Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies.

Tumor metastasis occurs in lung cancer, resulting in tumor progression and therapy failure. Anoikis is a mechanism of apoptosis that combats tumor metastasis; it inhibits the escape of tumor cells from the native extracellular matrix to other organs. Deciphering the regulators and mechanisms of anoikis in cancer metastasis is urgently needed to treat lung cancer.

Social Memory in the Mekong's Changing Floodscapes: Narratives of Agrarian Communities' Adaptation.

Rural adaptation encompasses place-based perceptions, behaviors, livelihoods, and traditional ways of life associated with local environments. These perceptions, norms, and practices are disturbed by coupled environment-development externalities. This study employs the Vietnamese Mekong floodplains as an exemplary case to illustrate how floods impact agrarian communities and how they have experienced flood alterations driven by hydropower development and climate change in recent years.

The critical role of dysregulated autophagy in the progression of diabetic kidney disease.

Diabetic kidney disease (DKD) is one of the major public health problems in society today. It is a renal complication caused by diabetes mellitus with predominantly microangiopathy and is a major cause of end-stage renal disease (ESRD). Autophagy is a metabolic pathway for the intracellular degradation of cytoplasmic products and damaged organelles and plays a vital role in maintaining homeostasis and function of the renal cells.

Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC, accounting for 90% of primary liver cancer) was the sixth most common cancer in the world and the third leading cause of cancer death in 2020. The number of new HCC patients in China accounted for nearly half of that in the world. HCC was of occult and complex onset, with poor prognosis.

Cross-lagged models of health-related quality of life and breastfeeding across different body mass index groups: A three-wave prospective longitudinal study.

Background: Bidirectional relationships between health-related quality of life (HRQoL) and breastfeeding outcomes during the perinatal period across different body mass index (BMI) groups have not been investigated. Understanding the nature of such relations can provide strategies the for development of targeted interventions.

Objectives: This study aims to longitudinally (1) investigate the patterns of HRQoL during the perinatal period across different BMI groups; (2) explore bidirectional associations between HRQoL, breastfeeding attitude, and positive breastfeeding status during the perinatal period, and (3) compare the aforementioned relationships across four BMI groups.

Priorities to inform research on marine plastic pollution in Southeast Asia.

Southeast Asia is considered to have some of the highest levels of marine plastic pollution in the world. It is therefore vitally important to increase our understanding of the impacts and risks of plastic pollution to marine ecosystems and the essential services they provide to support the development of mitigation measures in the region. An interdisciplinary, international network of experts (Australia, Indonesia, Ireland, Malaysia, the Philippines, Singapore, Thailand, the United Kingdom, and Vietnam) set a research agenda for marine plastic pollution in the region, synthesizing current knowledge and highlighting areas for further research in Southeast Asia.

Teacher-student relationships and adolescents' school satisfaction: Behavioural engagement as a mechanism of change.

Background: Teacher-student relationships have been linked to various aspects of students' school functioning, including social-emotional well-being in school, but the underlying mechanisms need more investigation.

Aims: In this study, we analysed longitudinal data to test if students' classroom behavioural engagement was a potential mechanism of change that explained how teacher-student relationships affect student school satisfaction.

Sample: We used an archival dataset with a sample of seventh graders (ages 11-14, M  = 12.

Selective border permeability: Governing complex environmental issues through and beyond COVID-19.

COVID-19 has changed the permeability of borders in transboundary environmental governance regimes. While borders have always been selectively permeable, the pandemic has reconfigured the nature of cross-border flows of people, natural resources, finances and technologies. This has altered the availability of spaces for enacting sustainability initiatives within and between countries.

Cohort matters: The relationships between living arrangements and psychological health from the Korean Longitudinal Study of Aging (KLoSA).

Background: Little is known about cohort variations in the relationships between living arrangements and psychological health among older adults. The current study evaluated whether cohort differences in the intergenerational support affect the differences in the mental health benefits of multigenerational living arrangements, and how they do so.

Methods: Using panel regression models with lagged variables based on South Korean data, we compared the shape of the relationships between living arrangements and psychological conditions of two cohorts of older adults.

COVID-19 and ASEAN responses: Comparative policy analysis.

Scholars and policy-makers agree that cross-border and multi-sector cooperation are essential components of coordinated efforts to contain the spread of COVID-19 infections. This paper examines the responses of ASEAN (Association of Southeast Asian Nation) member countries to the COVID-19 pandemic, including the limits of regional cooperation. ASEAN has pre-existing cooperative frameworks in place, including regional health security measures, which, at least theoretically, could assist the region's efforts to formulate cooperative responses to containing a global pandemic.

Moving towards sustainable coastal adaptation: Analysis of hydrological drivers of saltwater intrusion in the Vietnamese Mekong Delta.

Coastal lowlands are of particular importance in providing food, shelter, and livelihoods for large populations; yet aggravating effects caused by human activities and climate change have exposed these areas to multiple challenges. Located in the southernmost part of the Lower Mekong Basin, the Vietnamese Mekong Delta (VMD) is adversely affected by upstream hydropower development, localised water-engineering systems (dykes), climatic factors, and sea level rise. This paper examines how these drivers shape the adaptation strategies of rural communities in the coastal areas.

'You are not Young Anymore!': Gender, Age and the Politics of Reproduction in Post-reform China.

Based on in-depth interview data and popular culture texts, the current study has explored the politics of reproduction revolving around women's age in contemporary China. Conceptualizing reproduction as a site of contestation and politics between different, and often contradictory, sets of discourses and power structures, I pursue a feminist and social constructivist analysis of the politics of reproduction in the lives of a group of urban professional women who are yet to enter motherhood at their late 20s and 30s. I engage with Inhorn's (2009) concept of 'disrupted reproduction' to highlight the politically, morally and emotionally charged contestations in the 'problematized' reproductive lives of these women.

Doing Family in "Times of Migration": Care Temporalities and Gender Politics in Southeast Asia.

The prevailing labor migration regime in Asia is underpinned by rotating-door principles of enforced transience, where low-wage migrant labor gains admission into host nation-states based on short-term, time-limited contracts and where family reunification and permanent settlement at destination are explicitly prohibited. In this context, we ask how migrant-sending families in Southeast Asian "source" countries-Indonesia and the Philippines-sustain family life in the long-term absence of one or both parents (often mothers). Through temporal concepts of rhythm, rupture, and reversal, we focus on how temporal modalities of care for left-behind children intersect with gendered power geometries in animating transnational family politics around care.

China's Belt and Road Initiative: Views from the ground.

The Chinese government promotes the Belt and Road Initiative (BRI) as a global strategy for regional integration and infrastructure investment. With a projected US$1 trillion commitment from Chinese financial institutions, and at least 138 countries participating, the BRI is attracting intense debate. Yet most analysis to date focuses on broad drivers, risks, and opportunities, largely considered to be emanating from a coherent policy imposed by Beijing.

The Country That Never Retires: The Gendered Pathways to Retirement in South Korea.

Objectives: Among all Organization for Economic Cooperation and Development countries, South Korean older adults work until the latest age. We investigate the extent to which work experiences over the life course and family circumstances can be associated with older workers' incentives to remain in the labor force beyond the statutory pension age. We explore gender-specific patterns of labor force exit and labor force re-entry in later life.

Cross-lagged Models of Marital Relationships and Intergenerational Conflicts during Transition to Parenthood: Effect of Patrilineal Coresidence.

The transition to parenthood is one of the most stressful intra- and interpersonal adjustment periods for new parents. Bidirectional associations among intergenerational relationships during the transition to parenthood have received limited attention, and the complexity of reciprocal relationships varies in accordance with living arrangements. The objectives of this study were to explore (1) the bidirectional associations between marital relationships and conflicts with in-laws during the transition to parenthood and (2) the moderation of patrilineal coresidence on the aforementioned relationships.

Parental migration and disruptions in everyday life: reactions of left-behind children in Southeast Asia.

Increasing feminisation of transnational labour migration has raised concerns over potential 'care crises' at home, and consequently a 'care deficit' for children left in origin countries. Our paper focuses on how left-behind children from Indonesia and the Philippines understand, engage and react to changes in their everyday lives in their parents' absence. While many children had no say over their care arrangements, some were able to assert their agency in influencing their parents' decisions and eventually migratory behaviours.

The well-being of China's rural to urban migrant children: Dual impact of discriminatory abuse and poverty.

Background: Post-migration experiences of discriminatory abuse and poverty have been recognized as key risk factors for psychopathology and health problems among children. However, little research has explored these associations among children participating in the internal migration process. Building on the stress and coping framework (Lazarus & Folkman, 1984), this study investigated the influence of discriminatory abuse and poverty on depressive symptoms and health problems in a group of Chinese migrant children.

Is Life Satisfaction an Antecedent to Coping Behaviors for Adolescents?

Adolescence is a critical developmental stage to develop coping behaviors. However, little is known about the longitudinal relations between coping behaviors and subjective well-being factors in adolescents. Situated within a positive psychology framework and supported by well-being theories, this study aims to investigate if life satisfaction is an antecedent to predict four specific types of coping behaviors (two approach coping: social support seeking and problem solving; and two avoidant coping: internalizing and externalizing coping behaviors) in early adolescents? A cross-lagged panel design was applied with three-wave data with six months apart between each wave.

Under one roof? Left-behind children's perspectives in negotiating relationships with absent and return-migrant parents.

Children-whether left behind or as migrants-have remained largely invisible in Southeast Asian migration scholarship. Their experiences and perspectives on migration, as well as how they demonstrate agency within the limits of culturally/socially constructed childhoods influenced by a "hybridisation" of global and local conditions, are often overlooked in favour of adults'. This article addresses this research lacuna by focusing attention on how left-behind Indonesian and Filipino children between 9 and 11 years of age engage and react to the changes in their everyday lives brought about by both parental migration and parental return.

Scientizing Everyday Life, Rationalizing Eating Habits: The Rise of Nutrition Science in 1910s-1920s Japan.

Historians of science have noted that modern nation-states and capitalism necessitated the systematic creation and implementation of a wide array of knowledge and technologies to produce a more productive and robust population. Commonly labeled as biopolitical practices in Foucauldian sense, such endeavors have often been discussed in the realms of public hygiene, housing, birth control, and child mortality, among others. This article is an attempt to extend the scope of the discussion by exploring a relatively understudied domain of nutrition science as a critical case of social engineering and intervention, specifically during and after World War I in the case of Japan.

Immortal Medicine: Understanding the Resilience of Burmese Alchemic Practice.

The institutionalization of indigenous medicine in contemporary Myanmar (Burma) placed alchemy at the margins of the formal health system. The practice, however, remains very much alive. Here, I explore the resilience of alchemic medicine by unraveling the relationship between this practice and the social space within which it operates.