Sex differences in the relationship between body mass index in Chinese adolescents and future risk of hypertension: a decade-long cohort study.

Objective: This study aimed to investigate the relationship between body mass index (BMI) during adolescence and the future risk of developing hypertension, with a particular focus on potential sex differences.

Methods: This study was a secondary analysis based on a cohort study involving 2,020 adolescents aged 10-15 years who underwent health check-ups at the MJ Health Screening Center between 1999 and 2008. Cox proportional hazards regression models were used to evaluate the association between BMI and hypertension risk, with stratification by gender.

Gender Differences in the Prevalence and Associated Factors of Sarcopenia Among Maintenance Haemodialysis Patients in Vietnam.

Aim: The prevalence and associated factors of dialysis-related sarcopenia could vary greatly according to gender. This study aimed to determine the prevalence of sarcopenia in haemodialysis patients according to gender and to assess some factors related to sarcopenia.

Methods: A cross-sectional study was conducted in maintenance haemodialysis patients.

Association of metabolic score for insulin resistance with incident metabolic syndrome: a cohort study in middle-aged and older adult Chinese population.

Background: Recent studies suggest that the metabolic score for insulin resistance (MetS-IR) is an effective indicator of metabolic disorders. However, evidence on the relationship between MetS-IR and metabolic syndrome (MetS) among the Chinese middle-aged and older adult population is limited.

Objective: This cohort study aims to assess the associations of MetS-IR levels with MetS risk and its components.

Pathogenic variants in the Alport genes are prevalent in the Singapore multiethnic population with highest frequency in the Chinese.

Alport syndrome is a common monogenic kidney disease resulting from pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The estimated global population prevalence is one in 106 individuals for autosomal dominant (AD) and one in 2,320 for sex-linked (XL) conditions. Here, we aimed to estimate the population prevalence of individuals carrying pathogenic variants that cause Alport syndrome in Singapore, and to stratify the prevalence by ancestry.

Recurrent falls as the presentations of Gitelman syndrome in an octogenarian.

Gitelman syndrome (GS) is the most common hereditary renal tubular disorder, with a higher carrier frequency among Asians often overlooked in older adults. Electrolyte imbalances, such as those seen in GS, are crucial considerations for older adults experiencing recurrent falls. We described an 83-year-old diabetic female on metformin, who was admitted due to recurrent falls with the preceding dizziness and palpitations when standing.

Trends and regional variations in chronic ischemic heart disease and lung cancer-related mortality among American adults: Insights from retrospective CDC wonder analysis.

Introduction: Lung cancer remains the leading cause of cancer-related mortality in the United States and shares cardiovascular risk factors with chronic ischemic heart disease (CIHD). However, the cumulative mortality burden of these comorbid conditions is underexplored. This study aims to retrospectively assess mortality trends among American adults with concurrent lung cancer and CIHD.

Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning.

Background: Propanil toxicity is characterised by severe prolonged methaemoglobinaemia, cyanosis, acidosis, and progressive end-organ dysfunction. studies report propanil-induced kidney toxicity, which has not been studied clinically. This study determined the incidence of acute kidney injury and of methaemoglobinaemia after propanil self-poisoning and reported the diagnostic performance of novel and traditional biomarkers of acute kidney injury.

The utility of flexible and navigable suction access sheath (FANS) in patients undergoing same session flexible ureteroscopy for bilateral renal calculi: a global prospective multicenter analysis by EAU endourology.

Purpose: To assess the 30-day stone-free rate and peri-operative outcomes of flexible ureteroscopy (FURS) with flexible and navigable suction ureteral access sheaths (FANS) in adults undergoing same-sitting bilateral retrograde intrarenal surgery (SSB-RIRS).

Methods: Prospectively data of 115 adult patients with bilateral kidney stone disease undergoing SSB-RIRS across 14 global centers between July 2023 and March 2024 were analyzed. Patient demographics, stone characteristics and operative outcomes were recorded.

Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.

We performed ancestry and sex specific Phenome Wide Association Studies (PheWAS) to explore disease related outcomes associated with genetically predicted height. This is the largest PheWAS on genetically predicted height involving up to 840,000 individuals of diverse ancestry. We explored European, African, East Asian ancestries and Hispanic population groups.

Anti-hypertensive medication adherence, socioeconomic status, and cognitive aging in the Chinese community-dwelling middle-aged and older adults ≥ 45 years: a population-based longitudinal study.

Background: It remains unclear whether anti-hypertensive medication use is associated with cognitive aging in general Chinese middle-aged and older adults, as well as the interplay with socioeconomic status (SES). We aim to examine associations of anti-hypertensive medication adherence, SES, and cognitive aging in Chinese middle-aged and older adults.

Methods: Our study was based on the China Health and Retirement Longitudinal Study, an ongoing longitudinal national survey recruiting community-dwelling adults aged ≥ 45 years.

Introducing a new device for direct in-scope suction technique during flexible ureteroscopy for kidney stone disease: an EAU Section of Endourology prospective multicenter audit using the GLITZ system.

Background: The direct in-scope suction (DISS) involves a two-way adaptor mounted on a scope to aspirate and irrigate the pelvicalyceal system during flexible ureteroscopy. While integrated suction single-use scopes manage small dust particles effectively, they cannot remove particles >250 µm and are limited by single use.

Objectives: To evaluate perioperative outcomes of the GLITZ system, a lightweight suction accessory for flexible ureteroscopes, facilitating laser lithotripsy with integrated aspiration.

Efficacy of urinary [TIMP-2]⋅[IGFBP7], L-FABP, and NGAL levels for predicting community-acquired acute kidney injury in Japanese patients: a single-center, prospective cohort study.

Background: The combination of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) ([TIMP-2]⋅[IGFBP7]) has emerged as a strong predictor of acute kidney injury (AKI), which is associated with poor outcomes. However, most studies have focused on non-Asian populations, and comparisons of [TIMP-2]⋅[IGFBP7] with other AKI biomarkers in Asian populations have not been performed. Furthermore, no study has examined the efficacy of [TIMP-2]⋅[IGFBP7] for predicting community-acquired AKI.

Impact of relative deprivation and ethnicity on the incidence rate of amyotrophic lateral sclerosis.

: This study assessed a sizable cohort of patients with amyotrophic lateral sclerosis (ALS) in a relatively deprived and ethnically diverse area in the northwest of England. We aimed to evaluate the interaction of relative deprivation and ethnicity with the incidence of ALS. : Six hundred and ninety-three adults from Greater Manchester who were diagnosed with ALS between 1 January 2011 and 31 December 2021 were included in this study.

Clinically meaningful eGFR slope as a surrogate endpoint differs across CKD stages and slope evaluation periods: the CKD-JAC study.

Background: The slope of estimated glomerular filtration rate (eGFR) is a promising surrogate endpoint in patients with chronic kidney disease (CKD). However, current evidence is mainly derived from Western populations with CKD stages 1-3. In addition, stage-by-stage analysis has never been formally performed.

Associations Between Serum IL-17A, Renal Function and Diabetic Retinopathy in Type 2 Diabetes Mellitus: Evidence From a Chinese Han Population.

Background: Evidence suggested that IL-17A was associated with renal function in type 2 diabetes. We used ultra-sensitive measurement to detect the concentration of IL-17A in human peripheral blood and explored the association of IL-17A with diabetic kidney disease (DKD).

Methods: We recruited 138 participants from the Shanghai Diabetes Institute Inpatient Database of Shanghai Jiao Tong University Affiliated Sixth People's Hospital.

The implementation of genome sequencing in rare genetic diseases diagnosis: a pilot study from the Hong Kong genome project.

Background: Genome sequencing (GS) has revolutionised the diagnostic odyssey of patients with rare genetic diseases (RDs) and accelerated large-scale genome projects globally. However, the impact of GS on patients with RDs is yet to be investigated among genome projects in Asia. The Hong Kong Genome Project (HKGP) was implemented to benefit patients and families with RDs in Hong Kong, and to increase the inclusiveness of Chinese genomic data.

Association between obstructive sleep apnea and migraine: A United States population-based cohort study.

Objective: To determine the association between obstructive sleep apnea (OSA) and the incidence of migraine using a large population-based dataset, as well as to identify the at-risk target groups.

Background: Epidemiological and biochemical studies have provided evidence for the close connection between sleep disorders and migraine. Understanding the connections between OSA and migraine, as well as their shared risk factors, may provide new perspectives on the pathophysiology of both OSA and migraine and novel approaches to managing and treating these conditions.

Association of alcohol abstinence with risk of hyperuricemia in rural Chinese adults: the Henan Rural Cohort Study.

Background: Alcohol drinking can cause hyperuricemia (HUA), but few studies have explored alcohol abstinence's health effects, particularly the abstinence duration on HUA. This study aimed to evaluate the associations of abstinence with HUA in rural Chinese adults.

Methods: This was a cross-sectional study of 38,855 participants (15,371 males and 23,484 females) using the baseline data (2015-2017) from the Henan Rural Cohort Study.

Propensity Score Matched Analysis of Thulium Fiber vs Pulsed Thulium:Yttrium Aluminum Garnet Laser Lithotripsy in Flexible Ureteroscopy for Kidney Stone Disease Using a Flexible and Navigable Suction Ureteral Access Sheath: Results From a Prospective, Multicenter Study of the EAU Section of Endourology.

Objective: To evaluate outcomes after flexible ureteroscopy (F-URS) for renal stone(s) using a flexible and navigable suction ureteral access sheath (FANS-UAS) comparing Thulium fiber (TFL) vs pulsed Thulium:Yttrium aluminum garnet (p-Thulium:YAG) laser.

Methods: Data from adults who had F-URS in 5 centers were prospectively collected (April 2023-January 2024). All patients had a preoperative and within 30days CT scan.

Identifying Subgroups of Intersectional Stigma, Discrimination, and the Association with Mental Health Outcomes Among HIV-Positive Men Who Have Sex with Men: A Latent Class Analysis.

This study aimed to (1) identify latent classes of stigma and discrimination experiences among men who have sex with men (MSM) living with HIV; (2) examine the associations between class membership and mental health outcomes, and (3) investigate the moderating effects of social support and resilience. The study used the baseline (N = 224) and six-month follow-up data (N = 118) from a longitudinal cohort study on HIV and hypertension among African American and Asian Pacific American MSM in Hawai'i and Philadelphia from 2019 to 2023. Latent class analysis was conducted to characterize the patterns of stigma and discrimination experience.

Racial differences in diuretic therapy, B-type natriuretic peptide values, and prognosis in acute heart failure.

Background: Whether variability of B-type natriuretic peptide (BNP) values between races affects its clinical integration as a marker for congestion and predictor of prognosis in acute heart failure (AHF) remains unknown. We aimed to investigate the relationship between diuretic therapy, change in BNP value, and prognosis in AHF in relation to racial differences.

Methods: This analysis combined data from the AKINESIS and REALITY-AHF studies.

Nomogram to screen older adult patients attending the radiology department for sarcopenia.

Background: Sarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia risk.

Prevalence and Treatment Patterns of Anaemia in Individuals With Chronic Kidney Disease Across Asia: A Systematic Review and Meta-Analysis.

Aim: Anaemia is a significant complication of chronic kidney disease (CKD). However, its prevalence and treatment patterns in Asia are poorly understood. We sought to quantify prevalence of anaemia and its treatment in people with CKD across the region.

Chronic kidney disease.

Chronic kidney disease (CKD) is defined by persistent abnormalities of kidney function or structure that have consequences for the health. A progressive decline of excretory kidney function has effects on body homeostasis. CKD is tightly associated with accelerated cardiovascular disease and severe infections, and with premature death.

Recent Updates in the Diagnosis and Management of Kidney Diseases in Multiple Myeloma.

Multiple myeloma (MM) represents a difficult-to-treat plasma cell malignancy and the second most common hematologic malignancy in adults, significantly impacting kidney function. The spectrum of kidney involvement in MM is broad, encompassing electrolyte imbalances, tubular injury, and even rare glomerular diseases. The evolution of MM treatment modalities has led to notable improvements in the long-term survival of patients experiencing kidney-related complications.