1,216 results match your criteria: "Asian Institute of Nephrology & Urology[Affiliation]"

Background: Validation of protective associations of the lupus low disease activity state (LLDAS) against flare, irreversible damage, health-related quality of life, and mortality has enabled the adoption of treat-to-target strategies in patients with systemic lupus erythematosus (SLE). Previous validation studies were of short duration, limiting the ability to detect longer term signals in flare rate and irreversible damage. In addition, previous studies have focused on percent time at target, rather than actual periods of time that are more useful in clinical practice and trials.

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Purpose: The aim of this study is to evaluate the outcomes of retrograde intra renal surgery (RIRS) in the setting of large or multiple stones in children (<18 years).

Materials And Methods: Retrospective analysis was performed of paediatric RIRS cases at nine centres worldwide over a 6-year period. Patients were divided into two groups: Group 1 had a single stone <15 mm.

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  • - Eculizumab has been approved in Japan for treating atypical hemolytic-uremic syndrome (aHUS) since 2013, with a study evaluating its safety and effectiveness in adult patients who received at least one dose.
  • - The analysis included 79 patients, revealing improvements in key health indicators; however, only 35.3% achieved complete thrombotic microangiopathy (TMA) response, and renal function improvement was linked to the time between the last TMA episode and starting treatment.
  • - No unexpected safety concerns were reported, indicating that eculizumab is generally safe for use in this patient population, although treatment duration varied based on the effectiveness of the therapy.
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Background And Objective: The aim of this study was to evaluate the stone-free status (SFS) rate and complications after flexible ureteroscopy (fURS) for treatment of renal stones using a flexible and navigable suction (FANS) ureteral access sheath.

Methods: Data for adults undergoing fURS in 25 centers worldwide were prospectively collected (August 2023 to January 2024). Exclusion criteria were abnormal renal anatomy and ureteral stones.

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Background: Feedback is a crucial element in learning. While studies in the field of healthcare professions education have highlighted the process of educators feeding back to learners, relatively little investigation exists on learners feeding back to educators in Asian cultures. Studies show that recipients of effective feedback develop educational skills and reflective practice, but the process of giving feedback seems to have been mainly studied through surveys and questionnaires.

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  • The phase 3 DUPLEX trial is testing sparsentan, a new medication for patients with focal segmental glomerulosclerosis (FSGS), focusing on its safety and effectiveness.
  • This global study involves 371 patients aged 8 to 75, comparing sparsentan 800 mg to irbesartan 300 mg, while analyzing their baseline characteristics related to FSGS severity.
  • As the largest interventional study of its kind, DUPLEX aims to provide valuable insights into sparsentan's treatment effects across a diverse, worldwide patient population.
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Purpose: To assess the incidence of the most common intra- and early postoperative complications following RIRS in a large series of patients with kidney stones.

Methods: We conducted a retrospective analysis of patients with kidney stones who underwent RIRS across 21 centers from January 2018 to August 2021, as part of the Global Multicenter Flexible Ureteroscopy Outcome (FLEXOR) Registry.

Results: Among 6669 patients undergoing RIRS, 4.

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Purpose: To assess management and outcomes of bladder neck stenosis (BNS) post-transurethral resection of the prostate (TURP) in 12 centers.

Patients And Methods: A retrospective analysis of patients who underwent transurethral BN incision for stenosis following TURP from January 2015 and January 2023 was performed. Inclusion criteria included endoscopic diagnosis of BNS associated with obstruction and/or lower urinary tract symptoms.

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  • * Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are new medications that not only help control blood sugar in T2DM but also provide significant cardiovascular benefits for HF patients.
  • * Evidence shows that SGLT2i can enhance heart function and improve outcomes in HF whether patients have diabetes or not, making them valuable for a wide range of HF patients, especially in India.
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  • - In India, heart failure (HF) is a significant health issue, impacting younger individuals compared to Western countries, but many patients do not receive proper medical treatment.
  • - Selective β-1 blockers, like bisoprolol, are important in treating HF because they help lower heart rate and reverse negative heart and blood vessel changes associated with the condition.
  • - Despite the benefits of bisoprolol for various HF cases and comorbid conditions, its use in India remains suboptimal, prompting a consensus on its effectiveness and recommending it for better patient care.
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Background: Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are major genetic polycystic kidney diseases that can progress to end-stage kidney disease (ESKD). Longitudinal data on the clinical characteristics associated with clinical outcomes in polycystic kidney disease (PKD), including the development of ESKD and cardiovascular disease (CVD) are lacking in Japan. To address this unmet need the authors are establishing a novel, web-based, Nationwide Cohort Registry Study-the Japanese Registry of PKD (JRP).

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Objectives: To evaluate whether nephrotic syndrome (NS) and further corticosteroid (CS) use increase the risk of osteoporosis in Asian population during the period January 2000-December 2010.

Design: Nationwide population-based retrospective cohort study.

Setting: All healthcare facilities in Taiwan.

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The Safety of Outpatient Health Care : Review of Electronic Health Records.

Ann Intern Med

June 2024

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital; Harvard Medical School; and Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts (D.W.B.).

Article Synopsis
  • A study investigated patient safety in outpatient care across 11 sites in Massachusetts, focusing on the incidence of adverse events (AEs) among 3,103 patients in 2018.
  • Results showed that 7% of patients experienced at least one AE, with adverse drug events being the most frequent, while 23% of these AEs were deemed preventable.
  • The study found variations in AE rates based on factors like age and race, highlighting the need for improved patient safety measures in outpatient settings.
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Clinical implications of serum anti-PLA2R levels and glomerular PLA2R deposits in primary membranous nephropathy.

G Ital Nefrol

April 2024

MD, Consultant Pathologist, Department of Pathology, Apollo hospital, Greams lane, 21, Greams road, Thousand lights, Chennai, Tamil Nadu, India-600006.

The clinical implications of serum anti-PLA2R with glomerular PLA2R deposits in primary membranous nephropathy (PMN) is scarcely reported. Hence the study was designed to demonstrate the prevalence of serum anti-PLA2R levels and PLA2R staining in glomeruli in PMN and the clinical implications of the two parameters. Investigate the prevalence of anti PLA2R positivity in PMN.

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  • Cachexia, a condition linked to chronic diseases, significantly affects the quality of life and increases morbidity and mortality among patients undergoing hemodialysis, though its prognostic implications have not been widely studied.
  • In a study with 367 patients, the prevalence of cachexia was assessed using two definitions, revealing rates of 21.3% (Evans' criteria) and 35.2% (AWGC criteria).
  • The findings indicated that both definitions of cachexia correlated with higher risks of all-cause mortality and functional impairment, suggesting that early detection could improve outcomes for patients on hemodialysis.
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Circulating Proteins and IgA Nephropathy: A Multiancestry Proteome-Wide Mendelian Randomization Study.

J Am Soc Nephrol

August 2024

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China; and Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China.

Key Points: A multiancestry proteome-wide Mendelian randomization analysis was conducted for IgA nephropathy. The findings from the study would help prioritize new drug targets and drug-repurposing opportunities.

Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early diagnosis and targeted treatment remain challenging.

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Posttransplant thrombotic microangiopathy (PT-TMA) can be caused by calcineurin inhibitors (CNIs), ischemic injury, infections, or antibody-mediated rejection (ABMR). Delayed recognition can result in allograft loss. We describe the first reported case of successful reversal of refractory PT-TMA with eculizumab in India.

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  • * The risk of dementia is even higher for older adults living in minority-dominant neighborhoods, which is 2.19 times greater compared to White individuals in predominantly White neighborhoods.
  • * The study analyzed over 901,000 older adults from 2003 to 2019 and found that racial and ethnic segregation plays a critical role in the increased risk of dementia among minoritized adults with kidney failure.
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Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study.

J Nutr Health Aging

July 2024

Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Department of Anti-NBC Medicine, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Electronic address:

Article Synopsis
  • The study explored the link between anemia and overall mortality rates in Chinese centenarians, specifically analyzing a group of 1,002 participants over a nine-year period.
  • Results indicated that anemia significantly increased the risk of death, with a 29% higher likelihood of mortality and even higher rates in those with severe anemia (about 1.6 times more likely to die).
  • The findings underscore the importance of addressing anemia in elderly populations, highlighting the need for more research to understand its causes and impact on health outcomes.
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Background: Evidence for the long-term use of antiplatelet drugs to prevent hepatic vascular complications (HVC) is scarce in liver transplantation (LT).

Methods: From national claim data, LT recipients (about 80 % of living donor LT [LDLT]) without graft loss, HVC, or cardiovascular events within 1 year, were classified into those who took antiplatelets for ≥1 year (n = 1744) and for <1 year (n = 1975). Outcomes were compared after the 1-postoperative year index time point.

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Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans.

Int J Hypertens

May 2023

Division of Human Genetics, Department of Pathology and Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current hypertension guidelines recommend the use of antihypertensives belonging to the following classes: calcium channel blockers (CCB), angiotensin converting inhibitors (ACEI), angiotensin receptor blockers (ARB), diuretics, -blockers, and mineralocorticoid receptor antagonists (MRAs), to manage hypertension.

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Background/objectives: We investigated whether dietary interventions, i.e. a fasting mimicking diet (FMD, Prolon®) or glycocalyx mimetic supplementation (Endocalyx) could stabilize microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM) in the Netherlands, a patient population more prone to develop vascular complications.

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