Classifying tumour infiltrating lymphocytes in oral squamous cell carcinoma histopathology using joint learning framework.

Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, with increasing global incidence and have poor prognosis. Tumour-infiltrating lymphocytes (TILs) are recognized as a key prognostic indicator and play a vital role in OSCC grading. However, current methods for TILs quantification are based on subjective visual assessments, leading to inter-observer variability and inconsistent diagnostic reproducibility.

Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea.

Floricoccus penangensis ML061-4 was originally isolated from the leaf surface of an Assam tea plant (Camellia sinensis var. assamica) from Northern Thailand. To assess the functions encoded by the F.

Adsorption of emerging pollutants utilizing chitosan derivatives: Recent advances and future perspective.

Globalization resulted in technological advancement, and urban population growth. Consequently, pollution emerged as an imminent risk to the survival of all species on Earth. Consequently, on a worldwide basis, sustainability become a major issue for legislators.

Unraveling the nutritional potential of millet by-products through extraction of high value compounds for the development of novel food products.

Millets are drought-resistant crops that generate significant amount of by-products (bran, husk, stalk etc.) during harvesting and processing. These by-products are storehouse of nutrients and high value compounds including polyphenols, dietary fiber, proteins etc.

Role of micronutrients in production and reproduction of farm animals under climate change scenario.

Climate change poses significant challenges to livestock production worldwide. Wherein, it affects communities in developing nations primarily dependent on agriculture and animal husbandry. Its direct and indirect deleterious effects on agriculture and animal husbandry includes aberrant changes in weather patterns resulting in disturbed homeorhetic mechanism of livestock vis a vis indirectly affecting nutrient composition of feed and fodder.

Conductive Textile Embedded with Bioinspired Wettability for Prolonged and Energy Efficient Thermal Management.

The design of electrically conductive textiles appears to be a promising approach to combat the existing challenge of deaths caused by severe cold climates around the globe. However, reports on the scalable fabrication of tolerant conductive textiles maintaining a low electrical resistance with an ability for unperturbed and prolonged performance are scarce. Here, a breathable and wrappable water-repellent conductive textile (water-repellent CT) with electrothermal and photothermal conversion abilities at low external voltage and in weak solar light is introduced, respectively.

Fundamental Understanding of Bio-Nano Interface of Lysozyme on Polyphenol Coated Silver Nanoparticles: Mechanistic Insights into the Effect of Protein Corona on the Antibacterial Efficacy.

Recent times have witnessed revolutionary progress in the design and development of functionalized nanomaterials as promising tools for biomedicinal applications. However, the gap in the fundamental understanding of the "biological responses" of the nanomaterials after the formation of "protein-corona" when it is exposed to the body system has drawn a thin line from its discoveries to real clinical trial. In this article we have synthesized two different silver NPs capped with the polyphenols of (guava) leaf extract and the other with one of its major polyphenolic groups, morin.

A Comparative Double-blind Study to Evaluate the Efficacy of Coconut Water and Honey as Cytological Fixatives for Oral Smears.

Introduction: Ninety-five percent ethanol is the routinely used and standard cytological fixative. However, commercially available ethanol is expensive and not freely available in some institutions. There is always a search for an ideal alternative.

Profiling of Oral Squamous Cell Carcinoma of Lower Assam Region - A Hospital-Based Retrospective Study.

Background: Oral cancer is one of the ten most common cancers worldwide and the sixth most common type of all cancer in India. Among the oral malignancies, oral squamous cell carcinoma (OSCC) is the most common, accounting for more than 90% of oral cancer and hence a significant public health concern.

Aim: The aim of this study was to evaluate clinicopathological and demographic profiling of OSCC in a district and adjacent area of lower Assam.

Cone-beam Computed Tomography Evaluation Timings of Closure of Open Apex by Using Deciduous Tooth Pulp Autotransplantation for the Regenerative Endodontic Treatment of Permanent Teeth with Pulp Necrosis.

Regenerative endodontic therapy (RET) of young permanent teeth with necrotic pulps and apical periodontitis in young people, deciduous tooth pulp may be utilized as a natural, biologic scaffold. Recent developments in stem cell biology and material sciences are beneficial for new treatment methods. Previously traumatized and necrotic young permanent tooth was treated with RET protocol.

An electrically conductive dinuclear aluminium complex for the fabrication of a Schottky diode.

Electrical performances of a biphenyl-derived amido Schiff base ligand L and its dinuclear Al(iii) complex (complex 1) were investigated in a metal-semiconductor (MS) junction. Electrical studies revealed that complex 1 significantly enhanced the electrical conductivity and improved the characteristics of a Schottky barrier diode (SBD). The - characteristics demonstrated that complexation of ligand L with Al(iii) ion increased the conductivity by two orders of magnitude (conductivity of L = 1.

Fluorometric Turn Off Detection of Cu and Pd Ions Using 1-(Imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol.

The fused heterocycle 1-(imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol (LH) has been synthesized and characterized by spectroscopic methods. Probe LH upon irradiation with λ = 336 nm exhibited strong fluorescence with λ = 437 nm in MeOH/HEPES buffer (5 mM, pH = 7.4, 2:8, v/v).

Ribosome Biogenesis, Altered Metabolism and Ribotoxic Stress Response in Pancreatic Ductal Adenocarcinoma Tumor Microenvironment.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with a poor overall survival rate. Cellular stress response pathways promoting cancer cell fitness in harsh tumor microenvironment (TME) play a critical role in cancer growth and survival. The influence of oncogenic Kras, multi-functional heterogeneous cancer-associated fibroblasts (CAFs), and immunosuppressive TME on cancer cells makes the disease more complex and difficult to treat.

Ionic-liquid-supported copper-promoted synthesis of 3,5-disubstituted-1,2,4-triazoles.

The synthesis of triazoles plays an important role in drug discovery research. 1,2,4-triazoles are considered significant scaffolds among several bioactive heterocycles due to their extensive use in the pharmaceutical and agrochemical sectors. Consequently, the importance of the synthesis of 1,2,4-triazoles a sustainable method has increased.

Mitigating Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): The Role of Bioactive Phytoconstituents in Indian Culinary Spices.

Purpose Of Review: The term metabolic dysfunction-associated steatotic liver disease (MASLD) refers to a group of progressive steatotic liver conditions that include metabolic dysfunction-associated steatohepatitis (MASH), which has varying degrees of liver fibrosis and may advance to cirrhosis, and independent hepatic steatosis. MASLD has a complex underlying mechanism, with patients exhibiting diverse causes and phases of the disease. India has a pool prevalence of MASLD of 38.

Flow environment affects nutrient transport in soft plant roots.

This work estimates Michaelis-Menten kinetics parameters for nutrient transport under varying flow rates in the soft roots of Indian mustard () using a plant fluidic device. To find the metallic components within the roots, inductively coupled plasma mass spectrometry (ICP-MS) analysis was performed. The flow rate-dependent metabolic changes were examined using Raman spectral analysis.

A Contemporary Insight Into the Seroepidemiology of Herpes Simplex Virus Infection in the Sub-Himalayan Region: Seroepidemiology of HSV Infection in North India.

Infection by human herpes simplex virus type 1 and type 2 (HSV-1/2) is common globally though with wide regional variability. Seroepidemiology of HSV-1/2 infections is of utmost importance in formulating control strategies, but there is a paucity of data from many regions of India. This study aimed to determine the prevalence of anti-HSV-1/2 antibodies in Uttarakhand and adjoining areas and to study its pattern and distribution in different subgroups.

A Validated Method for Identification and Quantification of Anthocyanins in Different Black Rice (Oryza sativa L.) Varieties Using High-Performance Thin-Layer Chromatography (HPTLC).

Introduction: Black rice (Oryza sativa L.) has gained prominence as a functional food because of its rich content of anthocyanins and polyphenols, offering potential health benefits. However, comprehensive research addressing the diverse anthocyanin compositions in black rice cultivars remains limited.

State-of-the-art advances in homogeneous molecular catalysis for the Guerbet upgrading of bio-ethanol to fuel-grade bio-butanol.

The upgrading of ethanol to -butanol marks a major breakthrough in the field of biofuel technology, offering the advantages of compatibility with existing infrastructure while simultaneously offering potential benefits in terms of transport efficiency and energy density. With its lower vapour pressure and reduced corrosiveness compared to ethanol, -butanol is easier not only to manage but also to transport, eliminating the need for costly infrastructure changes. This leads to improved fuel efficiency and reduced fuel consumption.

Plant-microbe interactions: PGPM as microbial inoculants/biofertilizers for sustaining crop productivity and soil fertility.

Plant-microbe interactions play pivotal roles in sustaining crop productivity and soil fertility, offering promising avenues for sustainable agricultural practices. This review paper explores the multifaceted interactions between plants and various microorganisms, highlighting their significance in enhancing crop productivity, combating pathogens, and promoting soil health. Understanding these interactions is crucial for harnessing their potential in agricultural systems to address challenges such as food security and environmental sustainability.

Computational insight into the formation of cation-π/cation-lone pair complexes between 3d-metal (II) ions and furan.

Context: Cation-π and cation-lone pair interactions between 3d-metal (II) ions [Fe(II), Co(II), Ni(II) and Cu(II)] and furan are explored in the formation of 1:1 and 1:2 type complexes. Both cation-π (IE = -192.27 to -312.

Decrypting proteomics, transcriptomics, genomics, and integrated omics for augmenting the abiotic, biotic, and climate change stress resilience in plants.

As our planet faces increasing environmental challenges, such as biotic pressures, abiotic stressors, and climate change, it is crucial to understand the complex mechanisms that underlie stress responses in crop plants. Over past few years, the integration of techniques of proteomics, transcriptomics, and genomics like LC-MS, IT-MS, MALDI-MS, DIGE, ESTs, SAGE, WGS, GWAS, GBS, 2D-PAGE, CRISPR-Cas, cDNA-AFLP, HLS, HRPF, MPSS, CAGE, MAS, IEF, MudPIT, SRM/MRM, SWATH-MS, ESI have significantly enhanced our ability to comprehend the molecular pathways and regulatory networks, involved in balancing the ecosystem/ecology stress adaptation. This review offers thorough synopsis of the current research on utilizing these multi-omics methods (including metabolomics, ionomics) for battling abiotic (salinity, temperature (chilling/freezing/cold/heat), flood (hypoxia), drought, heavy metals/loids), biotic (pathogens like fungi, bacteria, virus, pests, and insects (aphids, caterpillars, moths, mites, nematodes) and climate change stress (ozone, ultraviolet radiation, green house gases, carbon dioxide).

Synergistic Adhesion and Shape Deformation in Nanowire-Structured Liquid Crystal Elastomers.

Nature provides many examples of the benefits of nanoscopic surface structures in areas of adhesion and antifouling. Herein, the design, fabrication, and characterization of liquid crystal elastomer (LCE) films are presented with nanowire surface structures that exhibit tunable stimuli-responsive deformations and enhanced adhesion properties. The LCE films are shown to curl toward the side with the nanowires when stimulated by heat or organic solvent vapors.