Garra dohjei, a new species of labeonine fish (Teleostei: Cyprinidae) from Meghalaya, India.

Garra dohjei, a new labeonine fish with transverse lobe and incipient proboscis is described from the Ñiangdai, a tributary of the Brahmaputra River, Meghalaya, India. The new species is distinguished from its congeners with transverse lobe and incipient proboscis, in having a well-developed transverse lobe with around 9-12 minute tubercles, deep transverse groove between transverse lobe and incipient proboscis, black spot immediately anterior to upper angle of gill opening, 5-6 dark black stripes on caudal peduncle, 33-35 lateral line scales, 9-10 predorsal scales, 16-circumpeduncular scales, 15 branched pectoral-fin rays, and total vertebrae 33.

Study of Glabranin as an Inhibitor Against Prostate Cancer: Molecular Docking, Molecular Dynamics Simulation, MM-PBSA Calculation and QSAR Prediction.

Unlabelled: Prostate cancer is the World's second most frequent malignancy, with the fifth-highest male mortality rate. In advanced prostate cancer patients, point mutations such as T877A and W741L are prevalent, imparting treatment resistance and hence promoting cancer development. The emergence of drug resistance in prostate cancer necessitates the development of suitable ligands to allow for stronger interactions with the receptors, which can inhibit cancer progression.

Deciphering the Interlinked CXCR4-Mediated Feedback Loop Among Signaling Pathways in Diabetic Wound Healing.

Diabetic chronic wounds and amputations are very serious complications of diabetes mellitus (DM) that result from an integration factor, including oxygen deprivation, elevated reactive oxygen species (ROS), reduced angiogenesis, and microbial invasion. These causative factors lead to tenacious wounds in an inflammatory state, which eventually results in tissue aging and necrosis. Wound healing in DM potentially targets C-X-C chemokine receptor type 4 (CXCR4) regulates several signalling pathways.

Unravelling the detoxification trail of potential toxic heavy metals: an insight into heavy metal auditing and ecological health upon valorisation by Lampito mauritii and Eudrilus eugeniae.

Evidence on prospective remediation of municipal solid waste contaminated with toxic heavy metals by Eudrilus eugeniae (Eu) and Lampito mauritii (L) is very scarce and yet to be explored. In this study, heavy metal detoxification potential of E. eugeniae and L.

Identifying genetic determinants of forage sorghum [Sorghum bicolor (Moench)] adaptation through GWAS.

Background: Forage sorghum is a highly valued crop in livestock feed production due to its versatility, adaptability, high productivity, and resilience under adverse environmental conditions, making it a crucial option for sustainable forage production. This study aimed to investigate ninety-five forage sorghum genotypes and identify the marker - trait associations (MTAs) in adaptive traits, including yield and flowering through genome-wide association studies (GWAS).

Results: Using 41,854 polymorphic SNPs, a GWAS involving the GLM, MLM, and FarmCPU models was performed to analyse fourteen adaptive traits.

Recent Advances in Multifaceted Drug Delivery Using Natural Polysaccharides and Polyacrylamide-Based Nanomaterials in Nanoformulation.

Rapid growth in nanotechnology, also known as 21st-century technology, is occurring in response to the increasing diversity of diseases. The development of safe and effective drug delivery methods to enhance bioavailability is of paramount importance. Researchers have focused on creating safe, cost-effective, and environmentally friendly nanoparticle construction processes.

CBAM-RIUnet: Breast Tumor Segmentation With Enhanced Breast Ultrasound and Test-Time Augmentation.

This study addresses the challenge of precise breast tumor segmentation in ultrasound images, crucial for effective Computer-Aided Diagnosis (CAD) in breast cancer. We introduce CBAM-RIUnet, a deep learning (DL) model for automated breast tumor segmentation in breast ultrasound (BUS) images. The model, featuring an efficient convolutional block attention module residual inception Unet, outperforms existing models, particularly excelling in Dice and IoU scores.

Advancing psoriasis drug delivery through topical liposomes.

Psoriasis, recognized as a chronic inflammatory skin disorder, disrupts immune system functionality. Global estimates by the World Psoriasis Day consortium indicate its impact on approximately 130 million people, constituting 4 to 5 percent of the worldwide population. Conventional drug delivery systems, mainly designed to alleviate psoriasis symptoms, fall short in achieving targeted action and optimal bioavailability due to inherent challenges such as the drug's brief half-life, instability, and a deficiency in ensuring both safety and efficacy.

Development of an efficient novel method for coronary artery disease prediction using machine learning and deep learning techniques.

Background: Heart disease is a severe health issue that results in high fatality rates worldwide. Identifying cardiovascular diseases such as coronary artery disease (CAD) and heart attacks through repetitive clinical data analysis is a significant task. Detecting heart disease in its early stages can save lives.

Enzyme Activity of Culturable Fungi and Bacteria Isolated from Traditional Agarwood Fermentation Basin Indicate Temporally Significant Lignocellulosic and Lipid Substrate Modulations.

Unlabelled: Agarwood oil is one of the costliest essential oils used in perfumery, medicine and aroma. Production of the oil traditionally involves a soaking/fermentation step. Studies have indicated a definite role of the diverse microorganisms growing during the open soaking step, and in the emergent aroma of the essential oil.

Phytosomes Nanocarrier with Insight Towards the Future in Cancer Therapy: A Mini-Review.

Cancer is classified as having one of the highest mortality rates on a global scale, presenting a significant challenge in its treatment, especially when conventional chemotherapy methodologies are used. Conversely, there is a growing interest in utilizing herbal medicine as an alternative to the treatment of cancer because of its lack of adverse effects compared to contemporary medical strategies. The incorporation of nanotechnology into therapy has attracted attention owing to its efficacy in the treatment of various illnesses.

Stability Indicating Method Development and Validation of Glycyrrhizin Using RP-HPLC-DAD: Application to Glycyrrhiza glabra Extract.

Glycyrrhiza glabra is commonly known as licorice. Licorice is the major source of glycyrrhizin. There is no reported stability indicating method for glycyrrhizin in the literature so far.

Two predators, one prey model that integrates the effect of supplementary food resources due to one predator's kleptoparasitism under the possibility of retribution by the other predator.

In ecology, foraging requires animals to expend energy in order to obtain resources. The cost of foraging can be reduced through kleptoparasitism, the theft of a resource that another individual has expended effort to acquire. Thus, kleptoparasitism is one of the most significant feeding techniques in ecology.

Redox-signalling and Redox Biomarkers in Cardiovascular Health and Disease.

Overproduction of reactive nitrogen and oxygen species (RNS and ROS) has been linked to the pathogenesis of diabetes, hypertension, hyperlipidemia, stroke, angina, and other cardiovascular diseases. These species are produced in part by the mitochondrial respiratory chain, NADPH oxidase, and xanthine oxidase. RNS and ROS both contribute to oxidative stress, which is necessary for the development of cardiovascular disorders.

Genetic gains in forage sorghum for adaptive traits for non - conventional area through multi-trait-based stability selection methods.

Introduction: In the Asian tropics, unpredictable weather increases the risk of abiotic stresses in sorghum areas, making it harder to meet predicted demand. Genotype-by environment interaction (GEI) and the lack of an effective multi-trait-based selection approach make it challenging to breed climateresilient forage sorghum that adapts to nonconventional areas.

Methods: The present investigation carried out to estimate genetic parameters, inter trait associations, genetic gain under selection (SGs) of 95 diverse forage sorghum genotypes.

Bone Tissue Engineering Scaffolds: Materials and Methods.

The wide development in biomedical, regenerative medicine, and surgical techniques has ensured that new technologies are developed to improve patient-specific treatment and care. Tissue engineering is a special field in biomedical engineering that works toward cell development using scaffolds. Bone tissue engineering is a separate branch of tissue engineering, in which the construction of bone, functionalities of bone, and bone tissue regeneration are studied in detail to repair or regenerate new functional bone tissues.

Phytocompounds as potential inhibitors of mycobacterial multidrug efflux pump Rv1258c: an in silico approach.

The number of infections and deaths caused by multidrug resistant (MDR) tuberculosis is increasing globally. One of the efflux pumps, that makes Mycobacterium tuberculosis resistant to a number of antibiotics and results in unfavourable treatment results is Tap or Rv1258c. In our study, we tried to utilize a rational drug design technique using in silico approach to look for an efficient and secure efflux pump inhibitor (EPI) against Rv1258c.

Enhancing Precatalyst Performance and Robustness through Aromaticity: Insights from Iridaheteroaromatics.

Despite the inherent stability-enhancing benefits of dπ-pπ conjugation-induced aromaticity, metallaaromatic catalysts remain underutilized in this context, despite their reactivity with organic functionalities in stoichiometric reactions. We present a strategy for synthesizing a diverse range of iridaheteroaromatics, (L^L)Ir(Cp*)I, including iridapyridylidene-indole, iridapyridene-indole, and iridaimidazole, via in situ deprotonation/metalation reactions utilizing [Cp*IrCl] and the respective ligands. These catalysts exhibit enhanced σ-donor and π-acceptor properties, intrinsic σ-π continuum attributes, and versatile binding sites, contributing to stability through enhanced dπ-pπ conjugation-induced aromaticity.

Highly Luminescent Eu-Incorporated Zr-MOFs as Fluorescence Sensors for Detection of Hazardous Organic Compounds in Water and Fruit Samples.

Considering the risk of toxic organic compounds to both human health and the environment, highly luminescent Eu-incorporated amino-functionalized zirconium metal-organic frameworks, namely, Eu/MOF and Eu@MOF were synthesized via the solvothermal method. The synthesized luminescent europium-incorporated MOFs act as outstanding sensor materials for diphenylamine and dinitrobenzene detection in water and fruit samples. The synergistic effect of Eu metal ions and amino-functionalized MOFs enhances the luminescent properties of the MOFs improving the fluorescence sensing ability toward the analytes.

Its all in the name: Another new Cyrtodactylus Gray (Squamata: Gekkonidae) from northern Mizoram, North-east India.

A new species of Cyrtodactylus is described from Vairengte town, situated in the Kolasib District of Mizoram State, north-eastern India. The new species is found to be a member of Indo-Burman Cyrtodactylus khasiensis clade based on ND2 gene sequences and morphological parameters, such as number of precloacal pores, mid-ventral scale rows, paravertebral tubercles on the trunk, dorsal tubercle rows, subdigital lamellae on pes and subcaudal scalation, making it the sixth endemic Cyrtodactylus from Mizoram and twenty second from north-east India. Moreover, phylogenetic evidence suggests the new species to be sister to the recently described C.

Overcoming Solubility Challenges: Self-emulsifying Systems for Enhancing the Delivery of Poorly Water-Soluble Antiviral Drugs.

The primary goal of drug formulation is to improve a drug's bioavailability in the body. However, poorly water-soluble drugs present challenging issues related to their solubility and bioavailability factors. Emerging technologies, such as lipid-based drug delivery systems, including micro- or nanoemulsifying drug delivery systems, have become increasingly relevant to address the above challenges.

Scrub typhus in Northeast India: epidemiology, clinical presentations, and diagnostic approaches.

Scrub typhus is one of the most neglected tropical diseases, a leading cause of acute undifferentiated febrile illness in areas of the 'tsutsugamushi triangle', diagnosed frequently in South Asian countries. The bacteria Orientia tsutsugamushi is the causative agent of the disease, which enters the human body through the bite of trombiculid mites (also known as chiggers) of the genus Leptotrombidium deliense. Diagnosis of the disease is challenging, as its early symptoms mimic other febrile illnesses like dengue, influenza and corona viruses.

Nano-emulsion encapsulation for the efficient delivery of bacteriophage therapeutics.

Antibiotic resistance has become the major concern for global public health. Phage therapy is being considered as an alternative for antibiotics to treat the multidrug resistant bacterial infections. Bacteriophage therapeutic developments has faced many challenges, including the drug formulations for sustainable phage delivery.

Visible light photocatalytic degradation of methylene blue and rhodamine B over silver-doped titanium dioxide nanocomposites supported on Fuller's earth.

Silver-doped-titanium dioxide nanoparticles supported on Fuller's earth, prepared by the sol-gel method, were characterized with XRD, TGA, zeta potential, SEM, EDX, TEM, XPS, photoluminescence and UV-DRS measurements. The material, Ag-TiO-Fuller's earth (AgTF), was tested for photocatalytic activity concerning the degradation of rhodamine B (RhB) and methylene blue (MB) in aqueous solution under visible light irradiation with pH, catalyst dosage, and dye concentration as the process variables. The degradation kinetics indicated pseudo-first-order kinetics with rate constant of (i) 0.