11,186 results match your criteria: "Asia University §China Medical University Hospital[Affiliation]"

To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients matched by sex, age, and index year.

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Bilateral inverse canine impaction: a case report.

J Med Case Rep

December 2024

School of Dentistry, China Medical University, Taichung, 404, Taiwan, Republic of China.

Background: Maxillary canine impaction can result in malocclusion, temporomandibular joint complications, and esthetic concerns, thus influencing craniofacial development. Although cases of impacted canines are not uncommon in clinical practice, the likelihood of simultaneous bilateral impaction is extremely low; very few reports have documented cases of bilaterally symmetrical, inversely impacted canines.

Case Presentation: This paper reports a rare case of maxillary canine impaction, a condition characterized by the abnormal eruption of teeth.

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Background: Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis.

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Article Synopsis
  • Gastrointestinal subepithelial lesions (SELs) can be benign or malignant, and diagnosing them accurately using endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is challenging, especially for smaller lesions (≤ 2 cm).
  • A retrospective study indicated that over 50% of patients with SELs of this size were diagnosed as gastrointestinal stromal tumors (GISTs), highlighting the necessity of using effective EUS-FNB techniques.
  • This multicenter study aims to compare the effectiveness of two types of EUS-FNB needles (22G Fork-tip vs. 22G Franseen) in obtaining adequate tissue samples from SELs ≤ 2 cm, with different endpoints focusing on sample quality and procedural outcomes.
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Transcriptomic data integration and analysis revealing potential mechanisms of doxorubicin resistance in chondrosarcoma cells.

Biochem Pharmacol

December 2024

Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan. Electronic address:

Chondrosarcoma is a type of bone cancer that originates from cartilage cells. In clinical practice, surgical resection is the primary treatment for chondrosarcoma, but chemotherapy becomes essential for patients with metastasis or tumors in surgically inaccessible sites. However, drug resistance often leads to treatment failure.

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BACKGROUND Ventriculoperitoneal (VP) shunt surgery is a widely used procedure for managing hydrocephalus; however, postoperative infections remain a serious complication, increasing morbidity and mortality. Known risk factors include prior surgeries, steroid use, and concurrent procedures. However, the role of liver cirrhosis, a condition that compromises immune function and predisposes patients to infections, has not been fully investigated in the context of neurosurgery.

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Background/aim: The disruption of cell-cycle control can lead to an imbalance in cell proliferation, often accompanied by genomic instability, which in turn can facilitate carcinogenesis. This study aimed to examine the impact of CDKN1A rs1801270 and rs1059234 polymorphisms on the risk of childhood acute lymphocytic leukemia (ALL) in Taiwan.

Materials And Methods: The genotypes of CDKN1A rs1801270 and rs1059234 in 266 childhood ALL cases and 266 controls were determined using PCR-RFLP techniques.

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Article Synopsis
  • Site-selective labeling techniques for protein modification are crucial for studying biological functions and dynamics within cells.
  • Despite advances, achieving specific modifications without altering protein functionality remains a challenge in the field.
  • The review explores various methodologies, including synthetic probes and computational approaches, that enhance our understanding of proteins and improve biopharmaceutical applications.
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Due to the frequent occurrence of food safety problems in recent years, healthy diets are gradually receiving worldwide attention. Chemical pigments are used in smart food packaging because of their bright colors and high visibility. However, due to shortcomings such as carcinogenicity, people are gradually looking for natural pigments to be applied in the field of smart food packaging.

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Background: Prisoner health is a major global concern, with prisoners often facing limited access to health care and enduring chronic diseases, infectious diseases, and poor mental health due to unsafe prison environments, unhygienic living conditions, and inadequate medical resources. In Taiwan, prison health is increasingly an issue, particularly concerning urinary diseases such as urinary tract infections. Limited access to health care and unsanitary conditions exacerbate these problems.

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The prevalence and contributing factors of mental health issues among health workers in Vietnam during the early 2022 Omicron wave remain underexplored. This study investigated the prevalence and factors associated with anxiety and stress among health workers in a Vietnamese hospital during this period. A cross-sectional study, conducted from February 28 to April 14, 2022, at Hanoi Medical University Hospital, assessed anxiety and stress among 754 frontline health workers using the DASS-21 questionnaire via a Google survey.

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Objectives: Endotype-based intervention has shown promise in treatment for patients with obstructive sleep apnea, and upper airway surgery is an important therapeutic option. However, the response to surgery varies among patients with obstructive sleep apnea. This study aims to examine changes in endotypic traits following upper airway surgery and their association with surgical outcome.

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Seasonal Variations in Triptan Prescription in Japan: A Nationwide Time-Series Analysis.

Brain Behav

December 2024

Department of Medical Affairs, Otsuka Pharmaceutical Co. Ltd, Tokyo, Japan.

Objective: This study aimed to investigate seasonal differences in migraine onset in Japan and associated trends in the prescription of triptan.

Background: The relationship between seasonal changes and the onset of migraine remains largely unknown.

Methods: We combined the large-scale medical claims data in Japan with city-level meteorological data presented by the Japan Weather Association.

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Nurses encounter many stressors and challenges at work, which can negatively affect their mental and physical health. Modern theories of resilience suggest that resilience is a dynamic process of positive adaptation to adversity. This process involves personal growth through adversity, developing effective coping strategies and inculcating the ability to cope with stress.

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Executive functions (EF) affect child competencies across domains in early childhood. Thus, this study examined: 1) the EF differences between young children with global developmental delays (GDD) and those with typical development (TD); 2) the relationship between mastery motivation (MM) and EF; 3) the association between developmental abilities and EF in both groups. Participants included 26 mother-child dyads of preschoolers with GDD (age 24-55 months) and 26 sex- and mental-age-matched dyads of TD preschoolers (age 15-29 months).

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Association between infant feeding and ADHD development in childhood: a birth cohort study in Taiwan.

J Child Psychol Psychiatry

December 2024

Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.

Background: Infant feeding plays a vital role in neurodevelopment, and a lack of breastfeeding and complementary feeding may increase the risk of developing attention-deficit/hyperactivity disorder (ADHD). However, empirical evidence on this relationship remains uncertain, as most studies are based on cross-sectional designs. Therefore, this study aimed to examine this temporal relationship using longitudinal data from a birth cohort.

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Dengue-related ocular complications were considered rare, but recent evidence points to a broader spectrum of manifestations, including uveitis. This study utilized the Taiwan National Health Insurance Research Database (NHIRD) to investigate the incidence of uveitis in dengue patients, aiming to fill this research gap. This population-based, retrospective cohort study utilized the Taiwan National Health Insurance Research Database (NHIRD) and included patients with and without Dengue fever.

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Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.

J Affect Disord

March 2025

Mind-Body Interface Research Centre (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; An-Nan Hospital, China Medical University, Tainan, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background: Device-based treatments exist in psychiatry for decades, but are usually operated by clinicians and require multiple office visits. Near-infrared transcranial photobiomodulation (tPBM) is a safe neurostimulation modality with potential antidepressant and hypnotic effects. We investigated the feasibility and efficacy of adjunctive tPBM treatment, self-administered by a wearable headband.

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Aims: This study evaluated the effectiveness of a pressure injury educational intervention on nurses' knowledge, attitudes, self-efficacy and perceived barriers.

Background: Pressure injuries remain a global healthcare challenge. Efficient teaching strategies like immersive learning are crucial to translating theoretical knowledge into practical skills.

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Vaccine hesitancy primarily consists of confidence, complacency, and convenience, including geographical accessibility. However, few studies in developed countries have focused on the association between geographical accessibility to vaccination services and vaccination status and previous studies have shown conflicting results. This cross-sectional study aimed to clarify the association between the number of medical facilities within a 15-minute driving distance from the place of residence and influenza vaccination status, using a large nationwide internet survey in Japan ( = 27,440).

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Ether-Linked Glycerophospholipids Are Potential Chemo-Desensitisers and Are Associated With Overall Survival in Carcinoma Patients.

J Cell Mol Med

December 2024

Graduate Institute of Biomedical Sciences, Program for MD/PhD, Research Center for Cancer Biology, School of Medicine, China Medical University, Taichung, Taiwan.

Article Synopsis
  • Lipid reprogramming plays a significant role in cancer development, prognosis, and response to treatment, with both autonomous and nonautonomous sources contributing to this process.
  • Research has identified ether-linked phosphatidyl-ethanolamine (PE O-) as a key lipid that enhances resistance to chemotherapy and promotes tumor progression in epithelial ovarian cancer (EOC).
  • Analysis revealed that PE O- is associated with reduced sensitivity to common chemotherapy drugs (cisplatin/paclitaxel) and its gene expression correlates positively with patient outcomes, suggesting that targeting PE O- could improve treatment effectiveness in EOC.
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Incidence and Risk of Cardiovascular Outcomes in Patients With Anorexia Nervosa.

JAMA Netw Open

December 2024

Health Data Analytics and Statistics Center, Office of Data Science, Taipei Medical University, New Taipei City, Taiwan.

Importance: Anorexia nervosa (AN) is commonly associated with cardiovascular complications.

Objective: To investigate the trajectories of the risk of cardiovascular conditions in a nationwide cohort of patients with AN in Taiwan.

Design, Setting, And Participants: From a population-based health insurance database from January 1, 2011, to December 31, 2021, this longitudinal cohort study identified patients with AN and controls through propensity score matching at a 1:10 ratio according to sex, age, urbanization level of residence, socioeconomic status, and year of diagnosis.

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Intrinsic Capacity and Life Quality Among Taiwanese Older People: A Cross-Sectional Study.

OTJR (Thorofare N J)

December 2024

International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK.

Intrinsic capacity (IC), an internal composite ability proposed by the World Health Organization, is fundamental to older people's health. The present study examined potential models explaining the association between IC and quality of life (QoL) among older people in Taiwan. Frailty, basic activities of daily living (BADL), and instrumental activities of daily living (IADL) were hypothesized to be mediators in the association between IC and QoL.

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Background: Early childhood caries (ECC) is a prevalent health problem that negatively affects both overall health and oral health-related quality of life (OHRQoL). This study investigated the association between health belief model (HBM) constructs and oral health behaviors, dental caries, and OHRQoL in preschool children in China.

Methods: A total of 1562 preschool children aged 3 to 6 years were recruited from six public kindergartens in Hangzhou, Zhejiang Province, by using stratified cluster sampling.

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Using machine learning and natural language processing in triage for prediction of clinical disposition in the emergency department.

BMC Emerg Med

December 2024

Department of Bioinformatics and Medical Engineering, Asia University, No. 500, Liufeng Rd., Wufeng Dist, Taichung City, 413305, Taiwan.

Background: Accurate triage is required for efficient allocation of resources and to decrease patients' length of stay. Triage decisions are often subjective and vary by provider, leading to patients being over-triaged or under-triaged. This study developed machine learning models that incorporated natural language processing (NLP) to predict patient disposition.

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