7,442 results match your criteria: "Aplasia Cutis Congenita"
Pediatr Int
December 2024
Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
Background: Clinical studies have shown that diffuse chorioamniotic hemosiderosis (DCH) is a risk factor for bronchopulmonary dysplasia (BPD). However, the details of the underlying mechanism are unknown. We focused on iron, one of the blood components that diffuses within the amniotic cavity in DCH.
View Article and Find Full Text PDFPediatr Dermatol
December 2024
Department of Pediatric Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
We describe a 1-day old female with features of keratitis-ichthyosis-deafness (KID) syndrome and natal teeth. Genetic analysis confirmed GJB2 263C and A88V de novo pathogenic variants consistent with KID syndrome. Natal teeth were promptly extracted to avoid the risk of aspiration.
View Article and Find Full Text PDFClin Oral Investig
December 2024
Postgraduate in Oral Surgery, University of Florence, Florence, Italy.
Background: Tooth agenesis refers to the absence of one or more of the deciduous or permanent teeth. Tooth agenesis results from a series of disrupted reciprocal ectodermal mesenchymal interactions taking place during the early stages of tooth development.
Methods: A narrative literature review was performed to describe the main genetic syndromes associated with tooth agenesis.
Ann Med Surg (Lond)
December 2024
Nepal Medical College and Teaching Hospital, Kathmandu, Nepal.
Introduction: Bart syndrome is a rare genetic disorder characterized by epidermolysis bullosa (EB), aplasia cutis congenita, that is congenital local absence of skin and nail abnormalities.
Case Presentation: The authors herein, present a case of a 14-year-old boy with Bart syndrome. The syndrome was diagnosed clinically.
Cell Commun Signal
December 2024
CNR Institute of Biochemistry and Cell Biology, Monterotondo, Rome, 00015, Italy.
Connexins (Cxs) are fundamental in cell-cell communication, functioning as gap junction channels (GJCs) that facilitate solute exchange between adjacent cells and as hemichannels (HCs) that mediate solute exchange between the cytoplasm and the extracellular environment. Mutations in the GJB1 gene, which encodes Cx32, lead to X-linked Charcot-Marie-Tooth type 1 (CMTX1), a rare hereditary demyelinating disorder of the peripheral nervous system (PNS) without an effective cure or treatment. In Schwann cells, Cx32 HCs are thought to play a role in myelination by enhancing intracellular and intercellular Ca signaling, which is crucial for proper PNS myelination.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Department of Plastic and Reconstructive Surgery, Monash Health, Melbourne, VIC, Australia.
Aplasia cutis congenita (ACC) is a rare congenital condition characterized by the absence of skin and subcutaneous tissue, typically affecting the scalp. This case report presents a female infant born at 38+3 weeks with a posterior midline scalp defect measuring 15×12.5 mm, involving skin, subcutaneous tissue, and calvarium.
View Article and Find Full Text PDFAnticancer Res
December 2024
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
Orphanet J Rare Dis
December 2024
Department of Dermatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 67, Aarhus N, 8200, Denmark.
Semin Pediatr Neurol
December 2024
Dell Medical School, The University of Texas at Austin, Austin, TX, USA. Electronic address:
BMJ Case Rep
November 2024
Endocrinology, Nizam's Institute of Medical Sciences, Hyderabad, India
Am J Med Genet A
November 2024
Pediatric Genetics, Ege University, Izmir, Turkey.
Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies (EDFAOB) is a rare neuroectodermal syndrome caused by somatic mosaic mutations in the RHOA gene. It presents with linear skin hypopigmentation, facial and limb asymmetry, dental and acral anomalies, and leukoencephalopathy, generally preserving intellectual and neurological functions. We report two cases of EDFAOB.
View Article and Find Full Text PDFJ Exp Med
January 2025
Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK.
J Craniofac Surg
November 2024
Department of Surgery, The University of Illinois College of Medicine, Shriners Hospital for Children-Chicago, UIHealth UIC Craniofacial Center, Chicago, IL.
Normal speech production is a complex mechanism requiring the coordination of several organs of the oral cavity. The lip, hard and soft palates, and teeth all play a role in normal speech production. In cases of craniofacial birth conditions such as cleft lip and palate or ectodermal dysplasia, one or more of these areas may be compromised.
View Article and Find Full Text PDFCureus
October 2024
Department of Dermatology, Naval Medical Center San Diego, San Diego, USA.
We report a case of a patient with genetic sequencing-confirmed X-linked hypohidrotic ectodermal dysplasia without the typical characteristic hair growth abnormalities with the disorder. While this patient had already received guidance from a genetic counselor about his condition, many cases of ectodermal dysplasia go underdiagnosed or misdiagnosed due to mild or atypical presentations. With gene therapies emerging, the authors hope to highlight the importance of recognizing the disorder in patients who have not yet received a diagnosis to better manage their clinical course and guide future life decisions.
View Article and Find Full Text PDFGenes Genet Syst
November 2024
Department of Biology, Institute of Graduate Education, Adiyaman University.
The ClinVar accession number on p. 176 (SCV002817173) should be replaced with the correct number, SCV002817373. The PDF file for DOI: https://doi.
View Article and Find Full Text PDFPediatr Blood Cancer
January 2025
Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
We report two neurocutaneous melanocytosis (NCM) patients who required ventriculoperitoneal shunt placement and subsequently developed intraperitoneal melanoma. These patients with NCM are at an increased risk for developing NRAS-associated melanomas in the central nervous system, which in turn may lead to symptomatic hydrocephalus requiring cerebrospinal fluid diversion. Due to the rarity of NCM, current knowledge on disease progression and appropriate management is limited.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
December 2024
Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China; Hubei Clinical Research Center for Reproductive Medicine, Shiyan, Hubei, China; Shiyan Key Laboratory of Reproduction and Genetics (Renmin Hospital, Hubei University of Medicine), Shiyan, Hubei, China; Biomedical Engineering College, Hubei University of Medicine, Shiyan, Hubei, China; Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, Hubei, China. Electronic address:
Objective: This study conducted genetic testing and analysis on the fetal tissue of a terminated pregnancy to clarify the cause of the fetal abnormalities.
Methods: A fetus with multiple malformations detected during mid-pregnancy was terminated. Trio whole exome sequencing (Trio-WES) was performed on the fetal tissue.
Immunol Med
November 2024
Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
Eur J Med Genet
December 2024
Department of Clinical Genetics, Aarhus University Hospital, Olof Palmes Allé 49, 8200 Aarhus N, Denmark.
Hypohidrotic Ectodermal Dysplasia is a syndrome with hypotrichosis, hypohidrosis, and hypodontia as the main symptoms. The prevalence is estimated to one in 5000-10,000 persons. In 10-15% the disease is caused by pathogenic variants in EDAR, and most of the known causal variants to date are missense or nonsense variants.
View Article and Find Full Text PDFInt J Dermatol
October 2024
Division of Dermatology, Department of Medicine, Endeavor Health, Skokie, IL, USA.
Int J Mol Sci
October 2024
Research Centre for Medical Genetics, 115522 Moscow, Russia.
Semin Pediatr Neurol
October 2024
Division of Child Neurology, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. Electronic address:
Semin Pediatr Neurol
October 2024
University of Texas at Austin, Dell Children's Medical Center, United States.
Semin Pediatr Neurol
October 2024
Department of Neurology, Dell Medical School, The University of Texas at Austin, 1601 Trinity St., Bldg. B, Stop Z0700, Austin, TX 78712, United States. Electronic address:
Semin Pediatr Neurol
October 2024
The University of Texas at Austin, Dell Medical School, Department of Neurology, 1601 Trinity Street, Building B, Austin, TX 78712, USA; Dell Children's Medical Center, 4910 Mueller Blvd. Suite 300 Austin, TX 78723, USA. Electronic address: