5 results match your criteria: "Ascension-St John Hospital and Wayne State University School of Medicine[Affiliation]"
Detection of atrial fibrillation by implantable loop recorders following cryptogenic stroke: A retrospective study of predictive factors and outcomes.
J Electrocardiol
May 2022
Department of Cardiac Electrophysiology, Ascension St. John Hospital, Detroit, MI, USA.
Article Synopsis
- Cryptogenic strokes make up 40% of ischemic strokes, and this study aimed to investigate the relationship between atrial fibrillation (AF) detection via implantable loop recorders (ILRs) in patients who experienced these strokes.
- The study included 172 patients and found a 14% detection rate of AF over an average monitoring period of around 4.5 months, with certain factors like older age, male sex, and stroke patterns increasing the likelihood of detection.
- Most patients diagnosed with AF were prescribed anticoagulation therapy to help prevent future strokes, highlighting the importance of identifying AF in this group.
Elevated Cardiac Troponin in Clinical Scenarios Beyond Obstructive Coronary Artery Disease.
Med Sci Monit
September 2019
Department of Medicine, Ascension St. John Hospital and Wayne State University School of Medicine, Detroit, MI, USA.
In this systematic review article, we aim to summarize the most up-to-date evidence regarding elevations of cardiac troponin, especially in clinical scenarios other than obstructive coronary artery disease. The accurate interpretation of raised cardiac troponin is challenging because it relies on unconfirmed postulations and dogmatic knowledge (e.g.
View Article and Find Full Text PDFReal-world use of telavancin in the treatment of osteomyelitis.
Diagn Microbiol Infect Dis
October 2019
Ascension-St John Hospital and Wayne State University School of Medicine, Grosse Pointe Woods, Michigan, USA.
Article Synopsis
- * 87.5% of patients experienced improvement or cure by the end of telavancin therapy, while 94.6% saw similar results three months later.
- * Common side effects of telavancin included gastrointestinal issues like nausea (25.8%) and vomiting (9.7%), but many patients still had favorable treatment outcomes.
Urocortin Induces Phosphorylation of Distinct Residues of Signal Transducer and Activator of Transcription 3 (STAT3) via Different Signaling Pathways.
Med Sci Monit Basic Res
May 2019
Center for Heart and Vessel Preclinical Studies, Department of Internal Medicine, St. John Hospital and Medical Center, Wayne State University, Detroit, MI, USA.
BACKGROUND Urocortin (Ucn) is a member of the hypothalamic corticotrophin-releasing factor family and has been shown to reduce cell death in the heart caused by ischemia/reperfusion (I/R) injury. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor known to function as a pro-survival and anti-apoptotic factor, whose activation depends on a variety of cytokines, including IL-6. A recent study demonstrated that urocortin induced IL-6 release from cardiomyocytes in a CRF-R2-dependent manner, suggesting a possible link between CRF-R2 stimulation and STAT3 activation.
View Article and Find Full Text PDFAutophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients.
Med Sci Monit Basic Res
February 2019
Center for Heart and Vessel Preclinical Studies, Department of Internal Medicine, St. John Hospital and Medical Center, Wayne State University, Detroit, MI, USA.
BACKGROUND Although originally described as a survival mechanism, it is unknown whether and to what extent autophagy is implicated in the terminal stages of heart failure. Here, we studied magnitude and evolution of autophagy in patients with intractable heart failure. MATERIAL AND METHODS Myocardial samples were obtained from 22 patients with ischemic cardiomyopathy and idiopathic dilated cardiomyopathy who were undergoing cardiac transplantation.
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