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Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells.
PLoS One
January 2016
Department of Internal Medicine, Division of Cardiology, Nephrology, Pulmonology and Neurology, Asahikawa Medical University (AMU), Asahikawa, Japan.
Article Synopsis
- Microalbuminuria may indicate worse outcomes for coronary artery disease patients, particularly those with acute myocardial infarction, due to its impact on endothelial progenitor cell (EPC) function.
- A study involving 45 AMI patients showed that those with microalbuminuria had higher rates of late in-stent loss after treatment compared to those with normal albumin levels.
- Despite having more circulating EPCs, the microalbuminuria group exhibited reduced adhesion and increased cellular senescence, as indicated by lower sirtuin-1 mRNA expression and higher levels of SA-β-gal-positive cells.