Interrupted Plancher Rearrangement Initiated by Dearomative Epoxide-Indole Cyclization: Formal Umpolung Reactivity of Indoles.

We herein report the serendipitous discovery of the interrupted Plancher rearrangement initiated by an HFIP-promoted dearomative epoxide-indole cyclization, unlocking a new blueprint to the formal C3 umpolung reactivity of indoles. This rapid complexity generating cascade process paves the way toward a new class of fused-bridged indolines in high yields and under full regio- and diastereocontrol. The reaction is amenable to a wide range of substituents in the starting materials.

Burns Caused by Hand Sanitisers: The Trail of a Collateral Damage Left Behind by the Covid Pandemic.

Background: The current COVID-19 pandemic has changed human lifestyle to follow COVID-19 Appropriate Behaviours (CAB) and that includes social distancing, and the use of masks and sanitiser for hand hygiene. With increased use of sanitiser; the incidence of burns due to sanitiser has been reportedly on the rise. The study analysed the reported burn incidences due to sanitiser, found the relation between sanitiser and the aetiology of burn and formulated guidelines for its safe use.

Beyond Decay: Exploring the Age-associated Variations in and in Dental Caries.

Background: and play an important role in the etiopathogenesis and progression of dental caries (DC). Their quantification and identification may be helpful for epidemiological and early intervention measures.

Objectives: We conducted the study to evaluate the colony counts of and with the location of DC and correlate their prevalence with the age of the patient.

A highly sensitive facile plasmonic scheme for assessment of melamine in raw milk.

This work presents two novel devices with a microcontroller and two different light sensors, namely, Light Dependent Resistor (LDR) and Ambient Light Sensor (ALS), which can provide a quantitative output from the colorimetric variations of citrate capped borohydride reduced silver nanoparticles (AgNPs) and citrate capped gold nanoparticles (AuNPs) upon addition of melamine adulterated milk. The limit of detection (LOD) of the LDR setup with AgNPs and AuNPs was found to be 1.24 ppm and 1.

Beyond Access to Sanitary Pads: A Comprehensive Analysis of Menstrual Health Scheme Impact Among Rural Girls in Northeast India.

Menstrual hygiene management among girls in rural India poses a substantial challenge for public health, education, and quality of life, exacerbated by limited access and affordability of menstrual products. In response to these issues, the Government of India initiated the Menstrual Hygiene Scheme (MHS) to enhance access and awareness. This study evaluates the impact of the MHS in Assam and Tripura designated" treatment states" with consistent pad supply from 2017 to 2021 compared to neighboring" control states" with negligible pad distribution.

Biomimetic Approach for Optimal Designing of the Shape and Controlled Release of Therapeutics from Tricompartmental Microcarriers for Managing Parkinson's Disease.

Inspired by the intricate cellular morphology and the discoid shape of red blood cells (RBCs), biomimetic tricompartmental microcarriers (TCM) with controlled release profiles were engineered using an electrohydrodynamic--jetting technique for efficient management of Parkinson's disease (PD). While jetting, Levodopa (LD), CD (Carbidopa), and ENT (Entacapone) (3 PD drugs) were directly encapsulated in the three individual compartments of the TCM used for oral administration. The optimal shape and controlled release profiles were obtained by employing the Taguchi orthogonal L9 design-of-experiment approach by systematically varying the processing parameters, i.

Tuning of a Hydrogen-Bonded Organic Framework by Liquid-Assisted Mechanosynthesis between Trans-Aconitic Acid and Isonicotinamide.

Cocrystallization of trans-aconitic acid (TACA) and isonicotinamide (INA) using liquid assisted mechanochemical grinding results in a unique supramolecular hydrogen-bonded organic framework (HOF) system encapsulating various organic solvents (liquid guest) with the formation of channel inclusion compounds. Dimension and shape of the framework is dependent on the solvent used during liquid assisted grinding (LAG). Although crystal structure of the cocrystal (TACA) ⋅ (INA) ⋅ (HO)@(INA) has been determined by Single Crystal X-ray diffraction (SCXRD), crystal structures of 3 cocrystal HOFs were determined by microcrystal electron diffraction (MicroED) and synchrotron X-ray diffraction due to lack of suitable single crystal.

Solid Lipid Nanoparticles and Nanostructured Lipid Particles: A Comparative Review on Lipid-Based Nanocarriers.

Lipid-based nanocarriers have emerged as promising vehicles for the delivery of various therapeutic agents, owing to their biocompatibility, stability, and ability to encapsulate both hydrophilic and hydrophobic drugs. Among these lipid-based nanocarriers, Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) have gained significant attention in the field of drug delivery. This comparative review aims to provide a comprehensive analysis of SLNs and NLCs, focusing on their formulation, physicochemical properties, drug-loading capacity, stability, and drug release profiles.

Surface modification unleashes light emitting applications of APbX perovskite nanocrystals.

Engineering the surface of metal halide perovskite nanocrystals (MHPNCs) is crucial for optimizing their optical properties, repairing surface defects, enhancing quantum yield, and ensuring long-term stability. These enhancements make surface-engineered MHPNCs ideal for applications in light-emitting devices (LEDs), displays, lasers, and photodetectors, contributing to energy efficiency. This article delves into an introduction to MHPNCs, their structure and types, particularly the ABX type (where A represents monovalent organic/inorganic cations, B represents divalent metal ions mainly Pb metal, and X represents halide ions), synthesis methods, unique optical properties, surface modification techniques using various agents (particularly inorganic molecules/materials, organic molecules, polymers, and biomolecules) to tune optical properties and applications in the aforementioned light-emitting technologies, challenges and opportunities, including advantages and disadvantages of surface-modified APbX MHPNCs, and a summary and future outlook.

The theragnostic advances of exosomes in managing leukaemia.

Leukaemia, a group of haematological malignancies, presents ongoing diagnosis, prognosis, and treatment challenges. A major obstacle in treating this disease is the development of drug resistance. Overcoming drug resistance poses a significant barrier to effective leukaemia treatment.

Revisiting the Emerging Role of Light-Based Therapies in the Management of Spinal Cord Injuries.

The surge in spinal cord injuries (SCI) attracted many neurobiologists to explore the underlying complex pathophysiology and to offer better therapeutic outcomes. The multimodal approaches to therapy in SCI have proven to be effective but to a limited extent. The clinical basics involve invasive procedures and limited therapeutic interventions, and most preclinical studies and formulations are yet to be translated due to numerous factors.

A neural network integrated mathematical model to analyze the impact of nutritional status on cognitive development of child.

Cognitive development is a crucial developmental aspect of children. It is a concise field of study in psychology and neuroscience that focuses on various developmental aspects of the brain. Among all other factors, nutritional status is believed to play a very important role in cognitive development.

Study of contaminated snow cover using remote sensing in the Eastern Himalayas of Arunachal Pradesh, India.

Snow is considered contaminated when any foreign materials are deposited/mixed with it, which can accelerate melting and significantly impact the snow cover's radiative balance. Such an enhanced melting rate results in a reduction in freshwater sources at the catchment level. In optical remote sensing, snow contamination is widely studied using a normalizing difference index called the snow contamination index.

Systematic review of experimental paradigms and deep neural networks for electroencephalography-based cognitive workload detection.

This article summarizes a systematic literature review of deep neural network-based cognitive workload (CWL) estimation from electroencephalographic (EEG) signals. The focus of this article can be delineated into two main elements: first is the identification of experimental paradigms prevalently employed for CWL induction, and second, is an inquiry about the data structure and input formulations commonly utilized in deep neural networks (DNN)-based CWL detection. The survey revealed several experimental paradigms that can reliably induce either graded levels of CWL or a desired cognitive state due to sustained induction of CWL.

Recent advances in platelet-rich plasma and its derivatives: therapeutic agents for tissue engineering and regenerative medicine.

Platelet rich plasma (PRP) is a suspension of bioactive factors and chemokine enriched plasma. Platelets are a distinctive source of membrane bound and soluble proteins that are released upon their activation. The higher count of platelets renders PRP with an array of tissue regenerative abilities.

Morphology Transition of Tripeptides from Porous Spherical to Rod-like Nanostructures for Small-Molecule Adsorption.

Peptides possess a remarkable propensity to adopt distinct morphologies, ranging from simple aggregates to complex structures such as fibrils and nanotubes. Morphology transformation in peptides is intricately linked to the physicochemical properties of peptides and external factors such as pH, temperature, and solvent conditions. Thus, it is more complex.

Integrating traditional QSAR and read-across-based regression models for predicting potential anti-leishmanial azole compounds.

Leishmaniasis, a neglected tropical disease caused by various Leishmania species, poses a significant global health challenge, especially in resource-limited regions. Visceral Leishmaniasis (VL) stands out among its severe manifestations, and current drug therapies have limitations, necessitating the exploration of new, cost-effective treatments. This study utilized a comprehensive computational workflow, integrating traditional 2D-QSAR, q-RASAR, and molecular docking to identify novel anti-leishmanial compounds, with a focus on Glycyl-tRNA Synthetase (LdGlyRS) as a promising drug target.

Utilization of agrowaste for arsenic biosorption: enhancing efficacy and assessing the suitability of plant and animal growth in post-adsorbed solution.

Arsenic is known to have detrimental effects on living bodies when exposed to contaminated groundwater. Therefore, a cost-effective way to eliminate arsenic from aquatic sources is essential. Our study evaluated the efficacy of eight different types of easily accessible agricultural wastes for arsenic removal.

Hydrates of N-((10-Chloroanthracen-9-yl)methyl)-3-(1H-imidazol-1-yl)propan-1-ammonium Cobalt(II), Copper(II), and Zinc(II) 2,6-Pyridinedicarboxylate: Reversible Crystallization.

In a quest to explore interconvertible assemblies of hydrates of cobalt(II), copper(II), and zinc(II) 2,6-pyridinedicarboxylate (), complexes having cation of a chloro-substituted analogue N-{(10-chloroanthracen-9-yl)methyl}-3-(1H-imidazol-1-yl)propan-1-amine were investigated. In the case of cobalt and copper complexes, a crystallized stable hydrate and a less stable methanol hydrate were guided by concentration-dependent crystallizations. The unit-cells of the crystals of the methanol hydrates of the two cobalt and copper complexes each belong to the P1̅ space group but have different stoichiometries as well as large differences in packing.

Unraveling Chlorite Oxidation Pathways in Equatorially Heteroatom-Substituted Nonheme Iron Complexes.

The first-coordination sphere of catalysts is known to play a crucial role in reaction mechanisms, but details of how equatorial ligands influence the reactivity remain unknown. Heteroatom ligated to the equatorial position of iron centers in nonheme iron metalloenzymes modulates structure and reactivity. To investigate the impact of equatorial heteroatom substitution on chlorite oxidation, we synthesized and characterized three novel mononuclear nonheme iron(II) complexes with a pentadentate bispidine scaffold.