Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients.

FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breast cancer remain elusive.

Fungal Disease Response Centre: Pioneering Diagnostic Approach for Regions With Dispersed Hospital Centres.

Background: Access to fungal disease diagnosis is crucial for reducing mortality, yet it varies widely across Argentina, especially outside Buenos Aires. In regions like Santa Fe and Paraná, where most healthcare facilities are under 150 beds, maintaining specialised mycology labs is challenging.

Objectives: This work describes the establishment and first-year results of a centralised Fungal Disease Response Centre (FDRC) and referral network serving this region, covering approximately 1 million inhabitants.

Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina.

Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low).

Interactive and unimodal relationships between plant biomass, abiotic factors, and plant diversity in global grasslands.

Grasslands cover approximately a third of the Earth's land surface and account for about a third of terrestrial carbon storage. Yet, we lack strong predictive models of grassland plant biomass, the primary source of carbon in grasslands. This lack of predictive ability may arise from the assumption of linear relationships between plant biomass and the environment and an underestimation of interactions of environmental variables.

Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial.

Patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) primary breast cancer (BC) have low pathological complete response (pCR) rates with neoadjuvant chemotherapy. A subset of ER+/HER2- BC contains dense lymphocytic infiltration. We hypothesized that addition of an anti-programmed death 1 agent may increase pCR rates in this BC subtype.

Insights from a century of data reveal global trends in ex situ living plant collections.

Ex situ living plant collections play a crucial role in providing nature-based solutions to twenty-first century global challenges. However, the complex dynamics of these artificial ecosystems are poorly quantified and understood, affecting biodiversity storage, conservation and utilization. To evaluate the management of ex situ plant diversity, we analysed a century of data comprising 2.

Pleistocene Refugia Inferred from Molecular Evidence in a Forest-Dwelling Harvestman (Arachnida, Opiliones, Gonyleptidae) Support a Biogeographic Split in Subtropical Argentina.

This paper addresses the population genetic structure of the forest-dwelling gonyleptid Geraeocormobius sylvarum (Arachnida, Opiliones). Phylogeographic analyses using cytochrome oxidase subunit I (COI) were conducted on 186 individuals from 43 localities in Argentina and Paraguay, arranged into nine operational sectors and defined upon geographic and vegetation features. Given the current environmental uniformity, it was aimed to assess whether molecular fingerprints of G.

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Introducción: La Terapia de Estimulación Cognitiva (TEC) se originó en el Reino Unido. Se trata de un programa de estimulación que ha demostrado en un estudio multicéntrico, leatorizado y de diseño controlado beneficios en la cognición y la calidad de vida de los pacientes con demencia. La TEC fue adaptada e implementada en más de 30 países.

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Introducción: El accidente cerebrovascular es un factor de riesgo para el trastorno neurocognitivo. Se ha reportado la presencia de trastorno neurocognitivo post accidente cerebrovascular en el 20 al 80 % de los casos, según diferentes series. Asimismo, se reportan síntomas neuropsiquiátricos luego de ese evento, siendo lo más frecuente la depresión.

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Objetivo: evaluar la calidad, hábitos y algunos trastornos del sueño días previos a la declaración del fin de la pandemia por COVID-19. Método: estudio observacional de corte transversal. Encuesta en línea distribuida a través de una plataforma web desde el 1 de marzo al 15 de abril 2023.

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Introducción y objetivo: La Frontal Systems Behavior Scale (FrSBe) es una escala autoadministrable que evalúa cambios comportamentales (apatía, desinhibición y disfunción ejecutiva) luego de una lesión cerebral. El objetivo del trabajo fue obtener indicadores de rendimiento del puntaje total y las sub-escalas de la FrSBe para adultos de habla hispana de la Provincia de Buenos Aires, Argentina, analizar el efecto de variables demográficas y obtener datos normativos del instrumento. Materiales y métodos: se incluyeron 169 participantes y 83 familiares de esos participantes de Buenos Aires que completaron una encuesta para datos demográficos y la versión en español de la FrSBe.

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Objetivo: El acceso efectivo a servicios esenciales es crucial para algunas personas con autismo. En Argentina, el certificado único de discapacidad (CUD) asegura derechos y beneficios esenciales para las personas con autismo. Analizar la demanda de CUD relacionadas con el autismo puede ofrecer valiosos conocimientos sobre las necesidades de esta población.

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El trastorno por déficit de atención e hiperactividad (TDAH) ha sido tradicionalmente concebido como una condición privativa de la infancia. Sin embargo, una creciente evidencia sugiere que el TDAH persiste en la vida adulta, manifestándose de diversas maneras. A pesar de su prevalencia y de las significativas consecuencias en la vida cotidiana, el TDAH en adultos ha sido considerablemente subestimado y subdiagnosticado, lo que resulta en una carga sustancial tanto para los individuos afectados como para su entorno familiar y social.

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El suicidio representa un desafío crítico de salud pública. La presente revisión narrativa se propuso actualizar la evidencia disponible sobre detección y prevención del riesgo, con la finalidad de promover líneas de acción para el abordaje temprano e integral de este complejo y multicausal problema; evaluar la posibilidad de fortalecer políticas, programas y acciones para potenciar los recursos existentes y/o promover la creación de otros nuevos. La prevención destaca la necesidad de estrategias personalizadas y colaboración interdisciplinaria.

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Reseña de la obra: Salud Mental y Psiquiatría en la práctica de Atención Primaria de la Salud, editada por Juan Pablo Giménez y Julia Acuña y Albert Botto. Instituto Milenio para la Investigación en Depresión y Personalidad, MIDAP, Santiago de Chile, 2024.

Extracting the fingerprints of sequences of random rhythmic auditory stimuli from electrophysiological data.

It has been classically conjectured that the brain assigns probabilistic models to sequences of stimuli. An important issue associated with this conjecture is the identification of the classes of models used by the brain to perform this task. We address this issue by using a new clustering procedure for sets of electroencephalographic (EEG) data recorded from participants exposed to a sequence of auditory stimuli generated by a stochastic chain.

FhaA plays a key role in mycobacterial polar elongation and asymmetric growth.

Unlabelled: Mycobacteria, including pathogens like , exhibit unique growth patterns and cell envelope structures that challenge our understanding of bacterial physiology. This study sheds light on FhaA, a conserved protein in , revealing its pivotal role in coordinating cell envelope biogenesis and asymmetric growth. The elucidation of the FhaA interactome in living mycobacterial cells reveals its participation in the protein network orchestrating cell envelope biogenesis and cell elongation/division.

Comparison of clinical artificial oocyte activation protocols on mouse egg activation and embryo development.

Artificial oocyte activation (AOA) with Ca2+ ionophores is an experimental procedure that benefits patients who fail to obtain fertilized eggs. However, the impact of non-physiological Ca2+ increases on cellular events involved in egg-embryo transition and early development remains poorly understood. Using the mouse model, this study compares common Ca2+ ionophore protocols applied in clinical practice - one or two exposures to A23187 or a single exposure to ionomycin - focusing on embryonic development and cellular events associated with egg activation.

Muscular anatomy of the forelimb of Leopardus geoffroyi: Functional and phylogenetic aspects in Feliformia, part I. Proximal forelimb.

Anatomical knowledge is fundamental for all species. In particular, myology allows a deeper understanding of ecomorphology-especially for those species hard to observe in the wild-and may be an important source for phylogenetic information. In this study, we analyzed the myological variation of the musculature of the shoulder and arm of the forelimb in species of the suborder Feliformia and its relationship with the phylogenetic history and the locomotor behavior, habitat, and predatory habits of the species within this group, using Leopardus geoffroyi as a case study.

Point prevalence survey of antibiotics in a pediatric tertiary hospital in the Republic of Panama.

Objective: To conduct a point prevalence survey (PPS) of antibiotic use in the main pediatric tertiary-level hospital in Panama City to establish antibiotic prevalence and identify key areas for addressing antimicrobial resistance.

Methods: This point prevalence survey (PPS) conducted in a tertiary-level hospital in Panama followed the Pan American Health Organization's adaptation of the methodology proposed by the World Health Organization for PPSs on antibiotic use. Information obtained included patients' demographic characteristics, antimicrobial prescriptions, indication for antimicrobial use, and prescription's adherence to guidelines.

Pectin obtention from agroindustrial wastes of using green solvents (citric acid and natural deep eutectic solvents). Chemical, thermal, and rheological characterization.

The use of green solvents, citric acid (CA), and natural deep eutectic solvents (NADES) for the obtention of pectin from wastes (pulp and peel) of was studied. The NADES used comprised citric acid-glucose-water (N1) or lactic acid-glucose-water (N2). The fractions rich in pectin obtained after exposure to NADES showed lower yield (≈4 g/100 g CA vs.

Biological activities of lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites.

This research was designed to investigate the metabolite profiling, phenolics content, and the trypanocidal, nematicidal, antibacterial, antifungal, and free radical scavenging properties of Motyka. The air-dried material was extracted successively with dichloromethane and methanol (UlMeOH). Two phases were obtained from the extract with dichloromethane, one soluble in methanol (UlDCM-s) and the other insoluble (UlDCM-i).

Palovarotene in fibrodysplasia ossificans progressiva: review and perspective.

Introduction: Palovarotene is a retinoic acid receptor gamma agonist that was studied in phase-2 and phase-3 clinical trials for the inhibition of new heterotopic ossification (HO) in fibrodysplasia ossificans progressiva (FOP). Despite numerous setbacks and regulatory delays, palovarotene is now the first approved FOP treatment in the U.S.