119,281 results match your criteria: "Argentina; Institute of Experimental Medicine[Affiliation]"
Cardiovasc Diabetol
January 2025
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of cardiometabolic diseases, extending their therapeutic applications far beyond glycemic control in type 2 diabetes (T2D) and obesity. This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential.
View Article and Find Full Text PDFClin Breast Cancer
January 2025
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA; Harvard Medical School, Boston, MA.
Background: We sought to evaluate prognostic factors in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) and their relationship with short- and long-term overall survival (OS).
Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we evaluated patients with de novo HER2-positive MBC diagnosed from 2010 to 2018. Univariate analyses were performed to determine effect of each variable on OS.
Br J Anaesth
February 2025
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Intensive Care Unit, Hospital Universitario La Princesa, Madrid, Spain.
Despite the maturity and sophistication of anaesthesia workstations, improvements in our understanding of intraoperative mechanical ventilation, and use of less invasive surgical techniques, postoperative pulmonary complications (PPCs) are still a common problem in surgical patients of all ages. PPCs are associated with a higher incidence of perioperative morbidity and mortality, longer hospital stays, and higher healthcare costs. PPCs are strongly associated with anaesthesia-induced atelectasis, which predisposes to lung damage when partially collapsed lungs are subjected to mechanical ventilation.
View Article and Find Full Text PDFBMJ Glob Health
January 2025
School of Public Health, Imperial College London, London, UK.
Introduction: Faced with a backdrop of an increasing chronic disease burden from an ageing global population compounded with rising healthcare costs, health systems are required to implement cost-effective, safe and equitable care through efficient service delivery models. One approach to achieving this is through Starfield's 4Cs of primary healthcare (PHC), which delineates the key attributes of a high-performing PHC system that upholds the pillars of care coordination, first contact of care, continuity of care and comprehensive care. Therefore, this study aims to explore and elucidate the key themes and subthemes related to and extending beyond Starfield's 4Cs of PHC by integrating findings from a comprehensive literature review and a qualitative study.
View Article and Find Full Text PDFJ Allergy Clin Immunol
January 2025
Division of Allergy & Immunology, Icahn School of Medicine at Mount Sinai; New York, NY, USA.
Background: The 2006 National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network (NIAID/FAAN) anaphylaxis criteria are widely used in clinical care and research. In 2020, the World Allergy Organization (WAO) published modified criteria that have not been uniformly adopted. Different criteria contribute to inconsistent care and research outcomes.
View Article and Find Full Text PDFIntroduction: Iatrogenic injury to the ilioinguinal nerve and its branches during anterior inguinal hernia repair is a cause of chronic inguinal pain in up to 12 % of patients undergoing this operation. The risk of nerve injury is high, given the nerves' relatively small caliber and strictly-confined space through which they pass. In the current report, we describe using a novel fluorescence imaging system developed to detect nerve autofluorescence in a 66-year-old man who presented with a left-sided Type II inguinal hernia and underwent inguinal hernioplasty.
View Article and Find Full Text PDFRev Esp Patol
January 2025
Breast Surgery, Breast Unit, Hospital Universitario Austral, Buenos Aires, Argentina.
Malignant adenomyoepithelioma of the breast is a rare and challenging tumor in terms of diagnosis and treatment. It is exceptional to find this condition in a patient who has had breast cancer treated with breast-conserving surgery and radiotherapy. We present the case of a 46-year-old female patient with a history of invasive lobular carcinoma of the breast, who presented one year later with a malignant adenomyoepithelioma in the same breast, which recurred three times, despite undergoing various surgical treatments and even adjuvant chemotherapy regimen.
View Article and Find Full Text PDFClin Infect Dis
January 2025
GSK, Wavre, Belgium.
Background: In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine (RSVPreF3-Mat), a higher rate of preterm birth was observed in the vaccine (6.8%) versus the placebo group (4.9%).
View Article and Find Full Text PDFPhys Rev Lett
December 2024
CERN, Geneva, Switzerland.
Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.
View Article and Find Full Text PDFVet Res Commun
January 2025
Faculdade de Ciências Agrárias, Universidade Federal da Grande Dourados, Rodovia Dourados - Itahum, km 12, Cidade Universitária, Dourados, MS, Brasil.
Aflatoxin is a mycotoxin produced by fungi of the genus Aspergillus that is present in various foods. Probiotics are well-established products in aquaculture, and due to their effective contribution to the intestine, they can be used as an aflatoxin adsorbent. This study evaluated the effects of aflatoxin B1 (AFB1) on enzymatic activity and intestinal function in Piaractus mesopotamicus (pacu) fingerlings fed diets containing a probiotic-based adsorbent (PBA).
View Article and Find Full Text PDFEvolution
January 2025
Centro de Investigaciones en Ciencias de la Tierra (CICTERRA), Universidad Nacional de Córdoba, Córdoba, Argentina.
The role of phenotypic modularity in the evolution of skull morphology in birds has been a subject of debate in recent years. Furnariids (ovenbirds and woodcreepers), a spectacular avian adaptive radiation, are distinguished in their cranial morphology as the only passerines with two types of cranial kinesis, constituting a great model to test whether the evolution of novelties linked to kinesis was associated with shifts in patterns of evolutionary modularity and allometry in the avian skull. Our analyses by means of geometric morphometric tools and phylogenetic comparative methods show that the beak and neurocranium of furnariids evolved in a modular fashion and shaped by the cranial kinesis evolution.
View Article and Find Full Text PDFCrit Care Med
January 2025
Department of Surgery, Neurology and Neurosurgery Unit, Federal University of Góias, Góias, Brazil.
Objectives: Balancing oxygen requirements, neurologic outcomes, and systemic complications from transfusions in traumatic brain injury (TBI) patients is challenging. This review compares liberal and restrictive transfusion strategies in TBI patients.
Data Sources: Electronic databases were searched from inception to October 2024.
Photochem Photobiol
January 2025
Departamento de Química, Universidad Nacional de Rio Cuarto, Río Cuarto, Argentina.
In 1963, Eduardo Lissi and Juan Grotewold started a chemical kinetics and photochemistry group at the School of Sciences at the University of Buenos Aires (Facultad de Ciencias Exactas y Naturales, FCEN, UBA). Political circumstances in Argentina and in Chile were a great determinant of the evolution, dispersion, and re-encounters of the group members. The initial graduate students in the group developed their own research groups working in various Countries and on a variety of projects.
View Article and Find Full Text PDFArch Argent Pediatr
January 2025
Hospital Italiano de Buenos Aires, City of Buenos Aires, Argentina.
Hyperparathyroidism is a rare entity in pediatrics. It is defined as the increased production of parathyroid hormone. It may be due to a primary defect of the parathyroid glands (primary hyperparathyroidism) or to a compensatory parathyroid hormone production to correct hypocalcemia states of various origins (secondary hyperparathyroidism).
View Article and Find Full Text PDFAm J Gastroenterol
January 2025
Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Background And Aims: The comparative efficacy of advanced therapies to improve health-related quality of life (HR-QoL) in Crohn's disease (CD) is unknown. We aimed to compare the impact of approved advanced therapies for moderate-to-severe CD on HR-QoL.
Methods: We searched MEDLINE, Embase, and Cochrane CENTRAL from inception to December 2023.
Arch Argent Pediatr
January 2025
National Committee of Internal Medicine, Sociedad Argentina de Pediatría.
Arch Argent Pediatr
January 2025
Infectious Diseases Service, Hospital de Niños Sor María Ludovica, La Plata, Argentina.
Mucormycosis is an opportunistic fungal infection with high mortality, especially in immunocompromised patients. This article emphasizes the importance of early diagnosis and aggressive treatment. We describe the case of a child with leukemia treated with corticosteroids, vincristine, and daunorubicin, who developed rhino-orbital mucormycosis.
View Article and Find Full Text PDFArch Argent Pediatr
January 2025
Pediatric Nephrology and Renal Transplant Service, Hospital Italiano de Buenos Aires, City of Buenos Aires, Argentina.
Arch Argent Pediatr
January 2025
Fundación Centro de Salud e Investigaciones Médicas (CESIM), Santa Rosa, Argentina.
Introduction. Sleep-disordered breathing (RBD), from habitual snoring to obstructive sleep apnea syndrome (OSAS), can influence brain functioning by affecting executive functions such as attention and inhibitory control. Objective.
View Article and Find Full Text PDFKnee
December 2024
Stockholm Sports Trauma Research Center, FIFA Medical Centre of Excellence, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Background: Some patients submitted to isolated ACL reconstruction may have symptomatic postoperative rotational instability. The objective of this study was to evaluate a population with mild rotatory instability after ACL reconstruction, which was submitted to an isolated extra-articular procedure.
Methods: Patients submitted to an isolated extra-articular procedure after ACL reconstruction were retrospectively evaluated.
In Vitro Model
February 2024
IFIBYNE-UBA-CONICET, Buenos Aires, Argentina.
In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlighting key findings from our recent investigations. Simple cell lines, including HEK, PC12, SHSY5Y, and N2a cells, provide valuable insights into critical signaling pathways and hidden facets of the neuroinflammatory landscape. Focusing on specific outcomes, including the impact of interleukin-6 (IL-6) and acid-sensing ion channels (ASIC1a), the study sheds light on neuroinflammatory processes.
View Article and Find Full Text PDFFront Plant Sci
January 2025
Departamento de Producción Agrícola, Universidad de Chile, Santiago, Chile.
IJID Reg
March 2025
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Objectives: Advanced HIV disease (AHD) at HIV care enrollment is common in Latin America and may bias cross-sectional care continuum estimates. We therefore explored the impact of AHD on HIV care continuum outcomes using a longitudinal approach.
Methods: We analyzed trajectories of 26,174 adult people with HIV enrolled at Caribbean, Central and South America network for HIV epidemiology (CCASAnet) sites (2003-2019) using multi-state Cox regression across five stages: (i) enrolled without antiretroviral therapy (no-ART); (ii) on ART without viral suppression (viral load ≥200 copies/m; ART + non-VS); (iii) on ART with viral suppression (viral load <200 copies/ml; ART + VS); (iv) lost to follow-up; (v) death.
Indian J Occup Environ Med
December 2024
Department of Atomic Energy, Variable Energy Cyclotron Centre (VECC), Government of India, Kolkata, West Bengal, India.
Introduction: Fatal and non-fatal occupational injuries are one of the most important public health problems all over the world. Its number greatly varies from country to country over the years. Worldwide approximately 4% of global gross domestic product (GDP) is lost due to occupational injuries.
View Article and Find Full Text PDFBackground: Heart Failure (HF) quality of care (QoC) is associated with clinical outcomes. Therefore, we investigated differences in HF QoC across worldwide regions (with differing national income) and the association of quality indicators with outcomes.
Methods: We examined the quality of care (QoC) in acute heart failure (HF) patients across different regions using quality indicators (QIs) from the European Society of Cardiology (ESC) and the American Heart Association (AHA) to evaluate QoC.