GC-MS and HPTLC Fingerprinting Analysis and Evaluation of Antimicrobial Activity of Naga Chilli: An In Vitro and In Silico Approach.

Naga chilli (Capsicum chinense Jacq.) have garnered significant attention due to the plant's possible health benefits and variety of phytochemical components. Utilizing cutting-edge analytical techniques such as gas chromatography-mass spectrometry (GC-MS) and high-performance thin layer chromatography (HPTLC) in conjunction with bioautography, this study conducts a thorough phytochemical profiling and biological activity assessment of the Naga chilli plant.

SAGPNet: A shape-aware and adaptive strip self-attention guided progressive network for SAR marine oil spill detection.

The oil spill is a significant source of marine pollution, causing severe harm to marine ecosystems. Detecting oil spills accurately using synthetic aperture radar (SAR) images is crucial for protecting the environment. However, oil spill targets in SAR images are small and resemble other objects "look-alike".

Deciphering the structural and biochemical aspects of xylosidase from Pseudopedobacter saltans.

Xylose, a key constituent of the heterogeneous hemicellulose polymer, occurs in lignocellulosic biomass and forms xylan polymers through β-1,4 glycosidic linkages. The β-1,4-xylosidase enzyme was isolated from Pseudopedobacter saltans (PsGH43) to find an effective enzyme with enhanced activity to depolymerize xylo-oligosaccharides. β-1,4-xylosidase belongs to the GH43 family as classified in the Carbohydrate-Active Enzyme Database (CAZy).

Adaptive Compression and Reconstruction for Multidimensional Medical Image Data: A Hybrid Algorithm for Enhanced Image Quality.

Spatial regions within images typically hold greater priority over adjacent areas, especially in the context of medical images (MI) where minute details can have significant clinical implications. This research addresses the challenge of compressing medical image dimensions without compromising critical information by proposing an adaptive compression algorithm. The algorithm integrates a modified image enhancement module, clustering-based segmentation, and a variety of lossless and lossy compression techniques.

Insights into AI advances in immunohistochemistry for effective breast cancer treatment: a literature review of ER, PR, and HER2 scoring.

Breast cancer is a significant health challenge, with accurate and timely diagnosis being critical to effective treatment. Immunohistochemistry (IHC) staining is a widely used technique for the evaluation of breast cancer markers, but manual scoring is time-consuming and can be subject to variability. With the rise of Artificial Intelligence (AI), there is an increasing interest in using machine learning and deep learning approaches to automate the scoring of ER, PR, and HER2 biomarkers in IHC-stained images for effective treatment.

Rationally designed Cu(II) Schiff base metal complex anchored on NiFeO@chitosan: an efficient heterogeneous and magnetically retrievable hybrid nanocatalyst for the one-pot multi-component synthesis of bioactive 1-amidoalkyl-2-naphthols.

We reported, herein, the fabrication of a Cu(II) Schiff base metal complex, immobilized on chitosan surface coated on NiFeO MNPs, intended as a novel heterogeneous and magnetically recyclable nanocatalyst, NiFeO@CS@CuSB. The synthesis process starts with the preparation of NiFeO MNPs followed by coating with chitosan and then subsequent immobilization of the Cu(II) Schiff base metal complex on its surface. Through comprehensive characterization of the prepared nanocatalyst using FT-IR, PXRD, SEM, EDS, TEM, SAED, VSM, BET, XPS, and ICP-AES, the structure, surface morphology, elemental composition, and characteristics of the catalyst are revealed.

Psychological empowerment-a mechanism for well-being of teachers: Psychometric evaluation of a tool.

Background: Psychologically empowered employees are more innovative and proactive. Individual well-being is greatly impacted by psychological empowerment. Examining school teachers' "psychological empowerment" is important since it motivates them more than external circumstances and contributes to their well-being.

Recent Advances in 4D Printing: A Review of Current Smart Materials, Technologies, and Drug Delivery Systems.

Research on shape memory materials (SMM) or smart materials, along with advancements in printing technology, has transformed three-dimensional (3D) printing into what we now refer to as 4D printing. In this context, the addition of time as a fourth dimension enhances 3D printing. 4D printing involves the creation of 3D-printed objects that can change their shapes into complex geometries when influenced by external stimuli such as temperature, light, or pH over time.

Advancements in electromagnetic microwave absorbers: Ferrites and carbonaceous materials.

Heightened levels of electromagnetic (EM) radiation emitted by electronic devices, communication equipment, and information processing technologies have become a significant concern recently. So, substantial efforts have been devoted for developing novel materials having high EM absorption properties. This critical review article provides an overview of the advancements in understanding and developing such materials.

Exploring the role of carbon quantum dots as countermeasure for SARS-CoV-2 virus.

The world witnessed disturbingly rapid unfolding of COVID-19 pandemic with emergence of SARS-CoV-2 virus resulting in severe morbidity and mortality and it still persists through incessant transmission across the globe even after years. Since the last decade, carbon quantum dots (CQDs) have gained much attention due to their favourable aqueous solubility, nano size (<10 nm), inherent fluorescence, biocompatibility, and environment friendliness. In the wider search for effective strategies for treatment, prevention, and diagnosis of SARS-CoV-2 virus, nanotechnology-based formulation using CQDs have emerged as an interesting option.

A non-enzymatic dual sensing approach for the detection of cholesterol in real samples using silk fiber functionalized phosphorene quantum dots.

Reliable point-of-care (POC) detection of the specific biomarkers responsible for different diseases is crucial for health monitoring. For the routine detection of important biomarkers, rapid, precise, and cost-effective analytical techniques are more and more in demand. Cardiovascular diseases like hypertension, myocardial infarction, and stroke can occur due to high cholesterol levels.

Technological innovations in margarine production: Current trends and future perspectives on trans-fat removal and saturated fat replacement.

The margarine market is growing globally due to its lower cost, ease of availability, large-scale commercialization, and expanding market in the bakery and confectionary industries. Butter contains greater amounts of saturated fat and has been associated with cardiovascular diseases. The trans fats generated through the hydrogenation process have several adverse impacts on human health, such as the risk of atherosclerosis, coronary heart disease, postmenopausal breast cancer, vision and neurological system impairment, type II diabetes, and obesity.

Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways.

Breast cancer remains one of the most prevalent and challenging cancers to treat due to its complexity and heterogenicity. Cellular processes such as metabolic reprogramming and epithelial-to-mesenchymal transition (EMT) contribute to the complexity of breast cancer by driving uncontrolled cell division, metastasis, and resistance to therapies. Strategically targeting these intricate pathways can effectively impede breast cancer progression, thereby revealing significant potential for therapeutic interventions.

Impact of foliar application of phyllosphere yeast strains combined with soil fertilizer application on rice growth and yield.

Background: The application of beneficial microbes in agriculture is gaining increasing attention as a means to reduce reliance on chemical fertilizers. This approach can potentially mitigate negative impacts on soil, animal, and human health, as well as decrease climate-changing factors. Among these microbes, yeast has been the least explored, particularly within the phyllosphere compartment.

Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study.

Introduction: Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.

Methods And Analysis: We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India.

Estimating the structural and spatial variables of allantoinase enzyme critical for protein adsorption.

Designing enzyme-based sensors necessitates a comprehensive exploration of macromolecular properties. Integrating enzymes with a suitable transducer involves immobilizing them onto a surface, facilitated through adsorption or entrapment techniques. Allantoin, a stable biomarkers metabolite, holds promise for detecting oxidative stress-related complications through its enzyme.

Principles and biomechanical response of normal gait cycle to measure gait parameters for the alignment of prosthetics limb: A technical report.

The limb amputations caused due to emergent incidents of trauma injuries and vascular diseases currently represent crucial global problems. The patients/amputees with limb amputation who lost the residual limb (knee-ankle foot system) must depend on the prosthetic limb. Prosthetic clinicians and technicians have attempted to develop optimal limb prosthetics that will enhance the ability and functional elements of the patients/users.

Enhancing the optoelectronic properties of SnS mixed-phase heterostructure engineering.

SnS holds great promise in optoelectronics, especially in photovoltaic devices, due to its exceptional intrinsic electronic properties and optimal optical absorption. However, its prospective applications are often limited by structural instability or oxidation, leading to internal or external defect states. This study proposes a mixed-phase SnS/h-BN heterostructure to enhance chemical and thermal stability while preserving the intrinsic optoelectronic properties of SnS.

Measuring up: Ensuring Intra- and Interobserver Reliability in Stretched Penile Length with the SPLINT Technique.

Background: A discrepancy between the true and measured value of stretched penile length (SPL) may be a result of errors that can either be systematic or random. Hence, it becomes important to focus on the quality of measurements to prevent any iatrogenic harm to the patients.

Objective: The objective of this study was to assess the magnitude of intra- and interobserver variations in the measurement of SPL with the SPLINT technique.

Exploring the antidiabetic activity of potential probiotic bacteria isolated from traditional fermented beverage.

Type 2 Diabetes continues to be one of the major public health issues worldwide without any sustainable cure. The modulation of gut microbiota is believed to be caused by probiotic bacteria and several probiotic strains have previously shown antidiabetic activity. The present study aims to isolate potential probiotic bacteria from traditionally used fermented rice beer of Assam, India and to investigate its anti-hyperglycemic effect.

Molecular genetic characterization of porcine reproductive and respiratory syndrome virus outbreak in Assam, India and neighbouring regions.

Porcine reproductive and respiratory syndrome (PRRS) is a significant swine disease with no effective vaccine due to high viral mutation rates. This study investigates a natural PRRS outbreak through molecular, pathological, and serological analyses. Nineteen affected pigs were clinically examined, and 10 underwent post-mortem examination.

In-silico identification and validation of Silibinin as a dual inhibitor for ENO1 and GLUT4 to curtail EMT signaling and TNBC progression.

The aberrant metabolic reprogramming endows TNBC cells with sufficient ATP and lactate required for survival and metastasis. Hence, the intervention of the metabolic network represents a promising avenue to alleviate the Warburg effect in TNBC cells to impair their invasive and metastatic potential. Multitudinous in-silico analysis identified Enolase1 (ENO1) and the surface transporter protein, GLUT4 to be the potential targets for the abrogation of the metabolic network.

Essential oil constituents of regional ethnomedicinal plants as potential inhibitors of SARS-CoV-2 M: an integrated molecular docking, molecular dynamics and QM/MM study.

The scientific community has achieved a remarkable milestone by creating efficacious vaccines against the SARS-CoV-2 virus. The treatment alternatives are still restricted, though. The bioactive ingredients present in natural plants are known to exhibit diverse pharmacological effects against many diseases.