3,526 results match your criteria: "Aortitis"

Objectives: Thoracic aortic aneurysms and dissections provide a complex surgical cohort termed thoracic aortic surgery. Regular follow-up at specialist clinics with cross-sectional imaging is recommended. Identifying risk factors that lead to re-operations as well as the requirement for and appropriate length of follow-up remain points of debate.

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Venereal syphilis, caused by Treponema pallidum, is a major global health problem. Untreated latent syphilis can progress to tertiary syphilis, often leading to severe complications such as cardiac involvement, particularly syphilitic aortitis, which may manifest decades after the initial infection. We present a case of a 46-year-old woman who developed an ascending aortic aneurysm and severe aortic valve insufficiency due to late-stage syphilis.

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Objectives: Onco-rheumatology, the intersection of oncology and rheumatology, is an emerging field requiring further definition. This study aimed to identify the knowledge and skills essential for rheumatologists in clinical oncology.

Methods: We retrospectively reviewed consultations with the onco-rheumatology department of a high-volume tertiary cancer centre in Japan from January 2020 to December 2023.

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Aortitis is an uncommon cause of aortic aneurysms. Arterial inflammation can lead to irreversible vascular damage. Early recognition is necessary for treatment to prevent permanent consequences of vessel inflammation.

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Granulocyte Colony-Stimulating Factor-Associated Aortitis Unveiled by 18F-FDG PET/CT.

Clin Nucl Med

December 2024

From the Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.

In oncology, G-CSF (granulocyte colony-stimulating factor) is often administered to counteract chemotherapy-induced neutropenia. Recent studies have highlighted a significant side effect, G-CSF-associated aortitis, with an incidence of ~0.4%.

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Background: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis usually affects small blood vessels and is characterized by the presence of circulating autoantibodies (c-ANCA or p-ANCA). The risk of cardiovascular events is threefold higher compared to general population, and cardiac manifestations include myocarditis, pericarditis, valvulitis, aortitis, or coronary arteritis. Coronary involvement is very rare, but it is a potentially life-threatening manifestation.

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IgG4-Related Arterial Disease: An Unusual Case of Aortitis.

J Rheumatol

December 2024

Eric Hachulla, MD, PhD, Hospital Center, Université de Lille, Institute for Translational Research in Inflammation (INFINITE), and Inserm, Lille; and CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de référence des maladies autoimmunes systémiques rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.

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Most reported cases of large vessel vasculitis (LVV) following coronavirus disease 2019 (COVID-19) have involved adults, with paediatric cases being rare. We present the case of a 14-year-old boy who developed LVV following COVID-19. Initially, he presented with fever and cough, and nasopharyngeal polymerase chain reaction testing confirmed COVID-19.

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Extraintestinal manifestations in inflammatory bowel disease (IBD) most frequently involve the joints, skin, and organs such as the liver and pancreas. Inflammation of the aorta is less commonly described in pediatrics, although it has been described in adults. We report a case of an adolescent female with Crohn's disease who presented with worsening diarrhea, vomiting, and weight loss, found to have aortitis on imaging.

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Article Synopsis
  • Interleukin-1 is a key pro-inflammatory cytokine linked to the development of inflammatory diseases, where its absence in knockout mice leads to conditions like aortitis, arthritis, and dermatitis.
  • Research shows that transferring T cells from these IL-1Ra KO mice into nude mice causes similar inflammatory diseases, raising questions about which specific T cell subsets are involved.
  • The study found increased levels of a particular CD4+ T cell subset that produces granulocyte macrophage colony-stimulating factor (GM-CSF) in IL-1Ra KO mice, suggesting these cells play a significant role in the enhanced inflammation observed in these models.
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Introduction: We conducted a comprehensive comparative analysis of the Okazaki, Umehara, and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for diagnosing immunoglobulin G4-related disease (IgG4-RD).

Materials And Methods: A retrospective study was conducted in a single tertiary hospital, using expert clinical judgment as the gold standard. We compared the diagnostic accuracy of the Okazaki, Umehara, and ACR/EULAR criteria in a cohort of 41 patients with suspected IgG4-RD.

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Background: Takayasu arteritis (TA) and tuberculosis (TB) share similar histopathological and immunological characteristics. Studies comparing patients with TA with or without active or latent TB infection (LTBI) have revealed some differences in clinical and angiographic profiles. Patient with TA and history of TB exhibited more constitutional symptoms and structural damage to the aorta.

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Background: IgG4-related disease (IgG4-RD) is a relapsing-remitting, fibroinflammatory, multisystem disorder. Cardiovascular involvement from IgG4-RD has not been systematically characterised. In this study, we sought to evaluate consecutive patients with IgG4-RD using a detailed multiparametric cardiovascular magnetic resonance (CMR) imaging protocol.

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Giant cell aortitis combined with arteritis and coarctation of the aorta in 3.5-month child: A case report and literature review.

Cardiovasc Pathol

November 2024

Department of Pathology and Forensic Medicine, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Lviv, 69, Pekarska str., 79010. Electronic address:

Article Synopsis
  • The case details a rare instance of giant cell aortitis (GGA) combined with aortic coarctation in a 3.5-month-old girl, showcasing its uniqueness in medical literature.
  • The infant experienced severe symptoms following a viral infection, leading to multiple organ failure and death just 20 hours after hospitalization.
  • Pathological examinations revealed significant inflammation and structural abnormalities in the aorta and its branches, marking this case as the youngest documented patient with this rare combination of conditions.
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Takayasu arteritis and spondyloarthritis are two rheumatological diseases whose co-existence is well-documented in the literature. Data on the presence of inflammatory back pain in Takayasu arteritis without a diagnosis of spondyloarthritis, however, is scarce. Here, we present a 33-year-old man who was admitted to the emergency department with acute-onset chest pain associated with left carotidynia, carotid bruit, and left arm claudication, normal electrocardiogram and computed tomography angiographic features suggesting Takayasu arteritis, including stenosis and occlusion of the aorta and its branches.

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Introduction: Melioidosis is caused by Burkholderia pseudomallei and primarily affects non-vascular organ systems. We present a case of a melioidotic penetrating aortic ulcer (PAU) with unusual clinical features of vascular infection. The patient was successfully treated with a single-stage neoaortoiliac system procedure, highlighting the challenges in managing melioidotic aortic infections.

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FDG PET/CT in large vessel vasculitis.

J Med Imaging Radiat Oncol

October 2024

Department of Nuclear Medicine and PET, The Prince of Wales Hospital, Sydney, New South Wales, Australia.

Large vessel vasculitides (LVV) such as giant cell arteritis, Takayasu arteritis and aortitis/periaortitis are characterised by immune-mediated inflammation of medium to large arteries. Clinical disease manifestations can be non-specific and diagnostic imaging plays an important role in the diagnostic pathway. In recent years, FDG PET/CT has proven to be a powerful metabolic tool that can provide a wholed body, non-invasive assessment of vascular inflammation.

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Imaging studies have transformed the diagnosis of large vessel vasculitis (LVV) involvement in giant cell arteritis (GCA). A positron emission tomography/computed tomography (PET/CT) scan with 18-fluorodeoxyglucose (18F-FDG) has emerged as a valuable tool for assessing LVV. We aimed to determine the utility of an 18F-FDG-PET/CT scan in detecting LVV in GCA in the ARTESER registry.

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Atypical Presentation of Tertiary Syphilis.

Radiol Cardiothorac Imaging

October 2024

From the Departments of Radiology (P.C., L.C.) and Internal Medicine (J.S., D.F.), University Hospital Gabriel Montpied, 58 rue Montalembert, F-63000 Clermont-Ferrand, France; and Department of Radiology, Institut Pascal, TGI, UMR6602 CNRS SIGMA Université Clermont Auvergne, Clermont-Ferrand, France (L.C.).

Syphilis is a sexually transmitted infection characterized by multiple stages. Cardiovascular involvement is a manifestation of tertiary syphilis, occurring between 10 and 40 years after the primary infection. The authors present a case of atypical presentation of tertiary syphilis in a 49-year-old male patient who was admitted to the hospital with bilateral transient loss of vision.

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Article Synopsis
  • The study aimed to investigate the differences in cytotoxic CX3CR1+ T cell subsets between two types of large vessel vasculitis: giant cell arteritis (GCA) and Takayasu's arteritis (TAK).
  • Scientists analyzed blood samples from 30 patients (22 with GCA and 8 with TAK) and 16 healthy individuals to compare the proportion of CX3CR1+ CD4+ and CD8+ T cells, as well as their presence in inflamed arteries.
  • The results reveal a significant increase in CX3CR1+ CD4+ T cells in GCA, associated with inflammation severity, while no such correlation was found in TAK, suggesting that these cells play a crucial role
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Article Synopsis
  • A 54-year-old woman was admitted with recurrent abdominal pain and new chest pain, leading to the discovery of a thoracic aortic aneurysm, suspected to involve intramural hematoma or aortitis.
  • Initial conservative treatment was followed by surgical intervention after imaging suggested intramural hematoma, but surgery revealed severe aortitis without hematoma, indicating complex diagnostic challenges.
  • Further examination identified IgG4-related disease linked to chronic lymphocytic leukemia (CLL), highlighting the need for a multidisciplinary approach and various diagnostic methods to accurately assess aortic conditions.
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Incidentally detected noninfectious thoracic aortitis: A clinical approach.

Cleve Clin J Med

October 2024

Associate Professor, Division of Rheumatology, University of Alberta, Edmonton, Canada

Article Synopsis
  • * Treatment depends on the underlying cause, so patients must undergo comprehensive evaluations and tests, along with consultations from specialists in vasculitis.
  • * Due to a high risk of future vascular issues, patients with aortitis require ongoing monitoring through regular check-ups and imaging studies.
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[Periaortic gas and signs of dissection of a mycotic aneurysm in the descending thoracic aorta due to Clostridium septicum].

Inn Med (Heidelb)

September 2024

Klinik für Kardiologie, DRK Köpenick, Salvador-Allende-Str. 2-8, 12559, Berlin, Deutschland.

Article Synopsis
  • * Given the link between Clostridium septicum and colorectal cancer, a colonoscopy was conducted, resulting in the identification and removal of an adenocarcinoma.
  • * Five months later, the patient experienced severe symptoms, and a CT scan showed a mycotic aneurysm in the aorta, prompting a conservative treatment approach due to his delicate health condition.
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