Recirculatory Solvotaxis of a Nematic Droplet on Water Surface Enabling Miniaturization.

Self-organized contact line instabilities (CLI) of a macroscopic liquid crystal (LC) droplet can be an ingenious pathway to generate a large collection of miniaturized LC drops. For example, when a larger drop of volatile solvent (e.g.

Anaemia and iron deficiency in India: a venous blood-based survey of adolescents, adults, and the elderly in eight states.

Background: Surveys based on capillary blood show that anaemia is rampant in India, but capillary blood haemoglobin (Hb) may not accurately reflect venous blood Hb concentrations. Further, iron deficiency (ID) is thought to be the main cause of anaemia, there are no venous blood-based surveys to confirm this.

Methods: A community-based (urban, slum and rural) cross-sectional, venous blood survey was conducted in eight Indian states to estimate anaemia and ID prevalences from Hb and inflammation-corrected plasma ferritin concentrations in adolescents, adults, and elderly.

Boosting skin cancer diagnosis accuracy with ensemble approach.

Skin cancer is common and deadly, hence a correct diagnosis at an early age is essential. Effective therapy depends on precise classification of the several skin cancer forms, each with special traits. Because dermoscopy and other sophisticated imaging methods produce detailed lesion images, early detection has been enhanced.

Economic burden of breast cancer in India, 2000-2021 and forecast to 2030.

Background Breast cancer represents a significant public health concern in India, accounting for 28% of all cancer diagnoses and imposing a substantial economic burden. This study introduces a novel approach to forecasting the number of breast cancer cases (based on prevalence rates) and estimating the associated economic impact in India using the autoregressive integrated moving average (ARIMA) model. Methods Data on the prevalence of breast cancer in India from 2000 to 2021 were obtained from the Global Burden of Disease (GBD) database.

Gender bias in acute myocardial infarction care in India: Nationwide retrospective study of 41832 patients.

Background: Various studies have documented gender differences in the management and outcomes of acute myocardial infarction (AMI) in developed countries. Gender differences in the management of AMI in India is not known.

Objectives: To document the gender differences in the management and outcomes of AMI in India.

Chronic pulmonary aspergillosis in tea population of Assam.

Background: Chronic pulmonary aspergillosis (CPA) is a disease commonly caused by Aspergillus fumigatus and other Aspergillus species characterized by cavitary lung lesions. Tea garden population is an agrarian population of Assam, mostly associated with tea plantations. Assam is a major tea-producing state with 803 tea gardens producing approximately 50% of the total tea in India, of which 177 are present in the Dibrugarh district alone.

Ferric Chloride Mediated Dearomative Spirocyclization of Biaryl Ynones: Synthesis of 3,3-Spiroindanones.

Ferric chloride mediated dearomative spirocyclization of biaryl ynones for the synthesis of new series of densely functionalized 3,3-spiroindanone derivatives has been reported. This study is the first to describe the regioselective synthesis of a five-membered ring from biaryl ynones. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields (up to 87 %) and with high stereoselectivities.

Nipah virus survey in of eastern and northeastern region of India, 2022-2023.

Introduction: India has experienced seven outbreaks of the Nipah virus (NiV) since 2001, primarily occurring in the southern and eastern regions of the country. The southern region has been the main site for these outbreaks. In contrast, the eastern region, which borders Bangladesh, has not reported any outbreaks since 2007.

Influence of mothers' and frontline health workers' knowledge, attitude, and practices on infant and young child feeding and child nutrition: a cross-sectional study in aspirational districts of Assam, India.

The knowledge, attitude, and practices (KAP) of mothers and frontline health workers (FLWs) regarding optimal Infant and Young Child Feeding (IYCF) are essential for mitigating undernutrition and associated morbidities among under-five children. The study assessed the KAP of mothers (of children aged 0-60 months) and FLWs regarding recommended IYCF practices, the association of mother's KAP with their demographic characteristics and children's nutritional outcomes, and the prevalence of stunting, wasting, and underweight among children aged 0-60 months in five high-focus districts of Assam. Data were collected from 389 mothers, 456 children, and 138 FLWs using a standard method.

Amplification-free CRISPR/Cas based dual-enzymatic colorimetric nucleic acid biosensing device.

Nucleic acid testing (NAT) is widely considered the gold standard in analytical fields, with applications spanning environmental monitoring, forensic science and clinical diagnostics, among others. However, its widespread use is often constrained by complicated assay procedures, the need for specialized equipment, and the complexity of reagent handling. In this study, we demonstrate a fully integrated 3D-printed biosensensing device employing a CRISPR/Cas12a-based dual-enzymatic mechanism for highly sensitive and user-friendly nucleic acid detection.

Ecosystem productivity and carbon dynamics in Keibul Lamjao National Park, Manipur, India: a gray relational analysis perspective.

An in-depth understanding of carbon dynamics and ecosystem productivity is essential for conservation and management of different ecosystems. Ecosystem dynamics and carbon budget are assessed by estimating net ecosystem production (NEP) across different global ecosystems. An ecological productivity assessment of forest and floating meadow ecosystems in Keibul Lamjao National Park (KLNP), Manipur, North East India, was conducted using the multi-criteria decision-making process namely, gray relational analysis (GRA).

Effect of concentration gradient on spiral wave dynamics in the Belousov-Zhabotinsky reaction system.

The oscillatory Belousov-Zhabotinsky (BZ) reaction is often used for the study of rotating spiral waves that are responsible for life-threatening cardiac arrhythmia. In this work, we explore the influence of a concentration gradient on the dynamics of spiral waves in the BZ-reaction system. Using ion-exchange resin beads, we introduce a gradient of hydrogen ions in a thin layer of BZ gel hosting a spiral wave.

Unique duck rearing practice in irrigated rice paddy fields driving recurrent H5N1 avian influenza outbreaks in two districts of Kerala, India.

Highly pathogenic avian influenza (HPAI) outbreaks have repeatedly occurred in two districts of Kerala state, India, over the last few years. The outbreaks in the wetland areas coincided with the arrival of migratory birds. At the time, the factors responsible for local transmission in ducks were not known.

Direct Stereoselective Synthesis of 2-Deoxyglycosides via Visible-Light-Induced Photoacid-Catalyzed Activation of Glycosyl -[1-(-MeO-Phenyl)vinyl]benzoates (PMPVBs) as Donors.

The photoacid-catalyzed synthesis of 2-deoxy glycosides is presented using stable glycosyl -[1-(-MeO-Phenyl)vinyl]benzoate (PMPVB) donors and employing the eosin Y and diphenyl disulfide (PhSSPh) catalytic system in the presence of blue LED lights. The remote activation of the alkene functionality under the photoacid catalysis followed by a 5-- cyclization led to the generation of oxocarbenium ions that were trapped to provide the glycosylated products in excellent yields and decent selectivities under mild conditions. This method is also useful for the photoacid-catalyzed synthesis of -methoxybenzyl-alkyl ethers.

Tuning the properties of soy protein isolate-based adhesive using various sustainable additives.

This work investigates the adhesive property of Soy Protein Isolate (SPI) polymer solution by studying mechanical properties of composites formed using waste wood granules and SPI solutions. To improve the adhesive strength of SPI solution, Carboxymethyl Cellulose Sodium (NaCMC) was mixed (in the weight ratios of 9:1 and 8:2) due to its strong gel formation capabilities. The adhesive performance of these composites was further investigated in the presence and absence of non-toxic additives, including sorbitol (SOR) and stearic acid (SA).

Whole-Genome Sequencing of Antimicrobial Resistant , a Novel Sequence Type 5655 from Retail Fish Market, Assam, India.

is a recently described species that can be differentiated from . However, in clinical settings, they are frequently misidentified as . In this study, our objective was to conduct genomic characterization and bioinformatics analysis of subsp.

Beyond Fang's fury: a computational study of the enzyme-membrane interaction and catalytic pathway of the snake venom phospholipase A toxin.

Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.

Herbal Medicine for the Management of Wounds: A Systematic Review of Clinical Studies.

Background: Cuts and wounds are unfortunate yet inevitable events. Traditional remedies have historically harnessed various plants for wound healing, undergoing clinical and pre-clinical scrutiny. Hence, this systematic review focuses on clinically researched herbal formulations for wound healing.

β-Caryophyllene attenuates oxidative stress and inflammatory response in LPS induced acute lung injury by targeting ACE2/MasR and Nrf2/HO-1/NF-κB axis.

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), is a clinical syndrome that can cause pulmonary edema, inflammation, oxidative stress, and immunological dysregulations. β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, possesses a variety of pharmacological properties and has the potential to be a therapeutic agent. This study aimed to comprehend the effect of BCP on Nrf2/HO-1/NF-κB and ACE2/MasR axis in a rat model of ALI by lipopolysaccharide (LPS) and the underlying mechanisms during this process.

CAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment.

The world's one of the major causes of death are cancer. Cancer is still a complex disease over the years that needs to be cured. Traditional cytotoxic approaches, although they have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy and low efficiency of cancer cells.

UTF1 Expression is Important for the Generation and Maintenance of Human iPSCs.

Background: Undifferentiated embryonic cell transcription factor 1 (UTF1) is predominantly expressed in pluripotent stem cells and plays a vital role in embryonic development and pluripotency maintenance. Despite its established importance in murine models, the role of UTF1 on human induced pluripotent stem cells (iPSCs) has not been comprehensively studied.

Methods: This study utilized CRISPR/Cas9 gene editing to create UTF1 knockout in human fibroblasts and iPSCs.