970 results match your criteria: "Aragón Health Science Institute[Affiliation]"

Occurrence and cross contamination of Escherichia albertii in retail chicken outlets in Bangladesh.

Int J Food Microbiol

January 2025

Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, Japan; Asian Health Science Institute, Osaka Metropolitan University, Osaka, Japan; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan; School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan. Electronic address:

Escherichia albertii is an emerging zoonotic pathogen linked to human gastrointestinal illnesses, with poultry meats being considered as a key source of human infections. However, there is little information regarding the distribution and characteristics of this bacterium in Bangladesh. This study investigated the occurrence, antimicrobial resistance, and virulence of E.

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Developing a behaviour change intervention using information about greenhouse gas emissions to reduce liquid antibiotic prescribing.

Res Social Adm Pharm

January 2025

Newcastle University, Faculty of Medical Sciences, UK; Great North Children's Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK; Population Health Science Institute, Newcastle University, UK. Electronic address:

Introduction: The determinants of antimicrobial prescribing often involve social influence, which can be harnessed through behaviour change techniques (BCTs). While previous studies have used BCTs to address antimicrobial resistance, there is a lack of evidence regarding their application to address climate change-related issues in antibiotic prescribing. This study aimed to develop a behaviour change intervention (BCI) using information about greenhouse gas emissions to reduce liquid antibiotic prescribing.

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Aim: The study compares knowledge, skills, anxiety, satisfaction and self-confidence regarding suctioning between students trained using a partial task trainer with moulage and those using a low-fidelity simulator.

Background: Moulage application in simulation has been used in nursing skills training, such as intravenous therapy, pressure ulcer and burn care, but not for suctioning.

Design: A randomized controlled study with pre-test, post-test design.

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Background: Nonattendance at colonoscopy is associated with reduced colorectal cancer (CRC) survival.

Purpose: The aim of this research was to quantify barriers to colonoscopy and test the effectiveness of behavior change techniques (BCTs) to address them.

Methods: Two studies were conducted.

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Treatment effects in pharmacological clinical randomized controlled trials are mainly due to placebo.

J Clin Epidemiol

December 2024

Change Health Science Institute, Basel, Switzerland; Next Society Institute, Kazimieras Simonavicius University, Vilnius, Lithuania.

Objectives: The placebo response in clinical trials has four components: regression to the mean (RTM), measurement artifacts, natural tendency (NT) of the disease, and the genuine placebo effect. Our objective is to determine what contributes to the size of the placebo-effect in clinical trials by meta-regressions of randomized placebo-controlled clinical trials.

Study Design And Setting: We identified five diseases where data on the rates of NT were available to search for a sample of n = 150 (5x30) randomized controlled trials.

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Introduction: International guidelines make recommendations for the delivery of safe, high-quality primary care for people with dementia including prescribing, personalised care planning and regular holistic reviews. It is unclear how the quality and safety of this healthcare varies with socio-economic factors.

Objective: This scoping review aimed to understand the depth and breadth of existing evidence exploring socio-economic variation in the quality and safety of primary care for people with dementia.

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Nordic nutrition recommendations 2023 (NNR2023) advised for the first time certain amounts of foods from food-groups based on scientific data on healthy and environment-friendly diet. The food-based-dietary-guidelines are intended for adults and children above age two, but children's energy requirement and intake are lower than those of adults. In this review, reference amounts of food from different food-groups are calculated for children to align with the combination recommended for adults in NNR2023.

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Women football observers' experiences: a perspective from system justification and glass ceiling.

Front Psychol

November 2024

Department of Physical Education and Sports, Health Science Institute, Cukurova University, Adana, Türkiye.

Introduction: The legitimization theory of the system explains that despite people's inherent drive towards personal and group interests, they tend to support social systems. Understanding the sources of social pressure and the glass ceiling perceptions of female football observers is the main aim of this study in terms of examining attitudes within the legitimized system. To this end, the study sought to answer how female football observers are constructed in a marginalized position within the male-dominated football culture through sources of social pressure, and how they accommodate the acceptance of legitimizing the system despite encountering glass ceiling barriers in the context of Turkey.

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Background: The anatomy of the proximal tibia presents treatment challenges, and there is currently no widely accepted surgical fixation method for fractures in this region. The aim of this study is to evaluate the efficacy, benefits, and differences between intramedullary nailing (IMN) with a 4-hole Limited Contact Dynamic Compression Plate (LC-DCP) combination and IMN with an 8-hole LC-DCP combination in unstable fractures of the proximal metaphyseal region of the tibia.

Methods: An oblique fracture was created in the metaphyseal region, forming a 30-degree angle in the sagittal plane in three tibial models.

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Objectives: For healthcare professionals (HCPs) to provide optimal support for women experiencing domestic violence (DV), it is important to understand what type of support women expect from HCPs. The objective of this study was to explore what kind of support women who experienced DV in Sri Lanka expect from HCPs.

Design: A qualitative descriptive design was used.

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Inferring human phenotypes using ancient DNA: from molecules to populations.

Curr Opin Genet Dev

February 2025

Bakar Computational Health Science Institute, University of California San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA. Electronic address:

Article Synopsis
  • The study reviews how ancient DNA (aDNA) has improved our understanding of human migrations but has limitations in linking genetic information to observable traits (phenotypes).
  • It discusses recent advancements in predicting ancient phenotypes using machine learning techniques and emphasizes the challenges posed by the complex genetic traits found in various human populations.
  • The authors suggest a new method that combines predictions of molecular traits, which are more stable over time, with non-genetic factors to enhance the understanding of ancient individuals' characteristics.
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Construct validity of the Hand10 questionnaire in patients with hand osteoarthritis.

J Bodyw Mov Ther

October 2024

Department of Orthopedics and Traumatology, Etlik City Hospital, Ankara, Turkey.

Background: The Hand10 questionnaire is a short, easy-to-understand, visual questionnaire developed for the functional assessment of upper extremity disorders. It consists of visuals of each item as well as facial expressions that reflect the degree of difficulty during the function. It has been stated that the Hand10 questionnaire is suitable for application in the elderly population due to its stated features.

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Feline hemotropic mycoplasmosis is an emerging infectious disease in domestic cats caused by a group of hemotropic species, including three main species: (), Mycoplasma hemominutum (Mhm), and Mycoplasma turicensis (Mt). The primary objective of this investigation was to ascertain the molecular prevalence and characterization of hemotropic mycoplasmas in domestic cats from twenty-three districts of Konya province in Türkiye. For this purpose, 384 apparently healthy cats belonging to different breeds were enrolled in this study.

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Objectives: This study was conducted to determine the relationship between climate change concerns and mental well-being levels in adult individuals.

Design: A descriptive and correlational study.

Sample: The study was conducted with 513 adult individuals who applied to primary healthcare institutions between May and October 2022 in Türkiye.

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Postprandial hyperglycemia, typical manifestation of Type 2 Diabetes Mellitus (T2DM), is associated with notable global morbidity and mortality. Preventing the advancement of this condition by delaying the rate of glucose absorption through inhibition of α-amylase and α-glucosidase enzymatic activities is of utmost importance. Finding a safe antidiabetic drug is essential since those that are currently on the market have drawbacks like unpleasant side effects.

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The overall aim of this paper was to provide background knowledge to the Nordic Nutrition Recommendations 2023 Committee for integrating environmental sustainability in a framework for national Food-Based Dietary Guidelines (FBDG) within the Nordics and Baltics. Additionally, this paper aims to give an overview of recent Nordic scientific literature on environmental impact of foods and dietary patterns and of the FBDG of the Nordics. Finally, we suggest methods for developing national sustainable FBDG.

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Diabetes is a major global health issue and as current treatments fail, the search for new antidiabetic drugs is crucial. This investigation, focusing on identifying potential antidiabetic compounds from the endangered plant species Vepris glandulosa, led to the isolation of two known alkaloids, choisyine acetate (1) and choisyine (2). The study established the in vitro inhibitory activities and in silico molecular interaction of the two alkaloids with α-amylase based on IC values, Linewaever-Burk/Dixon plot kinetic analyses and Molecular docking, respectively.

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Research progress on pyroptosis and its effect on the central nervous system.

Neurobiol Dis

October 2023

Laboratory of Research in Parkinson's Disease and Related Disorders, Health Science Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

Pyroptosis is an inflammatory and lysis type of programmed cell death. In the canonical pyroptosis signaling pathway, the NLRP3 inflammasome activates inflammatory caspase-1, which then shears cut the executor protein GSDMD. The N domains of GSDMD move to heterogeneous membranes, form pores, and release inflammatory cytokines IL-1β and IL-18, causing cell membrane swelling and rupture.

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Diet-related behaviors affecting health and substance use among children and adolescents.

Clin Exp Pediatr

December 2024

Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Unhealthy diet-related behaviors and poor diet quality during childhood and adolescence are the main factors contributing to noncommunicable diseases such as obesity, dyslipidemia, diabetes, hypertension, and cardiometabolic syndrome. Unhealthy diet-related behaviors can become lifelong habits associated with mental health problems, including depression, anxiety, attention deficit hyperactivity disorder, and substance abuse issues such as smoking, drinking, and other chemical compounds. Children and adolescents are in the developmental stages of brain structure, function, and neurotransmission systems, which can make them more susceptible to substance abuse (tobacco, alcohol, and drugs).

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Article Synopsis
  • Aspergillus species are linked to various conditions in bronchiectasis, including ABPA, AS, and increased IgG levels indicating exposure or infection.
  • A study of nearly 10,000 bronchiectasis patients revealed 6.1% with ABPA, 5.7% with AS, and 8.1% with elevated Aspergillus-specific IgG levels, with these conditions associated with more severe lung issues and exacerbations.
  • Long-term follow-up showed that those with raised IgG levels faced more frequent and severe exacerbations, particularly affecting patients not on inhaled corticosteroids.
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IMPACT organizational survey highlighting provision of services for patients with locally advanced and recurrent colorectal cancer across Great Britain and Ireland.

Colorectal Dis

December 2024

Improving Outcomes for Advanced Colorectal Tumours, Association of Coloproctologists of Great Britain and Ireland, London, UK.

Article Synopsis
  • The study aims to understand how multidisciplinary teams (MDTs) in Great Britain and Ireland provide clinical services for patients with locally advanced and recurrent colorectal cancer, to support future service improvements.
  • A survey with 12 questions was distributed to all colorectal cancer MDTs in GB&I, with a high response rate of 93.5%, encompassing 175 participating teams.
  • Results showed significant variation in available services, including surgical options and specialized care, with only a minority of hospitals offering certain advanced surgical techniques and dedicated support for patients.
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Background: Novice nurses often find endotracheal suctioning signs unfamiliar. The Endotracheal Suction Assessment Tool© (ESAT©) aids pediatric nurses in suctioning but lacks an adult equivalent. A valid and reliable ESAT© for assessing intensive care unit patients' suction needs across different populations is necessary.

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In Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer's Disease Therapy.

Int J Mol Sci

September 2024

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Our study took an innovative approach by evaluating, in vivo, the efficacy of intranasal (IN) administration of liposomal formulations of donepezil, memantine, and beta-site amyloid precursor protein-cleaving enzyme (BACE-1) siRNA, and their combination as a "triple-drug therapy" in treating Alzheimer's disease (AD). Female APP/PS1 homozygous, transgenic mice were used as an AD model. The spatial short-term memory of the APP/PS1 mice was evaluated by a Y-maze behavioral test.

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Article Synopsis
  • Distal radioulnar joint (DRUJ) instability is a common issue after injuries, causing chronic pain and limited function, and current single suture button treatments are often inadequate.
  • This study tested whether a double suture button technique could offer better stability than single constructs for DRUJ instability using cadaver models.
  • Results showed the double suture button significantly reduced movement and restored stability across various positions, outperforming the single construct methods.*
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