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Assaf-Harofeh Medical Center[Affiliation] Publications | LitMetric

2,987 results match your criteria: "Assaf-Harofeh Medical Center[Affiliation]"

Does treatment in an epilepsy clinic affect epilepsy-related admissions?

Seizure

December 2024

Neurology Department, Shamir-Assaf Harofeh Medical Center, Zerifin, Israel; Faculty of Medicine, Tel Aviv University, Israel.

Background: Epilepsy-related emergency hospitalizations are associated with risks to patients. Neurologist ambulatory care can improve seizure control and decrease the rates of ED visits and emergency hospitalizations.

Aims: To evaluate the etiologies for emergency epilepsy-related admissions in patients with and without prior epilepsy clinic follow-up, and to identify possible factors that may influence admission rates.

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Introduction: Despite the declining public health emergency status, COVID-19 still poses significant risks, especially for immunocompromised individuals. We aimed to evaluate the effectiveness of tixagevimab-cilgavimab (T-C) prophylaxis in preventing severe COVID-19 in patients with hematologic malignancies (HM) treated with anti-CD20 therapy during the early Omicron variant phase of the pandemic.

Methods: The European Society of Clinical Microbiology and Infectious Diseases Study Group for Respiratory Viruses (ESGREV) conducted a multicenter retrospective cohort study involving 15 centers from 5 countries.

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Article Synopsis
  • A study investigates how a mother's experience of childhood abuse impacts her child's temperament, focusing on factors like self-objectification and body boundaries.
  • The research involved 440 women shortly after childbirth, with assessments of maternal history and infant temperament taken three months later.
  • Results showed that mothers’ self-objectification and feelings of disrupted body boundaries mediated the links between their childhood abuse and their infants’ emotional responses and regulation abilities.
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  • Alzheimer's disease (AD) is a leading cause of dementia, particularly influenced by maternal inheritance but lacking consistent X chromosome risk factors.
  • A new analysis method suggested a 70% risk from the X chromosome in patients with amnestic mild cognitive impairment or early AD but did not confirm this in a larger Utah Population Database study due to methodological issues.
  • Future studies should focus on identifying X chromosome contributions to late-onset Alzheimer's by looking at newly diagnosed patients rather than relying on data from deceased individuals.
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The association of prenatal volatile organic compounds exposure and newborn anthropometrics: A cross-sectional study.

Int J Hyg Environ Health

December 2024

Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel.

Background: Several studies have associated prenatal exposure to volatile organic compounds (VOCs) with adverse health outcomes among newborns. However, little is known about the associations of VOCs at relatively low concentrations with newborn outcomes. Hence, this study aimed to investigate the potential associations between prenatal exposure to VOCs and VOC mixtures with newborn anthropometric measures.

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Introduction: This prospective, observational study investigated the impact of patient/anesthesiologist interactions and socioeconomic factors on administering intravenous analgesics and anxiolytics during elective Cesarean delivery under spinal anesthesia. The study explored the role of emotional experiences and psychosocial characteristics on intraoperative administration of intravenous adjuncts.

Methods: The study included 502 patient/anesthesiologist dyads from two hospitals in Israel.

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  • Ventriculoperitoneal shunt tip migration into inguinal hernias is common in children but rare in adults, with very few cases documented.
  • This report highlights a unique case where two catheter tips from different shunts migrated into an inguinal hernia, leading to malfunction.
  • The issue was resolved by shortening the distal catheters and suturing them to the abdominal wall, restoring shunt function.
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Bone Mineral Density Screening in People With Epilepsy and Intellectual Disability.

Am J Intellect Dev Disabil

November 2024

Revital Gandelman-Marton and Jacques Theitler, Neurology Department, Shamir-Assaf Harofeh Medical Center, Zerifin, and Faculty of Medicine, Tel Aviv University, Israel.

Vitamin D measurements and dual energy x-ray absorptiometry (DXA) scans are recommended in people with intellectual disability and/or epilepsy in order to prevent bone-linked harm. The prevalence of vitamin D supplementation and bone mineral density screening were evaluated in 68 people with epilepsy and intellectual disability (EID) and 68 matched controls with epilepsy without intellectual disability. DXA scans were not performed in any of the people with EID but were performed in 11.

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  • A study investigated sex-based differences in colonoscopy indications and findings by analyzing data from 287,930 colonoscopy procedures performed between 2016 and 2021.
  • Results showed that women were more likely to undergo colonoscopies due to abdominal pain, constipation, diarrhea, and anemia, while men had more procedures related to positive FOBT, rectal bleeding, and surveillance.
  • In terms of findings, men had higher rates of colorectal cancer and polyps, while women had better bowel preparation, underscoring the need for tailored approaches in diagnosing and managing gastrointestinal diseases based on sex.
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  • Hyperbaric oxygen therapy (HBOT) is gaining attention as a treatment for neurological and psychological disorders by promoting brain recovery and neuroplasticity.
  • It works through several cellular mechanisms, improving processes like mitochondrial function, neurogenesis, synaptogenesis, and reducing inflammation.
  • Clinical benefits include better cognitive function, recovery from brain injuries, and symptom relief for PTSD and fibromyalgia, suggesting HBOT's potential in neuromodulation deserves more research.
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Why provide 40 sessions of hyperbaric oxygen therapy to patients with traumatic brain injury?

Med Gas Res

March 2025

Aviv Clinics, The Villages, FL, USA; Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel; School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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The impact of glucagon-like peptide-1 receptor agonist on the gastric residue in upper endoscopy.

Diabetes Res Clin Pract

November 2024

Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Faculty of Medicine, Tel Aviv University, Zerifin, Israel.

Aim: We aimed to investigate the association between Glucagon-like-peptide-1 receptors agonists (GLP1-RA) use and gastric residue on esophagogastroduodenoscopy (EGD).

Methods: A multicenter, retrospective study included all EGDs conducted across seven gastroenterology departments. EGDs with the diagnosis of "poor preparation" or described as a poor preparation in the endoscopist's report were considered as gastric residue.

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Esophageal high-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders, but it may be poorly tolerated and unsuccessful. We sought to evaluate a protocol for sedation and endoscopy-assisted (SEA) HRM in patients who previously failed standard HRM and assess patient perspectives towards it. Adult patients who previously failed HRM were prospectively enrolled.

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IL-7-dependent and -independent lineages of IL-7R-dependent human T cells.

J Clin Invest

October 2024

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

Article Synopsis
  • Some babies with a specific mutation in the IL7R gene have a serious immune problem called SCID, where they lack a certain type of immune cells called T cells, but still have normal B and NK cells.
  • In a study of 6 adults who have a similar genetic issue, they showed low levels of T cells but had relatively normal levels of other immune cells, indicating a more specific problem in T cell development.
  • Even though their T cells didn’t grow well in the lab, the study hints that there might be another way T cells can develop that doesn’t depend solely on the IL-7 cytokine.
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The field of vascular medicine has undergone a profound transformation in the 21 century, transforming our approach to assessment and treatment. Atherosclerosis, a complex inflammatory disease that affects medium and large arteries, presents a major challenge for researchers and healthcare professionals. This condition, characterized by arterial plaque formation and narrowing, poses substantial challenges to vascular health at individual, national, and global scales.

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  • The study introduces a modification to the stenting technique for hypospadias repair in toilet-trained boys, suggesting the use of a mid-urethral stent (MUS) to maintain continence while enabling normal urination.
  • A retrospective assessment of 545 boys who underwent repairs revealed similar complication rates between those using the new technique and traditional stenting methods.
  • The findings indicate that implementing the MUS is a safe option that does not heighten the risk of complications compared to standard practices.
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  • An interatrial shunt is being studied as a potential treatment for heart failure, aimed at lowering left atrial pressure and improving symptoms and outcomes for patients.
  • In a clinical trial involving 508 patients, participants were randomly assigned to receive either the shunt or a placebo, with their progress tracked over a maximum of two years.
  • Results showed that while the shunt had no major safety issues, it did not significantly improve overall effectiveness compared to the placebo, although it appeared to reduce adverse cardiovascular events in patients with reduced left ventricular ejection fraction.
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: Terminal ileitis (TI) is often identified on CT scans in emergency settings. Diagnosing Crohn's disease (CD) as a cause of TI is crucial due to its significant long-term implications. This study aimed to differentiate CD from other causes of acute TI and develop a predictive model for CD diagnosis.

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Importance: Stereotypical motor movements (SMMs) are a form of restricted and repetitive behavior, which is a core symptom of autism spectrum disorder (ASD). Current quantification of SMM severity is extremely limited, with studies relying on coarse and subjective caregiver reports or laborious manual annotation of short video recordings.

Objective: To assess the utility of a new open-source AI algorithm that can analyze extensive video recordings of children and automatically identify segments with heterogeneous SMMs, thereby enabling their direct and objective quantification.

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Objective: Despite recommendations to initiate antiseizure medication treatment once the diagnosis of epilepsy is confirmed, a certain proportion of patients with epilepsy who should receive antiseizure medication treatment remain untreated. We aimed to evaluate the rate of and the reasons for the treatment gap in patients with epilepsy who were referred to their first visit in our epilepsy clinic.

Methods: We retrospectively reviewed the computerized database and the medical records of all the patients with epilepsy who had their first visit in our outpatient epilepsy clinic during a 10-year period (2012-2021).

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Continued PPI use and gastrointestinal evaluations after a negative pH study in patients with throat symptoms from possible extraesophageal GERD.

Acta Gastroenterol Belg

August 2024

The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel and The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Article Synopsis
  • Recent guidelines suggest that upfront pH testing in patients with EE-GERD could reduce unnecessary GI investigations and lower costs if a negative result is found.
  • A study involving 59 patients showed that 64.4% had negative pH tests, but those results did not lead to fewer follow-up appointments or less reliance on proton pump inhibitors (PPIs).
  • The findings challenge the effectiveness of upfront pH testing, as many patients remained on PPIs despite negative results and continued to have similar rates of GI follow-ups as those with positive tests.
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Background:  Social media networks have been found to provide emotional, instrumental, and social support, which may contribute to improved adherence to postbariatric surgery care recommendations.

Objectives:  This study aimed to evaluate the impact of an online social media-based, health care professional-led, educational and support program on patients' long-term engagement with and adherence to follow-up guidelines, self-care recommendations, and weight management after bariatric surgery.

Methods:  An observational cohort study, employing mixed methods, accompanied a 12-week interactive, structured, social media psychoeducational intervention program delivered on Facebook.

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Epidemiology and risk factors for angiodysplasias of the upper and lower gastrointestinal tract: A large population-based study.

Dig Liver Dis

August 2024

The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, School of Medicine Faculty of Medical and Health Sciences, Tel Aviv University, Zerifin, Israel.

Article Synopsis
  • Gastrointestinal angiodysplasia (GIAD) is a rare condition, with an overall prevalence of 0.092%, primarily affecting older adults, particularly those aged 71-80, where the prevalence peaks at 0.37%.
  • A study identified significant risk factors for GIAD, including liver cirrhosis, hypertension, and aortic stenosis, along with demographic factors like female gender, and noted that GIADs are less common in patients with malignancies.
  • Understanding the associated clinical conditions and demographics of GIAD can aid in better recognizing its causes and developing effective treatment strategies for this rare gastrointestinal issue.
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