Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis.

Purpose: This meta-analysis aimed to review the safety and efficacy of topical cyclosporine A (CsA) and topical tacrolimus in allergic eye disease.

Methods: A systematic search identified thirteen studies and a total of 445 patients for inclusion, making this the largest meta-analysis published on the subject. The current review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Do inflammatory bowel disease patient preferences from treatment outcomes differ by ethnicity and gender? A cross-sectional observational study.

Background: Inflammatory bowel disease (IBD) patients' expectations of treatment outcomes may differ by ethnicity.

Aim: To investigate treatment preferences of Jewish and Arabs patients.

Methods: This prospective survey ranked outcomes treatment preferences among Arab IBD patients, based on the 10 IBD-disk items compared to historical data of Jews.

The impact of intensive staff education on rate of Clostridium difficile-associated disease in hospitalized geriatric patients.

Background: Toxin-producing Clostridium difficile is the most common cause of nosocomial diarrhea in geriatric units.

Aim: The purpose of study was to check the impact of intensive staff education on rate of Clostridium difficile-associated disease in hospitalized geriatric patients.

Methods: The sampling frame was all patients suffering from diarrhea checked for Clostridium difficile toxin during the years 2017-2018.

Correction: Hyperbaric oxygen can induce angiogenesis and recover erectile function.

This has been corrected in both the PDF and HTML versions of the Article.

To check or not to check. Rectal ESBL colonization in hospitalized elderly patients.

Background: The worldwide spread of extended-spectrum-beta-lactamase (ESBL) producing bacteria has affected health care. ESBL confers resistance to the majority of beta-lactam antibiotics.

Materials And Methods: We intended to quantify the rates of rectal ESBL-positive and negative patients that eventually developed fever and urinary tract infection (UTI).

Hyperbaric oxygen can induce angiogenesis and recover erectile function.

Erectile dysfunction (ED) is caused by microvascular or macrovascular insufficiency in the majority of patients. Recent studies have shown that hyperbaric oxygen therapy (HBOT) can induce angiogenesis in different body organs. The effect of HBOT on the non-surgery-related ED has not been investigated yet.

Dose-Dependent Teratology in Humans: Clinical Implications for Prevention.

Since the inception of clinical teratology, the vast majority of scientific work has focused on identification of drugs and environmental agents causing malformations in humans as a dichotomous variable (i.e. yes or no), as well as the relative and absolute risks of such occurrences.

Comparative characteristic of antimicrobial resistance in geriatric hospital: a retrospective cohort study.

Background And Aims: To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients.

Methods: Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines.

Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance.

The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, <10% of the brain is active at any given time, it utilizes almost all the oxygen delivered. In order to perform complex tasks or more than one task (multitasking), the oxygen supply is shifted from one brain region to another, via blood perfusion modulation.

Ruxolitinib for the management of myelofibrosis: Results of an international physician survey.

Background: Ruxolitinib is established as treatment for symptomatic myeloproliferative neoplasm (MPN)-associated myelofibrosis. The strict inclusion and exclusion criteria and dose modification rules that applied to the COMFORTI and II studies that led to the licensing of ruxolitinib are not always applicable to routine clinical practice. Thus physicians now face decisions regarding ruxolitinib use that were not addressed in these pivotal trials.

Self-retaining support implant: an anchorless system for the treatment of pelvic organ prolapse-2-year follow-up.

Introduction And Hypothesis: The search for an improved vaginal mesh prompted the development of a new anchorless implant. The objective was to report on outcome after 2 years of a technique using a self-retaining support (SRS) implant.

Methods: Patients with anterior vaginal wall prolapse, with/without apical prolapse, were recruited.

Pre-admission CHA2DS2-VASc score and outcome of patients with acute cerebrovascular events.

Background: The CHA2DS2-VASc score has been recommended for the assessment of thromboembolic risk in patients with atrial fibrillation. Data regarding the association between the pre-admission CHA2DS2-VASc score and the outcome of patients with stroke and TIA are scarce. We aimed to assess the predictive value of pre-admission CHA2DS2-VASc score for early risk stratification of patients with acute cerebrovascular event.

A novel swine model of ricin-induced acute respiratory distress syndrome.

Pulmonary exposure to the plant toxin ricin leads to respiratory insufficiency and death. To date, in-depth study of acute respiratory distress syndrome (ARDS) following pulmonary exposure to toxins is hampered by the lack of an appropriate animal model. To this end, we established the pig as a large animal model for the comprehensive study of the multifarious clinical manifestations of pulmonary ricinosis.

The molecular and phenotypic spectrum of IQSEC2-related epilepsy.

Objective: IQSEC2 is an X-linked gene associated with intellectual disability (ID) and epilepsy. Herein we characterize the epilepsy/epileptic encephalopathy of patients with IQSEC2 pathogenic variants.

Methods: Forty-eight patients with IQSEC2 variants were identified worldwide through Medline search.

The Evolution of Nephrectomy and Patient Characteristics in Metastatic Renal Cell Carcinoma Patients Enrolled Into First-Line Tyrosine Kinase Inhibitors Clinical Trials.

Introduction: The objective of this study was to compare rates of nephrectomy (Nx) in, and characteristics of, patients with metastatic renal cell carcinoma (mRCC) enrolled in prospective clinical trials of tyrosine kinase inhibitors (TKIs) that were completed through (Group 1) versus after (Group 2) 2007.

Patients And Methods: Searching online databases, we retrospectively identified phase I to III trials with ≥ 15 patients with mRCC treated with first-line TKIs, alone or in combination with other agent(s).

Results: Of 70 trials identified, 42 were included in the analysis (n = 6074 patients).

Isolated Torsion of Accessory Fallopian Tube in a Young Adolescent.

Background: Accessory fallopian tube is a rare anatomical variation, which might rarely cause gynecological complications such as infertility, ectopic pregnancy, cystic swelling, and pyosalpinx. It is usually diagnosed by surgeons during diagnostic laparoscopy for other purposes. We present a rare case of isolated accessory tube torsion in a young adolescent.

Achieving the "Minimal Scarring" Concept in Bariatrics by Port-Site Relocation.

Background: The aim of single incision laparoscopic surgery (SILS) and other types of trans-umbilical procedures (TU) has been to perform operations with minimal or no visible scars. However, in bariatric surgery, they are in particular demanding and the final esthetic advantage is in question given the long-term abdominal skin alteration, or abdominoplasty. We propose an alternative rationale and approach to achieve the minimal scarring concept in bariatric surgery.

Rembrandt's Ocular Pathologies.

Purpose: This article aims to medically and artistically analyze various ophthalmological ailments documented in self-portraits of Rembrandt to determine if those ailments were medical conditions or stylistic and age-related changes.

Methods: A systematic literature review using Pub Med and Google Scholar found 232 results from a search of "Rembrandt" and more than 5,000 results for "Rembrandt Aging." After extensive review of the literature, the authors found 17 relevant sources.

[Initial treatment of primary spontaneous pneumothorax by a team which does not include a thoracic surgeon].

Primary Spontaneous Pneumothorax (PSP) refers to air in the pleural cavity occurring in the absence of overt underlining pulmonary disease. Smoking is an important predisposing factor for PSP. Once PSP is diagnosed the size of the PSP should be assessed according to a chest radiogram.

Vaginal müllerian cyst: an unusual cause of vaginal bleeding in a 16-month-old girl.

Background: Vaginal bleeding in premenarchal girls is always abnormal and its source must be identified for appropriate management. Examination under anesthesia and vaginoscopy are commonly employed for evaluation of the vagina as a source of bleeding, and the examination may occasionally reveal vaginal pathology.

Case: A 16-month-old otherwise healthy girl presented with spotting.

The legal guardians' dilemma: Decision making associated with invasive non-life-saving procedures.

Background: ICU patients frequently undergo non-life-saving invasive procedures. When patient informed consent cannot be obtained, legal guardianship (LG), often from a close relative, may be required by law. The objective of this cohort study was to investigate the attitudes of LGs of ICU patients regarding the process of decision making for invasive non-life-saving procedures.

Lessons from cases of mortality due to food allergy in Israel: cow's milk protein should be considered a potentially fatal allergen.

Background: Most reports in the medical literature on food allergy mortality are related to peanut and tree nut. There is limited knowledge regarding these reactions and often only a partial medical history is described.

Objective: To record and characterize all known cases of mortality due to food allergy in Israel occurring during the period 2004-2011.