Potentilla fulgens root extract rich in polyphenols ameliorate diabetic foot ulcers in wistar rats via regulating oxidative stress and connective tissue markers.

Background: Potentilla fulgens (Wall.) ex Hook. (Rosaceae), commonly known as 'Bajradanti' is native to the lower Himalayan regions inclusive of the North-East India.

Assessment of different U-Net backbones in segmenting colorectal adenocarcinoma from H&E histopathology.

Adenocarcinoma, the most prevalent type of colorectal cancer, makes up roughly 95 % of all cases and is associated with a notably high mortality rate. Owing to the various risk factors which might include personal choices and habits or genetic factors, the risk of developing the cancer for every individual might vary. However, given the statistics, the rate of acquiring the disease is pretty high.

Investigation of the physicochemical factors affecting the in vitro digestion and glycemic indices of indigenous indica rice cultivars.

Rice (Oryza sativa) is a vital food crop and staple diet for most of the world's population. Poor dietary choices have had a significant role in the development of type-2 diabetes in the population that relies on rice and rice-starch-based foods. Hence, our study investigated the in vitro digestion and glycemic indices of certain indigenous rice cultivars and the factors influencing these indices.

Microbial exopolysaccharides: Classification, biosynthetic pathway, industrial extraction and commercial production to unveil its bioprospection: A comprehensive review.

Polysaccharides, found universally in all living-species, exhibit diverse biochemical structures and play crucial roles in microorganisms, animals, and plants to defend against pathogens, environmental stress and climate-changing. Microbial exopolysaccharides are essential for cell adhesion and stress resilience and using them has notable advantages over synthetic polysaccharides. Exopolysaccharides have versatile structures and physicochemical properties, used in food systems, therapeutics, cosmetics, agriculture, and polymer industries.

Nano-interface enhanced electrochemical sensing of hazardous organochlorine pesticides and prospects with ZnO based nanomaterials.

Detection and analysis of organochlorine pesticides (OCP) residue is getting significant research importance because of their extensive use despite their hazardous effects on the health of people and the ecosystem. Despite the implementation of regulations and bans to safeguard human health and the environment, reports frequently reveal the continued use of these harmful chemicals in quantities exceeding the recommended limits set by regulatory boards. Data on the use of OCP from India, the most populous country, and African countries is not very encouraging.

Transfusion medicine hackathon: Nurturing the innovative ideas to revolutionize voluntary blood donation.

Background And Objective: Blood transfusion is an essential component of health care. However, several issues can hamper the promotion and sustainability of voluntary blood donation programs. This article is about a hackathon in the field of transfusion medicine that was designed to stimulate original ideas to promote voluntary blood donation.

A Special Insight on the Causal Agents and Mode of Occurrence of Japanese Encephalitis (JE) Infections in Rural Regions of Assam, India.

Introduction: Japanese Encephalitis (JE) is a life-threatening disease, especially in the Indian subcontinent. Knowledge about the nature and ecology of the dispersal of JE virus (JEV) vectors needs to be increased. This study mechanistically explores the ecology of JEV vectors and the mode and frequency of occurrence of Acute Encephalitis Syndrome (AES) and JEV infections.

Retraction: Visible-light driven reaction of CO with alcohols using a Ag/CeO nanocomposite: first photochemical synthesis of linear carbonates under mild conditions.

Retraction of 'Visible-light driven reaction of CO with alcohols using a Ag/CeO nanocomposite: first photochemical synthesis of linear carbonates under mild conditions' by Anil Malik , , 2023, , 1313-1316, https://doi.org/10.1039/D2CC05152D.

Retraction: Light-induced synthesis of unsymmetrical organic carbonates from alcohols, methanol and CO under ambient conditions.

Retraction of 'Light-induced synthesis of unsymmetrical organic carbonates from alcohols, methanol and CO under ambient conditions' by Sandhya Saini , , 2021, , 12800-12803, https://doi.org/10.1039/D1CC05833A.

Complete mitochondrial genome sequence analysis revealed double matrilineal components in Indian Ghoongroo pigs.

This research aimed to characterize the mitochondrial genome of the Ghoongroo (GH) pig, a notable breed in India, along with its crossbred varieties, to elucidate their matrilineal components, evolutionary history, and implications for conservation. Seven pigs (5 GH, 2 crossbred, namely Rani and Asha) were sequenced for complete mitochondrial genome, while 24 pigs (11 GH, 6 Rani, and 7 Asha) were sequenced for the complete D-loop of the mitochondrial genome. The genome size of these pigs was determined to be 16,690 bp.

Unveiling the Cytotoxic Potential of Quercetin-Loaded Magnetic Bacterial Bots against Cervical Cancer.

Bacterial bots are potent vehicles in cancer theranostics where bacteria are used typically as cargos for drug delivery. However, living bacteria themselves may aid in their efficiency in killing the tissues. For example, living bacteria may be functionalized with magnetic and luminescent nanoparticles along with drugs in order to achieve the targeted delivery and release of payloads that would include the bacteria.

Impact of Oxidative Stress and Neuroinflammation on Sarco/Endoplasmic Reticulum Ca-ATPase 2b Downregulation and Endoplasmic Reticulum Stress in Temporal Lobe Epilepsy.

Epilepsy is one of the most common neurological disorders. Calcium dysregulation and neuroinflammation are essential and common mechanisms in epileptogenesis. Sarco/endoplasmic reticulum (ER) Ca-ATPase 2b (SERCA2b), a crucial calcium regulatory pump, plays pathological roles in various calcium dysregulation-related diseases.

From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair.

Peripheral nerve repair (PNR) is a major healthcare challenge due to the limited regenerative capacity of the nervous system, often leading to severe functional impairments. While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). However, the inherently slow nerve growth rate (∼1 mm/day) and prolonged neuroinflammation, delay recovery even with the use of passive (no-conductive) NGCs, resulting in muscle atrophy and loss of locomotor function.

Pseudovascular squamous cell carcinoma of the buccal mucosa-a rare case report and review of literature.

Squamous cell carcinoma is the most common malignancy of the head and neck. Pseudovascular squamous cell carcinoma (PSCC) is a rare variant that occurs commonly in the skin of the head and neck. However, oral cavity involvement is extremely rare, with only a few cases reported to date.

Association between TLR 2 (rs3804099), TLR4 (rs4986790), and TLR 9 (rs187084) polymorphism and leukemia risk: a systematic review and meta-analysis.

Toll-like receptors (TLRs) are crucial components of innate immunity. A specific form of genetic variation in TLR genes may increase the chance of developing leukemia. The present investigation conducted a comprehensive meta-analysis to examine the correlation between three TLR polymorphisms, namely TLR2 (rs3804099), TLR4 (rs4986790), and TLR9 (rs187084), within the leukemia risk group.

Optimizing etodolac and quercetin loaded MSNs using taguchi design: an approach for enhancing drug loading efficiency.

The application of mesoporous silica nanoparticles (MSN) as a drug carrier system got immense attention in the past few years due to their exceptional high drug loading efficiency. However, the process of drug loading is quite challenging compared to other lipid-based drug delivery systems. Hence, the MSNs using different catalysts were synthesized, and their mesoporous material characteristic was confirmed by the type IV adsorption-desorption isotherm using BET analyzer.

Sustainable remediation of abandoned coal mines using vermicompost: a case study in Ledo coal mine, India.

Coal mining in India, especially open-cast mining, substantially strengthens the economy while concurrently causing environmental deterioration, such as soil pollution with toxic chemicals and heavy metals. This study sought to examine the efficacy of vermicompost as a remediation technique for Mine Tailing Soil (MTS) in the Ledo Coal Fields. During a 120-day duration, different concentrations of vermicompost (20%, 30%, and 40%) were administered to MTS, and the impacts on soil physicochemical parameters, fertility, and plant growth were evaluated.

Red and NIR light-triggered enhancement of anticancer and antibacterial activities of dinuclear Co(II)-catecholate complexes.

Photoactive complexes of bioessential 3d metals, activable within the phototherapeutic window (650-900 nm), have gained widespread interest due to their therapeutic potential. Herein, we report the synthesis, characterization, and light-enhanced anticancer and antibacterial properties of four new dinuclear Co(II) complexes: [Co(phen)(cat)] (Co-1), [Co(dppz)(cat)] (Co-2), [Co(phen)(esc)] (Co-3), and [Co(dppz)(esc)] (Co-4). In these complexes, phen (1,10-phenanthroline) and dppz (dipyrido[3,2-:2',3'-]phenazine) act as neutral N,N-donor ligands, while cat and esc serve as O,O-donor catecholate ligands derived from catechol (1,2-dihydroxybenzene) and esculetin (6,7-dihydroxy coumarin).

A study on indolo[3,2,1-]carbazole donor-based dye-sensitized solar cells and effects from addition of auxiliary donors.

Density functional theory has been employed to study indolo[3,2,1-]carbazole donor-based dyes, incorporating one and two units of 2,4-dimethoxybenzene auxiliary donors. Electrostatic potential analysis highlights the dye with one auxiliary donor (D2) as having the highest charge-donating capability. Structural analysis shows that auxiliary donors enhance planarity, reduce steric hindrance, and improve π-conjugation.

Enhancing prosthetic hand control: A synergistic multi-channel electroencephalogram.

Electromyogram (EMG) has been a fundamental approach for prosthetic hand control. However it is limited by the functionality of residual muscles and muscle fatigue. Currently, exploring temporal shifts in brain networks and accurately classifying noninvasive electroencephalogram (EEG) for prosthetic hand control remains challenging.

Photo-induced nitroxyl anion/HNO release from a nitrosyl complex of Mn(II)-porphyrinate.

A nitrosyl complex of Mn-porphyrinate, 1 has been synthesized and characterized. It was found to donate a nitroxyl anion (NO) to suitable acceptors in dichloromethane solution in the presence of visible light. The evolution of NO and the characteristic reaction with PPh in the presence of H confirms the NO/HNO donation.

Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study.

Background: Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.

Methods: This cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities.