Clinical remission in patients with severe eosinophilic asthma treated with mepolizumab: A analysis of RELIght study.

Remission of asthma can occur as part of the natural history of the disease; however, the use of biologics can result in disease remission in some patients. In this post hoc analysis of the RELIght study, we aimed to evaluate clinical remission in real life among patients treated with mepolizumab, to detect possible differences between "remitters" and "nonremitters," and to evaluate possible predictors of remission. Clinical remission was defined as the absence of asthma exacerbations, discontinuation of oral corticosteroids (OCS), achievement of asthma control (Asthma Control Test [ACT] ≥ 20), and stable or improved lung function.

Impact of Chlorella sorokiniana feed additive on poultry growth health and oxidative stress in erythrocytes.

Microalgae, have emerged as a potentially promising feed additive option due to their beneficial nutritional profile rich in bioactive compounds. The present study examines the incorporation of Chlorella sorokiniana (at 0.1% and 1%) into chicken feed compared to control feed and its effect on growth and health parameters of poultry grown at pilot plant scale.

Molecular classification of endometrial cancer: Impact on adjuvant treatment planning.

Objective: The traditional histopathological analysis of endometrial cancer (EC) is the main risk group classification tool (low, intermediate, high-intermediate, and high) for the implementation of adjuvant treatment. The International Federation of Gynecology and Obstetrics staging system of EC has incorporated a new molecular classification that serves as a new triage tool for optimal treatment planning for these patients. Our study aimed to investigate the prognostic role of the new molecular classification in EC.

Raman scattering of water in vicinity of polar complexes: Computational insight into baseline subtraction.

Water is a greatly convenient solvent in Raman spectroscopy. However, non-additive effects sometimes make its signal difficult to subtract. To understand these effects, spectra for clusters of model ions, including transition metal complexes and water molecules, were simulated and analyzed.

Squamous Cell Carcinoma of the Ovary: A Rare Case.

Ovarian squamous cell carcinoma (SCC) is a rare entity among primary ovarian cancers. This type of cancer typically originates from the transformation of mature cystic teratomas, commonly known as dermoid cysts, and occasionally from associations with endometriosis or Brenner's tumors. The typical clinical scenario involves presentation in postmenopausal women, with symptoms arising from tumor growth or metastasis.

Unmasking a Rare Genetic Mutation: The Importance of Genetic Testing in Refractory Hypertriglyceridemia.

Background/objective: Genetic causes of hypertriglyceridemia like familial chylomicronemia syndrome can be overlooked in everyday practice. We report a patient with a rare genetic mutation, highlighting the importance of genetic testing for timely diagnosis and prevention of complications.

Case Report: A 45-year-old Hispanic female presented with serum triglyceride levels of 749 mg/dL, refractory to rosuvastatin 10 mg daily and omega-3 ethyl esters 2 g daily.

Endovascular Management of an Isolated Common Iliac Artery Aneurysm in a Patient with an Ectopic Pelvic Kidney: A Case Report.

Isolated iliac aneurysms are rare, and their management becomes complex when accompanied by ectopic pelvic kidneys due to altered vascular anatomy. We report a 58-year-old male with an incidentally discovered 53.5 mm left common iliac artery (CIA) aneurysm and an ectopic pelvic kidney.

Ideological religious nationalism: measurement, construct validity, and cross-cultural comparisons.

Ideological religious nationalism (IRN) is a worldview that advocates the integration of religious beliefs with national policy and laws and the religious moralization of politics. However, the psychological mechanisms, individual differences, and socio-political consequences related to IRN are unclear. Across five studies ( = 1,349), we established construct validity for a novel scale assessing IRN that is adaptable across different contexts.

Flush endovenous laser ablation (fEVLA) in the treatment of lower limb venous insufficiency a systematic review and meta-analysis.

Purpose: To assess the safety and efficacy of flush endovenous laser ablation (fEVLA) in the treatment of chronic venous insufficiency.

Materials And Methods: Following the PRISMA 2020 guidelines, a systematic review aiming to identify studies published from inception to March 2024 was conducted. The investigation covered single-arm studies and studies comparing fEVLA to standard EVLA (sEVLA).

Design, additive manufacturing, and characterization of an organ-on-chip microfluidic device for oral mucosa analogue growth.

Introduction: Α customized organ-on-a-chip microfluidic device was developed for dynamic culture of oral mucosa equivalents (Oral_mucosa_chip-OMC).

Materials And Methods: Additive Manufacturing (AM) was performed via stereolithography (SLA) printing. The dimensional accuracy was evaluated via microfocus computed tomography (mCT), the surface characteristics via scanning electron microscopy (SEM), while the mechanical properties via nanoindentation and compression tests.

R4Alz-R: a cutting-edge tool for spotting the very first and subtle signs of aging-related cognitive impairment with high accuracy.

The accurate diagnosis of aging-related neurocognitive disorders as early as possible, even in a phase that is characterized by the absence of clinical symptoms, is nowadays the holy grail of the neurosciences. R4Alz-R is a novel cognitive tool designed to objectively detect the subtle cognitive changes that emerge as the very first result of the aging processes and could be developed and broadened in a continuum from healthy aging to subjective cognitive impairment (SCI) and mild cognitive impairment (MCI), before reaching some type of dementia. The goal of the present study was to examine whether the R4Alz-R battery has the potential to detect these subtle changes.

Subclinical Mastitis in Lacaune Sheep: Etiologic Agents, the Effect on Milk Characteristics, and an Evaluation of Infrared Thermography and the YOLO Algorithm as a Preprocessing Tool for Advanced Analysis.

This study aimed to investigate the incidence of subclinical mastitis (SCM), the implicated pathogens, and their impact on milk quality in dairy sheep in Greece. Furthermore, we preliminarily evaluated infrared thermography and the application of AI tools for the early, non-invasive diagnosis of relevant cases. In total, 660 milk samples and over 2000 infrared thermography images were obtained from 330 phenotypically healthy ewes.

The Effect of Dark Chocolate Consumption on Arterial Function in Endurance Male Runners: Prospective Cohort Study.

Foods rich in polyphenols have beneficial effects on health. This study aimed to examine the impact of dark chocolate on endurance runners' arterial function. Forty-six male amateur runners, aged 25-55, participated.

The Effect of Intraset Rest Periods on External and Internal Load During Small-Sided Games in Soccer.

The purpose of this study was to compare the internal and external load in continuous and intermittent small-sided games (SSG) formats. Eight semi-professional soccer players participated in the study, and they completed three protocols: (a) I-intermittent SSG protocol (Int-I, 4 sets of 4 min with a 3 min recovery); (b) Continuous SSG protocol (Con, 2 sets of 8 min with a 3 min recovery); (c) II-SSG protocol (Int-II, 4 sets of 4 min, where each set includes 1 min of exercise with varying recovery periods (10, 20, 30 s), with a 3 min recovery period between sets). A one-way analysis of variance (ANOVA) was used to analyze the dependent variables, with significance determined at < 0.

Impact of a Three-Month Training Break on Swimming Performance in Athletes with Intellectual Disability.

This study aimed to ascertain whether there were any differences in anthropometrics, heart rate, and swimming performance parameters in athletes with intellectual disabilities (ID) before and after a three-month training break. A total of 21 athletes participated in the study, comprising 16 males and 5 females, with a mean age of 28.3 ± 8.

Impact of Mast Cell Activation on Neurodegeneration: A Potential Role for Gut-Brain Axis and Infection.

Background: The innate immune response aims to prevent pathogens from entering the organism and/or to facilitate pathogen clearance. Innate immune cells, such as macrophages, mast cells (MCs), natural killer cells and neutrophils, bear pattern recognition receptors and are thus able to recognize common molecular patterns, such as pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs), the later occurring in the context of neuroinflammation. An inflammatory component in the pathology of otherwise "primary cerebrovascular and neurodegenerative" disease has recently been recognized and targeted as a means of therapeutic intervention.

The Efficacy of Fecal Microbiota Transplantation in Mouse Models Infected with from the Perspective of Metabolic Profiling: A Systematic Review.

: This systematic review evaluates the effectiveness of fecal microbiota transplantation (FMT) in treating infection (CDI) in mouse models using a metabolomics-based approach. : A comprehensive search was conducted in three databases (PubMed, Scopus, Google Scholar) from 10 April 2024 to 17 June 2024. Out of the 460 research studies reviewed and subjected to exclusion criteria, only 5 studies met all the inclusion criteria and were analyzed.

Correlation of Red Blood Cell Morphology with Serum Cobalamin and Folate Concentration in Dogs with Chronic Diarrhea: A Retrospective Study.

: Chronic diarrhea in dogs is a prevalent condition that significantly impacts canine health, often leading to weight loss, dehydration, and malnutrition. Diagnosing and treating chronic diarrhea is challenging due to its multifactorial nature, necessitating collaboration among veterinarians across various specialties. Measuring cobalamin and folate levels is a crucial diagnostic step for all dogs with chronic diarrhea.

Prevalence and Risk Factors for Atherosclerotic Cardiovascular Disease in 7704 Individuals: An Analysis from the Greek Registry for the Prevalence of Familial Hypercholesterolemia (GRegistry-FH).

The intention of this study was to profile the cohort from the Greek Registry for the prevalence of Familial Hypercholesterolemia (GRegistry-FH) by estimating the prevalence of coronary artery disease (CAD), myocardial infarction (MI), stroke, dyslipidemia, arterial hypertension, diabetes mellitus (DM), pre-DM, smoking, abnormal thyroid function (ATF), and lipid values. The GRegistry-FH is a prospective study involving door-to-door interviews conducted by trained interviewers. Overall, 7704 individuals aged ≥18 years, randomly selected from all the regions of Greece, participated.

Comparative Analysis of 2-Point Jump Shot and Free Throw Kinematics in High- and Low-Level U18 Male Basketball Players.

: This study examined the influence of competition level and player position on shooting accuracy and kinematic parameters in U18 male basketball players, focusing on two-point jump shots and free throws. : Thirty-eight higher-level (HL-group) and forty-one lower-level (LL-group) participants, categorized into guard, forward, and center subgroups, completed a two-point basketball shooting test, followed by a free-throw shooting test after a 30 min interval. These tests were administered using a crossover, counterbalanced approach with the Latin square method to ensure effective randomization.

Anxiety, Depression, and Quality of Life in Women with Breast Cancer and Type 2 Diabetes: A Pilot Study in North Greece.

: The incidence of breast cancer, as well as diabetes mellitus (DM), has continuously increased in recent years. The concurrent study of these diseases is particularly important, as there is a strong correlation between them due to hormonal, biochemical, and environmental factors. Moreover, the underlying metabolic dysfunction in this case could affect the treatment of breast cancer, as well as overall survival.

Integration of Genomic Tests in Prostate Cancer Care: Implications for Clinical Practice and Patient Outcomes.

Prostate cancer (PCa) is a common malignancy in men and is among the leading causes of cancer-related death worldwide. Genomic tests assess disease aggressiveness and guide treatment, particularly in low- and intermediate-risk PCa. We reviewed the literature on the use of four genomic tests (Prolaris, Promark, Oncotype DX, and Decipher) in assessing the prognosis of PCa and their use in treatment decision-making.

"Chasing Rainbows" Beyond Kaposi Sarcoma's Dermoscopy: A Mini-Review.

The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavelengths occurs according to the physics principles of scattering, absorption, and interference of light, creating the optical effect of RP. Even though the RP is regarded as a highly specific dermoscopic indicator of Kaposi's sarcoma, in the medical literature, it has also been documented as an atypical dermoscopic finding of other non-Kaposi skin entities.