Prevalence and mortality associated with multidrug-resistant infections in adult intensive care units in Argentina (PREV-AR).

Unlabelled: Data from low and middle-income countries (LMICs) on multidrug-resistant microorganisms (MDROs) in intensive care units (ICUs) are scarce. Working in several ICUs in Argentina, we sought to estimate the prevalence and characteristics of MDRO infections and carbapenemase-producing Enterobacterales (CPE) colonization. Mortality associated with MDRO infection was also evaluated.

Alternative Magnification Devices for Microsurgical Training: Comparative Analysis.

Aim: To determine if low-cost magnification devices (USB computer microscope, smartphone) enable the acquisition and maintenance of basic microsurgical skills by comparing skills learned using these devices against those learned using a surgical microscope. Determining whether skills acquired using these devices can be transferred to the surgical microscope.

Material And Methods: Twelve neurosurgical participants, ranging from faculty to postgraduate year-1 trainees, were randomly divided into three groups for training using a surgical microscope, smartphone, or USB microscope.

Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer.

In triple-negative breast cancer (TNBC), pro-tumoral macrophages promote metastasis and suppress the immune response. To target these cells, a previously identified CD206 (mannose receptor)-binding peptide, mUNO was engineered to enhance its affinity and proteolytic stability. The new rationally designed peptide, MACTIDE, includes a trypsin inhibitor loop, from the Sunflower Trypsin Inhibitor-I.

VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens.

VACCIMEL is a therapeutic cancer vaccine composed of four irradiated allogeneic human melanoma cell lines rationally selected to cover a wide range of melanoma tumor-associated antigens (TAA). We previously demonstrated that vaccination in the adjuvant setting prolonged the distant-metastasis-free survival of cutaneous melanoma patients and that T cells reactive to TAA and the patient's private neoantigens increased during treatment. However, immune responses directed to vaccine antigens that may arise from VACCIMEL's somatic mutations and human polymorphisms remain unexplored.

Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection.

Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin.

Hematological parameters of the European hake () in Toroneos Gulf, northern Greece: A case study.

Background: The European hake () is a commercially valuable demersal species widely distributed in the Mediterranean Sea. Assessing the condition of fish populations in their natural habitats is challenging due to the lack of reliable reference points.

Objective: This study aimed to utilize hematological analysis as an economical method to evaluate the physiological and health status of European hake, addressing the gap in hematological data for this species.

Confinement Induces Morphological and Topological Transitions in Multivesicles.

The study of self-assembly in confined spaces has gained significant attention among amphiphilic superstructures and colloidal design. The additional complexity introduced by interactions between contents and their containers, along with the effects of shape and lipid mixing, makes multivesicular bodies an interesting subject of study. Despite its promising applications in biomedicine, such as drug delivery and biomimetic materials, much remains unexplored.

Results of the Latin American Pediatric Oncology Group (GALOP-2011) Trial for Patients With Localized Ewing Sarcoma: A Multicentric Study of Interval-Compressed Multiagent Chemotherapy.

Background: GALOP investigators developed a prospective cooperative protocol for localized Ewing sarcoma (ES) incorporating interval-compressed chemotherapy (VDC/IE, vincristine, doxorubicin, cyclophosphamide/ifosfamide and etoposide). After completing conventional treatment, patients were randomized to 1 year of metronomic chemotherapy (vinblastine and cyclophosphamide).

Methods: Phase III randomized prospective trial.

Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients.

FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breast cancer remain elusive.

Fungal Disease Response Centre: Pioneering Diagnostic Approach for Regions With Dispersed Hospital Centres.

Background: Access to fungal disease diagnosis is crucial for reducing mortality, yet it varies widely across Argentina, especially outside Buenos Aires. In regions like Santa Fe and Paraná, where most healthcare facilities are under 150 beds, maintaining specialised mycology labs is challenging.

Objectives: This work describes the establishment and first-year results of a centralised Fungal Disease Response Centre (FDRC) and referral network serving this region, covering approximately 1 million inhabitants.

Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina.

Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low).

Interactive and unimodal relationships between plant biomass, abiotic factors, and plant diversity in global grasslands.

Grasslands cover approximately a third of the Earth's land surface and account for about a third of terrestrial carbon storage. Yet, we lack strong predictive models of grassland plant biomass, the primary source of carbon in grasslands. This lack of predictive ability may arise from the assumption of linear relationships between plant biomass and the environment and an underestimation of interactions of environmental variables.

Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial.

Patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) primary breast cancer (BC) have low pathological complete response (pCR) rates with neoadjuvant chemotherapy. A subset of ER+/HER2- BC contains dense lymphocytic infiltration. We hypothesized that addition of an anti-programmed death 1 agent may increase pCR rates in this BC subtype.

Insights from a century of data reveal global trends in ex situ living plant collections.

Ex situ living plant collections play a crucial role in providing nature-based solutions to twenty-first century global challenges. However, the complex dynamics of these artificial ecosystems are poorly quantified and understood, affecting biodiversity storage, conservation and utilization. To evaluate the management of ex situ plant diversity, we analysed a century of data comprising 2.

Pleistocene Refugia Inferred from Molecular Evidence in a Forest-Dwelling Harvestman (Arachnida, Opiliones, Gonyleptidae) Support a Biogeographic Split in Subtropical Argentina.

This paper addresses the population genetic structure of the forest-dwelling gonyleptid Geraeocormobius sylvarum (Arachnida, Opiliones). Phylogeographic analyses using cytochrome oxidase subunit I (COI) were conducted on 186 individuals from 43 localities in Argentina and Paraguay, arranged into nine operational sectors and defined upon geographic and vegetation features. Given the current environmental uniformity, it was aimed to assess whether molecular fingerprints of G.

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Introducción: La Terapia de Estimulación Cognitiva (TEC) se originó en el Reino Unido. Se trata de un programa de estimulación que ha demostrado en un estudio multicéntrico, leatorizado y de diseño controlado beneficios en la cognición y la calidad de vida de los pacientes con demencia. La TEC fue adaptada e implementada en más de 30 países.

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Introducción: El accidente cerebrovascular es un factor de riesgo para el trastorno neurocognitivo. Se ha reportado la presencia de trastorno neurocognitivo post accidente cerebrovascular en el 20 al 80 % de los casos, según diferentes series. Asimismo, se reportan síntomas neuropsiquiátricos luego de ese evento, siendo lo más frecuente la depresión.

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Objetivo: evaluar la calidad, hábitos y algunos trastornos del sueño días previos a la declaración del fin de la pandemia por COVID-19. Método: estudio observacional de corte transversal. Encuesta en línea distribuida a través de una plataforma web desde el 1 de marzo al 15 de abril 2023.

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Introducción y objetivo: La Frontal Systems Behavior Scale (FrSBe) es una escala autoadministrable que evalúa cambios comportamentales (apatía, desinhibición y disfunción ejecutiva) luego de una lesión cerebral. El objetivo del trabajo fue obtener indicadores de rendimiento del puntaje total y las sub-escalas de la FrSBe para adultos de habla hispana de la Provincia de Buenos Aires, Argentina, analizar el efecto de variables demográficas y obtener datos normativos del instrumento. Materiales y métodos: se incluyeron 169 participantes y 83 familiares de esos participantes de Buenos Aires que completaron una encuesta para datos demográficos y la versión en español de la FrSBe.

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Objetivo: El acceso efectivo a servicios esenciales es crucial para algunas personas con autismo. En Argentina, el certificado único de discapacidad (CUD) asegura derechos y beneficios esenciales para las personas con autismo. Analizar la demanda de CUD relacionadas con el autismo puede ofrecer valiosos conocimientos sobre las necesidades de esta población.

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El trastorno por déficit de atención e hiperactividad (TDAH) ha sido tradicionalmente concebido como una condición privativa de la infancia. Sin embargo, una creciente evidencia sugiere que el TDAH persiste en la vida adulta, manifestándose de diversas maneras. A pesar de su prevalencia y de las significativas consecuencias en la vida cotidiana, el TDAH en adultos ha sido considerablemente subestimado y subdiagnosticado, lo que resulta en una carga sustancial tanto para los individuos afectados como para su entorno familiar y social.

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El suicidio representa un desafío crítico de salud pública. La presente revisión narrativa se propuso actualizar la evidencia disponible sobre detección y prevención del riesgo, con la finalidad de promover líneas de acción para el abordaje temprano e integral de este complejo y multicausal problema; evaluar la posibilidad de fortalecer políticas, programas y acciones para potenciar los recursos existentes y/o promover la creación de otros nuevos. La prevención destaca la necesidad de estrategias personalizadas y colaboración interdisciplinaria.