10 results match your criteria: "Artemisinin Research Center and the Institute of Chinese Materia Medica[Affiliation]"
Recent pharmacological advances in the repurposing of artemisinin drugs.
Med Res Rev
November 2021
Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood (Artemisia annua). Beyond their well-characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti-inflammatory, and anticancer activities. With concerted efforts in further preclinical and clinical studies, artemisinin-based drugs have the potential to be viable treatments for a great variety of human diseases.
View Article and Find Full Text PDFCorrigendum: Quercetin Induces Apoptosis Via Downregulation of VEGF/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.
Front Pharmacol
February 2021
Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, China.
[This corrects the article DOI: 10.3389/fphar.2020.
View Article and Find Full Text PDFGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
January 2021
Hong Kong Baptist University, School of Chinese Medicine, Hong Kong, China.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.
Front Pharmacol
December 2020
Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, China.
Article Synopsis
- Acute myeloid leukemia (AML) is a serious blood cancer marked by the rapid growth of immature myeloid cells, and quercetin, a flavonoid, shows potential as a treatment but needs more research on its effects in AML.
- This study finds that quercetin triggers cell death in AML cells through apoptosis, which is dependent on caspases, and also causes a decrease in mitochondrial membrane potential and Bcl-2 proteins.
- The researchers identified that quercetin's effects involve downregulating VEGFR2 and the PI3K/Akt signaling pathways, which play a crucial role in the apoptosis process, demonstrating that these pathways are key upstream regulators in quercetin-induced cell death in AML
Artemisinin-Ginkgo biloba extract combination therapy for Plasmodium yoelii.
Parasitol Int
February 2021
CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:
Malaria remains a widespread life-threatening infectious disease, leading to an estimated 219 million cases and around 435,000 deaths. After an unprecedented success, the antimalarial progress is at a standstill. Therefore, new methods are urgently needed to decrease drug resistant and enhance antimalarial efficacy.
View Article and Find Full Text PDFNeglected interstitial space in malaria recurrence and treatment.
Nano Res
July 2020
CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China.
The interstitial space, a widespread fluid-filled compartment throughout the body, is related to many pathophysiological alterations and diseases, attracting increasing attention. The vital role of interstitial space in malaria infection and treatment has been neglected current research efforts. We confirmed the reinfection capacity of parasites sequestrated in interstitial space, which replenish the mechanism of recurrence.
View Article and Find Full Text PDFMalaria eradication.
Lancet
April 2020
Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100070 Beijing, China. Electronic address:
Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic.
Lancet
April 2020
Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:
Suboptimal dosing triggers artemisinin partner drug resistance.
Lancet Infect Dis
November 2019
Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:
A Temporizing Solution to "Artemisinin Resistance".
N Engl J Med
May 2019
From the Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (J.W., C.X., F.L.L., T.J., Y.T.), and the ShenZhen People's Hospital, ShenZhen (J.W., C.X.) - both in China; the Department of Pharmacology and Biological Sciences, National University of Singapore, Singapore (J.W., C.X.); the Centre for Diagnostics and Antimicrobial Resistance, Institute for Infection and Immunity, St. George's University of London and St. George's University Hospitals NHS Foundation Trust, London (S.K.); and the Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany (S.K.).