSIS.

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Three-Year Outcomes With Fractional Flow Reserve-Guided or Angiography-Guided Multivessel Percutaneous Coronary Intervention for Myocardial Infarction.

Circ Cardiovasc Interv

June 2024

Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital européen Georges Pompidou, France (E.P., D.B., N.D.).

Background: In patients with multivessel disease with successful primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction, the FLOWER-MI trial (Flow Evaluation to Guide Revascularization in Multivessel ST-Elevation Myocardial Infarction) showed that a fractional flow reserve (FFR)-guided strategy was not superior to an angiography-guided strategy for treatment of noninfarct-related artery lesions regarding the 1-year risk of death from any cause, myocardial infarction, or unplanned hospitalization leading to urgent revascularization. The extension phase of the trial was planned using the same primary outcome to determine whether a difference in outcomes would be observed with a longer follow-up.

Methods: In this multicenter trial, we randomly assigned patients with ST-segment-elevation myocardial infarction and multivessel disease with successful percutaneous coronary intervention of the infarct-related artery to receive complete revascularization guided by either FFR (n=586) or angiography (n=577).

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Pregnancy outcomes in women with imported malaria in mainland France: A retrospective study from 2004 to 2014.

Travel Med Infect Dis

July 2024

Service de parasitologie-mycologie, Centre National de Référence du paludisme, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, 47 Boulevard de L'Hôpital, 75013, Paris, France; UMRS 1136, Institut Pierre-Louis d'épidémiologie et de santé publique (IPLESP), Sorbonne Université, 27 Rue Chaligny, 75571, Paris 12, France; UPMC, Faculté de médecine, Sorbonne Université, Université Pierre-et-Marie-Curie, 91 Boulevard de l'Hôpital, 75013, Paris, France.

Objectives: There is little data on pregnant women with imported malaria in high-income countries, especially regarding offspring outcomes. We wanted to determine pregnancy outcomes of imported malaria in pregnant women in mainland France.

Patients And Methods: We conducted a retrospective, descriptive study of outcomes in pregnant women hospitalized with malaria from 2004 to 2014 in two regions of mainland France.

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Mechanically Ultra-Robust Fluorescent Elastomer for Elaborating Auxetic Composite.

Small

September 2024

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing, 100029, China.

Fluorescent elastomers are predominantly fabricated through doping fluorescent components or conjugating chromophores into polymer networks, which often involves detrimental effects on mechanical performance and also makes large-scale production difficult. Inspired by the heteroatom-rich microphase separation structures assisted by intensive hydrogen bonds in natural organisms, an ultra-robust fluorescent polyurethane elastomer is reported, which features a remarkable fracture strength of 87.2 MPa with an elongation of 1797%, exceptional toughness of 678.

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Spontaneous perforation of the common bile duct: an uncommon complication of primary sclerosing cholangitis.

Eur Radiol

October 2024

Sorbonne Université, Faculté de Médecine Pierre Et Marie Curie and Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, 75012, Paris, France.

Objectives: To describe the MR features and prognosis of patients with an uncommon complication of primary sclerosing cholangitis (PSC) characterized by a spontaneous perforation of the common bile duct (CBD) resulting in a peri-biliary collection and a pseudo-cystic appearance of the CBD.

Methods: A single-center cohort of 263 patients with PSC who had at least two MRIs between 2003 and 2022 and a minimum follow-up of 1 year was retrospectively analyzed. MRI data (characteristics of CBD perforation and MR features of PSC) and clinical data were assessed.

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Article Synopsis
  • - The study aimed to assess radiation protection practices among endourologists in Europe, focusing on compliance with recommendations from the International Commission on Radiation Protection (ICRP) and measuring annual radiation exposure from 2017 to 2020.
  • - A survey of 10 endourologists revealed that while most use basic protective gear such as lead aprons and thyroid shields, advanced protections like leaded gloves and glasses are less common; additionally, the mean radiation exposure was below safety thresholds for the chest, eyes, and extremities.
  • - The findings indicated that endourologists effectively adhered to radiation safety standards, with the ALARA (As Low As Reasonably Achievable) protocol in place to further minimize exposure during procedures like per
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Practice of pediatric aphereses - in particular when caring for low-weight children - differs from the practice of adult aphereses, since pediatric aphereses represent low numbers of procedures, which has practical implications in terms of practical training and retraining for involved healthcare personnel, as needed for habilitation and validation of ongoing competencies. A specific training is mandatory in order to ensure both the child and the staff safety during and after collection, as well as ensure high quality of the collected cell product and that its meets predefined specifications that depend on its intended use. Low and very low-weight children deserve a particular attention for a number of procedural and clinical aspects: the nature and quality of venous accesses to ensure proper operation of the cell separator, management of hemodynamic fluctuations in relation with the relative importance of the extracorporeal blood volume as compared to the total blood volume of the child, risks and clinical manifestations of citrate toxicity, minimization of stress during the procedure that may include but is not limited to pharmacological sedation.

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Allogeneic haematopoietic cell transplantation (alloHCT) has curative potential counterbalanced by its toxicity. Prognostic scores fail to include current era patients and alternative donors. We examined adult patients from the EBMT registry who underwent alloHCT between 2010 and 2019 for oncohaematological disease.

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This study reports the development and validation of a new analytical method for simultaneous speciation analysis of Se and Hg in fish muscle. For this purpose, four Se species (selenite/Se(IV), selenate/Se(VI), selenomethionine/SeMet, and selenocysteine/SeCys) and two Hg species (inorganic mercury/iHg and methylmercury/MeHg) were extracted simultaneously by microwave-assisted enzymatic hydrolysis and then separated by HPLC in less than 15 min by using a column with both anion and cation exchange mechanisms and a mobile phase consisting of a mixture of methanol 5% (v/v), 45 mM HNO, 0.015% 2-mercaptoethanol, and 1.

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Rationale and design of the direct oral anticoagulants for prevention of left ventricular thrombus after anterior acute myocardial infarction (APERITIF) trial.

Am Heart J

December 2023

Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Paris, France; French Alliance for Cardiovascular Trials (FACT), Paris, France.

Background: Anterior acute myocardial infarction (AMI) is associated with an increased risk of left ventricular (LV) thrombus formation. We hypothesized that adding low-dose oral rivaroxaban to the usual antiplatelet regimen would reduce the risk of LV thrombus in patients with large AMI.

Study Design: APERITIF is an investigator-initiated, multicenter randomized open-label, blinded end-point (PROBE) trial, nested in the ongoing "FRENCHIE" registry, a French multicenter prospective observational study, in which all consecutive patients admitted within 48 hours of symptom onset in a cardiac Intensive Care Unit (ICU) for AMI are included (NCT04050956).

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A new beginning in continuity.

Arch Cardiovasc Dis

November 2023

Cardiology Department, Bichat Hospital, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France.

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