Flood-induced variation and source apportionment of microplastics in Jia Bharali River of mid-Brahmaputra Valley, India.

In the present time, microplastics (MPs) are a cause of growing concern in freshwater environments throughout the globe. Flood accelerates the transport of MPs from river into the marine environment. However, there is a lack of research on the impact of flood on microplastic abundance and distribution in Indian rivers.

Unraveling the role of RIPKs in diabetic kidney disease and its therapeutic perspectives.

Nephropathy is the microvascular complication of diabetes mellitus and is the leading cause of chronic kidney disease. This review discusses the implications of receptor-interacting protein kinase (RIPK) family members and their regulation of inflammation and cell death pathways in the initiation and progression of diabetic kidney disease. Hyperglycemia leads to reactive oxygen species (ROS) generation and RIPK1 overexpression, the first regulator of necroptosis.

Binding Interaction Between Two Mutant Myocilin Olfactomedin Domain Monomers in a Homodimer.

In myocilin-associated glaucoma, pathogenic missense mutations accumulate mainly in the olfactomedin domain (mOLF) of myocilin. This makes the protein susceptible to aggregation, where mOLF-mOLF dimerization is possibly an initial stage. Nevertheless, there are no molecular level studies that have probed the nature of interactions occurring between two mOLF domains and the key characteristics of the resulting dimer complex.

Unraveling microbial landscapes: high-throughput amplicon sequencing reveals distinct bacterial communities and potential health risks in potable springs of the Indian Himalayas.

Spring water is a vital drinking resource for residents in the Eastern Himalayas' Sikkim, India. While our initial investigations into spring water quality highlighted concerning levels of fecal coliform bacteria, the bacterial community composition (BCC) of these springs remains largely unexplored. This study sought to elucidate the BCC of Himalayan spring water, exploring its effects on water quality and delving into the unique bacterial ecology of these high-altitude springs.

Cyclometalated Ruthenium-Complex-Catalyzed Selective Oxidation of Olefins to Carbonyls.

Cyclometalated ruthenium(II)-complex-catalyzed selective oxidative scission of olefins to carbonyls is described. A strong C-donor ligand, paired with a rigid backbone and redox activity of ruthenium, provided high catalytic activity and a long lifetime for olefin oxidation. The catalyst tolerates numerous functional groups and applies to challenging biomass-, natural-product-, sugar-, amino-acid-, and fatty-acid-derived substrates.

Chromosome scale genome assembly and annotation of coconut cultivar Chowghat Green Dwarf.

The high-quality genome of coconut (Cocos nucifera L.) is a crucial resource for enhancing agronomic traits and studying genome evolution within the Arecaceae family. We sequenced the Chowghat Green Dwarf cultivar, which is resistant to the root (wilt) disease, utilizing Illumina, PacBio, ONT, and Hi-C technologies to produce a chromosome-level genome of ~ 2.

Identification of antimalarial phytoconstituents from Tinospora sinensis (Lour.) Merr. Stem by in vitro whole cell assay and multiple targets directed in silico screening against Plasmodium falciparum.

Ethnopharmacological Relevance: Tinospora sinensis (Lour.) Merr., from the family Menispermaceae, is widely used in Indian folk and Ayurvedic medicine.

Harnessing insects mediated plastic biodegradation: Current insight and future directions.

Plastic polymers pose a significant challenge due to their resistance to degradation, resulting in their persistent accumulation in the environment and exacerbating a critical environmental concern. Urgent innovation and novel management technologies are essential to tackle this issue. Plastic biodegradation, distinguished by its environmentally friendly and safe attributes, has garnered substantial attention as a viable solution.

Extended-spectrum β - lactamase inhibitory potential of : an and computational studies.

Extended-spectrum β-lactamases (ESBL) producing enterobacteriales are a major global health concern since they often result in the ineffectiveness of empirical antibiotic therapy with β-lactams. This study aims to identify potential medicinal plants that can inhibit β-lactamase and subsequently enhance the activity of the β-lactams against resistant bacterial strains. A synergistic study of extract exhibited good synergistic activity against a CTX-M-producing organism, which was confirmed using an agar-based diffusion bioassay method.

Exploring Antimalarial and Cytotoxic Activities of Hibiscus cannabinus and Corchorus capsularis Extracts Through In-Vitro and In-Silico Approaches.

Malaria is an infectious disease, endemic to tropical and sub-tropical regions causing half a million people's deaths every year. Bioactive compounds derived from medicinal plants are used to treat malaria disease and its complications. H.

Cognitive Dysfunction in Unipolar Depression.

Background: Cognitive dysfunctions play a critical role in the psychopathology of depression. They regulate various psychosocial and functional outcomes and affect workplace functionality, productivity, and relapses. An objective evaluation of affected cognitive domains is germane in understanding the relapses and functional recovery in depression.

A Qualitative Study on Lived Experiences of Psychotherapists Working with Trauma.

Background: Psychotherapists, while treating clients with a history of traumatic experiences, are exposed to vicarious trauma, which affects their mental health as well as their quality of caregiving. The present research tries to gain an insight into the lived experiences of psychotherapists while treating clients with traumatic experiences.

Methods: In-depth individual interviews were conducted with five psychotherapists (two males and three females) with a minimum duration of continuous professional practice of 3.

Parts-Per-Million Level Loading Cyclometalated Ru(II)-NHC Catalyzed Selective Oxidation of Olefins to Carbonyls.

Oxidative cleavage of olefins is a useful reaction in organic synthesis. The most well-known catalytic system is the osmium based Lemieux-Johnson catalyst, which generally requires high catalyst loading and tends to suffer from rapid overoxidation to produce the acid predominantly. Hence, the development of a mild, general, and selective method toward the oxidative cleavage of alkenes to carbonyl compounds is highly desired.

Rhodium-Catalyzed Meta-C-H Arylation of Arenes with Varied Linker Lengths: Bridging Catalytic Selectivity with Structural Diversity.

The directing group (DG)-assisted approach has so far been the major route to achieve selective C-H activation at both proximal and distal positions. While rhodium catalysts are highly effective in DG-assisted ortho-C-H arylation, meta-C-H arylation with rhodium has not yet been reported. In this study, we present the first example of Rh-catalyzed meta-C-H arylation of arenes.

Maximizing Blue Energy via Densely Grafted Soft Layers in Nanopores.

We investigate energy generation from salinity gradients inside a nanopore that is connected to reservoirs at both ends. We consider that the inner wall surfaces are grafted with a densely grafted polyelectrolyte layer (PEL). We developed the PEL grafting density-dependent correlation of dielectric permittivity, molecular diffusivity, and dynamic viscosity in this endeavor.

Exploring northeast India's culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance.

This study investigated the isolation and bioactivity of Actinomycetia from the soil of Northeast India, a region rich in microbial diversity. A total of 187 presumptive Actinomycetia isolates were obtained and 53 were found to exhibit antimicrobial properties. Phylogenetic analysis based on 16 S rRNA gene sequencing revealed that the isolates were predominantly from the genus Streptomyces.

CO selectivity and adsorption performance of KCO-modified zeolite: a temperature-dependent study.

High-performing zeolite materials for carbon dioxide capture are promising for applications such as flue gas CO capture. Potassium carbonate-loaded zeolites can offer a plethora of benefits. In this work, for the first time, zeolite-Y impregnated with KCO was studied as a gas adsorbent (CO, CH, and N) and characterized using TGA (thermogravimetric analyzer), XRD, BET, FTIR, FETEM (Field-Emission Transmission Electron Microscope), and XPS.

Translating Solid-Phase Conformational Memory in the Prophecy of Multi-stimuli Responsive Low Molecular Weight Gels.

Polymorphism and its screening to select the best-performing form is in high demand. In low molecular weight organogels (LMWG), gelators are designed as they contain flexible groups, functionalities capable of varied H-bonding, and increased the potential to show polymorphism. We synthesized a bis-urea based LMWG G1 and isolated three distinct polymorphic phases (Form I, II, and III).