New species and records of the Rhamphomyia subgenus Holoclera (Diptera, Empididae) from the Palaearctic Region.

New data on the Palaearctic subgenus Holoclera Schiner of dance flies of the genus Rhamphomyia Meigen (Diptera: Empididae) are reported. Three new species are described: Rhamphomyia (Holoclera) richterae sp. nov.

A new species of Metopeurum Mordvilko, 1914 (Hemiptera: Aphididae) from the Transcaucasus, with a key to the species of this genus.

The new aphid species Metopeurum caucasicum sp. nov. living on Achillea millefolium and five species of Tanacetum, namely T.

Review of the brevicollis group of the genus Geodromicus Redtenbacher, 1857 (Coleoptera: Staphylinidae: Omaliinae: Anthophagini).

The brevicollis species group of the genus Geodromicus Redtenbacher, 1857 is reviewed. All three Western Palaearctic species of the group, including G. alborzensis sp.

On some new and little-known Palaearctic species of the genus Leptochilus de Saussure, 1853 (Hymenoptera: Vespidae: Eumeninae).

Two new species are described: Leptochilus (Euleptochilus) barkalovi Fateryga, sp. nov. from Turkmenistan and L.

Does coiling of the proximal end of the ureteral stent affect stent-related symptoms?

Objective: To evaluate the impact of coiling of the proximal end of the ureteral stent on stent-related symptoms (SRS) in in subgroup of patients undergoing preoperative ureteral stenting preceding flexible retrograde intrarenal surgery (RIRS).

Materials And Methods: We performed a prospective comparative study including patients undergoing stent placement 7-10 days prior to RIRS. Patients were divided into 2 groups; in Group 1 coiling of proximal end of the DJ was present, while in Group 2 coiling was absent.

Novel variants impairing Sp1 transcription factor binding in the COL7A1 promoter cause mild cases of recessive dystrophic epidermolysis bullosa.

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and most often severe genodermatosis characterized by recurrent blistering and erosions of the skin and mucous membranes after minor trauma, leading to major local and systemic complications. RDEB is caused by loss-of-function mutations in COL7A1 encoding type VII collagen (C7), the main component of anchoring fibrils which form attachment structures stabilizing the cutaneous basement membrane zone. Most of the previously reported COL7A1 mutations are located in the coding or intronic regions.

Furopyridine Derivatives as Potent Inhibitors of the Wild Type, L858R/T790M, and L858R/T790M/C797S EGFR.

The treatment of patients with nonsmall cell lung cancer (NSCLC) using epidermal growth factor receptor (EGFR) inhibitors is complicated by drug-sensitive activating L858R/T790M and L858R/T790M/C797S mutations. To overcome drug resistance, a series of furopyridine (PD) compounds were virtually screened to identify potent EGFR inhibitors using molecular docking and molecular dynamics (MD) simulations based on the solvated interaction energy (SIE) method. Several PD compounds identified from virtual screening demonstrated the potential to suppress both wild-type and mutant forms of EGFR, with IC values in the nanomolar range.

Possible Risk Factors Contributing to Atrial Fibrillation Occurrence in Heart Failure With Mildly Reduced Ejection Fraction.

Background: Heart failure (HF) is often accompanied by atrial fibrillation (AF), which significantly worsens the outcome of both diseases. Half of individuals with HF has AF, and HF occurs in more than one-third of individuals with AF. Thus, HF and AF are commonly encountered together and are closely interrelated with similar risk factors.

Guillain-Barré Syndrome in Africa: Understanding, Addressing, and Empowering.

Introduction: Guillain-Barré Syndrome (GBS) is a spectrum of peripheral neuropathies characterized by rapid symmetrical limb weakness and sensory symptoms. GBS can be life-threatening and requires intensive care, particularly for patients with imminent respiratory failure. In Africa, limited research and high therapy costs pose challenges.

Mental healthcare for older adults among countries in World Psychiatric Association Zone 10.

Objectives: This study aimed to compare mental healthcare services for older adults aged ≥65 years among countries in World Psychiatric Association (WPA) Zone 10.

Methods: A culturally sensitive questionnaire was developed and sent to the presidents of national psychiatric associations of the eight countries in WPA Zone 10 (Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Russia, and Uzbekistan).

Results: Psychiatric associations of six countries responded to the questionnaire (Armenia and Moldova did not respond).

Synthesis of enantiomerically enriched β-substituted analogs of (S)-α-alanine containing 1-phenyl-1H-1,2,3-triazole groups.

A synthesis of new enantiomerically enriched derivatives of (S)-α-aminopropionic acid, containing in the β-position 1,2,3-triazole groups coupled with a o-, m- and p-substituted phenyl residue, was developed based on Cu(I) catalyzed [3 + 2] cycloaddition of azides with alkynes. As the starting materials was used the square-planar Ni(II)complex of the Schiff base of propargylglycine with the chiral auxiliary BPB (Benzylprolylbenzophenone) and 1,4-substituted phenyl azides. The assignment of the (S)-absolute configuration of the α-carbon atom of the amino acid residue of the main diastereomeric complexes of the cycloaddition products was carried out on the basis of positive Cotton effects in the region of 480-580 nm of the circular dichroism spectra.

Insights into earthquake-induced tsunamis in the Caucasus' largest Lake Sevan.

By leveraging the Okada model, the study makes the first-ever attempt to examine earthquake-induced tsunamis in Lake Sevan, related to the activation of underwater segments of the active Pambak-Sevan-Syunik Fault (PSSF), the largest geological structure in the Republic of Armenia (RA). Situated in the Arabian-Eurasian continental collision zone, the basin of Sevan, the largest freshwater lake in the Caucasus region, is characterized by a variety of geological hazards capable of producing events of inter-related triggering. Among other threats, the lake tsunami hazard has remained unexplored.

Diversity and Distribution of Bacterial and Parasitic Tick-Borne Pathogens in Armenia, Transcaucasia.

Background: Variations in the distribution and prevalence of pathogens in ticks can have significant consequences for human health. Information on these variables in Transcaucasia is scarce, so the aim of our study was to conduct a large-scale study to detect selected tick-borne infectious agents in Armenia.

Methods: Overall, 209 adult ticks were collected from different hosts including 4 samples from human clothes.

New taxonomic and faunistic data on the funnel-weavers (Araneae, Agelenidae) of Turkiye and the Caucasus, with five new species.

New taxonomic and faunistic data on the agelenid spiders of Turkiye and the Caucasus are provided. Five species are described as new to science: (♂♀; Turkiye: Antalya), (♂♀; Turkiye: Antalya), (♂; Turkiye: Antalya), (♂♀; Georgia: Imereti), and (♂♀; Armenia: Kotayk). Dimitrov, 2020, is proposed as a new junior synonym of Brignoli, 1978.

A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.

We present a computational model that integrates mechanobiological regulations, angiogenesis simulations and models natural callus development to simulate bone fracture healing in rodents. The model inputs include atomic force microscopy values and micro-computed tomography on the first-day post osteotomy, which, combined with detailed finite element modeling, enables scrutinizing mechanical and biological interactions in early bone healing and throughout the healing process. The model detailed mesenchymal stem cell migration patterns, which are essential for tissue transformation and vascularization during healing, indicating the vital role of blood supply in the healing process.