Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines.

Greener production of compost from agricultural biomass residues amended with mule dung for agronomic application.

In this study agro-waste (Agwt) was aerobically composted using cow dung (CD) and mule dung (MD). Totally six different sets of compost treatments were prepared, as T1 (Agwt + CD, 1:1), T2 (Agwt + MD, 1:1), T3 (Agwt + CD, 1:3), T4 (Agwt + MD, 1:3), T5 (Agwt + CD, 3:1) and T6 (Agwt + MD, 3:1) in individual containers. All the compost treatments were degraded for 90 days.

Vermiconversion of biowastes with low-to-high C/N ratio into value added vermicompost.

Seaweed (T1), sugarcane trash (T2), coir pith (T3) and vegetable waste (T4) with cowdung (1:1, w/w) were vermicomposted using Eudrilus eugeniae (50 days). The pH in vermicomposts showed a decrease while electrical conductivity showed increment. The organic matter content, organic carbon, lignin, cellulose, C/N and C/P ratios in vermicompost was significantly lower than compost.

Dissecting the functional role of microRNA 21 in osteosarcoma.

Osteosarcoma (OS) is considered to be a malignant bone tumour that mainly affects the long bones, but it is also involved in other bones of the body. Currently, surgery and chemotherapy have achieved some response to patients with OS, but they are not increasing the survival rate as well as treatment options. Researchers made lot of drug options for OS, but yet, no treatment is existing in sight for the disease and needs a new insight into the molecular and signaling pathways for the disease.

Seaweeds as bioresources for vermicompost production using the earthworm, Perionyx excavatus (Perrier).

Fifteen days pre-decomposed seaweeds, Halimeda gracilis, Gracilaria corticata, Sargassum wightii and Sargassum swartzii spiked with cowdung (1:1) were vermicomposted using Perionyx excavatus for 60 days. The pH in the vermicompost showed insignificant reduction while electrical conductivity showed significant enhancement (P < 0.05).

MicroRNA21 and the various types of myeloid leukemia.

Myeloid leukemia (ML) is heterogeneous cancer classified by abnormal growth of myeloid cells due to genetic aberrations and mutations. It is generally categorized by clonal disorders of hematopoietic stem cells and differentiation. The molecular mechanism behind the myeloid malignancies is not yet known, but recent sequencing analysis reveals all the mutated factors.

Facile Synthesis and Characterization of ZrO₂ Nanoparticles via Modified Co-Precipitation Method.

The crystalline Zirconium oxide (ZrO2) nano particles were synthesized using optimized content of Zirconium nitrate (Zr(NO3)2·3H2O) with varying KOH concentration (0.5, 1 and 1.5 M) by co-precipitation method.

Computational Identification of microRNA-17-3p in Breast Cancer Cells.

Background: MicroRNAs (miRNAs) are small, highly conserved non-coding RNA molecules involved in the RNA silencing and post-transcriptional regulation of gene expression. miRNAs are well conserved in both plants and animals, and are thought to be a vital and evolutionarily ancient component of gene regulation and also act as oncogenes or tumor suppressors. It is known that Express Sequence Tags (EST) are a short sub-sequence of cDNA sequence, which contain information of condition or tissue specific transcripts (coding and non-coding) of an organism.

Expression and methylation of circulating microRNA-510 in essential hypertension.

Hypertension (HTN) is one of the most common emerging disease in developing countries. It alters endothelial cell structure and function, resulting in several diseases, such as cardiovascular disease, peripheral vasculopathy, cerebrovascular disease and nephropathy. Although much progress has been made in researching HTN in recent years, early diagnosis and treatment of HTN are not yet satisfactory, and progression control/treatment is still poor.

Deciphering the role of microRNA 21 in cancer stem cells (CSCs).

Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21-25 nucleotides (nt) in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3'-untranslated (UTR) region and play a very important role in cancer biology. Recent evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation, apoptosis, and invasion.