22 results match your criteria: "Arthur Jarvis University[Affiliation]"
BMC Geriatr
December 2024
Department of Chemical Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Background: The number of people reaching old age is rising, bringing an increase in age-related diseases like cardiovascular conditions and cognitive dysfunction. Cognitive impairment (CI) impacts various brain functions, affecting daily activities and quality of life. Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, has been implicated in CI.
View Article and Find Full Text PDFToxicol Rep
December 2024
Department of Human Anatomy, Arthur Jarvis University, Nigeria.
Doxorubicin, as an antibiotic causes toxicity in human tissues through the generation of oxidant species; however, (Solanaceae) is ethnopharmacologically and scientifically reported to possess antidotal activities. This study was designed to validate the antidotal potency of the plant's bioactive compounds on rats' testes following induction with doxorubicin through the evaluation of oxidative stress markers, lipid peroxidation indices, testes' histological sections, and profiling of the plant's bioactive compounds against some proteins. The collection and preparation of the plant extract, testicular toxicity induction, seminal analysis, assay of testosterone and oxidative stress markers, lipid peroxidation profiling, histomorphological studies, retrieval of catalase, superoxide dismutase, and glutathione peroxidase from PDB, GC-MS, ADME, and docking analyses followed standard protocols.
View Article and Find Full Text PDFSci Rep
December 2024
Immunology Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia.
The tumor-suppressing p-53 binding protein is a crucial protein that is involved in the prevention of cancer via its regulatory effect on a number of cellular processes. Recent evidence indicates that it interacts with a number of other proteins involved in cancer in ways that are not fully understood. An understanding of such interactions could provide insights into novel ways p53 further exerts its tumour prevention role via its interactions with diverse proteins.
View Article and Find Full Text PDFJ Parasit Dis
June 2024
Department of Biochemistry, Arthur Jarvis University, Akpabuyo, Cross River State Nigeria.
Plasmodium parasite causes malaria and affects the biochemical, physiological, and histoarchitecture of the hepatocytes and blood. The resultant effect leads to alterations in the metabolic activities of the liver, erythrocytes, as well as the buffer system. Therefore, we investigated the antiplasmodial activity, histomorphological studies of the hepatocytes and alterations in biochemical parameters in infected mice administered with the herbal formulation of aqueous extracts of stem bark and leaves.
View Article and Find Full Text PDFGerontol Geriatr Med
September 2024
Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
Malnutrition is a multifactorial problem affecting older adults especially in developing countries like Nigeria. Eighty-five subjects which comprise 55 older adults and 30 controls were recruited. Total protein, Albumin, Calcium, Vitamin-C and Vitamin D were estimated using Biuret's method, Bromo-Cresol Green method, O-Cresolphthalein-Complexone, High performance liquid chromatography, and ELISA methods respectively.
View Article and Find Full Text PDFHeliyon
September 2024
Department of Biological Sciences, Faculty of Natural and Applied Sciences, Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
Contamination of chicken with metals is on the increase, despite its known attendant health risks to human consumers. The study aimed to evaluate the concentration of some metals in various organs of chicken, their sources, and the health risks they pose to human consumers. Samples of liver, meat, gizzard, borehole water, soil, diets, and droppings were investigated for the presence of some metals (Cr, Co, Mn, Zn, Al, As, Cd, Ni, and Hg), and their sources using principal component analysis (PCA).
View Article and Find Full Text PDFJ Public Health Res
January 2024
Biomedical Engineering Department, Faculty of Health Sciences and Technology, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria.
Background: Rate and pattern of under-five mortality is a reflection of a society's healthcare system and quality of life. This study is aimed at reviewing the causes of infants and under-five morbidity and mortality in Calabar, Southern Nigeria.
Methods: This study used retrospective descriptive cross-sectional design.
BMC Complement Med Ther
February 2024
Department of Biochemistry, Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
Background: Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the disease's high fatality rate. This work identified the phytochemical components of Nauclea latifolia roots and docked the chemical compounds against target proteins, and examined the in vivo antiplasmodial effect of the roots on Plasmodium berghei-infected mice.
Methods: Standard protocols were followed for the collection of the plant's roots, cleaning, and drying of the roots, extraction and fraction preparation, assessment of the in vivo antiplasmodial activity, retrieval of the PfEMP-1 and PfPKG proteins, GCMS, ADME, and docking studies, chromatographic techniques were employed to separate the residual fraction's components, and the Swis-ADME program made it possible to estimate the drug's likeness and pharmacokinetic properties.
Afr Health Sci
June 2023
Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, University of Calabar, Nigeria.
Introduction: c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies.
Methods: Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster of differentiation markers performed via immunocytochemistry.
Biol Trace Elem Res
October 2024
Department of Medical Laboratory Science, College of Medicine of the University of Lagos, Idi-Araba, Lagos, Nigeria.
With the rising worries of potential metal contamination in cooked noodles, this study aimed at unravelling, for the first time, the possible source of metal contamination in cooked noodles. Noodles cooked with full spices (CWFS), cooked with half spices (CWHS), cooked with quarter spices (CWQS), and cooked with no spices (CWNS: control) and their spices were analysed for metals using inductively coupled plasma-atomic emission spectrometry. The microbiological quality of the noodles was also evaluated.
View Article and Find Full Text PDFGerms
December 2022
PhD, Department of Microbiology, Faculty of Biological Sciences, University of Calabar, P.M.B 1115, Etta Agbo Rd, Calabar, Cross River State, Nigeria.
Risk and predisposing factors for viral zoonoses abound in the sub-Saharan Africa (SSA) region with significant public health implications. For several decades, there have been several reports on the emergence and re-emergence of arbovirus infections. The lifetime burden of arboviral diseases in developing countries is still poorly understood.
View Article and Find Full Text PDFGerms
December 2022
B.MLS, M.Sc, Ph.D, Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Arthur Jarvis University, Brigadier Dan Archibong Drive, Ndon Obori Ikot Effanga, Akpabuyo, Cross River State, Nigeria and Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, PMB 1115, Cross River State, Nigeria.
Introduction: Leprosy is a chronic granulomatous infectious disease caused by that mostly result in immunological reactions that affect the skin, peripheral nervous system and mucosa of the upper respiratory tract. This study aimed to evaluate hematological parameters among subjects with leprosy and deduce biomarkers for onset of leprosy reaction.
Methods: This was a cross-sectional study performed from September 1, 2018 to August 1, 2019.
Heliyon
August 2023
Department of Anatomy, Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
Recent researches suggests magnesium as an adjuvant medication for COVID 19 patients. Magnesium relaxes skeletal muscles, an effect when prolonged in intestinal smooth muscles can cause severe discomfort such as bloating, vomiting, constipation and nausea. The objectives of this study was to ascertain if magnesium will cause relaxation of the intestinal (ileum) smooth muscles as it does in skeletal muscles.
View Article and Find Full Text PDFComput Biol Med
July 2023
Department of Chemistry, Tshwane University of Technology, Pretoria, South Africa.
Similar to the more well-known carbon nanotubes, gallium nitride nanotubes (GaNNT) are among the materials that scientists have found to be extremely helpful in transporting drugs and to provide significant potential for multi-modal medical therapies. Here, the potential of Cu, Ag, and Au-doped GaNNT for smart delivery of the anticancer medication hydroxyurea (HU) was extensively investigated employing quantum chemical analysis and density functional theory (DFT) computation at the B3LYP-GD3BJ/def2-SVP level of theory. The systematic approach used in this study entails examining the exo (outside)-and endo (inside) loading of HU utilizing the investigated nanotubes in order to understand the adsorption, sensing processes, bonding types, and thermodynamic properties.
View Article and Find Full Text PDFFood Chem Toxicol
May 2023
Department of Biological Sciences, Faculty of Natural and Applied Sciences, Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
The exposure of bottled water to sunlight leaches heavy metals into the water, thereby deteriorating its quality and this informed the study. Three plastic bottle brands (n = 100 per brand) were exposed to sunlight for different durations. The leaching of contaminants was exposure duration dependent.
View Article and Find Full Text PDFHeliyon
February 2023
Department of Bioscience and Biotechnology, University of Medical Sciences, Ondo City, Ondo State, Nigeria.
Heavy metal co-resistance with antibiotics appears to be synergistic in bacterial isolates via similar mechanisms. This synergy has the potential to amplify antibiotics resistance genes in the environment which can be transferred into clinical settings. The aim of this study was to assess the co-resistance of heavy metals with antibiotics in bacteria from dumpsite in addition to physicochemical analysis.
View Article and Find Full Text PDFBMC Complement Med Ther
February 2023
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.
Background: One of the main challenges of wound healing is infection with multi-drug resistant (MDR) bacteria such as Staphylococcus aureus. The spectrum of antibiotics used to treat them is declining; thus, there is a need for alternatives. Our study was designed to evaluate the antimicrobial properties of honey, its pharmacokinetics (ADMET) properties and in-silico analysis of its bioactive compounds against dihydropteroate synthase of S.
View Article and Find Full Text PDFAIDS Res Ther
December 2022
School of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain.
Background: Acquired immunodeficiency syndrome (AIDS) is an acquired defect of the cellular immunity associated with the infection by the human immunodeficiency virus (HIV). The disease has reached pandemic proportion and has been considered a public health concern. This study is aimed at analyzing the trend of HIV/AIDS research in Nigeria.
View Article and Find Full Text PDFBMC Complement Med Ther
July 2022
Department of Biological Science (Microbiology Unit), Faculty of Natural and Applied Sciences, Arthur Jarvis University, Akpabuyo, Cross River State, Nigeria.
Background: Staphylococcus aureus has prevailed against the majority of antibiotics currently in clinical use, making it a significant global public health problem. As a safer alternative, bioactive compounds have been explored. Annona muricata has been shown to possess antimicrobial activity.
View Article and Find Full Text PDFEthiop J Health Sci
November 2021
Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, 40001, Enugu, Nigeria.
Background: The coronavirus disease 2019 (COVID-19) is a highly contagious and pathogenic viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Since it was first reported in Wuhan, China, it has spread across the continents. The study is aimed at describing epidemiological indices of COVID-19 as reported by the World Health Organization and to examine correlations with some country specific measures of general health status.
View Article and Find Full Text PDFGerms
September 2021
Ph.D, M.Sc, B.Sc, Department of Public Health, Faculty of Allied Medical Sciences, University of Calabar, PMB 1115 Calabar, Nigeria.
Introduction: After the World Health Organization declared COVID-19 a pandemic, a hand full of cases and deaths have been recorded globally, Nigeria inclusive.
Methods: A retrospective analysis of the COVID-19 weekly disease update report by the Nigeria Centre for Disease Control (NCDC) covering February 29, 2020 (Week 9) and March 28, 2021 (Week 12) was adopted for this study. Data were curated from the NCDC database.
Advancements in electronic health record system allow patients to store and selectively share their medical records as needed with doctors. However, privacy concerns represent one of the major threats facing the electronic health record system. For instance, a cybercriminal may use a brute-force attack to authenticate into a patient's account to steal the patient's personal, medical or genetic details.
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