Quality of life measures for people following stroke: a structured content review.

Introduction: Patient Reported Outcome Measures (PROMs) are used widely to collect patient perspectives on their Health-Related Quality of Life (HRQoL) after stroke. Existing reviews on PROMs typically report the psychometric properties but rarely focus on the content validity. We performed a structured review of the content of items of stroke-specific HRQoL outcomes.

Rehabilitation of post-stroke aphasia by a single protocol targeting phonological, lexical, and semantic deficits with speech output tasks: a randomized controlled trial.

Background: The defective spoken output of persons with aphasia has anomia as a main clinical manifestation. Improving anomia is therefore a main goal of any language treatment.

Aim: This study assessed the effectiveness of a novel, 2-week, rehabilitation protocol (PHOLEXSEM), focused on PHonological, SEmantic, and LExical deficits, aiming at improving lexical retrieval, and, generally, spoken output.

Cardiac Tumor with Dual Component of Myxoma and Angiofibroma Presented with Syncope: An Extremely Rare Case Report.

Background: Primary cardiac tumors (PCT), such as myxoma, are rare and predominantly benign. Angiofibroma tumors are an extremely rare subtype of PCT, reported in less than ten cases. In this study, we presented a mixed tumor of myxoma and angiofibroma for the first time in the human heart.

Investigation of caregiver burden, quality of life, and occupational performance of primary caregivers of individuals having experienced a stroke with and without aphasia.

Background: Individuals having experienced a stroke need the help of an individual to perform their activities of daily living. Therefore, the disease affects not only patients but also their caregivers.

Objectives: This study aimed to investigate how aphasia affects caregivers' burden of care, quality of life, and occupational performance.

Neuroanatomical correlates of language impairment in non-fluent variant of primary progressive aphasia.

Introduction: Non-fluent variant of primary progressive aphasia (nfvPPA) is a neurodegenerative disorder with a predominantly speech and language impairment. Apraxia of speech and expressive agrammatisms along with decreased speech fluency and impaired grammar comprehension are the most typical disorder manifestations but with the course of the disease other language disturbances may also arise. Most studies have investigated these symptoms individually, and there is still no consensus on whether they have similar or different neuroanatomical foundations in nfvPPA.

Hyperglycemia-induced isolated aphasic status epilepticus a case-report and literature review.

Neurological manifestations of nonketotic hyperglycemia are frequently seen, with mainly symptoms of confusion or coma. While hyperglycemia-induced seizures are less common, isolated aphasic status epilepticus is very rare, difficult to diagnose, and may be unrecognized by clinicians. In this case report, a 51-year-old man who presented with confusion and incoherent speech for two weeks is discussed.

Communication training program for nurses caring for patients with aphasia: a quasi-experimental study.

Background: Nurses are key communication partners for patients with aphasia. Nurses' skills are vital for improving the patients' environment and nursing performance. This study develops and evaluates the effectiveness of a communication training program for nurses who care for patients with aphasia.

The Epilepsy-Aphasia Syndrome gene, Cnksr2, Plays a Critical Role in the Anterior Cingulate Cortex Mediating Vocal Communication.

Epilepsy Aphasia Syndrome (EAS) is a spectrum of childhood disorders that exhibit complex co-morbidities that include epilepsy and the emergence of cognitive and language disorders. CNKSR2 is an X-linked gene in which mutations are linked to EAS. We previously demonstrated Cnksr2 knockout (KO) mice model key phenotypes of EAS analogous to those present in clinical patients with mutations in the gene.

[Analysis of the clinical features and prognosis of neuro-Behcet's syndrome in 5 children].

To investigate the clinical features and prognosis of neuro-Behçet's syndrome (NBS) in children. The clinical, brain magnetic resonance imaging and laboratory data of 5 children with NBS diagnosed in the Department of Pediatrics, General Hospital of Ningxia Medical University and Department of Rheumatology and Immunology, Children's Hospital Affiliated to Capital Institute of Pediatrics from April 2014 to April 2024 were analyzed retrospectively. The follow-up method was retrospective outpatient or inpatient visit to evaluate the treatment effect of NBS.

[Case of ictal aphasia and post-ictal aphasia due to focal epilepsy associated with cerebral hemorrhage].

The patient was a 69-year-old right-handed woman. She had sensory aphasia, and the brain MRI revealed a subacute phase hemorrhage in the left subcortical temporal lobe. We speculated that the patient had post-ictal aphasia due to symptomatic epileptic seizures associated with cerebral hemorrhage.

Postoperative fragmentation and distal migration of Carotid Stent in vascular Eagle Syndrome.

Objectives: Vascular Eagle syndrome (ES) is a rare condition involving vessel compression by an elongated styloid process, leading to neurologic symptoms. Here, we present the case of a patient with a complication of carotid artery stenting for vascular ES and discuss the implications of treatment of this rare condition.

Case Description: A 35-year-old previously healthy male patient presented with transient aphasia and right-sided hemiparesis following ischemic stroke in left frontal lobe.

[Evaluation of the effectiveness of the drug Cortexin in combination with the use of the application Aphasia.No (Afaziyam.Net) in the correction of speech disorders in patients with cerebral infarction].

Objective: Assessing the effectiveness of using a complex that includes the use of the drug Cortexin and classes using the mobile application Aphasia.No (Afaziyam.Net) in working with speech disorders in patients with acute stroke.

[The effectiveness of drug therapy in the rehabilitation of patients with post-stroke aphasia].

Objective: To evaluate the effectiveness of the restoration of aphasic disorders in patients in the early recovery period of ischemic stroke (IS) who received complex therapy, which included speech therapy and injections of the drug Cellex.

Material And Methods: The study included 62 right-handed patients with aphasia hospitalized in the acute period of IS in Ramenskoye Hospital, who subsequently underwent the second stage of rehabilitation in the neurological department of the Moscow regional clinical institute .a.

The Active Ingredients of Semantic Naming Treatment: Evidence From Mandarin-English Bilingual Adults With Aphasia.

Purpose: Following the Rehabilitation Treatment Specification System (RTSS) framework, the current study investigated the active ingredients in the modified semantic feature analysis (mSFA) targeting either noun or verb retrieval in Mandarin-English bilingual adults with aphasia (BWA).

Method: Twelve Mandarin-English BWA completed mSFA treatment for nouns and verbs. Eight of them completed both noun and verb treatment, while four completed either type of treatment.

TEleRehabilitation foR Aphasia (TERRA) phase II trial design.

Background And Purpose: Despite comprehensive evidence that supports the utility of aphasia therapy in persons with chronic (≥6 months) stroke-induced aphasia, the amount of therapy provided to patients in the United States is typically far less than what is likely necessary to maximize recovery. Two potential contributors to this discrepancy are limited access to rehabilitation services due to the availability of providers and logistical difficulties with transportation. One way to increase access to aphasia therapy is to rely on telerehabilitation.

Item response theory for the color-picture version of Boston naming test in a Chinese sample with neurodegenerative diseases.

Background: Although Boston Naming Test has been thoroughly validated at a global level, there is limited assessment of item-level properties using modern psychometric methods.

Objective: This study aimed to investigate the construct validity and item-level properties of the color-picture version of Boston Naming Test (CP-BNT) in a Chinese cohort with neurodegenerative diseases.

Methods: This retrospective study included 424 participants, consisting of 118 normal controls, 152 with Alzheimer's disease, 101 with primary progressive aphasia, and 53 with other neurodegenerative diseases.

Leveraging relatedness-based measures in people with language disorders: A scoping review.

Understanding lexico-semantic processing is crucial for dissecting the complexities of language and its disorders. Relatedness-based measures, or those which investigate the degree of relatedness in meaning between either task items or items produced by participants, offer the opportunity to harness novel computational and analytical techniques from cognitive network science. Recognizing the need to deepen our understanding of lexico-semantic deficits through diverse experimental and analytical approaches, this review explores the use of such measures in research into language disorders.

The Underestimated Role of Iron in Frontotemporal Dementia: A Narrative Review.

The term frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders characterized by the progressive degeneration of the frontal and temporal lobes of the brain with language impairment and changes in cognitive, behavioral and executive functions, and in some cases motor manifestations. A high proportion of FTD cases are due to genetic mutations and inherited in an autosomal-dominant manner with variable penetrance depending on the implicated gene. Iron is a crucial microelement that is involved in several cellular essential functions in the whole body and plays additional specialized roles in the central nervous system (CNS) mainly through its redox-cycling properties.

Two novel variants in GRN: the relevance of CNV analysis and genetic screening in FTLD patients with a negative family history.

Background: Frontotemporal lobar degeneration (FTLD) is one of the leading causes of early onset dementia. Pathogenic variants in GRN have been reported to cause 5-25% of familial and 5% of sporadic FTLD. Here, we present two novel, likely pathogenic variants in GRN.

Investigating the involvement of the left and right hemisphere in speech production and its correlation with handedness - a repetitive transcranial magnetic stimulation study.

Purpose: While traditional theories suggest a link between language lateralization and handedness, recent evidence indicates more complex neural networks underlying speech processing. This study aimed to investigate the involvement of the left and right hemispheres in speech production using repetitive transcranial magnetic stimulation (rTMS).

Methods: A cohort of 58 healthy volunteers with a median age of 23 (range 19-34) were included in the study.

Gesture profiles distinguish primary progressive aphasia variants: A preliminary study.

Background: Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive language deficits. The main variants of PPA -semantic (svPPA), logopenic (lvPPA), and nonfluent (nfvPPA)- can be challenging to distinguish. Limb apraxia often co-occurs with PPA, but it is unclear whether PPA variants are associated with different gesture deficits.

Bimodal aphasia and dysgraphia: Phonological output buffer aphasia and orthographic output buffer dysgraphia in spoken and sign language.

We report a case of crossmodal bilingual aphasia-aphasia in two modalities, spoken and sign language-and dysgraphia in both writing and fingerspelling. The patient, Sunny, was a 42 year-old woman after a left temporo-parietal stroke, a speaker of Hebrew, Romanian, and English and an adult learner, daily user of Israeli Sign language (ISL). We assessed Sunny's spoken and sign languages using a comprehensive test battery of naming, reading, and repetition tasks, and also analysed her spontaneous-speech and sign.

Altered neurovascular coupling in semantic variant primary progressive aphasia.

Background: Semantic variant primary progressive aphasia (svPPA) is one of the main clinical phenotypes of frontotemporal lobar degeneration. Changes in both neuronal activity and cerebral perfusion have been observed in svPPA, suggesting a possible breakdown of neurovascular coupling (NVC).

Objective: To investigate alterations in NVC and their correlations with clinical manifestations in svPPA patients.

Psycho-oncological burden in patients with brain metastases undergoing neurological surgery.

Purpose: The development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine.

Augmenting Verb-Naming Therapy With Neuromodulation Decelerates Language Loss in Primary Progressive Aphasia.

Purpose: The purpose of the study was to evaluate Verb Network Strengthening Treatment (VNeST) paired with the transcranial direct current stimulation (tDCS) of the left inferior frontal gyrus, which was compared to VNeST paired with a sham stimulation in primary progressive aphasia (PPA).

Method: A double-blind, within-subject, sham-controlled crossover design was used. Eight participants with PPA were enrolled.