Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves' disease: role of TRAbs.

Graves' disease (GD) is an autoimmune disorder characterized by activation of the TSH receptor by stimulatory autoantibodies (TSH Receptor Antibodies, or TRAbs), leading to unregulated thyroid hormone production. Diagnosis is largely based on the typical clinical picture and laboratory thyroid panel. Establishment of elevated serum levels of TRAbs by competitive binding assay or cell-binding assay has its unique role in diagnosis and management of GD, especially in the differential diagnosis, therapy selection, prognostication, evaluation of thyroid function during pregnancy, peri-conceptional and neonatal thyroid workup, and in certain special situation.

Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström's Macroglobulinemia in Remission: An Unusual Report with Review.

Waldenström macroglobulinemia (WM) is a rare lymphoproliferative malignancy presenting with para-proteinemia. The symptoms are attributable to both lymphoproliferation and IgM flare. Gastrointestinal manifestations are not uncommon.

Transcatheter pulmonary valve implantation with custom-made 35-mm Myval™ transcatheter heart valve.

Transcatheter pulmonary valve implantation (TPVI) is the standard of care in patients with repaired tetralogy of Fallot (rTOF) presenting with right ventricular outflow tract (RVOT) dysfunction. However, the feasibility of TPVI is limited by the high cost and nonavailability of larger-sized valves for dilated native RVOT of rTOF patients. We report the first successful TPVI with a custom-made 35 mm balloon-expandable valve (Myval™) in a 30-year-old rTOF patient with severe pulmonary regurgitation and RV dysfunction.

Short-term and long-term changes in natriuretic peptide levels after bariatric surgery: a systematic review and meta-analysis.

Bariatric surgery (BS) has demonstrated cardiovascular benefits in patients and was previously proven to be associated with an increased natriuretic peptide level without cardiac dysfunction. However, new studies have emerged, which require us to re-examine the relationship and extent of the correlation between BS, weight loss, and cardiac natriuretic peptide levels. A systematic search was conducted.

Treatment Versus Observation in Early Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Purpose: Early gestational diabetes mellitus (eGDM) refers to elevated blood glucose levels not meeting the criteria for overt diabetes before 20 weeks gestation. Observational studies link eGDM to adverse outcomes, but randomized controlled trial (RCT) evidence on early intervention benefits remains inconclusive. To address this, we performed a systematic review and meta-analysis (SRM) of RCTs on this subject.

Hospitalizations in patients with systemic sclerosis: Differences between limited and diffuse cutaneous subtypes.

Aim: Systemic sclerosis is associated with significant morbidity and mortality. It remains unclear from the literature if there are differences between the subtypes of systemic sclerosis and the rate of hospitalization. Our study investigates the rates of all types of hospitalizations between limited and diffuse cutaneous systemic sclerosis.

Colours of India: Uniting Endocrinologists in Fitness and Friendship.

Colours of India is an annual cultural phenomenon that transcends the boundaries of professional conferences, uniting endocrinologists through the universal language of music and dance. Since its inception in 2016, this vibrant event has brought together teams from across India and other participating countries, showcasing diverse dance forms while fostering friendships, promoting wellness, and celebrating cultural diversity within the medical community.

Olmesartan: 360-degree Perspectives Befitting an Angiotensin Receptor Blocker.

India has a high burden of hypertension (HTN), which is often poorly controlled, leading to hypertension-mediated organ damage (HMOD). In the management of HTN, angiotensin receptor blockers (ARBs) assume prime importance, being first-line agents for most patient subgroups. Olmesartan is a highly efficacious ARB that demonstrates sustained blood pressure (BP) reduction over 24 hours.

Reverse Sleeve Placement in Complex Total Hip Arthroplasty for a Patient with Severe Valgus Deformity of the Trochanter-Surgical Technique and Case Report.

Introduction: It is rare to encounter a patient with severe valgus deformity of the greater trochanter with severe osteoarthritis of the hip joint. The treatment, that is total hip arthroplasty (THA) in such a case presents with a surgical challenge in proper placement of the femoral stem. Traditionally, an osteotomy procedure to correct the femoral deformity was warranted followed by THA.

Long-Term Outcome of One-Anastomosis Gastric Bypass: 10-Year Follow-Up of a Single Institution Series.

Background: This study aims to evaluate the long-term efficacy, safety, nutritional status, and resolution of obesity complications of patients following one-anastomosis gastric bypass (OAGB).

Methods: A retrospective observational study of patients who underwent OAGB in our center between January 2011 and December 2013 was performed.

Results: During the study period, 152 patients underwent OAGB procedure in our center.

Optimization of Infant Nutrition: Exploring Feeding Practices Among Indian Mothers.

Objective: This study aims to investigate infant and young child feeding practices in an outpatient setting in India.

Material And Methods: About 103 parents of healthy children aged ≤6 years seeking outpatient pediatric care at an urban tertiary care hospital over one month were included in this observational study. Data regarding feeding practices was collected using a pre-designed and pretested questionnaire.

The High Burden of Asymptomatic Kidney Diseases in Individuals with HIV: A Prospective Study from a Tertiary Care Center in India.

Background: HIV infection is associated with a significant kidney disease burden. This study is aimed to screen for kidney disease in all HIV patients on highly active anti retroviral therapy (HAART), study clinico-histological correlation, and assess the impact of early diagnosis on the clinical course.

Materials And Methods: It was a prospective, longitudinal study done in a tertiary care hospital.

Robotic-Assisted Vesicovaginal Fistula Repair: A Comparative Analysis Between Hugo RAS and da Vinci Xi Systems.

Objective: To compare the outcomes of vesicovaginal fistula (VVF) repair using two different robotic systems.

Design: This retrospective comparative study analysed the surgical outcomes of VVF repair utilizing two different robotic platforms: the Hugo RAS Medtronic robot and the da Vinci Xi robot.

Methods: VVF repair was performed with da Vinci Xi system (n = 15) and Hugo RAS Medtronic robot (n = 11) in a non-randomized fashion.

Identifying key factors for recurrence of genetic disorder: insights from Indian families with multiple affected children.

This study investigates the factors contributing to the recurrence of severe genetic conditions in multiple children of the same couple, focusing on a cohort of 26 families who had more than one child affected by the same genetic disorder. Conducted at a genetic clinic in India, the study employed a qualitative methodology guided by COREQ guidelines, using semi-structured interviews to explore the interplay of individual beliefs, healthcare provider practices, and systemic healthcare inefficiencies. The interviews were transcribed and analyzed using a combination of content analysis and grounded theory, which allowed for the identification of recurrent themes and emerging ideas.