Seaweed Extract Protected Human Mesenchymal Stem Cells From Oxidative Stress Through NRF2 Activation.

Previous studies have shown that seaweed extracts (HMEs) possess antioxidant properties, but the molecular mechanisms accounting for this activity are not known. Thus, the present study investigated the molecular mechanisms through which HME exerted its antioxidant activity in human mesenchymal stem cells (WJ-MSCs). After the isolation of HME, its chemical composition was analyzed with gas chromatography mass spectrometry, indicating that it contained amino acids, organic acids, organic amides, sugar alcohols, saturated fatty acids, hydrogenated diterpene alcohols, and other organic compounds.

Combined stochastic modelling of pathogenic and spoilage microorganisms.

Quantitative microbiological risk assessment (QMRA) of pathogens in food safety is well established, but steps are being taken to expand this methodology to food spoilage. Parallels can be drawn between the steps involved in a QMRA for pathogens and its application to specific spoilage organisms (SSO). During hazard characterisation for pathogens, the appropriate dose-response model is used to link the hazard level to the health outcome by estimating the probability of illness, resulting from the ingestion of a certain dose of the hazard.

Risk assessment of oligomers and potentially harmful chemical compounds from food packaging simulated using an in vitro digestion model.

The objective of this study, PLASTOGEST, was to evaluate the risk associated with oligomers and other potentially harmful chemical compounds when consumed by humans through food. This research systematically reviewed existing literature and applies untargeted analysis to assess the fate of non-intentionally added substances (NIAS) and intentionally added substances (IAS) during in vitro digestion. Polyethylene terephthalate and polybutylene terephthalate oligomers and simulation of real food conditions were used to evaluate migration and how these oligomers behave during in vitro digestion.

Short Root Anomaly and Transverse Hemimelia: A Rare Case Presentation.

A case of Short Root Anomaly (SRA), hypodontia and taurodontism with the associated finding of transverse hemimelia, is presented. Although there is no documented evidence of a link between SRA and hemimelia, the shared genetic, environmental and metabolic factors suggest the possibility of a common underlying mechanism.

A retrospective study of the aetiology of increased mean platelet volume in dogs presented to a small animal teaching hospital in Greece.

Background: The aetiology of increased mean platelet volume in dogs is currently uncertain. Our aim was to investigate the aetiology of increased mean platelet volume in dogs with and without thrombocytopenia.

Methods: The database of a teaching hospital was retrospectively searched for dogs with increased mean platelet volume (>14.

Salvage endoscopic nasopharyngectomy in locally recurrent carcinoma adjacent to the internal carotid artery-A case report.

Key Clinical Message: In cases adjacent to critical structures, such as the internal carotid artery, surgeons should meticulously explore the feasibility of surgery before declaring the neoplasm unresectable.

Abstract: Salvage treatment for locally recurrent carcinoma of the nasopharynx constitutes a unique challenge. Surgery remains the gold standard treatment modality.

Repair of chronic and large rotator cuff tears using extra-synovial autografts: An experimental study in rabbits.

Purpose: To investigate whether and how extra-synovial autografts can enhance the reconstruction of chronic and large rotator cuff tears in a rabbit subscapularis model.

Methods: Twenty rabbits were used to create a large subscapularis tear bilaterally. Six weeks later, the right shoulder of each rabbit was operated to repair the tear with an extra-synovial autograft, whereas the left shoulder did not undergo any surgery.

Fusion of a maxillary third molar with a supernumerary fourth molar: A case report.

Key Clinical Message: Dental fusion should be included in differential diagnosis when panoramic radiograph reveals changes in tooth shape or size. The use of specialized dental photographic techniques can augment the dentists' knowledge and awareness of such conditions.

Abstract: Dental fusion of impacted teeth may show up as a change in tooth shape and size on the first radiographic examination.

Atrial Fibrillation Ablation in Congenital Heart Disease: Therapeutic Challenges and Future Perspectives.

The increasing prevalence of atrial fibrillation (AF) in adults with congenital heart disease raises significant questions regarding its management. The unique underlying anatomic and physiological background further adds to the difficulty in eliminating the AF burden in these patients. Herein, we provide an overview of the current knowledge on the pathophysiology and risk factors for AF in adult congenital heart disease, with a special focus on the existing challenges in AF ablation.

Adverse events related to accessory devices used during ureteroscopy: Findings from a 10-year analysis of the Manufacturer and User Facility Device Experience (MAUDE) database.

Objectives: The objective of this study was to evaluate adverse events and device events related to accessories used during ureteroscopy (URS).

Materials And Methods: Analysis was performed of the records available in the Manufacturer and User Facility Device Experience database in the United States. Information was collected on characteristics of problem, timing, manufacturer verdict, successful completion of planned surgery, prolonged anaesthesia and injury to patient or staff.

Preperitoneal vas deferens infiltration in high-risk prostate cancer.

Objectives: The objective of this study is to evaluate the prevalence and the importance of preperitoneal vas deferens (VD) infiltration in high-risk prostate cancer (PCa).

Patients And Methods: In this prospectively designed study, we included 332 high-risk PCa patients with a Briganti score >5%, who were treated by robot-assisted radical prostatectomy between July 2017 and February 2022 at the Urology Department, SLK Kliniken Heilbronn. In addition to the standard histological analysis of the distal VD, which was attached to the prostate specimen, we analysed the infiltration status of preperitoneal VD in this cohort.

Dominant gingers - Discovery and inheritance of a new shell polymorphism in the great pond snail .

Color polymorphism is a classic study system for evolutionary genetics. One of the most color-polymorphic animal taxa is mollusks, but the investigation of the genetic basis of color determination is often hindered by their life history and the limited availability of genetic resources. Here, we report on the discovery of shell color polymorphism in a much-used model species, the great pond snail .

Determination of plastic polyester oligomers in real samples and their bioeffects.

Plastics are ubiquitously, becoming part of our everyday life. Recently, the issue of human exposure to micro- and nanoplastic particles and potentially resulting toxicological consequences has been broached, triggered by the discovery of microplastics in foodstuff and dietary exposure via contaminated food and beverages. Within this EU-FORA fellowship project, a determination and quantification of plastic polyester plastics oligomers in food samples was performed to assess exposure at these categories of 'nanoplastics', evaluating them as potential contaminants or as indicators and marker compounds of the exposure to specific nanoplastics/microplastics from polyesters, such as polyethylene terephthalate (PET) and polybutylene terephthalate (PBT).

Investigating the role of genetic variation in and in the domestication of gilthead seabream ( Linnaeus) and European seabass ( Linnaeus).

Gene function conservation is crucial in molecular ecology, especially for key traits like growth and maturation in teleost fish. The and genes are known to influence age-at-maturity in Atlantic salmon, but their impact on other fish species is poorly understood. Here, we investigated the association of and in the domestication of gilthead seabream and European seabass, both undergoing selective breeding for growth-related traits in the Mediterranean.

Hysteroscopic resection as a safe minimally invasive technique for the management of cornual pregnancy: A case report and literature review.

Hysteroscopic resection of ectopic cornual pregnancy following MRI imaging is a safe and effective treatment option without significantly impacting fertility potential or increasing the risk of future obstetrical complications.

Host-associated genetic differentiation and origin of a recent host shift in the generalist parasitic weed .

Branched broomrape, (L.) Pomel, is a globally distributed parasitic weed of economic importance. In Europe, where it is native, it can infest several crops, notably tomato, tobacco, and hemp.

Fetal and neonatal alloimmune thrombocytopenia: A rare case report of prenatal treatment.

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare but serious condition. The first-line antenatal management of FNAIT consists of weekly IVIG with or without corticosteroids, ideally starting before 16 weeks of gestation.

Is the course of the cervicofacial division of the facial nerve consistent with the adjacent vessels?

Individual facial nerve branching patterns can be difficult to predict. The superficial course of its terminal branches poses them at risk of injury during head and neck surgeries. We report the rare course of a branch of the facial nerve deep into the posterior facial vein.

Rise and fall: Results of a multidisciplinary study and 5-year long monitoring of conservation translocation of the European ground squirrel.

The current publication gives a detailed assessment of the results from a population reinforcement of a European ground squirrel's () colony in south-eastern Bulgaria. The reinforcement was planned and implemented along with multidisciplinary research of the adaptation process (including radiotelemetry, parasitological study and assessment of the stress in the animals) and regular monitoring (yearly burrow counting). Although the donor and recipient populations were genetically similar, morphometrical data indicated variations in the body size probably due to the difference in population densities in the two sites.