679 results match your criteria: "Asahi University School of Dentistry[Affiliation]"

Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell collection methods rely heavily on the enzymatic digestion of dissected DP tissue to isolate and propagate primary cells, which often results in low recovery rates and reduced cell survival, particularly from deciduous teeth.

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Antiferroptotic properties of allicin and related organosulfur compounds-diallyl disulfide and diallyl trisulfide-from Garlic.

Food Chem Toxicol

January 2025

Life Science Research Center, Institute for Advanced Study, Gifu University, Gifu, 501-1193, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan; Institute for Glyco-core Research (iGCORE), Gifu University, Gifu 501-1193, Japan.

Allicin (diallyl thiosulfinate) is an abundant bioactive compound in garlic (Allium sativum L.) with broad-spectrum antiinflammatory, antifungal, antioxidant, and antitumor properties. The bioactive compounds of garlic including allicin may also help reduce the incidence of various diseases, although the individual contributions and precise mechanisms are still largely unknown.

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Recent progress in materials chemistry has resulted in the development of several ceramic materials that are now being used in dental implants. The advantages of ceramic materials over conventional metallic materials are that they do not induce allergic reactions in individuals with metal allergies, they do not interfere with magnetic resonance imaging, and they provide improved esthetics. In addition, some ceramic materials are tougher than metallic materials and less brittle.

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Article Synopsis
  • This study examines how chewing movements change in dementia patients, focusing on the relationship between mandibular movement and cognitive function.
  • Sixty-three residents from long-term care facilities chewed rice crackers while their movements were recorded for analysis.
  • Results showed that as cognitive function declined, patients exhibited less circular chewing motions and more linear ones, which may hinder their ability to eat solid foods effectively.
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Propriospinal myoclonus at sleep onset (PSM-S) is a sudden myoclonic jerk that occurs during the transition from wakefulness to sleep. It is a sleep-related movement disorder that causes difficulty falling asleep due to involuntary movements that spread caudally and rostrally through the propriospinal tract. Diagnosis requires observation of movements and polysomnography (PSG), and there are few reports.

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Tongue and jaw movement assessed by 3D motion capture during gum chewing.

Front Physiol

August 2024

Division of Comprehensive Prosthodontics, Faculty of Dentistry and Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Article Synopsis
  • - The study investigates 3D tongue movements during chewing using electromagnetic articulography (EMA), highlighting the tongue's role in mastication, swallowing, and articulation despite its hidden location in the mouth.
  • - Ten healthy young volunteers had EMA sensors placed on their tongues and jaw to track movements while chewing gum, enabling detailed spatial and sequential analysis of the tongue's motion.
  • - Results showed that the tongue moves in concert with the jaw, with specific patterns during chewing phases, such as the anterior tongue moving downward more than the posterior and the tongue reaching forward when the jaw is pulled back.
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Objectives: Interleukin (IL)-2 production by mouse spleen cells stimulated with an anti-CD3 antibody is significantly enhanced by caffeic acid phenethyl ester (CAPE), a major constituent of Chinese propolis (CP). In this study, we evaluated the functional significance of IL-2 in CAPE-treated activated spleen cells.

Methods: Mouse spleen cells were stimulated with an anti-CD3 monoclonal antibody in the presence of CAPE.

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Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo.

J Cell Biol

November 2024

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Membrane remodeling drives a broad spectrum of cellular functions, and it is regulated through mechanical forces exerted on the membrane by cytoplasmic complexes. Here, we investigate how actin filaments dynamically tune their structure to control the active transfer of membranes between cellular compartments with distinct compositions and biophysical properties. Using intravital subcellular microscopy in live rodents we show that a lattice composed of linear filaments stabilizes the granule membrane after fusion with the plasma membrane and a network of branched filaments linked to the membranes by Ezrin, a regulator of membrane tension, initiates and drives to completion the integration step.

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Article Synopsis
  • The study addresses the challenge of inconsistent labeling in medical images, which affects diagnosis using deep learning models, particularly for oral exfoliative cytology.
  • Researchers developed a convolutional neural network (CNN) by using annotations from multiple oral pathologists, processing six whole-slide images into 14,535 labeled tiles.
  • The probabilistic model outperformed other approaches, achieving the highest classification performance and accuracy, suggesting that this method could enhance the reliability of AI in capturing diverse medical diagnoses.
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This in vivo mouse model study was conducted to investigate the temporal alteration of the function of CD36 in salivary secretion. CD36 was highly expressed in the parotid gland of BALB/c mice. No significant variations were shown in the CD36 levels in the 8-, 48-, and 72-week-old animals.

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Pilot study on the relationship between oral function or subjective symptoms and appetite.

J Oral Rehabil

November 2024

Department of Dysphagia Rehabilitation, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry, Gifu, Japan.

Objective: This pilot study evaluated the relationships between appetite and oral function, and between appetite and the subjective symptoms of decreased oral function.

Methods: Seventy-one adult dental clinic patients (22 males, 66.0 ± 14.

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Background: This study investigated the correlation between the prevalence of dental caries and the presence and type of abuse.

Methods: Participants were 534 children admitted for care at two child guidance centers (CGCs) in Niigata, Japan. Data pertaining to abuse, including the reason for temporary protective care and the type of abuse, and the oral examination results of the children, were collected.

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Recently, we and others generated induced tissue-specific stem/progenitor (iTS/iTP) cells. The advantages of iTS/iTP cells compared with induced pluripotent stem (iPS) cells are (1) easier generation, (2) efficient differentiation, and (3) no teratomas formation. In this study, we generated mouse induced pancreatic stem cells (iTS-P cells) by the plasmid vector expressing ().

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Introduction: A dental humanoid robot, SIMROID, is able to replicate the actions characteristic of human beings and enable training for communicating with patients and coping with unexpected situations. This study assessed user experiences via a survey questionnaire following hands-on training on the SIMROID.

Materials And Methods: A total of 112 participants, consisting of 50 high school students who visited AUSD (Asahi University School of Dentistry) to participate in open campus events, 42 fourth-year students at AUSD and 20 dental students from Mexico State Autonomy University, University of Siena and Peking University took the survey.

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This study aimed to conduct a cross-sectional data analysis of the alveolar bone mineral density (al-BMD) in 225 patients of various ages and different sexes. The al-BMD value in the mandibular incisor region was calculated using a computer-aided measurement system (DentalSCOPE) for intraoral radiography. All participants with intact teeth (101 males and 124 females; age range, 25-89 years) were divided into three age-segregated groups (25-49, 50-74, and > 75 years).

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Introduction: Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (Aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. Many cohort studies indicate that tooth loss is a risk factor for AD. The detailed mechanisms underlying the association between AD and tooth loss, however, are not yet fully understood.

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Objectives: Several therapeutic agents have been developed and used for the clinical treatment of systemic lupus erythematosus (SLE). In cases where SLE is accompanied by severe organ failures, such as neuropsychiatric lupus erythematosus (NPSLE) and acute onset of lupus nephritis, the use of potent immunosuppressive drugs, such as cyclophosphamide, is necessary. However, potent immunosuppressive drugs are known to increase infection risks.

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Surface pre-reacted glass-ionomer (S-PRG) filler is a bioactive glass filler capable of releasing various ions. A culture medium to which was added an S-PRG filler eluate rich in boron was reported to enhance alkaline phosphatase (ALP) activity in human dental pulp-derived stem cells (hDPSC). To clarify the role of boron eluted from S-PRG fillers, the modified S-PRG filler eluate with different boron concentrations was prepared by using an anion exchange material.

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Hyperplastic dental follicles (HDFs) represent odontogenic hamartomatous lesions originating from the pericoronal tissues and are often associated with impacted or embedded teeth. These lesions may occasionally feature unique calcifying bodies, known as calcifying whorled nodules (CWNs), characterized by stromal cells arranged in a whorled or spiral fashion. CWNs are typically observed in multiple calcifying hyperplastic dental follicles or regional odontodysplasia.

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Article Synopsis
  • - The study investigates why de Quervain's disease, a form of stenosing tenosynovitis occurring at the wrist, happens more in the dorsal part of the first extensor compartment compared to the palmar part, focusing on anatomical differences.
  • - Researchers analyzed 35 wrists from 23 cadavers, finding that the palmar septum was thicker and more connected to surrounding muscles than the dorsal septum, which is more fragile.
  • - The findings suggest that the robust structure of the palmar septum may contribute to fewer symptoms of de Quervain's disease, which could enhance the understanding and treatment of this condition.
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Introduction: The purposes of this study were to evaluate the effect of the combined use of object detection for the classification of the C-shaped canal anatomy of the mandibular second molar in panoramic radiographs and to perform an external validation on a multicenter dataset.

Methods: The panoramic radiographs of 805 patients were collected from 4 institutes across two countries. The CBCT data of the same patients were used as "Ground-truth".

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Cluster of differentiation (CD)44 is a marker of dental pulp stem cells and is involved in odontoblast differentiation and calcification. Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) is also expressed in odontoblasts and dental pulp stem cells and is involved in inflammation suppression and tooth regeneration. Resolvin E1, a bioactive lipid, is a CMKLR1 ligand that mediates the chemerin-CMKLR1 interaction and suppresses pulpal inflammation.

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