3 results match your criteria: "Arthur Riggs Diabetes and Metabolism Research Institute of City of Hope[Affiliation]"
Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice.
Sci Rep
May 2024
Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes AND Metabolism Research Institute of City of Hope, 1500 E. Duarte Rd., Duarte, CA, 91010, USA.
Article Synopsis
- Scientists are trying to find better ways to check if tiny clusters of cells (islets) from donors are good enough before putting them into people with Type 1 diabetes.
- They studied the genes related to low oxygen levels (hypoxia) in these islets from 85 donors to see how it affects transplantation results in mice.
- The research showed that checking these hypoxia-related genes can help predict how well the transplant will work, which could be a faster method than the usual tests done in mice.
Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Front Endocrinol (Lausanne)
March 2022
Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute of City of Hope, Duarte, CA, United States.
Skeletal muscle accounts for ~80% of insulin-stimulated glucose uptake. The Group I p21-activated kinase 1 (PAK1) is required for the non-canonical insulin-stimulated GLUT4 vesicle translocation in skeletal muscle cells. We found that the abundances of PAK1 protein and its downstream effector in muscle, ARPC1B, are significantly reduced in the skeletal muscle of humans with type 2 diabetes, compared to the non-diabetic controls, making skeletal muscle PAK1 a candidate regulator of glucose homeostasis.
View Article and Find Full Text PDFEvidence for functional G-coupled protein receptors 43 and 120 in subcutaneous and intramuscular adipose tissue of Angus crossbred steers.
J Anim Sci
June 2021
Department of Animal Science, Texas A&M University, College Station, TX 77843, USA.
We conducted 3 independent experiments to demonstrate functional G-coupled protein receptor 43 (GPR43) and GPR120 in bovine intramuscular (i.m.) and subcutaneous (s.
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