2 results match your criteria: "Araba Txagorritxu University Hospital[Affiliation]"
OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized clinical trial.
Radiother Oncol
November 2022
Radiation Oncology Department, Araba Txagorritxu University Hospital, Jose Atxotegi Kalea, s/n, 01009 Gasteiz, Spain. Electronic address:
Background And Purpose: In breast cancer (BC) patients, the involvement of four or more lymph nodes (LN) is an indication of regional irradiation. The optimal treatment strategy remains unclear when fewer nodes are involved and lymphadenectomy is not performed. We designed a clinical trial to show the non-inferiority of Incidental (INC) compared to intentional (INT) irradiation of axillary nodes in patients with early-stage BC and low burden LN involvement.
View Article and Find Full Text PDFOPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized open label trial.
Radiat Oncol
October 2020
Araba Txagorritxu University Hospital, Vitoria, Spain.
Article Synopsis
- The OPTIMAL study investigates the effectiveness of incidental irradiation of axillary lymph nodes in early-stage breast cancer patients with limited sentinel lymph node involvement, using advanced molecular techniques for better treatment standardization.
- Patients are randomly assigned to receive either comprehensive irradiation (including axillary and supraclavicular areas) or limited irradiation (only the breast and tumor bed) after conservative surgery, with the goal of demonstrating that the incidental approach is not worse regarding disease-free survival over five years.
- The study aims to address the lack of consensus in treating breast cancer patients with few affected lymph nodes and hopes that the One-Step Nucleic Acid Amplification (OSNA) technique can help identify which patients will