Development and validation of Believers' Death Anxiety Scale: integrating religious dimensions into death anxiety assessment.

Background And Objectives: Death anxiety has traditionally been measured without considering religious beliefs related to death, such as afterlife, the grave, and punishment. The present study was aimed at developing and validating a new scale to address this limitation.

Methods: The study was carried out in four phases and recruited a total of 2250 conveniently selected participants aged 18-59.

Assessing the psychometric properties of the Biphasic Sleep Scale (BiSS): A novel 16-item self-report measure.

Biphasic sleep, characterized by nighttime sleep plus daytime napping, has demonstrated some cognitive, health and performance impacts when compared with consolidated monophasic sleep. This motivated the development and validation of the Biphasic Sleep Scale, reported in this paper. Scale development involved a literature review, expert input and individual interviews.

Patient-derived tumor organoids: A preclinical platform for personalized cancer therapy.

Patient-derived tumor organoids (PDTOs) represent a significant advancement in cancer research and personalized medicine. These organoids, derived from various cancer types, have shown the ability to retain the genetic and molecular characteristics of the original tumors, allowing for the detailed study of tumor biology and drug responses on an individual basis. The success rates of establishing PDTOs vary widely and are influenced by factors such as cancer type, tissue quality, and media composition.

Evaluating the Anti-inflammatory Efficacy of a Novel Bipyrazole Derivative in Alleviating Symptoms of Experimental Colitis.

Aims: This aims to assess the efficacy of 2', 3, 3, 5'-Tetramethyl-4'-nitro-2'H-1, 3'-bipyrazole (TMNB), a novel compound, in colitis treatment.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with limited effective treatments available. The exploration of new therapeutic agents is critical for advancing treatment options.

Variants Underlie Polycystic Kidneys in Prenatal and Neonatal Cases.

Background: Nephronophthisis (NPHP) is an autosomal recessive genetic disorder that can cause early-onset kidney failure. plays an important role in early kidney development and encodes a protein that interacts with other proteins within the primary cilium. mutations are known to cause nephronophthisis 16 (NPHP-16).

Heme oxygenase 1 inhibitor discovery and formulation into nanostructured lipid carriers as potent and selective treatment against triple negative metastatic breast cancer.

Heme oxygenase-1 (HO-1) has been identified as a potential new target in anticancer therapy, being overexpressed in different tumors and crucial for cell proliferation. Advances in the development of specific HO-1 inhibitors should support the understanding of controlling HO-1 activity as antitumoral strategies, opening the path for future therapeutic applications. In the present study, small series of new HO-1 inhibitors were synthesized by joining a butylimidazolic pharmacophore together with a hydrophobic moiety spaced by a 2-oxybenzamide central linker.

Bodyweight and obesity perceptions among adults in Bahrain.

Background: One-third of the Bahraini population is classified as obese; however, research on the public perceptions of obesity in the country is limited.

Aim: This study evaluated perceptions of obesity among adults attending public healthcare clinics in Bahrain.

Methods: This cross-sectional, observational study combined questionnaires from 2 previously published obesity surveys to obtain data on the anthropometric measurements of weight and height from 356 participants in Bahrain.

Primary care physicians' attitudes, practices, and perceived barriers toward depression screening in older people in the Kingdom of Bahrain.

Purpose: This study aimed to explore attitudes, practices, and perceived barriers of primary care physicians (PCPs) toward depression screening in older people.

Methods: This cross-sectional study enrolled PCPs from randomly selected representative primary care centers in Bahrain. A self-administered piloted semi-structured questionnaire was used for data collection.

Statin-associated regulation of hepatic PNPLA3 in patients without known liver disease.

Background And Objectives: Statins are used for metabolic dysfunction-associated steatotic liver disease (MASLD) (NAFLD) treatment, but their role in this context is unclear. Genetic variants of patatin-like phospholipase domain containing 3 (PNPLA3) are associated with MASLD susceptibility and statin treatment efficacy. Access to liver biopsies before established MASLD is limited, and statins and PNPLA3 in early liver steatosis are thus difficult to study.

Genetically Confirmed Wilson Disease: A Retrospective Cohort Study From Bahrain.

Introduction Wilson disease (WD) is a rare inherited autosomal recessive disorder caused by a mutation in the gene. This mutation affects copper metabolism, leading to the accumulation of copper in the liver, brain, cornea, and other tissues. If not treated, WD can lead to significant morbidities.

Triple Therapy with Telmisartan, Amlodipine, and Rosuvastatin (TAR) Versus Telmisartan/Amlodipine (TA) and Telmisartan/Rosuvastatin (TR) Combinations in Hypertension and Dyslipidemia: A Systematic Review and Meta-analysis.

Introduction: Hypertension and dyslipidemia are common contributors to cardiovascular disease (CVD), often occurring together. Effectively Managing both is key to reducing mortality and morbidity, but complex regimens reduce adherence.

Aim: This study investigated the comparative efficacy and safety of a three-drug regimen (TAR) containing telmisartan, amlodipine, and rosuvastatin against two-drug combinations (TA and TR) for managing hypertension and dyslipidemia.

Parental Knowledge and Awareness Regarding Early Orthodontic Consultation in Children: A Cross-Sectional Study.

Objective: The present study aimed to assess parental knowledge and awareness of early orthodontic consultation in children.

Methods: This cross-sectional study was conducted among parents of schoolchildren who were randomly selected from public schools in the Al Ahsa region of Saudi Arabia, using a convenience sampling technique. Data were collected using a prevalidated, pretested study questionnaire distributed to parents through the schoolchildren.

Smartphone Application-Based Addiction Scale: Psychometric Evidence Across Nine Asian Regions Using Advanced Analytic Methods.

Introduction: A smartphone is a device with various functions, including wifi, application functions, mobile networks, ease of mobility, and the capability of using mobile data. Because of the aforementioned functions, people may use smartphones frequently. The Smartphone Application-Based Addiction Scale (SABAS) is a six-item questionnaire assessing smartphone addiction with promising psychometric properties.

Effect of poor glycemic control on the prevalence and determinants of anemia and chronic kidney disease among type 2 diabetes mellitus patients in Jordan: An observational cross-sectional study.

Background And Objectives: Anemia and chronic kidney disease (CKD) are common findings in diabetic patients. Lack of glycemic control is associated with increased risk of diabetic complications. This study aimed to determine the effect of poor glycemic control on the prevalence and determinants of anemia and CKD among type 2 diabetes mellitus (T2DM) patients in Jordan.

The Knowledge, Concerns, and Beliefs of Mothers Towards Febrile Convulsions and Its Management in Aseer, Saudi Arabia.

Introduction Febrile convulsions are common in children aged six months to five years, causing significant parental distress despite being generally harmless. Various beliefs about their causes exist, including high fever and supernatural factors. Previous studies indicate that mothers' education levels and occupations influence their knowledge and attitudes toward febrile convulsions.

The quality of psychosocial health and psychosocial illness among women with and without shelter homes: a cross-sectional study.

Background: Existing research on the psychosocial wellbeing of sheltered women is primarily from Western contexts, with limited studies from collectivistic cultures like Pakistan. This study aims to compare the psychosocial health and illness of sheltered women in Pakistan with those of women living with their families.

Methods: A total of 184 sheltered women and 207 women from the general population from four Pakistani cities participated in this study.

The First Reported Case of Hafnia alvei Granulomatous Mastitis in Humans.

Granulomatous mastitis (GM) is an uncommon, chronic inflammatory breast disease, mostly idiopathic. Occasionally, the causative organism is isolated. It is characterized histologically by polymorph nuclear neutrophils' predominance and the absence of caseous necrosis.

Factors associated with adherence to preventive measures against COVID-19, among adult Bahraini residents.

The COVID-19 pandemic has been a life-altering experience. It compelled individuals to alter their attitudes and habits and adopt measures to prevent the risks of infection. This research discusses factors that determine adherence to these measures, with the aim of enhancing compliance in future pandemics.